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The map label for this gene is 126174828

Identifier: 126174828

GI number: 126174828

Start: 3058300

End: 3059460

Strand: Direct

Name: 126174828

Synonym: Sbal_2615

Alternate gene names: NA

Gene position: 3058300-3059460 (Clockwise)

Preceding gene: 126174825

Following gene: 126174829

Centisome position: 59.65

GC content: 47.2

Gene sequence:

>1161_bases
ATGCCATTTTATGTGAAACAAGGCCAGATCCCCCATAAGCGCCATATCGCATTTGAAAAGGAAAACGGCGAGCTTTACCG
TGAAGAGTTGTTCTCAACCCATGGTTTTTCCAATATTTATTCCAATAAATATCACCACAACATGCCAACCAAAGCGTTGG
AAGTAGCACCTTACAACCTAGGCCACGGTGCCAATTGGGAAGACTCGCTGGTCCAAAACTATAAACTCGATTCCCGCGAT
GCCGACCGTGAAGGTAATTTTTTCAGCGCCCGTAACAAGATTTTTTATAACAATGACTTAGCACTTTATACCGCCAAAGT
CACCGCCGATACCGACGAGTTTTACCGTAATGCCTATGCCGATGAGGTGGTTTTTGTCCACGAAGGCGAAGGCACACTCT
ACAGCGAGTACGGCACGATTAAGGTTCAAAAGTGGGACTATCTCGTGATCCCACGCGGCACGACTTATCAACTTAAATTC
AACGATTACAGCAATGCGCGACTTTTCGTTATCGAGTCATTCTCTATGGTGGAAGTGCCTAAGCATTTCCGTAACGAGTA
TGGTCAGCTATTAGAATCGGCACCTTATTGCGAGCGCGATTTGCGCGTGCCCACATTGCAAGATGCTGTGGTTGAGCGCG
GCGCCTTCCCCTTAGTGTGTAAGTTTGGCGATAAATACCAACTCACCACACTTGAATGGCATCCCTTTGATTTAGTGGGT
TGGGATGGCTGTGTTTACCCTTGGGCATTCAACATTACTGAATACGCGCCAAAGGTGGGCAAAATCCATCTGCCGCCTTC
TGATCACTTAGTCTTTACTGCCCATAACTTTGTGATTTGTAACTTCGTGCCGCGCCCTTACGATTTCCACCCGAAATCGA
TTCCAGCGCCTTATTACCACAACAATATCGATAGCGACGAAGTTTTGTATTACGTCGATGGCGACTTTATGAGCCGCACG
GGCATTGAAGCGGGTTACATGACCTTACATCAAAAAGGTGTGGCCCACGGCCCACAACCGGGTCGCACTGAAGCCTCGAT
TGGCAAGAAAGAAACCTATGAATACGCAGTGATGGTGGACACGTTCGCCCCACTTAAATTAACCGAACATGTACAAAATT
GCATGAGCAAAGACTACAACCGCTCTTGGCTAGAAGACTAG

Upstream 100 bases:

>100_bases
TTCAAGCAACTAAATTGATAACAAGATCACACTAATGCAACTTGCAGCATAACGACCAGCGATGTAGGTAATCCTGCAAC
GCAATATTGAAGGAATAACC

Downstream 100 bases:

>100_bases
CCCTAAGCCACCAGCGCACCGAAACGGTTGCGTATCCCAACGTAATTAAAGGGATAAAGAGTGTCGGCGGTTGAACTAAA
ATAATGAGGAAAACATCATG

Product: homogentisate 12-dioxygenase

Products: 4-maleylacetoacetate

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MPFYVKQGQIPHKRHIAFEKENGELYREELFSTHGFSNIYSNKYHHNMPTKALEVAPYNLGHGANWEDSLVQNYKLDSRD
ADREGNFFSARNKIFYNNDLALYTAKVTADTDEFYRNAYADEVVFVHEGEGTLYSEYGTIKVQKWDYLVIPRGTTYQLKF
NDYSNARLFVIESFSMVEVPKHFRNEYGQLLESAPYCERDLRVPTLQDAVVERGAFPLVCKFGDKYQLTTLEWHPFDLVG
WDGCVYPWAFNITEYAPKVGKIHLPPSDHLVFTAHNFVICNFVPRPYDFHPKSIPAPYYHNNIDSDEVLYYVDGDFMSRT
GIEAGYMTLHQKGVAHGPQPGRTEASIGKKETYEYAVMVDTFAPLKLTEHVQNCMSKDYNRSWLED

Sequences:

