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The map label for this gene is nadC [H]

Identifier: 126176107

GI number: 126176107

Start: 4611303

End: 4612184

Strand: Direct

Name: nadC [H]

Synonym: Sbal_3917

Alternate gene names: 126176107

Gene position: 4611303-4612184 (Clockwise)

Preceding gene: 126176097

Following gene: 126176108

Centisome position: 89.93

GC content: 47.96

Gene sequence:

>882_bases
ATGTTAGAAAACGATATTCGCCAGTCAGTAAAATCCGCACTCAGTGAAGACTTAGGCGGCACCGAAATCAACGATCAAAC
CAAGGCCATCGCTTATGGTGATATCACAGCAATGTTGATCCCTGCTGATAAGTACGCTGAAGCCACCCTTATTACCCGTG
AAGAAGGCGTTTTTTGTGGAAAAGCATGGGCCGAACAAGTTTTTAATCAACTCGGTGGGGAAGTAGCACTGCATTGGCAT
GTGGATGATGGCGATCTGGTATTACCTAACCAGTTACTGTGTGAACTATCGGGCCCAGCGCGCACGATTCTCACCGGCGA
ACGCACGGCAATGAACTTTATCCAAACCCTGTCTGGCGTTGCGACCTTAACTAAGCATTATGTCGATAAACTGGTGGGCA
CTCACACTCGCCTATTAGATACTCGCAAAACCATTCCAGGCCTGCGCACCGCCCAGAAATATGCCGTCACCTGCGGCGGC
GGCAAAAACCATCGCATTGGCTTATATGATGCATTTTTGATTAAAGAAAACCACATTATGGCCTGTGGTGGCATTCGCCA
AGCCGTAGATACCGCCCGCAGCTTGTACCCGAACAAACCCGTTGAAGTCGAAGTGGAATCACTCGAAGAACTCGCCTTAG
CACTCGACTCTGGCACAGATATCATCATGTTAGATAACTTCGACATAACTAAGATGGTCGAAGCGGTTGAAATGAACAAT
CAATATAAAGCGAAAGGCGCCAGCGCTAAGCTTGAAGTCTCCGGCAATGTCACCTTAGACACTTTAGCCGAATTTGCCAA
AACCGGTGTCGACTATATCTCAGTTGGTGCTCTCACTAAGCATGTTCGCGCCCTAGACTTGTCTCTTCGATTAAAAGCCT
AA

Upstream 100 bases:

>100_bases
CACAATCTTCCAAGCTGTTCCGTGAGACCTAAGGCCGTGGTAATCTTAACCTAAGATGCAAGTAGGTCGTCAGTAATTAA
AGAATGCAAGGACCCCGCTC

Downstream 100 bases:

>100_bases
ACACTCATTCCCTAGAATGTGAAACGTTCGCTGAAAGCACCTTAGAACGTTTCACTTTCAACCTATTCTAGAGCGATACA
TTTCTTCATAGTTCCACGAG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MLENDIRQSVKSALSEDLGGTEINDQTKAIAYGDITAMLIPADKYAEATLITREEGVFCGKAWAEQVFNQLGGEVALHWH
VDDGDLVLPNQLLCELSGPARTILTGERTAMNFIQTLSGVATLTKHYVDKLVGTHTRLLDTRKTIPGLRTAQKYAVTCGG
GKNHRIGLYDAFLIKENHIMACGGIRQAVDTARSLYPNKPVEVEVESLEELALALDSGTDIIMLDNFDITKMVEAVEMNN
QYKAKGASAKLEVSGNVTLDTLAEFAKTGVDYISVGALTKHVRALDLSLRLKA

Sequences:

>Translated_293_residues
MLENDIRQSVKSALSEDLGGTEINDQTKAIAYGDITAMLIPADKYAEATLITREEGVFCGKAWAEQVFNQLGGEVALHWH
VDDGDLVLPNQLLCELSGPARTILTGERTAMNFIQTLSGVATLTKHYVDKLVGTHTRLLDTRKTIPGLRTAQKYAVTCGG
GKNHRIGLYDAFLIKENHIMACGGIRQAVDTARSLYPNKPVEVEVESLEELALALDSGTDIIMLDNFDITKMVEAVEMNN
QYKAKGASAKLEVSGNVTLDTLAEFAKTGVDYISVGALTKHVRALDLSLRLKA
>Mature_293_residues
MLENDIRQSVKSALSEDLGGTEINDQTKAIAYGDITAMLIPADKYAEATLITREEGVFCGKAWAEQVFNQLGGEVALHWH
VDDGDLVLPNQLLCELSGPARTILTGERTAMNFIQTLSGVATLTKHYVDKLVGTHTRLLDTRKTIPGLRTAQKYAVTCGG
GKNHRIGLYDAFLIKENHIMACGGIRQAVDTARSLYPNKPVEVEVESLEELALALDSGTDIIMLDNFDITKMVEAVEMNN
QYKAKGASAKLEVSGNVTLDTLAEFAKTGVDYISVGALTKHVRALDLSLRLKA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=261, Percent_Identity=36.0153256704981, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1786299, Length=289, Percent_Identity=62.6297577854671, Blast_Score=329, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6321162, Length=297, Percent_Identity=33.6700336700337, Blast_Score=149, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31865; Mature: 31865

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLENDIRQSVKSALSEDLGGTEINDQTKAIAYGDITAMLIPADKYAEATLITREEGVFCG
CCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEECCCCCCCEEEEEECCCCEEH
KAWAEQVFNQLGGEVALHWHVDDGDLVLPNQLLCELSGPARTILTGERTAMNFIQTLSGV
HHHHHHHHHHCCCEEEEEEEECCCCEECCHHHHEECCCCCEEEEECCHHHHHHHHHHHHH
ATLTKHYVDKLVGTHTRLLDTRKTIPGLRTAQKYAVTCGGGKNHRIGLYDAFLIKENHIM
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCEE
ACGGIRQAVDTARSLYPNKPVEVEVESLEELALALDSGTDIIMLDNFDITKMVEAVEMNN
EECHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCC
QYKAKGASAKLEVSGNVTLDTLAEFAKTGVDYISVGALTKHVRALDLSLRLKA
CEECCCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHEEEEEEECC
>Mature Secondary Structure
MLENDIRQSVKSALSEDLGGTEINDQTKAIAYGDITAMLIPADKYAEATLITREEGVFCG
CCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEECCCCCCCEEEEEECCCCEEH
KAWAEQVFNQLGGEVALHWHVDDGDLVLPNQLLCELSGPARTILTGERTAMNFIQTLSGV
HHHHHHHHHHCCCEEEEEEEECCCCEECCHHHHEECCCCCEEEEECCHHHHHHHHHHHHH
ATLTKHYVDKLVGTHTRLLDTRKTIPGLRTAQKYAVTCGGGKNHRIGLYDAFLIKENHIM
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCEE
ACGGIRQAVDTARSLYPNKPVEVEVESLEELALALDSGTDIIMLDNFDITKMVEAVEMNN
EECHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCC
QYKAKGASAKLEVSGNVTLDTLAEFAKTGVDYISVGALTKHVRALDLSLRLKA
CEECCCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419294; 11677609; 9016724 [H]