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The map label for this gene is fumC [H]

Identifier: 126175992

GI number: 126175992

Start: 4461581

End: 4462984

Strand: Reverse

Name: fumC [H]

Synonym: Sbal_3801

Alternate gene names: 126175992

Gene position: 4462984-4461581 (Counterclockwise)

Preceding gene: 126175993

Following gene: 126175990

Centisome position: 87.04

GC content: 52.28

Gene sequence:

>1404_bases
ATGGCACAGCAATATCGAATCGAACAGGACACTATGGGTGAGGTAAAAGTCCCCGCGGACTGTTATTGGGGCGCGCAAAC
CGAGCGTTCACGGCAGCACTTTCGTATCGGTGTCGAAGCGTCAATGCCGATTGAAGTGATCCATGCATTTGGTTATCTCA
AAAAGGCCGCCGCCATCACCAATCAACAACTTGGCACTTTGACTCAAGCTAAAGCCCAACTGATTGCCAAAGTGTGCGAT
GAGCTGATTGCGGGCGAACTCGATACGCAATTTCCCTTAGTGATTTGGCAAACGGGCTCGGGCACGCAAACCAATATGAA
CGTCAATGAGGTGATCGCCTATCGCGGCCATGTGCTCTCGGGTGGGCAACTCATCGATGCGGTTAAATGTTTGCACCCCA
ATGACGATGTTAATCGCTCGCAATCTTCCAACGATACTTTTCCTACCGCCATGCACATTGCTGCCTATCGTCAAGCCGTA
GAGCTGGTTTTGCCCTGCATGACGTCACTACAGCAGAGCTTGCAGCACAAGGCCGAGGAATTTGCGCACCTAGTTAAAAT
CGGCCGCACGCATTTTATGGATGCGACACCGTTAACCTTGGGCCAAGAGTTTTCGGGTTACGCCGCGCAATTAAGTCATG
GCATCGAAGGCATTGAGCACAGTCTCAAGCGGGTGGCCGAGTTAGCCTTAGGTGCGACCGCCGTGGGTACTGGGCTGAAT
ACGCATAAGGATTACGCTGTTAAGGTGGCGGACAATATCGCAAAGCTCACAGGCTTGCCCTTAGTGACGGCGCCGAATAA
GTTTGCCGCCCTTGCTGCCCACGATGAATTAGTCGCCCTGTCGGCGGCCTATAAAGTCGCGGCGGTAGGTTTAATGAAGA
TCGCAAATGATATTAGGATGTTAGGTTCTGGCCCGCGCTGCGGCATCGCTGAGTTATTACTGCCTGAAAATGAACCGGGT
TCGTCCATCATGCCGGGCAAAGTCAACCCGACTCAGGTCGAGGCCATGACGATGGTGTGCGCGCAAATCATGGGCAATGA
TGTTGCCGTCGGCATTGGCGGCAGCAATGGTCAGTTTGAGCTCAATGTGTTTAAGCCGATGATCATCGCCAATGTGCTGC
AATCGGGGCGCTTATTGGGGGATGCTTGTCAGTCGTTTAACGATCACTGCGTGGTTGGCATAGTGGCGAACGAGCCGCAA
ATTGCTAAGCATGTGGAAAGCTCACTCATGCTAGTGACGGCGCTGAATCAACATATCGGTTATGAAAAGGCCGCTAAAAT
AGCCAAAAAAGCCCATAGCGAGCACAAGACACTGCGCCAAGCGGCATTAGAACTTGAGTTAGTTACGGCAGAAGAGTTCG
AGCTGTGGGTCGATGCCAACAAGATGTTAGGGCCAGACGCCTAA

Upstream 100 bases:

>100_bases
TAGTCGCTTTCCTTCTGAGAGCTTAGCTTGGAATGAATTGGTACTTTTACCCTGAGCGAGTATGGTGAACGCTTAGAGGG
TTTTAGCGAAGGAGATGCGC

Downstream 100 bases:

>100_bases
TGCTTAATTCATAACGTCTCAGCCTAGCTGCTGATAAATCAGCGAAATTGAGGCTGGCAATGAATCAAGATCGTGAGCCA
AGACAATGCGAAGAAACAGT

Product: fumarate hydratase, class II

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MAQQYRIEQDTMGEVKVPADCYWGAQTERSRQHFRIGVEASMPIEVIHAFGYLKKAAAITNQQLGTLTQAKAQLIAKVCD
ELIAGELDTQFPLVIWQTGSGTQTNMNVNEVIAYRGHVLSGGQLIDAVKCLHPNDDVNRSQSSNDTFPTAMHIAAYRQAV
ELVLPCMTSLQQSLQHKAEEFAHLVKIGRTHFMDATPLTLGQEFSGYAAQLSHGIEGIEHSLKRVAELALGATAVGTGLN
THKDYAVKVADNIAKLTGLPLVTAPNKFAALAAHDELVALSAAYKVAAVGLMKIANDIRMLGSGPRCGIAELLLPENEPG
SSIMPGKVNPTQVEAMTMVCAQIMGNDVAVGIGGSNGQFELNVFKPMIIANVLQSGRLLGDACQSFNDHCVVGIVANEPQ
IAKHVESSLMLVTALNQHIGYEKAAKIAKKAHSEHKTLRQAALELELVTAEEFELWVDANKMLGPDA

Sequences:

>Translated_467_residues
MAQQYRIEQDTMGEVKVPADCYWGAQTERSRQHFRIGVEASMPIEVIHAFGYLKKAAAITNQQLGTLTQAKAQLIAKVCD
ELIAGELDTQFPLVIWQTGSGTQTNMNVNEVIAYRGHVLSGGQLIDAVKCLHPNDDVNRSQSSNDTFPTAMHIAAYRQAV
ELVLPCMTSLQQSLQHKAEEFAHLVKIGRTHFMDATPLTLGQEFSGYAAQLSHGIEGIEHSLKRVAELALGATAVGTGLN
THKDYAVKVADNIAKLTGLPLVTAPNKFAALAAHDELVALSAAYKVAAVGLMKIANDIRMLGSGPRCGIAELLLPENEPG
SSIMPGKVNPTQVEAMTMVCAQIMGNDVAVGIGGSNGQFELNVFKPMIIANVLQSGRLLGDACQSFNDHCVVGIVANEPQ
IAKHVESSLMLVTALNQHIGYEKAAKIAKKAHSEHKTLRQAALELELVTAEEFELWVDANKMLGPDA
>Mature_466_residues
AQQYRIEQDTMGEVKVPADCYWGAQTERSRQHFRIGVEASMPIEVIHAFGYLKKAAAITNQQLGTLTQAKAQLIAKVCDE
LIAGELDTQFPLVIWQTGSGTQTNMNVNEVIAYRGHVLSGGQLIDAVKCLHPNDDVNRSQSSNDTFPTAMHIAAYRQAVE
LVLPCMTSLQQSLQHKAEEFAHLVKIGRTHFMDATPLTLGQEFSGYAAQLSHGIEGIEHSLKRVAELALGATAVGTGLNT
HKDYAVKVADNIAKLTGLPLVTAPNKFAALAAHDELVALSAAYKVAAVGLMKIANDIRMLGSGPRCGIAELLLPENEPGS
SIMPGKVNPTQVEAMTMVCAQIMGNDVAVGIGGSNGQFELNVFKPMIIANVLQSGRLLGDACQSFNDHCVVGIVANEPQI
AKHVESSLMLVTALNQHIGYEKAAKIAKKAHSEHKTLRQAALELELVTAEEFELWVDANKMLGPDA

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=468, Percent_Identity=62.3931623931624, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI266458395, Length=59, Percent_Identity=64.4067796610169, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787896, Length=459, Percent_Identity=59.2592592592593, Blast_Score=539, Evalue=1e-154,
Organism=Escherichia coli, GI87082375, Length=467, Percent_Identity=38.1156316916488, Blast_Score=312, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=61.9870410367171, Blast_Score=575, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=64.4171779141104, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6324993, Length=466, Percent_Identity=57.9399141630901, Blast_Score=545, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24640177, Length=466, Percent_Identity=59.656652360515, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24640179, Length=466, Percent_Identity=59.656652360515, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=58.8362068965517, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=57.4193548387097, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24583245, Length=464, Percent_Identity=51.0775862068966, Blast_Score=449, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50274; Mature: 50143

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHEEEEEECCCCCCCCC
>Mature Secondary Structure 
AQQYRIEQDTMGEVKVPADCYWGAQTERSRQHFRIGVEASMPIEVIHAFGYLKKAAAIT
CCCCCCCCCCCCCEECCCHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
NQQLGTLTQAKAQLIAKVCDELIAGELDTQFPLVIWQTGSGTQTNMNVNEVIAYRGHVLS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCEEC
GGQLIDAVKCLHPNDDVNRSQSSNDTFPTAMHIAAYRQAVELVLPCMTSLQQSLQHKAEE
CCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAHLVKIGRTHFMDATPLTLGQEFSGYAAQLSHGIEGIEHSLKRVAELALGATAVGTGLN
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCC
THKDYAVKVADNIAKLTGLPLVTAPNKFAALAAHDELVALSAAYKVAAVGLMKIANDIRM
CCCCCEEEHHHHHHHHCCCCEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGSGPRCGIAELLLPENEPGSSIMPGKVNPTQVEAMTMVCAQIMGNDVAVGIGGSNGQFE
HCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEE
LNVFKPMIIANVLQSGRLLGDACQSFNDHCVVGIVANEPQIAKHVESSLMLVTALNQHIG
EEEHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCC
YEKAAKIAKKAHSEHKTLRQAALELELVTAEEFELWVDANKMLGPDA
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]