>Translated_386_residues
MPFYVKQGQIPHKRHIAFEKENGELYREELFSTHGFSNIYSNKYHHNMPTKALEVAPYNLGHGANWEDSLVQNYKLDSRD
ADREGNFFSARNKIFYNNDLALYTAKVTADTDEFYRNAYADEVVFVHEGEGTLYSEYGTIKVQKWDYLVIPRGTTYQLKF
NDYSNARLFVIESFSMVEVPKHFRNEYGQLLESAPYCERDLRVPTLQDAVVERGAFPLVCKFGDKYQLTTLEWHPFDLVG
WDGCVYPWAFNITEYAPKVGKIHLPPSDHLVFTAHNFVICNFVPRPYDFHPKSIPAPYYHNNIDSDEVLYYVDGDFMSRT
GIEAGYMTLHQKGVAHGPQPGRTEASIGKKETYEYAVMVDTFAPLKLTEHVQNCMSKDYNRSWLED
>Mature_385_residues
PFYVKQGQIPHKRHIAFEKENGELYREELFSTHGFSNIYSNKYHHNMPTKALEVAPYNLGHGANWEDSLVQNYKLDSRDA
DREGNFFSARNKIFYNNDLALYTAKVTADTDEFYRNAYADEVVFVHEGEGTLYSEYGTIKVQKWDYLVIPRGTTYQLKFN
DYSNARLFVIESFSMVEVPKHFRNEYGQLLESAPYCERDLRVPTLQDAVVERGAFPLVCKFGDKYQLTTLEWHPFDLVGW
DGCVYPWAFNITEYAPKVGKIHLPPSDHLVFTAHNFVICNFVPRPYDFHPKSIPAPYYHNNIDSDEVLYYVDGDFMSRTG
IEAGYMTLHQKGVAHGPQPGRTEASIGKKETYEYAVMVDTFAPLKLTEHVQNCMSKDYNRSWLED

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR014710 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: 1.13.11.5

Molecular weight: Translated: 44794; Mature: 44662

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFYVKQGQIPHKRHIAFEKENGELYREELFSTHGFSNIYSNKYHHNMPTKALEVAPYNL
CCEEECCCCCCHHHCEEEECCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEEECCCCC
GHGANWEDSLVQNYKLDSRDADREGNFFSARNKIFYNNDLALYTAKVTADTDEFYRNAYA
CCCCCCHHHHHHHCCCCCCCCCCCCCEEECCCEEEECCCEEEEEEEEECCHHHHHHHCCC
DEVVFVHEGEGTLYSEYGTIKVQKWDYLVIPRGTTYQLKFNDYSNARLFVIESFSMVEVP
CCEEEEECCCCEEEECCCEEEEEECEEEEEECCCEEEEEECCCCCEEEEEEECCCHHHHH
KHFRNEYGQLLESAPYCERDLRVPTLQDAVVERGAFPLVCKFGDKYQLTTLEWHPFDLVG
HHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHCCCCEEEEECCCEEEEEEEEECCCEEEC
WDGCVYPWAFNITEYAPKVGKIHLPPSDHLVFTAHNFVICNFVPRPYDFHPKSIPAPYYH
CCCEECCEEECHHHHCCCCCEEECCCCCCEEEEECCEEEEEECCCCCCCCCCCCCCCCCC
NNIDSDEVLYYVDGDFMSRTGIEAGYMTLHQKGVAHGPQPGRTEASIGKKETYEYAVMVD
CCCCCCCEEEEECCCCHHHCCCCHHHEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEE
TFAPLKLTEHVQNCMSKDYNRSWLED
CCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PFYVKQGQIPHKRHIAFEKENGELYREELFSTHGFSNIYSNKYHHNMPTKALEVAPYNL
CEEECCCCCCHHHCEEEECCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEEECCCCC
GHGANWEDSLVQNYKLDSRDADREGNFFSARNKIFYNNDLALYTAKVTADTDEFYRNAYA
CCCCCCHHHHHHHCCCCCCCCCCCCCEEECCCEEEECCCEEEEEEEEECCHHHHHHHCCC
DEVVFVHEGEGTLYSEYGTIKVQKWDYLVIPRGTTYQLKFNDYSNARLFVIESFSMVEVP
CCEEEEECCCCEEEECCCEEEEEECEEEEEECCCEEEEEECCCCCEEEEEEECCCHHHHH
KHFRNEYGQLLESAPYCERDLRVPTLQDAVVERGAFPLVCKFGDKYQLTTLEWHPFDLVG
HHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHCCCCEEEEECCCEEEEEEEEECCCEEEC
WDGCVYPWAFNITEYAPKVGKIHLPPSDHLVFTAHNFVICNFVPRPYDFHPKSIPAPYYH
CCCEECCEEECHHHHCCCCCEEECCCCCCEEEEECCEEEEEECCCCCCCCCCCCCCCCCC
NNIDSDEVLYYVDGDFMSRTGIEAGYMTLHQKGVAHGPQPGRTEASIGKKETYEYAVMVD
CCCCCCCEEEEECCCCHHHCCCCHHHEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEEE
TFAPLKLTEHVQNCMSKDYNRSWLED
CCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: homogentisate; O2

Specific reaction: homogentisate + O2 = 4-maleylacetoacetate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]