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The map label for this gene is groEL [H]

Identifier: 126175902

GI number: 126175902

Start: 4333544

End: 4335181

Strand: Reverse

Name: groEL [H]

Synonym: Sbal_3708

Alternate gene names: 126175902

Gene position: 4335181-4333544 (Counterclockwise)

Preceding gene: 126175903

Following gene: 126175900

Centisome position: 84.55

GC content: 47.31

Gene sequence:

>1638_bases
ATGGCAGCTAAAGAAGTTGTATTTGGTAATGACGCTCGCGTAAGAATGCTGGCTGGCGTAAATATTCTAGCGAACGCAGT
AAAAGTGACCTTAGGCCCTAAAGGCCGTAACGTGGTATTAGACAAGAGCTTTGGCTCACCACTGATCACTAAAGACGGTG
TGTCTGTTGCCAAAGAAATCGAGTTAGAAGACAAATTCGAAAACATGGGCGCGCAAATGGTAAAAGAAGTTGCTTCTAAA
GCCAACGACGCCGCCGGTGATGGTACTACTACTGCAACTGTACTGGCTCAAGCCATTGTAGTTGAAGGCTTAAAAGCCGT
TGCAGCCGGTATGAACCCAATGGATCTGAAGCGCGGTATCGACAAAGCCGTTATCGCTGCAGTTGCTGAATTAAAAGCCT
TATCACAACCTTGTGCAGATTCAAAAGCGATTGCGCAAGTTGCGACTATCTCTGCAAACTCTGACGAATCTATCGGCGAA
ATCATCGCAACTGCGATGGAAAAAGTCGGTAAAGAAGGCGTGATCACCGTTGAAGAAGGCCAAGCGTTAGAAAACGAATT
GGACGTAGTAGAAGGTATGCAGTTTGACCGTGGCTACCTGTCTCCATACTTCATCAACAAGCCAGAAACCGGCAGCGTTG
AGTTAGACCACCCATTCGTACTGTTAGTAGACAAGAAAATCTCTAACATTCGCGAACTGTTACCTATCCTTGAAGGTCTG
GCAAAAACTGGTAAGCCATTGCTTATCGTTGCTGAAGACGTTGAAGGCGAAGCATTAGCAACATTAGTTGTGAACAATAT
GCGCGGTATCGTGAAAGTGGCTGCGGTTAAAGCCCCAGGCTTTGGCGATCGTCGTAAGGCAATGCTGCAAGACGTAGCAA
TCCTGACTGGCGGTACTGTTATTGCTGAAGAAATCGGCCTAGAGCTTGAAAAAGCAACGTTGGAAGATTTAGGTACAGCT
AAGCGTGTTGTGATCACTAAAGACAACACTACCATCATCGATGGTAACGGTGAGCAAACACAAATTGCTGCTCGTGTAAG
CCAAATCAAACAACAAGTTGAAGAATCAACGTCTGACTACGACAAAGAAAAACTGCAAGAGCGTATGGCTAAACTAGCTG
GCGGCGTAGCAGTGATTAAAGTTGGCGCAGCGACTGAAGTTGAAATGAAAGAGAAAAAAGCCCGCGTTGAAGATGCTCTG
CATGCAACTCGCGCTGCGGTAGAAGAAGGCGTGGTTCCTGGCGGCGGTGTTGCTCTGGTTCGCGTAGCTTCTAAGATCGC
TGAAGTAGAAGTATTAAACGAAGACCAAAAACACGGTGTGGTTATCGCACTGCGTGCAATGGAAGCGCCACTGCGTCAAA
TCGCCACTAACGCGGGTGAAGAAGCGTCAGTTGTTGCTAACACAGTGAAGAACGGTAGCGGTAACTTCGGTTACAACGCC
GGTAACGACACTTACGGTGACATGTTAGAAATGGGTATCCTTGACCCAACTAAAGTGACCCGTTGTGCATTGCAATTCGC
TGCGTCAATCGCAGGTCTGATGATCACTACAGAAGCTATGGTTGCTGAAATTCCACAAAATGCTAGCCAAGATATGGGCG
GTATGGGTGGCATGGGCGGAATGGGCGGCATGATGTAA

Upstream 100 bases:

>100_bases
CTTGATCCTGTCGGAAGCTGACCTGATGGCAGTAGTGGGTTAATCCTCAGCATCAATTCGACATTCCAATTAATCATTAA
AAATTTAAAGGATAATCAAG

Downstream 100 bases:

>100_bases
TTTTTGCTGGTCTAAAACGTTGATTACGGCGTTGCTGCTCGCTCACATACACACAACGTATGCTACGCTCACAGCGCCTT
GTACTGAACGTTTTATCCTG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MAAKEVVFGNDARVRMLAGVNILANAVKVTLGPKGRNVVLDKSFGSPLITKDGVSVAKEIELEDKFENMGAQMVKEVASK
ANDAAGDGTTTATVLAQAIVVEGLKAVAAGMNPMDLKRGIDKAVIAAVAELKALSQPCADSKAIAQVATISANSDESIGE
IIATAMEKVGKEGVITVEEGQALENELDVVEGMQFDRGYLSPYFINKPETGSVELDHPFVLLVDKKISNIRELLPILEGL
AKTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDVAILTGGTVIAEEIGLELEKATLEDLGTA
KRVVITKDNTTIIDGNGEQTQIAARVSQIKQQVEESTSDYDKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGVVPGGGVALVRVASKIAEVEVLNEDQKHGVVIALRAMEAPLRQIATNAGEEASVVANTVKNGSGNFGYNA
GNDTYGDMLEMGILDPTKVTRCALQFAASIAGLMITTEAMVAEIPQNASQDMGGMGGMGGMGGMM

Sequences:

>Translated_545_residues
MAAKEVVFGNDARVRMLAGVNILANAVKVTLGPKGRNVVLDKSFGSPLITKDGVSVAKEIELEDKFENMGAQMVKEVASK
ANDAAGDGTTTATVLAQAIVVEGLKAVAAGMNPMDLKRGIDKAVIAAVAELKALSQPCADSKAIAQVATISANSDESIGE
IIATAMEKVGKEGVITVEEGQALENELDVVEGMQFDRGYLSPYFINKPETGSVELDHPFVLLVDKKISNIRELLPILEGL
AKTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDVAILTGGTVIAEEIGLELEKATLEDLGTA
KRVVITKDNTTIIDGNGEQTQIAARVSQIKQQVEESTSDYDKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGVVPGGGVALVRVASKIAEVEVLNEDQKHGVVIALRAMEAPLRQIATNAGEEASVVANTVKNGSGNFGYNA
GNDTYGDMLEMGILDPTKVTRCALQFAASIAGLMITTEAMVAEIPQNASQDMGGMGGMGGMGGMM
>Mature_544_residues
AAKEVVFGNDARVRMLAGVNILANAVKVTLGPKGRNVVLDKSFGSPLITKDGVSVAKEIELEDKFENMGAQMVKEVASKA
NDAAGDGTTTATVLAQAIVVEGLKAVAAGMNPMDLKRGIDKAVIAAVAELKALSQPCADSKAIAQVATISANSDESIGEI
IATAMEKVGKEGVITVEEGQALENELDVVEGMQFDRGYLSPYFINKPETGSVELDHPFVLLVDKKISNIRELLPILEGLA
KTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDVAILTGGTVIAEEIGLELEKATLEDLGTAK
RVVITKDNTTIIDGNGEQTQIAARVSQIKQQVEESTSDYDKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGVVPGGGVALVRVASKIAEVEVLNEDQKHGVVIALRAMEAPLRQIATNAGEEASVVANTVKNGSGNFGYNAG
NDTYGDMLEMGILDPTKVTRCALQFAASIAGLMITTEAMVAEIPQNASQDMGGMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=525, Percent_Identity=52, Blast_Score=530, Evalue=1e-151,
Organism=Homo sapiens, GI31542947, Length=525, Percent_Identity=52, Blast_Score=530, Evalue=1e-151,
Organism=Escherichia coli, GI1790586, Length=532, Percent_Identity=81.7669172932331, Blast_Score=878, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=526, Percent_Identity=52.0912547528517, Blast_Score=540, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI193210679, Length=208, Percent_Identity=51.9230769230769, Blast_Score=213, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=54.5627376425855, Blast_Score=554, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6322524, Length=522, Percent_Identity=22.7969348659004, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24641193, Length=525, Percent_Identity=53.5238095238095, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24641191, Length=525, Percent_Identity=53.5238095238095, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=49.8091603053435, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=49.8091603053435, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=49.8091603053435, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI17864606, Length=553, Percent_Identity=42.1338155515371, Blast_Score=440, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24584129, Length=546, Percent_Identity=36.2637362637363, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI19921262, Length=546, Percent_Identity=36.2637362637363, Blast_Score=328, Evalue=4e-90,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57093; Mature: 56962

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00284 SERPIN ; PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEVVFGNDARVRMLAGVNILANAVKVTLGPKGRNVVLDKSFGSPLITKDGVSVAKEI
CCCCCEEECCCCCEEEECCHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHC
ELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVVEGLKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVIAAVAELKALSQPCADSKAIAQVATISANSDESIGEIIATAMEKVGKEGVITVEEG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCCEEEECCC
QALENELDVVEGMQFDRGYLSPYFINKPETGSVELDHPFVLLVDKKISNIRELLPILEGL
CHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEECCCEEEEECHHHHHHHHHHHHHHHH
AKTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDVAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCCH
IAEEIGLELEKATLEDLGTAKRVVITKDNTTIIDGNGEQTQIAARVSQIKQQVEESTSDY
HHHHHCCHHHHHHHHHCCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
DKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALV
CHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RVASKIAEVEVLNEDQKHGVVIALRAMEAPLRQIATNAGEEASVVANTVKNGSGNFGYNA
HHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCC
GNDTYGDMLEMGILDPTKVTRCALQFAASIAGLMITTEAMVAEIPQNASQDMGGMGGMGG
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCC
MGGMM
CCCCC
>Mature Secondary Structure 
AAKEVVFGNDARVRMLAGVNILANAVKVTLGPKGRNVVLDKSFGSPLITKDGVSVAKEI
CCCCEEECCCCCEEEECCHHHHHHHEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHC
ELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVVEGLKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVIAAVAELKALSQPCADSKAIAQVATISANSDESIGEIIATAMEKVGKEGVITVEEG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCCEEEECCC
QALENELDVVEGMQFDRGYLSPYFINKPETGSVELDHPFVLLVDKKISNIRELLPILEGL
CHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEECCCEEEEECHHHHHHHHHHHHHHHH
AKTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDVAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCCH
IAEEIGLELEKATLEDLGTAKRVVITKDNTTIIDGNGEQTQIAARVSQIKQQVEESTSDY
HHHHHCCHHHHHHHHHCCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
DKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALV
CHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RVASKIAEVEVLNEDQKHGVVIALRAMEAPLRQIATNAGEEASVVANTVKNGSGNFGYNA
HHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCC
GNDTYGDMLEMGILDPTKVTRCALQFAASIAGLMITTEAMVAEIPQNASQDMGGMGGMGG
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCC
MGGMM
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA