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The map label for this gene is fkpA [H]

Identifier: 126175283

GI number: 126175283

Start: 3603066

End: 3603536

Strand: Direct

Name: fkpA [H]

Synonym: Sbal_3082

Alternate gene names: 126175283

Gene position: 3603066-3603536 (Clockwise)

Preceding gene: 126175281

Following gene: 126175286

Centisome position: 70.27

GC content: 44.8

Gene sequence:

>471_bases
ATGAAAATGTTACTTGCCGTTGCTGTGATTGCTGGGGTGATTTTTTACTTCTTTACCTCGATGAACGGCCAAAAAGCCGC
TCAAGAGAATATCCGTTTAGGCAATGAATTTTTAACGCAAAACAAAACCAAAGAAGGTGTCATCACCACAGCTTCGGGTT
TGCAATATCAAGTATTGACTAAGGGCGATGGCACAGTTCATCCTAAAGCCAGCGATACAGTGACAGTGCATTACCATGGC
ACTTTGATCGACGGTACTGTGTTTGATAGTTCGGTTGATCGCGGCGAGCCTATCGCATTTCCGCTTAATCGGGTGATTAA
AGGCTGGACCGAGGGCGTACAACTTATGGTCGTTGGAGATAAAGTGCGTTTCTTTATCCCAAGTGAACTCGCCTACGGCA
ACAGTAGCACGGGCAAGATTGGCGGTGGTTCTGTGCTCATTTTTGATGTAGAACTGCTTAATATTGATTAA

Upstream 100 bases:

>100_bases
GGTAGCTGCAGATATCCCCCTCAACGCAGGTGCGAGTGCCAATAGCATCTCAAGCTAAAAAACTGATAATATGGCGAAAA
TTAACTAAGGTGCTCTTTAT

Downstream 100 bases:

>100_bases
ATCAGTCTTCAATGAGCCTAATTGCGTCATAAAAAGCCCTGCATTATCGCAGGGCTTTTTGTCTCTATAACTCAAAGAAT
ATTAGTATGTTGGATGATTA

Product: peptidylprolyl isomerase FKBP-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MKMLLAVAVIAGVIFYFFTSMNGQKAAQENIRLGNEFLTQNKTKEGVITTASGLQYQVLTKGDGTVHPKASDTVTVHYHG
TLIDGTVFDSSVDRGEPIAFPLNRVIKGWTEGVQLMVVGDKVRFFIPSELAYGNSSTGKIGGGSVLIFDVELLNID

Sequences:

>Translated_156_residues
MKMLLAVAVIAGVIFYFFTSMNGQKAAQENIRLGNEFLTQNKTKEGVITTASGLQYQVLTKGDGTVHPKASDTVTVHYHG
TLIDGTVFDSSVDRGEPIAFPLNRVIKGWTEGVQLMVVGDKVRFFIPSELAYGNSSTGKIGGGSVLIFDVELLNID
>Mature_156_residues
MKMLLAVAVIAGVIFYFFTSMNGQKAAQENIRLGNEFLTQNKTKEGVITTASGLQYQVLTKGDGTVHPKASDTVTVHYHG
TLIDGTVFDSSVDRGEPIAFPLNRVIKGWTEGVQLMVVGDKVRFFIPSELAYGNSSTGKIGGGSVLIFDVELLNID

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=43.9252336448598, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=43.9252336448598, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI206725530, Length=94, Percent_Identity=44.6808510638298, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI17149844, Length=94, Percent_Identity=44.6808510638298, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI17149842, Length=94, Percent_Identity=44.6808510638298, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4503727, Length=139, Percent_Identity=35.2517985611511, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=40.1869158878505, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI224809329, Length=97, Percent_Identity=42.2680412371134, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI224809327, Length=97, Percent_Identity=42.2680412371134, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI4758384, Length=97, Percent_Identity=42.2680412371134, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI4503729, Length=117, Percent_Identity=38.4615384615385, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI224809331, Length=96, Percent_Identity=42.7083333333333, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI8923659, Length=92, Percent_Identity=42.3913043478261, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI33469985, Length=88, Percent_Identity=37.5, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI192448443, Length=88, Percent_Identity=40.9090909090909, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI87082390, Length=123, Percent_Identity=54.4715447154472, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1789745, Length=132, Percent_Identity=47.7272727272727, Blast_Score=115, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17561782, Length=99, Percent_Identity=49.4949494949495, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71993519, Length=107, Percent_Identity=42.0560747663551, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17540882, Length=107, Percent_Identity=44.8598130841121, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324194, Length=101, Percent_Identity=47.5247524752475, Blast_Score=89, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320727, Length=97, Percent_Identity=50.5154639175258, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323566, Length=118, Percent_Identity=38.9830508474576, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323482, Length=91, Percent_Identity=40.6593406593407, Blast_Score=61, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=44.8598130841121, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI281363946, Length=91, Percent_Identity=48.3516483516484, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17352457, Length=91, Percent_Identity=48.3516483516484, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356629, Length=98, Percent_Identity=43.8775510204082, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=39.4230769230769, Blast_Score=73, Evalue=9e-14,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16843; Mature: 16843

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMLLAVAVIAGVIFYFFTSMNGQKAAQENIRLGNEFLTQNKTKEGVITTASGLQYQVLT
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHCCCCCCCEEEECCCCEEEEEE
KGDGTVHPKASDTVTVHYHGTLIDGTVFDSSVDRGEPIAFPLNRVIKGWTEGVQLMVVGD
CCCCEECCCCCCEEEEEEECEEEECEEECCCCCCCCCEEECHHHHHHHHCCCEEEEEECC
KVRFFIPSELAYGNSSTGKIGGGSVLIFDVELLNID
EEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEEECC
>Mature Secondary Structure
MKMLLAVAVIAGVIFYFFTSMNGQKAAQENIRLGNEFLTQNKTKEGVITTASGLQYQVLT
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHCCCCCCCEEEECCCCEEEEEE
KGDGTVHPKASDTVTVHYHGTLIDGTVFDSSVDRGEPIAFPLNRVIKGWTEGVQLMVVGD
CCCCEECCCCCCEEEEEEECEEEECEEECCCCCCCCCEEECHHHHHHHHCCCEEEEEECC
KVRFFIPSELAYGNSSTGKIGGGSVLIFDVELLNID
EEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]