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The map label for this gene is htpX

Identifier: 126174770

GI number: 126174770

Start: 2993273

End: 2994136

Strand: Reverse

Name: htpX

Synonym: Sbal_2557

Alternate gene names: 126174770

Gene position: 2994136-2993273 (Counterclockwise)

Preceding gene: 126174773

Following gene: 126174768

Centisome position: 58.4

GC content: 47.45

Gene sequence:

>864_bases
ATGAAGCGTATATTTTTATTGATTGCGACTAACCTAGCTGTGTTGCTAGTAGCCTCAATTGTAATGTCTATTCTAGGCGT
GAACACGTCTACTATGGGTGGACTGCTGGTGTTCGCTGCCATTTTTGGATTCGGTGGGGCCTTTATCAGCTTAGCCATTT
CAAAATGGATGGCGAAAAAGACCATGGGTTGTGAAGTGATCACTACCCCACGTGACAGTACCGAACGTTGGTTAGTAGAG
ACGGTTGCCCGTCAAGCTAAGCAAGCGGGAATTAAAATGCCAGAAGTGGCGATTTATCAATCACCCGACATGAACGCGTT
CGCTACAGGCCCAAGCAAAGACAATTCATTAGTGGCTGTGAGTACGGGTCTGTTATATGGCATGAGCCAAGATGAAATCG
AAGGCGTATTGGCCCACGAAGTGAGCCACGTTGCTAACGGTGACATGGTGACCTTGACACTGATCCAAGGGGTAGTTAAC
ACCTTCGTGATCTTCGCGGCTCGTGTGGTTGCTGGCATTATTAACAACTTTGTGTCGAGCAATGATGAAGAAGGCGAAGG
TTTAGGCATGTTCGCTTACATGGCCGTGGTTTTCGTGCTGGATATGTTATTCGGTATCTTGGCTTCAATCATCGTCGCTT
ACTTCTCACGTATTCGTGAGTACAAAGCCGATGAAGGCGCGGCCCGTTTAGCGGGTAAAGGCAAGATGATTGCTGCGCTT
GAACGTTTACGCCAAGGTCCAGAAAGCACGGCAATGCCTGCACAGATGTCTGCCTTTGGTATTAACGGCAAACGTTCAAT
GGCGGAAATGATGATGAGTCATCCTCCATTAGAAAAACGTATTGCAGCGTTAAGAGCAAGCTAA

Upstream 100 bases:

>100_bases
TTAAAAACTCTTTTCTTTTACCACTTGAATTTCGATGATTTGGACATATTATGTCTTTGAACAAAGTTAAATGGCATATT
CTTGCCCTAAAGGAGCTGAA

Downstream 100 bases:

>100_bases
TAGATAGTGAGTTCGCGCTTAAGTTTTAGTGCTTAGGCTGACTTGATATTAGATCTATGACTCTCAATATCGGGCTCAAA
CTTTGGTTTGAGCCCGATTT

Product: heat shock protein HtpX

Products: NA

Alternate protein names: Heat shock protein HtpX

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MKRIFLLIATNLAVLLVASIVMSILGVNTSTMGGLLVFAAIFGFGGAFISLAISKWMAKKTMGCEVITTPRDSTERWLVE
TVARQAKQAGIKMPEVAIYQSPDMNAFATGPSKDNSLVAVSTGLLYGMSQDEIEGVLAHEVSHVANGDMVTLTLIQGVVN
TFVIFAARVVAGIINNFVSSNDEEGEGLGMFAYMAVVFVLDMLFGILASIIVAYFSRIREYKADEGAARLAGKGKMIAAL
ERLRQGPESTAMPAQMSAFGINGKRSMAEMMMSHPPLEKRIAALRAS

Sequences:

>Translated_287_residues
MKRIFLLIATNLAVLLVASIVMSILGVNTSTMGGLLVFAAIFGFGGAFISLAISKWMAKKTMGCEVITTPRDSTERWLVE
TVARQAKQAGIKMPEVAIYQSPDMNAFATGPSKDNSLVAVSTGLLYGMSQDEIEGVLAHEVSHVANGDMVTLTLIQGVVN
TFVIFAARVVAGIINNFVSSNDEEGEGLGMFAYMAVVFVLDMLFGILASIIVAYFSRIREYKADEGAARLAGKGKMIAAL
ERLRQGPESTAMPAQMSAFGINGKRSMAEMMMSHPPLEKRIAALRAS
>Mature_287_residues
MKRIFLLIATNLAVLLVASIVMSILGVNTSTMGGLLVFAAIFGFGGAFISLAISKWMAKKTMGCEVITTPRDSTERWLVE
TVARQAKQAGIKMPEVAIYQSPDMNAFATGPSKDNSLVAVSTGLLYGMSQDEIEGVLAHEVSHVANGDMVTLTLIQGVVN
TFVIFAARVVAGIINNFVSSNDEEGEGLGMFAYMAVVFVLDMLFGILASIIVAYFSRIREYKADEGAARLAGKGKMIAAL
ERLRQGPESTAMPAQMSAFGINGKRSMAEMMMSHPPLEKRIAALRAS

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=288, Percent_Identity=57.2916666666667, Blast_Score=328, Evalue=3e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_SHEB2 (B8E719)

Other databases:

- EMBL:   CP001252
- RefSeq:   YP_002357715.1
- ProteinModelPortal:   B8E719
- SMR:   B8E719
- GeneID:   7088321
- GenomeReviews:   CP001252_GR
- KEGG:   sbp:Sbal223_1787
- HOGENOM:   HBG739460
- OMA:   NRFLTAN
- ProtClustDB:   PRK05457
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 30742; Mature: 30742

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 140-140

Signals:

None

Transmembrane regions:

HASH(0x163336f4)-; HASH(0x1258172c)-; HASH(0x171b24d4)-; HASH(0x171a7194)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
6.6 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIFLLIATNLAVLLVASIVMSILGVNTSTMGGLLVFAAIFGFGGAFISLAISKWMAKK
CCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMGCEVITTPRDSTERWLVETVARQAKQAGIKMPEVAIYQSPDMNAFATGPSKDNSLVAV
HCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCCCCCEEEE
STGLLYGMSQDEIEGVLAHEVSHVANGDMVTLTLIQGVVNTFVIFAARVVAGIINNFVSS
EHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NDEEGEGLGMFAYMAVVFVLDMLFGILASIIVAYFSRIREYKADEGAARLAGKGKMIAAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHH
ERLRQGPESTAMPAQMSAFGINGKRSMAEMMMSHPPLEKRIAALRAS
HHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHCH
>Mature Secondary Structure
MKRIFLLIATNLAVLLVASIVMSILGVNTSTMGGLLVFAAIFGFGGAFISLAISKWMAKK
CCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMGCEVITTPRDSTERWLVETVARQAKQAGIKMPEVAIYQSPDMNAFATGPSKDNSLVAV
HCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCCCCCEEEE
STGLLYGMSQDEIEGVLAHEVSHVANGDMVTLTLIQGVVNTFVIFAARVVAGIINNFVSS
EHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NDEEGEGLGMFAYMAVVFVLDMLFGILASIIVAYFSRIREYKADEGAARLAGKGKMIAAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHH
ERLRQGPESTAMPAQMSAFGINGKRSMAEMMMSHPPLEKRIAALRAS
HHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA