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The map label for this gene is pepB [H]

Identifier: 126175685

GI number: 126175685

Start: 4088446

End: 4089738

Strand: Reverse

Name: pepB [H]

Synonym: Sbal_3488

Alternate gene names: 126175685

Gene position: 4089738-4088446 (Counterclockwise)

Preceding gene: 126175693

Following gene: 126175684

Centisome position: 79.76

GC content: 51.35

Gene sequence:

>1293_bases
ATGAGTGAACTAAAAGTAACTGAATTAATGAAAGTGCAATTAACCAAAGAAGCGCCGGCCGCCCACTGGGGCAAAGCCGA
TGTGACTTATACTACCGACGGTGCGCAAATTCATTTAGCGGGTGGCGATGAGCTGCGTCAAATTCAAATGGCGGCCCGTA
AACTGCGCAGTCAAGGTATTAGCTGTGTGGTATTGGCTGGGCAGTTATGGGATCTGAATAGCCAGTGGGTGTTTGCCCAA
GGTTTCGCAACGGCAAAAACAGGCTATCAAATCCATTGGTGTGGTGATGAAGCTGTACAAGCAGAATTGCAACGTCGACT
CGATGTGGCAACCTTTGCCCGTCAACTGATCAACGATACGCCTGAAAACCTGTCGCCAGTAAAGCTTGCCCAACAAGCGG
CGAAATGGTTGGCTGAAATTGGTGGTGACAAAGTGAGTTATCGGATTATCGAAGGCGAAGCGCTGCTGGAAGAACAGTGG
ATTGGTATCCATGCTGTCGGTCGCGGCAGTGAGCGCCCACCGGCAATGTTAGAGTTAGACTTCAACCCATTAGCCGCCGA
TGCACCTGTATCTGTTGCGCTTGTGGGTAAAGGGATTACTTTTGATTCTGGCGGTTACAGCATCAAAGCTTCTGAAGGCA
TGTTAGGCATGAAATGCGACATGGGCGGCGCGGCGACTGTGACTGCAGCGCTCGGTTTAGCGATCAAATCAGGCCTAAAC
AAACGCGTTAAACTCTTCTTATGTTGTGCTGAAAACTTGATCAGCGGCCGTGCTTATAAGTTAGGCGATATCCTGACCTA
CAAAAATGGCGTGACAGTTGAAGTGGTGAACACAGATGCGGAAGGGCGCTTAGTGTTAGCCGATGGTCTGCAAGCCGCCT
CTGCGACAGGCGCTCCTTTTATTATCGATGCAGCGACCCTTACAGGCGCCGCTGTGATGGCAGTGGGTTCTAACTACAAC
GCGATTTTCTCGCCACAGACTGATGTGTTGCAACTGGCCCAGCAAAAAGCCACGAGTGTTGCCGAGCGTGTATGGCCGCT
GCCGCTGGATCCTTGGCACAAAGAAATGTGTCCATCAGCCTATGCTGACACAGCCAACAGCCGCGCAATGAAAGGCGGCG
GTGCTGGTGGTGCTTCTAATGCCGCTGGTTTCCTATGGCGTTTTGTTTCACCAGAAGCTAAATGGTTGCACGTTGATTTA
GCGGGCGCCTTTGAAGATTCAGCTTCTGCCATGTGGGGCGCGGGTGCAACGACCCACGGCGTATTGACCATTAGTGAATT
GATCAAAGGCTAA

Upstream 100 bases:

>100_bases
CTTCAGCCAATCGCTTTGCGTCATCGCCTGCTAGCAGTAAACTGCCGCCATAAAGTTTGTTCTGATTGTTCTAAAACGAA
TCGAAAAATAAGGATCCCTA

Downstream 100 bases:

>100_bases
GCCTAGATTTAAGTCTAGCGCTAAGACTCAGTTAGATAAGTCTGCGCAGATCCATTAAGGTTCTGCTGACTGGATTAACA
CCGCCTACGGGCGGTTTTTT

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSELKVTELMKVQLTKEAPAAHWGKADVTYTTDGAQIHLAGGDELRQIQMAARKLRSQGISCVVLAGQLWDLNSQWVFAQ
GFATAKTGYQIHWCGDEAVQAELQRRLDVATFARQLINDTPENLSPVKLAQQAAKWLAEIGGDKVSYRIIEGEALLEEQW
IGIHAVGRGSERPPAMLELDFNPLAADAPVSVALVGKGITFDSGGYSIKASEGMLGMKCDMGGAATVTAALGLAIKSGLN
KRVKLFLCCAENLISGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPFIIDAATLTGAAVMAVGSNYN
AIFSPQTDVLQLAQQKATSVAERVWPLPLDPWHKEMCPSAYADTANSRAMKGGGAGGASNAAGFLWRFVSPEAKWLHVDL
AGAFEDSASAMWGAGATTHGVLTISELIKG

Sequences:

>Translated_430_residues
MSELKVTELMKVQLTKEAPAAHWGKADVTYTTDGAQIHLAGGDELRQIQMAARKLRSQGISCVVLAGQLWDLNSQWVFAQ
GFATAKTGYQIHWCGDEAVQAELQRRLDVATFARQLINDTPENLSPVKLAQQAAKWLAEIGGDKVSYRIIEGEALLEEQW
IGIHAVGRGSERPPAMLELDFNPLAADAPVSVALVGKGITFDSGGYSIKASEGMLGMKCDMGGAATVTAALGLAIKSGLN
KRVKLFLCCAENLISGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPFIIDAATLTGAAVMAVGSNYN
AIFSPQTDVLQLAQQKATSVAERVWPLPLDPWHKEMCPSAYADTANSRAMKGGGAGGASNAAGFLWRFVSPEAKWLHVDL
AGAFEDSASAMWGAGATTHGVLTISELIKG
>Mature_429_residues
SELKVTELMKVQLTKEAPAAHWGKADVTYTTDGAQIHLAGGDELRQIQMAARKLRSQGISCVVLAGQLWDLNSQWVFAQG
FATAKTGYQIHWCGDEAVQAELQRRLDVATFARQLINDTPENLSPVKLAQQAAKWLAEIGGDKVSYRIIEGEALLEEQWI
GIHAVGRGSERPPAMLELDFNPLAADAPVSVALVGKGITFDSGGYSIKASEGMLGMKCDMGGAATVTAALGLAIKSGLNK
RVKLFLCCAENLISGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPFIIDAATLTGAAVMAVGSNYNA
IFSPQTDVLQLAQQKATSVAERVWPLPLDPWHKEMCPSAYADTANSRAMKGGGAGGASNAAGFLWRFVSPEAKWLHVDLA
GAFEDSASAMWGAGATTHGVLTISELIKG

Specific function: Probably plays an important role in intracellular peptide degradation [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=300, Percent_Identity=37.3333333333333, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI47155554, Length=293, Percent_Identity=36.518771331058, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI87082123, Length=427, Percent_Identity=49.6487119437939, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1790710, Length=315, Percent_Identity=37.7777777777778, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17556903, Length=296, Percent_Identity=36.1486486486487, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17565172, Length=309, Percent_Identity=26.537216828479, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221379063, Length=292, Percent_Identity=37.3287671232877, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI221379062, Length=292, Percent_Identity=37.3287671232877, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21357381, Length=292, Percent_Identity=37.3287671232877, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21355725, Length=295, Percent_Identity=32.2033898305085, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24661038, Length=295, Percent_Identity=32.2033898305085, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24662227, Length=297, Percent_Identity=28.6195286195286, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI161077148, Length=296, Percent_Identity=30.7432432432432, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI20130057, Length=296, Percent_Identity=30.7432432432432, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI20129969, Length=295, Percent_Identity=28.8135593220339, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21355645, Length=295, Percent_Identity=27.4576271186441, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24662223, Length=295, Percent_Identity=27.4576271186441, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20129963, Length=294, Percent_Identity=29.5918367346939, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19922386, Length=295, Percent_Identity=27.1186440677966, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24646701, Length=207, Percent_Identity=29.951690821256, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24646703, Length=207, Percent_Identity=29.951690821256, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21358201, Length=207, Percent_Identity=29.951690821256, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.23 [H]

Molecular weight: Translated: 45504; Mature: 45373

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELKVTELMKVQLTKEAPAAHWGKADVTYTTDGAQIHLAGGDELRQIQMAARKLRSQGI
CCCCCHHHHHEEEEECCCCCCCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCC
SCVVLAGQLWDLNSQWVFAQGFATAKTGYQIHWCGDEAVQAELQRRLDVATFARQLINDT
EEEEEECEEECCCCCEEEECCCEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
PENLSPVKLAQQAAKWLAEIGGDKVSYRIIEGEALLEEQWIGIHAVGRGSERPPAMLELD
CCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCCEEEEECCCCCCCCEEEEEC
FNPLAADAPVSVALVGKGITFDSGGYSIKASEGMLGMKCDMGGAATVTAALGLAIKSGLN
CCCCCCCCCEEEEEEECCEEECCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCC
KRVKLFLCCAENLISGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPF
CEEEEEEEEHHHHHCCCCEEECCEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCE
IIDAATLTGAAVMAVGSNYNAIFSPQTDVLQLAQQKATSVAERVWPLPLDPWHKEMCPSA
EEEEHHHCCEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCH
YADTANSRAMKGGGAGGASNAAGFLWRFVSPEAKWLHVDLAGAFEDSASAMWGAGATTHG
HHCCCCCCEECCCCCCCCCCCHHHEEEEECCCCEEEEEEEECCCCCCCCHHCCCCCCCCH
VLTISELIKG
HEEHHHHHCC
>Mature Secondary Structure 
SELKVTELMKVQLTKEAPAAHWGKADVTYTTDGAQIHLAGGDELRQIQMAARKLRSQGI
CCCCHHHHHEEEEECCCCCCCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCC
SCVVLAGQLWDLNSQWVFAQGFATAKTGYQIHWCGDEAVQAELQRRLDVATFARQLINDT
EEEEEECEEECCCCCEEEECCCEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
PENLSPVKLAQQAAKWLAEIGGDKVSYRIIEGEALLEEQWIGIHAVGRGSERPPAMLELD
CCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCCEEEEECCCCCCCCEEEEEC
FNPLAADAPVSVALVGKGITFDSGGYSIKASEGMLGMKCDMGGAATVTAALGLAIKSGLN
CCCCCCCCCEEEEEEECCEEECCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCC
KRVKLFLCCAENLISGRAYKLGDILTYKNGVTVEVVNTDAEGRLVLADGLQAASATGAPF
CEEEEEEEEHHHHHCCCCEEECCEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCE
IIDAATLTGAAVMAVGSNYNAIFSPQTDVLQLAQQKATSVAERVWPLPLDPWHKEMCPSA
EEEEHHHCCEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCH
YADTANSRAMKGGGAGGASNAAGFLWRFVSPEAKWLHVDLAGAFEDSASAMWGAGATTHG
HHCCCCCCEECCCCCCCCCCCHHHEEEEECCCCEEEEEEEECCCCCCCCHHCCCCCCCCH
VLTISELIKG
HEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA