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The map label for this gene is cynR [H]

Identifier: 126175393

GI number: 126175393

Start: 3736748

End: 3737638

Strand: Reverse

Name: cynR [H]

Synonym: Sbal_3192

Alternate gene names: 126175393

Gene position: 3737638-3736748 (Counterclockwise)

Preceding gene: 126175395

Following gene: 126175391

Centisome position: 72.9

GC content: 49.16

Gene sequence:

>891_bases
ATGCTCGATATCCATTGGTTAAAGACCTTTGTGACTTTGGCTGAACATAAGCATTTTGGCAAAGCGGCCACGGCGCTGCA
CATGACACAGCCCAATGTTAGCTTGCATATTAAGCAGTTAGAGCAAAGCACTCGAGTCAAGCTGATTGACCGCAATCCTT
TTCGATTAACGCAAGCGGGATTTCGCCTGTTAGAGAGCAGTCAGAAAACGTTAATGGAGCTGCAAATTTGTCAGGCGGAT
CTCAATGCGATTAATGACCTTAGCCAAGGCACCTTAACCATTGCCGCCAGCGACATTATCTCGCGGTTATTGTTGATCCA
GCCGTTTCAGCTCTTTAAGGCGGAGTTTCCGGGGATCGATTTCTCGCTGCTCAATACCACATCATCCCAAGCTTCTGAAC
TGGTGAAAAATGCTGAGGCCGATTTAGGGTTTGTGATCGCGCAAAAGGAGAGTCAGCCGCTGCATTTTACTGAGTTACAG
CAGATAAAATGGTGTGCAATAGGGGACAATTTACAGCAATGGCAGCAGGCAAACCTCTCTGTGGATACGCCCTTGGCTGA
GCAACCGACGTTGATTTTACTGGGCCATGATACGCGAACCCGCGAATTGCTCGATCCCGCACTGCCGTCGCTGAATTTGC
CGAATTACCGGATTATGGAGGTGGGCAGTGTGGACGCGCAAATCGATTGGGCCGAGGCGGGATTTGGGGTGGCGATCGTG
CCGGAGTTTTCGGTTTATACTAAGGCGAATTTGACCACTAAAGTCACCCCTTTGCCGCAATTCCCCACAACCAGTTTGGG
TTATATTGTGCGCCAGAATCAGATCCTGTCTAAGGCCATCAAGCAGCTATTATATTGGGTGAATCAAGAGATTATTCGCT
CGCAGCGATAG

Upstream 100 bases:

>100_bases
GTCATTTGAATAAGAGAAATTAATTATGGTTATCATCTCAATAAGGATTTCATATATCATTGGCTATAATTAACGCTAAT
ACACAGCAAAAGGAGGTTTT

Downstream 100 bases:

>100_bases
GGAATTAGTCAGCGACTAAGAGTAATTTTTCGTATTGGCCTGTGGCTTTTAGCAGTGATAAGCCCGCGTCGAGTTGGGTC
GCTAAGGTCTGCGCCTGTGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MLDIHWLKTFVTLAEHKHFGKAATALHMTQPNVSLHIKQLEQSTRVKLIDRNPFRLTQAGFRLLESSQKTLMELQICQAD
LNAINDLSQGTLTIAASDIISRLLLIQPFQLFKAEFPGIDFSLLNTTSSQASELVKNAEADLGFVIAQKESQPLHFTELQ
QIKWCAIGDNLQQWQQANLSVDTPLAEQPTLILLGHDTRTRELLDPALPSLNLPNYRIMEVGSVDAQIDWAEAGFGVAIV
PEFSVYTKANLTTKVTPLPQFPTTSLGYIVRQNQILSKAIKQLLYWVNQEIIRSQR

Sequences:

>Translated_296_residues
MLDIHWLKTFVTLAEHKHFGKAATALHMTQPNVSLHIKQLEQSTRVKLIDRNPFRLTQAGFRLLESSQKTLMELQICQAD
LNAINDLSQGTLTIAASDIISRLLLIQPFQLFKAEFPGIDFSLLNTTSSQASELVKNAEADLGFVIAQKESQPLHFTELQ
QIKWCAIGDNLQQWQQANLSVDTPLAEQPTLILLGHDTRTRELLDPALPSLNLPNYRIMEVGSVDAQIDWAEAGFGVAIV
PEFSVYTKANLTTKVTPLPQFPTTSLGYIVRQNQILSKAIKQLLYWVNQEIIRSQR
>Mature_296_residues
MLDIHWLKTFVTLAEHKHFGKAATALHMTQPNVSLHIKQLEQSTRVKLIDRNPFRLTQAGFRLLESSQKTLMELQICQAD
LNAINDLSQGTLTIAASDIISRLLLIQPFQLFKAEFPGIDFSLLNTTSSQASELVKNAEADLGFVIAQKESQPLHFTELQ
QIKWCAIGDNLQQWQQANLSVDTPLAEQPTLILLGHDTRTRELLDPALPSLNLPNYRIMEVGSVDAQIDWAEAGFGVAIV
PEFSVYTKANLTTKVTPLPQFPTTSLGYIVRQNQILSKAIKQLLYWVNQEIIRSQR

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=235, Percent_Identity=29.3617021276596, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788748, Length=298, Percent_Identity=26.510067114094, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI145693105, Length=291, Percent_Identity=23.0240549828179, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790399, Length=153, Percent_Identity=26.797385620915, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790208, Length=246, Percent_Identity=27.6422764227642, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI2367136, Length=162, Percent_Identity=29.6296296296296, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33297; Mature: 33297

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIHWLKTFVTLAEHKHFGKAATALHMTQPNVSLHIKQLEQSTRVKLIDRNPFRLTQAG
CCCHHHHHHHHHHHHHHCCCCHHHEEEEECCCCEEEHHHHCCCCCEEEEECCCCHHHHHH
FRLLESSQKTLMELQICQADLNAINDLSQGTLTIAASDIISRLLLIQPFQLFKAEFPGID
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCHHHHHHHCCCCC
FSLLNTTSSQASELVKNAEADLGFVIAQKESQPLHFTELQQIKWCAIGDNLQQWQQANLS
EEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHEEEEECCCCHHHHHHCCCC
VDTPLAEQPTLILLGHDTRTRELLDPALPSLNLPNYRIMEVGSVDAQIDWAEAGFGVAIV
CCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEHHCCCCCEEEE
PEFSVYTKANLTTKVTPLPQFPTTSLGYIVRQNQILSKAIKQLLYWVNQEIIRSQR
CCCEEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDIHWLKTFVTLAEHKHFGKAATALHMTQPNVSLHIKQLEQSTRVKLIDRNPFRLTQAG
CCCHHHHHHHHHHHHHHCCCCHHHEEEEECCCCEEEHHHHCCCCCEEEEECCCCHHHHHH
FRLLESSQKTLMELQICQADLNAINDLSQGTLTIAASDIISRLLLIQPFQLFKAEFPGID
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCHHHHHHHCCCCC
FSLLNTTSSQASELVKNAEADLGFVIAQKESQPLHFTELQQIKWCAIGDNLQQWQQANLS
EEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHEEEEECCCCHHHHHHCCCC
VDTPLAEQPTLILLGHDTRTRELLDPALPSLNLPNYRIMEVGSVDAQIDWAEAGFGVAIV
CCCCCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEHHCCCCCEEEE
PEFSVYTKANLTTKVTPLPQFPTTSLGYIVRQNQILSKAIKQLLYWVNQEIIRSQR
CCCEEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]