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The map label for this gene is mutY [H]

Identifier: 126175241

GI number: 126175241

Start: 3563227

End: 3564318

Strand: Direct

Name: mutY [H]

Synonym: Sbal_3039

Alternate gene names: 126175241

Gene position: 3563227-3564318 (Clockwise)

Preceding gene: 126175235

Following gene: 126175242

Centisome position: 69.49

GC content: 49.54

Gene sequence:

>1092_bases
ATGAAATCTACAGCCTCCTTCGCTACACGTATCGTCTCTTGGTACGACAATCACGGTCGTAAAACCCTCCCTTGGCAGCA
AGATAAAACCCCATATAGCGTATGGGTTTCTGAAATCATGCTGCAACAAACTCAGGTTGCGACTGTTATTCCCTATTACC
TTAAATTTATGGCGCGTTTCCCCGATGTGTTAGCACTTGCTAACGCGCCAGATGATGAGGTGTTGCATCATTGGACTGGC
CTTGGGTATTACGCTAGAGCGCGTAATCTACATAAAGCAGCCAAGATGATCCGCGACGATTATCAGGGATTATTTCCAAC
GGATTTTGAGCAAGTACTTGCGCTGCCTGGCATTGGCCGCTCAACGGCAGGCGCAGTATTGTCACTGTCTCTTGGCCAGC
ATCACCCGATCCTCGACGGTAACGTCAAACGCGTGTTAGCAAGACACGGCGCCATAGCAGGTTGGCCGGGGCAAAAAACG
GTCGAAGCGCAGCTTTGGCAGCTAACTGACACGTATACGCCGCAGCAAGATATTCAGAAATATAATCAAGCCATGATGGA
TATCGGCGCCAGTATTTGTACTCGTAGCAAACCTAACTGCGCCGCTTGCCCTGTGGCGATTGATTGCAAAGCTCAGCTGA
TTGGCAGACAAACCGATTTCCCTGGCAAAAAGCCTAAAAAAACCATACCGACCAAAGCGGCGTGGATGTTAGTGCTAATG
CAAGACAACCAAGTGTTTTTAGCTAAACGTCCGCCAGCGGGAATTTGGGGCGGACTTTGGTGTTTCCCTGAGTTTGCCAC
CCACGCCGCACTTGAAACCCACCTCGAAGAGCAAGGGTTTGCAGGGCAACAACTCGAATGGCTAACTGGCTTTAGGCACA
CGTTTAGCCACTTCCATTTAGATATTCAGCCCATGATGCTTAATTTAGATAACACCCACGGCAATAAAGAGAGCGTGGGC
GCTGTCATGGAACAAAATCAGTCTCTCTGGTATAACATAAGTCATCCTTCCAAAGTGGGACTCGCCGCCGCCACCGAGCG
CGTGCTAGCCAATTTGGGATCACTAGTTCAATCCGCAGTCAGTAAGGAATAA

Upstream 100 bases:

>100_bases
TATTTGAGAGTGCGAATTTAGCAGTGATTTTCGGCTTTTTAGCCCTTATCCCCTTGTCTTTGAGCTTGTCTAAGAAGATA
ACTGCCGCTACACTGCGCCG

Downstream 100 bases:

>100_bases
TCATGGCGCGTACAGTCAATTGCGTATATTTAAATAAAGAAGCCGACGGCCTAGACTTTCAACTGTATCCAGGTGATTTA
GGTAAGCGCATTTTTGATAA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MKSTASFATRIVSWYDNHGRKTLPWQQDKTPYSVWVSEIMLQQTQVATVIPYYLKFMARFPDVLALANAPDDEVLHHWTG
LGYYARARNLHKAAKMIRDDYQGLFPTDFEQVLALPGIGRSTAGAVLSLSLGQHHPILDGNVKRVLARHGAIAGWPGQKT
VEAQLWQLTDTYTPQQDIQKYNQAMMDIGASICTRSKPNCAACPVAIDCKAQLIGRQTDFPGKKPKKTIPTKAAWMLVLM
QDNQVFLAKRPPAGIWGGLWCFPEFATHAALETHLEEQGFAGQQLEWLTGFRHTFSHFHLDIQPMMLNLDNTHGNKESVG
AVMEQNQSLWYNISHPSKVGLAAATERVLANLGSLVQSAVSKE

Sequences:

>Translated_363_residues
MKSTASFATRIVSWYDNHGRKTLPWQQDKTPYSVWVSEIMLQQTQVATVIPYYLKFMARFPDVLALANAPDDEVLHHWTG
LGYYARARNLHKAAKMIRDDYQGLFPTDFEQVLALPGIGRSTAGAVLSLSLGQHHPILDGNVKRVLARHGAIAGWPGQKT
VEAQLWQLTDTYTPQQDIQKYNQAMMDIGASICTRSKPNCAACPVAIDCKAQLIGRQTDFPGKKPKKTIPTKAAWMLVLM
QDNQVFLAKRPPAGIWGGLWCFPEFATHAALETHLEEQGFAGQQLEWLTGFRHTFSHFHLDIQPMMLNLDNTHGNKESVG
AVMEQNQSLWYNISHPSKVGLAAATERVLANLGSLVQSAVSKE
>Mature_363_residues
MKSTASFATRIVSWYDNHGRKTLPWQQDKTPYSVWVSEIMLQQTQVATVIPYYLKFMARFPDVLALANAPDDEVLHHWTG
LGYYARARNLHKAAKMIRDDYQGLFPTDFEQVLALPGIGRSTAGAVLSLSLGQHHPILDGNVKRVLARHGAIAGWPGQKT
VEAQLWQLTDTYTPQQDIQKYNQAMMDIGASICTRSKPNCAACPVAIDCKAQLIGRQTDFPGKKPKKTIPTKAAWMLVLM
QDNQVFLAKRPPAGIWGGLWCFPEFATHAALETHLEEQGFAGQQLEWLTGFRHTFSHFHLDIQPMMLNLDNTHGNKESVG
AVMEQNQSLWYNISHPSKVGLAAATERVLANLGSLVQSAVSKE

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=369, Percent_Identity=34.6883468834688, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI190358497, Length=369, Percent_Identity=34.6883468834688, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI115298650, Length=369, Percent_Identity=34.6883468834688, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI6912520, Length=369, Percent_Identity=34.6883468834688, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI115298654, Length=369, Percent_Identity=34.6883468834688, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI115298652, Length=369, Percent_Identity=34.6883468834688, Blast_Score=189, Evalue=4e-48,
Organism=Escherichia coli, GI1789331, Length=348, Percent_Identity=57.7586206896552, Blast_Score=431, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40506; Mature: 40506

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTASFATRIVSWYDNHGRKTLPWQQDKTPYSVWVSEIMLQQTQVATVIPYYLKFMARF
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PDVLALANAPDDEVLHHWTGLGYYARARNLHKAAKMIRDDYQGLFPTDFEQVLALPGIGR
CHHEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCC
STAGAVLSLSLGQHHPILDGNVKRVLARHGAIAGWPGQKTVEAQLWQLTDTYTPQQDIQK
CCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHH
YNQAMMDIGASICTRSKPNCAACPVAIDCKAQLIGRQTDFPGKKPKKTIPTKAAWMLVLM
HHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEE
QDNQVFLAKRPPAGIWGGLWCFPEFATHAALETHLEEQGFAGQQLEWLTGFRHTFSHFHL
ECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEE
DIQPMMLNLDNTHGNKESVGAVMEQNQSLWYNISHPSKVGLAAATERVLANLGSLVQSAV
EEEEEEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
SKE
CCC
>Mature Secondary Structure
MKSTASFATRIVSWYDNHGRKTLPWQQDKTPYSVWVSEIMLQQTQVATVIPYYLKFMARF
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PDVLALANAPDDEVLHHWTGLGYYARARNLHKAAKMIRDDYQGLFPTDFEQVLALPGIGR
CHHEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCC
STAGAVLSLSLGQHHPILDGNVKRVLARHGAIAGWPGQKTVEAQLWQLTDTYTPQQDIQK
CCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHH
YNQAMMDIGASICTRSKPNCAACPVAIDCKAQLIGRQTDFPGKKPKKTIPTKAAWMLVLM
HHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEE
QDNQVFLAKRPPAGIWGGLWCFPEFATHAALETHLEEQGFAGQQLEWLTGFRHTFSHFHL
ECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEE
DIQPMMLNLDNTHGNKESVGAVMEQNQSLWYNISHPSKVGLAAATERVLANLGSLVQSAV
EEEEEEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
SKE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]