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The map label for this gene is mvaB [H]

Identifier: 126175037

GI number: 126175037

Start: 3333891

End: 3334814

Strand: Direct

Name: mvaB [H]

Synonym: Sbal_2832

Alternate gene names: 126175037

Gene position: 3333891-3334814 (Clockwise)

Preceding gene: 126175036

Following gene: 126175038

Centisome position: 65.02

GC content: 52.16

Gene sequence:

>924_bases
ATGTCGTTAGTCAATCTAAGCCAAGCAGCGGACGCCAAAGACAGGGTAAGCATCTTCGAGATGGGCGCGCGCGACGGCCT
GCAAAACGAAGTCGCTGTGCCAACGGCAGCTAAAATCGCCTTGATTGAATCGCTGGCAGATGCAGGGCTTAAGCGCATCG
AAGCCGGCAGTTTTGTGTCACCCAAATGGGTGCCACAAATGGCCGATTCTGCCGATGTGCTCAAGCAAATACAGCGTCAA
AGCGGCGTGGTGTATAGCGCGCTCACGCCCAACGTCAAAGGCTTTGAACTGGCACTGGATGCAAAAGCTTCCGAAGTAGC
GATATTTGGCGCCGCCTCACAAAGCTTTAGTCAGCGCAATATCAACTGCTCGATAGAAGAGTCGATTGAGCGCTTTATCC
CTTTGATGGAATTAGCAAAAGCGCACAATATTCCGGTGCGCGGCTATGTGTCCTGCGTGCTCGGCTGCCCCTACGAAGGT
GAGATAGCGGTCAGTGAAGTGGCCCGCGTGTCTGAAATCCTTTACAAAATGGGCTGTTACGAAATATCACTCGGTGACAC
TATCGGTGTAGGCACGCCGCAAAAAGCCCGTAGAATGCTGCAAACTGTGGCTGAACGTGTGCCTATGGATAAACTGGCGC
TACACTTTCACGACACCTATGGCCAAGCATTAGCTAACATTTTGGCCTGCTTAGACTTAGGTGTGCGGGTGTTTGACTCC
TCGGTTGCAGGTCTTGGTGGCTGCCCCTATGCCAAAGGCGCATCGGGCAATCTCGCCACCGAAGACTTAGTGTATATGCT
GCACGGCATGGGATTAGAAACGGGTATCGATTTACAAAAACTCGCTTTAGCAGGACAAGCTATCAGCACGCAGTTGAATC
GCAACAACGGCTCGAAAGTGGCCACAGCCCTGTTAGCAAAATAG

Upstream 100 bases:

>100_bases
TTCTACTTTAAGGCGGGCGAGCTGGTGACCGATGGCGCAACCTTGCTTAACGTTGAGCCGTTAGAGACAGAAGAGCCAAC
CGCGACCAAGGAAGCCTAAG

Downstream 100 bases:

>100_bases
AACAACAATAATTAACGACAACAACCGTTATTGAAAACGCGCGTTATTTCCCGCGCGTTTTATACAGCATAAAAGGACAT
CACAATGGCAGGACTCAATA

Product: pyruvate carboxyltransferase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSLVNLSQAADAKDRVSIFEMGARDGLQNEVAVPTAAKIALIESLADAGLKRIEAGSFVSPKWVPQMADSADVLKQIQRQ
SGVVYSALTPNVKGFELALDAKASEVAIFGAASQSFSQRNINCSIEESIERFIPLMELAKAHNIPVRGYVSCVLGCPYEG
EIAVSEVARVSEILYKMGCYEISLGDTIGVGTPQKARRMLQTVAERVPMDKLALHFHDTYGQALANILACLDLGVRVFDS
SVAGLGGCPYAKGASGNLATEDLVYMLHGMGLETGIDLQKLALAGQAISTQLNRNNGSKVATALLAK

Sequences:

>Translated_307_residues
MSLVNLSQAADAKDRVSIFEMGARDGLQNEVAVPTAAKIALIESLADAGLKRIEAGSFVSPKWVPQMADSADVLKQIQRQ
SGVVYSALTPNVKGFELALDAKASEVAIFGAASQSFSQRNINCSIEESIERFIPLMELAKAHNIPVRGYVSCVLGCPYEG
EIAVSEVARVSEILYKMGCYEISLGDTIGVGTPQKARRMLQTVAERVPMDKLALHFHDTYGQALANILACLDLGVRVFDS
SVAGLGGCPYAKGASGNLATEDLVYMLHGMGLETGIDLQKLALAGQAISTQLNRNNGSKVATALLAK
>Mature_306_residues
SLVNLSQAADAKDRVSIFEMGARDGLQNEVAVPTAAKIALIESLADAGLKRIEAGSFVSPKWVPQMADSADVLKQIQRQS
GVVYSALTPNVKGFELALDAKASEVAIFGAASQSFSQRNINCSIEESIERFIPLMELAKAHNIPVRGYVSCVLGCPYEGE
IAVSEVARVSEILYKMGCYEISLGDTIGVGTPQKARRMLQTVAERVPMDKLALHFHDTYGQALANILACLDLGVRVFDSS
VAGLGGCPYAKGASGNLATEDLVYMLHGMGLETGIDLQKLALAGQAISTQLNRNNGSKVATALLAK

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=301, Percent_Identity=61.4617940199336, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI109150427, Length=298, Percent_Identity=58.3892617449664, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI109150422, Length=298, Percent_Identity=58.3892617449664, Blast_Score=357, Evalue=5e-99,
Organism=Homo sapiens, GI260654708, Length=136, Percent_Identity=66.1764705882353, Blast_Score=182, Evalue=3e-46,
Organism=Escherichia coli, GI1786261, Length=295, Percent_Identity=27.1186440677966, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510563, Length=298, Percent_Identity=51.006711409396, Blast_Score=315, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24582381, Length=293, Percent_Identity=62.1160409556314, Blast_Score=377, Evalue=1e-105,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32621; Mature: 32490

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS01062 HMG_COA_LYASE ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVNLSQAADAKDRVSIFEMGARDGLQNEVAVPTAAKIALIESLADAGLKRIEAGSFVS
CCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PKWVPQMADSADVLKQIQRQSGVVYSALTPNVKGFELALDAKASEVAIFGAASQSFSQRN
CCCCHHHCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCEEEEEECCCHHHHHCC
INCSIEESIERFIPLMELAKAHNIPVRGYVSCVLGCPYEGEIAVSEVARVSEILYKMGCY
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCE
EISLGDTIGVGTPQKARRMLQTVAERVPMDKLALHFHDTYGQALANILACLDLGVRVFDS
EEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SVAGLGGCPYAKGASGNLATEDLVYMLHGMGLETGIDLQKLALAGQAISTQLNRNNGSKV
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHH
ATALLAK
HHHHHCC
>Mature Secondary Structure 
SLVNLSQAADAKDRVSIFEMGARDGLQNEVAVPTAAKIALIESLADAGLKRIEAGSFVS
CCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PKWVPQMADSADVLKQIQRQSGVVYSALTPNVKGFELALDAKASEVAIFGAASQSFSQRN
CCCCHHHCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCEEEEEECCCHHHHHCC
INCSIEESIERFIPLMELAKAHNIPVRGYVSCVLGCPYEGEIAVSEVARVSEILYKMGCY
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCE
EISLGDTIGVGTPQKARRMLQTVAERVPMDKLALHFHDTYGQALANILACLDLGVRVFDS
EEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SVAGLGGCPYAKGASGNLATEDLVYMLHGMGLETGIDLQKLALAGQAISTQLNRNNGSKV
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHH
ATALLAK
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]