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The map label for this gene is estA [H]

Identifier: 126174800

GI number: 126174800

Start: 3032043

End: 3032417

Strand: Reverse

Name: estA [H]

Synonym: Sbal_2587

Alternate gene names: 126174800

Gene position: 3032417-3032043 (Counterclockwise)

Preceding gene: 126174801

Following gene: 126174797

Centisome position: 59.14

GC content: 49.33

Gene sequence:

>375_bases
ATGTCAGTTTCTCTTGAGCGTATTGTCGTTGAACCTAAGACGCCTGCTACAGCCGTGGTTATTTGGTTACATGGATTAGG
GGATTCGGGTGCCGGATTTGCCCCCATTGTGCCTGCATTAGCTTTGCCTGCCGATCATGCTATCCGGTTTATTTTCCCCC
ATGCACCGGAGCAAGCCGTGACCATCAATGGCGGCTACGTCATGCGCGCTTGGTACGATATTAAAAGCATGGATTTGCAC
GACAGAGCTGATATGCAAGGCGTGCTTGAGTCGGAGAAAAGGGTTGCTGCATTAATTAATGAACAAATCGCGGCGGGTAT
TGCGAGTGAGCGTATCGTATTAGCAGGATTCAGTCAGCGGTGTTTTTCAAGATAG

Upstream 100 bases:

>100_bases
GGAATAAAGTACGCCAGCATAGTGCATAGTGGTTAACTTATAGATTTATCATCAGTTTTTAGTTGATGAGTGTTTAATAT
CGAATTGGGGATTTTTTAGT

Downstream 100 bases:

>100_bases
TTGTCACTCTTTGTTTAAAAATCAAGCTGCATTTATTACGCCTTCTACTGGTGCCTTATCTGGGTTGAGTGTTACAGCGC
CAACCGCTTCACAATTTCTA

Product: phospholipase/carboxylesterase

Products: NA

Alternate protein names: Esterase I [H]

Number of amino acids: Translated: 124; Mature: 123

Protein sequence:

>124_residues
MSVSLERIVVEPKTPATAVVIWLHGLGDSGAGFAPIVPALALPADHAIRFIFPHAPEQAVTINGGYVMRAWYDIKSMDLH
DRADMQGVLESEKRVAALINEQIAAGIASERIVLAGFSQRCFSR

Sequences:

>Translated_124_residues
MSVSLERIVVEPKTPATAVVIWLHGLGDSGAGFAPIVPALALPADHAIRFIFPHAPEQAVTINGGYVMRAWYDIKSMDLH
DRADMQGVLESEKRVAALINEQIAAGIASERIVLAGFSQRCFSR
>Mature_123_residues
SVSLERIVVEPKTPATAVVIWLHGLGDSGAGFAPIVPALALPADHAIRFIFPHAPEQAVTINGGYVMRAWYDIKSMDLHD
RADMQGVLESEKRVAALINEQIAAGIASERIVLAGFSQRCFSR

Specific function: Hydrolyzes carboxylic ester bonds with relatively broad substrate specificity [H]

COG id: COG0400

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase 2 family [H]

Homologues:

Organism=Homo sapiens, GI5453722, Length=119, Percent_Identity=41.1764705882353, Blast_Score=87, Evalue=3e-18,
Organism=Homo sapiens, GI9966764, Length=103, Percent_Identity=39.8058252427184, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17508057, Length=111, Percent_Identity=40.5405405405405, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323147, Length=109, Percent_Identity=38.5321100917431, Blast_Score=79, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45553055, Length=112, Percent_Identity=38.3928571428571, Blast_Score=89, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45553057, Length=112, Percent_Identity=38.3928571428571, Blast_Score=89, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21357257, Length=112, Percent_Identity=38.3928571428571, Blast_Score=89, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003140 [H]

Pfam domain/function: PF02230 Abhydrolase_2 [H]

EC number: =3.1.1.1 [H]

Molecular weight: Translated: 13425; Mature: 13293

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSLERIVVEPKTPATAVVIWLHGLGDSGAGFAPIVPALALPADHAIRFIFPHAPEQAV
CCCCCCEEEECCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCEE
TINGGYVMRAWYDIKSMDLHDRADMQGVLESEKRVAALINEQIAAGIASERIVLAGFSQR
EECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHH
CFSR
HCCC
>Mature Secondary Structure 
SVSLERIVVEPKTPATAVVIWLHGLGDSGAGFAPIVPALALPADHAIRFIFPHAPEQAV
CCCCCEEEECCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCEE
TINGGYVMRAWYDIKSMDLHDRADMQGVLESEKRVAALINEQIAAGIASERIVLAGFSQR
EECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHH
CFSR
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA