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The map label for this gene is cusC [C]

Identifier: 126175731

GI number: 126175731

Start: 4155446

End: 4156897

Strand: Reverse

Name: cusC [C]

Synonym: Sbal_3534

Alternate gene names: 126175731

Gene position: 4156897-4155446 (Counterclockwise)

Preceding gene: 126175732

Following gene: 126175725

Centisome position: 81.07

GC content: 50.76

Gene sequence:

>1452_bases
ATGAATACAAAAATATTTAATCGACACTTTTCGCCTCGTAGCTGCGCGATTGCTGTGGGCATGGCTTTAGGAATCGCCTT
GCTGAGTGGCTGTGGCAGTTTCATGCGTTCAGACTTTGAACCGCCCGCATTGGCGATTCCTGAACAGTGGCAAAACACCA
CAGTGAACGAGCAAGTAAAGGTCGATCCTTGGTGGCAGCAGTTTCATCAGCCTGAGCTCGATAAGCTGGTTAGCCAAGTG
TTGAGCACCAACAATGACTTAACGCTGGCGACCTTAACCCTGCGTAAAGCGCGCTTGCAGGCAGGGCTAACGCGGGACGA
TCTGTATCCGCAATTATCGGCCAATCTTGGTGCTTCGCGTAATCAGCCACTTGATGGTGGCGACGCGACTAAGAGTTATC
AAGCCAACTTGTCTGTCAGTTATGAGGTGGATTTGTGGGGCAAAGTGTCAGCCAATATTGACCAAGCCCAATGGGCGGCG
CTGGCGAGCGCGGAAGATAGGGAAAGCACCACCCAAAGCCTAGTGGCGACCACAGCATCCTTGTACTGGCAGATAGGTTA
TTTAAATCAACGGGTTGATTTAAGCCAAAAGAGCATAGCGTACAGCAAACAAACGTTAGATTTAACCCAAAGGCAGTATG
ATTCTGGGGCCGTGACGCAAGTGAATGTGCTTGAAGCTCAGCGCAGTATGGCGGGACAAGAGGCGGCCCATAGTCAGCTT
ATTCAGCAATTAACTGTGGCTAAAAATGCCCTCGCGATATTACTGAATCAGGCACCTGCAGCTGTTCCTGCGCAGAGTTT
AGCCTCAGGCGAAACTTGGGTTGAGATTAAACAGCTCCCCGATGTGGCGGTGCCGGACGTTAGCGTGGGTGTACCCGCAG
ATTTATTAGTGAGACGCCCAGATGTGAAGGCCTCCTTGTATCAACTGCGCTCCGCCTTGGCGAGTAAAGATGCGACCTAT
GCGAGTTATTTTCCAAGCCTGAGTTTAACCGGCGGTGTTGGGGAGTCGACCTCTGAGTTAAAAGAGTTGTTACGCAATCC
CGTTGGCAGTTTAGGCGCAGGGCTAGTCTTGCCCTTTTTGCAGTGGAATCAAATGCAAATCAATAATGACATTGCCGATA
TCGATTATCAAACCGCAGTGGTTAATTATCGCAAGACGCTTTATTCCGCCTTTGAAGATGTCGATAACGCGATTTCGGCT
AAGCAGCAATATCGTTATCAAGGGGAGAAGTTGGCGCAACAATTTAGCGCCGCGGCAGCCGTTGAAGCCATTTATGAGAG
TCAGTACCGCAATGGCGCTATCGGTATTCAGAATTGGATTGATGCCCAAGAGAATCGTCGCAGCGCCGAGGCGGCTTTGC
TCGAGAATCGTTACAACCAACTCACCGCCCAAGCGACGCTTTATCAAGCCCTTGGCGGCAGCGATATCGCCCCGCCTTTG
GCAAAGGAATAG

Upstream 100 bases:

>100_bases
GCCTGTTCGACCTTAATTGGTGTGCTATTTGGTTTCTTACCCGCCCGCAATGCGGCGCAGTTAGATCCCGTTGACGCATT
AGCCAGAGAGTAATAACACC

Downstream 100 bases:

>100_bases
CGCATTGTTGTAAAAGCATCACAGCGCGACAGAAAAATAAAAAACCGCTATTAATAGCGGTTTTTCGTTTTTATATAACT
CAGGCAAGCGCAAGCCTCTG

Product: RND efflux system outer membrane lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNTKIFNRHFSPRSCAIAVGMALGIALLSGCGSFMRSDFEPPALAIPEQWQNTTVNEQVKVDPWWQQFHQPELDKLVSQV
LSTNNDLTLATLTLRKARLQAGLTRDDLYPQLSANLGASRNQPLDGGDATKSYQANLSVSYEVDLWGKVSANIDQAQWAA
LASAEDRESTTQSLVATTASLYWQIGYLNQRVDLSQKSIAYSKQTLDLTQRQYDSGAVTQVNVLEAQRSMAGQEAAHSQL
IQQLTVAKNALAILLNQAPAAVPAQSLASGETWVEIKQLPDVAVPDVSVGVPADLLVRRPDVKASLYQLRSALASKDATY
ASYFPSLSLTGGVGESTSELKELLRNPVGSLGAGLVLPFLQWNQMQINNDIADIDYQTAVVNYRKTLYSAFEDVDNAISA
KQQYRYQGEKLAQQFSAAAAVEAIYESQYRNGAIGIQNWIDAQENRRSAEAALLENRYNQLTAQATLYQALGGSDIAPPL
AKE

Sequences:

>Translated_483_residues
MNTKIFNRHFSPRSCAIAVGMALGIALLSGCGSFMRSDFEPPALAIPEQWQNTTVNEQVKVDPWWQQFHQPELDKLVSQV
LSTNNDLTLATLTLRKARLQAGLTRDDLYPQLSANLGASRNQPLDGGDATKSYQANLSVSYEVDLWGKVSANIDQAQWAA
LASAEDRESTTQSLVATTASLYWQIGYLNQRVDLSQKSIAYSKQTLDLTQRQYDSGAVTQVNVLEAQRSMAGQEAAHSQL
IQQLTVAKNALAILLNQAPAAVPAQSLASGETWVEIKQLPDVAVPDVSVGVPADLLVRRPDVKASLYQLRSALASKDATY
ASYFPSLSLTGGVGESTSELKELLRNPVGSLGAGLVLPFLQWNQMQINNDIADIDYQTAVVNYRKTLYSAFEDVDNAISA
KQQYRYQGEKLAQQFSAAAAVEAIYESQYRNGAIGIQNWIDAQENRRSAEAALLENRYNQLTAQATLYQALGGSDIAPPL
AKE
>Mature_483_residues
MNTKIFNRHFSPRSCAIAVGMALGIALLSGCGSFMRSDFEPPALAIPEQWQNTTVNEQVKVDPWWQQFHQPELDKLVSQV
LSTNNDLTLATLTLRKARLQAGLTRDDLYPQLSANLGASRNQPLDGGDATKSYQANLSVSYEVDLWGKVSANIDQAQWAA
LASAEDRESTTQSLVATTASLYWQIGYLNQRVDLSQKSIAYSKQTLDLTQRQYDSGAVTQVNVLEAQRSMAGQEAAHSQL
IQQLTVAKNALAILLNQAPAAVPAQSLASGETWVEIKQLPDVAVPDVSVGVPADLLVRRPDVKASLYQLRSALASKDATY
ASYFPSLSLTGGVGESTSELKELLRNPVGSLGAGLVLPFLQWNQMQINNDIADIDYQTAVVNYRKTLYSAFEDVDNAISA
KQQYRYQGEKLAQQFSAAAAVEAIYESQYRNGAIGIQNWIDAQENRRSAEAALLENRYNQLTAQATLYQALGGSDIAPPL
AKE

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Attached To The Outer Membrane By A Lipid Anchor [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=461, Percent_Identity=27.9826464208243, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI2367348, Length=490, Percent_Identity=24.0816326530612, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 52782; Mature: 52782

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTKIFNRHFSPRSCAIAVGMALGIALLSGCGSFMRSDFEPPALAIPEQWQNTTVNEQVK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCEEE
VDPWWQQFHQPELDKLVSQVLSTNNDLTLATLTLRKARLQAGLTRDDLYPQLSANLGASR
CCHHHHHHCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCHHHCCHHHHCCCCCCC
NQPLDGGDATKSYQANLSVSYEVDLWGKVSANIDQAQWAALASAEDRESTTQSLVATTAS
CCCCCCCCCCCCEECCEEEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
LYWQIGYLNQRVDLSQKSIAYSKQTLDLTQRQYDSGAVTQVNVLEAQRSMAGQEAAHSQL
HHHEEHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHH
IQQLTVAKNALAILLNQAPAAVPAQSLASGETWVEIKQLPDVAVPDVSVGVPADLLVRRP
HHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEHHHCCCCCCCCCCCCCCHHHHEECC
DVKASLYQLRSALASKDATYASYFPSLSLTGGVGESTSELKELLRNPVGSLGAGLVLPFL
CHHHHHHHHHHHHHHCCCHHHHHCCCCEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
QWNQMQINNDIADIDYQTAVVNYRKTLYSAFEDVDNAISAKQQYRYQGEKLAQQFSAAAA
HCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAIYESQYRNGAIGIQNWIDAQENRRSAEAALLENRYNQLTAQATLYQALGGSDIAPPL
HHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
AKE
CCC
>Mature Secondary Structure
MNTKIFNRHFSPRSCAIAVGMALGIALLSGCGSFMRSDFEPPALAIPEQWQNTTVNEQVK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCEEE
VDPWWQQFHQPELDKLVSQVLSTNNDLTLATLTLRKARLQAGLTRDDLYPQLSANLGASR
CCHHHHHHCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCHHHCCHHHHCCCCCCC
NQPLDGGDATKSYQANLSVSYEVDLWGKVSANIDQAQWAALASAEDRESTTQSLVATTAS
CCCCCCCCCCCCEECCEEEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
LYWQIGYLNQRVDLSQKSIAYSKQTLDLTQRQYDSGAVTQVNVLEAQRSMAGQEAAHSQL
HHHEEHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHH
IQQLTVAKNALAILLNQAPAAVPAQSLASGETWVEIKQLPDVAVPDVSVGVPADLLVRRP
HHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEHHHCCCCCCCCCCCCCCHHHHEECC
DVKASLYQLRSALASKDATYASYFPSLSLTGGVGESTSELKELLRNPVGSLGAGLVLPFL
CHHHHHHHHHHHHHHCCCHHHHHCCCCEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
QWNQMQINNDIADIDYQTAVVNYRKTLYSAFEDVDNAISAKQQYRYQGEKLAQQFSAAAA
HCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAIYESQYRNGAIGIQNWIDAQENRRSAEAALLENRYNQLTAQATLYQALGGSDIAPPL
HHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
AKE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]