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The map label for this gene is dapA

Identifier: 126174765

GI number: 126174765

Start: 2989031

End: 2989915

Strand: Reverse

Name: dapA

Synonym: Sbal_2552

Alternate gene names: 126174765

Gene position: 2989915-2989031 (Counterclockwise)

Preceding gene: 126174768

Following gene: 126174764

Centisome position: 58.31

GC content: 47.34

Gene sequence:

>885_bases
ATGATAAACGGAAGCATCGTAGCCTTAATCACGCCAATGAACAGTGATGGCTCAGTAGATTTTGCAAGTCTTGAAAGGTT
AGTCGAATTCCATATTGACCAAGGCACAGATGCCATTGTGGCCGTTGGTACTACTGGCGAGTCAGCAACTCTGCCTATGT
CTGAGCATGTAACGGTCGTTTCACAAACCGTTAAATTTGCTGCGGGCCGTGTTCCTGTCATTGGTGGCAATGGTGCCAAT
GCCACATCTGAAGCCGTTGAGCTCACCAAGTCCTTATCTAAGGTGGGTGTTGCCGCTATGCTTGGCGTAACGCCATATTA
TAATAAGCCAACTCCTAAGGGATTGATTGCACATTATAAAGCCGTGGCTGCCAGCACAGATATTCCACAAATTCTTTATA
ATGTCCCTGGCCGTACTGCCGTTGATATGTTGCCAGAGACCGTTGCCGAGTTAGTCAGCGTTAGCAACATTATTGGCGTA
AAAGAAGCGACCGGTGACTTATCCCGTGTAAAACGTCTGCGCGAACTGTGCGGCGACGATTTCCTTTTGTATAGCGGCGA
TGATGCCACTGCCAGAGAGTTCTTACTCTTAGGTGGCAATGGCGTGATTTCAGTGGCGAACAACATAGTGCCACAAGCCT
TTAAAGCTATGTGTGATGCGGCGCTTGCCGGTAATGCTGAGCTTGCGCTGAGCATAGACACACCACTGCGCGGTTTATAT
AGCACACTCTTTTGTGAAGCCAATCCTATCCCAGTTAAATGGGCTGCCCATCGTATGGGTTTGATTGAATGTGGCCATAT
TCGTTTACCTTTGACTGAACTTTCTGAGCAATGTCATGGTCTGTTGATAGAAGCAATGACTCGTGCCCAGATAGAGGTTA
AATAA

Upstream 100 bases:

>100_bases
ATGCTACCATAACTAATTCAATTTGAGAGCCCCGTTAATGCTTGTCATTAGTGGTTGGCATCAGTACCATAGCGAATCCT
GAAATCTTGGGGAAAGTCAG

Downstream 100 bases:

>100_bases
TTAATGTTAAAGAAAGTCACCCCACTGATCTTAGTTGCTGCCGTTGCAGCCTGTAGTTCGCCACTCGATCGCCGTCAAGC
GAATGGAACTGAAGACTATG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MINGSIVALITPMNSDGSVDFASLERLVEFHIDQGTDAIVAVGTTGESATLPMSEHVTVVSQTVKFAAGRVPVIGGNGAN
ATSEAVELTKSLSKVGVAAMLGVTPYYNKPTPKGLIAHYKAVAASTDIPQILYNVPGRTAVDMLPETVAELVSVSNIIGV
KEATGDLSRVKRLRELCGDDFLLYSGDDATAREFLLLGGNGVISVANNIVPQAFKAMCDAALAGNAELALSIDTPLRGLY
STLFCEANPIPVKWAAHRMGLIECGHIRLPLTELSEQCHGLLIEAMTRAQIEVK

Sequences:

>Translated_294_residues
MINGSIVALITPMNSDGSVDFASLERLVEFHIDQGTDAIVAVGTTGESATLPMSEHVTVVSQTVKFAAGRVPVIGGNGAN
ATSEAVELTKSLSKVGVAAMLGVTPYYNKPTPKGLIAHYKAVAASTDIPQILYNVPGRTAVDMLPETVAELVSVSNIIGV
KEATGDLSRVKRLRELCGDDFLLYSGDDATAREFLLLGGNGVISVANNIVPQAFKAMCDAALAGNAELALSIDTPLRGLY
STLFCEANPIPVKWAAHRMGLIECGHIRLPLTELSEQCHGLLIEAMTRAQIEVK
>Mature_294_residues
MINGSIVALITPMNSDGSVDFASLERLVEFHIDQGTDAIVAVGTTGESATLPMSEHVTVVSQTVKFAAGRVPVIGGNGAN
ATSEAVELTKSLSKVGVAAMLGVTPYYNKPTPKGLIAHYKAVAASTDIPQILYNVPGRTAVDMLPETVAELVSVSNIIGV
KEATGDLSRVKRLRELCGDDFLLYSGDDATAREFLLLGGNGVISVANNIVPQAFKAMCDAALAGNAELALSIDTPLRGLY
STLFCEANPIPVKWAAHRMGLIECGHIRLPLTELSEQCHGLLIEAMTRAQIEVK

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=213, Percent_Identity=30.9859154929577, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI13540533, Length=241, Percent_Identity=25.3112033195021, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1788823, Length=276, Percent_Identity=52.8985507246377, Blast_Score=304, Evalue=4e-84,
Organism=Escherichia coli, GI1789620, Length=277, Percent_Identity=28.158844765343, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI87082415, Length=282, Percent_Identity=28.0141843971631, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1786463, Length=253, Percent_Identity=30.0395256916996, Blast_Score=102, Evalue=3e-23,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_SHEB2 (B8E724)

Other databases:

- EMBL:   CP001252
- RefSeq:   YP_002357720.1
- ProteinModelPortal:   B8E724
- SMR:   B8E724
- GeneID:   7088326
- GenomeReviews:   CP001252_GR
- KEGG:   sbp:Sbal223_1792
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- ProtClustDB:   PRK03170
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31001; Mature: 31001

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 161-161 BINDING 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINGSIVALITPMNSDGSVDFASLERLVEFHIDQGTDAIVAVGTTGESATLPMSEHVTVV
CCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHH
SQTVKFAAGRVPVIGGNGANATSEAVELTKSLSKVGVAAMLGVTPYYNKPTPKGLIAHYK
HHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
AVAASTDIPQILYNVPGRTAVDMLPETVAELVSVSNIIGVKEATGDLSRVKRLRELCGDD
HHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHCCCC
FLLYSGDDATAREFLLLGGNGVISVANNIVPQAFKAMCDAALAGNAELALSIDTPLRGLY
EEEECCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHH
STLFCEANPIPVKWAAHRMGLIECGHIRLPLTELSEQCHGLLIEAMTRAQIEVK
HHHHCCCCCCCEEHHHHHCCEEEECCEECCHHHHHHHHHHHHHHHHHHCEEEEC
>Mature Secondary Structure
MINGSIVALITPMNSDGSVDFASLERLVEFHIDQGTDAIVAVGTTGESATLPMSEHVTVV
CCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHH
SQTVKFAAGRVPVIGGNGANATSEAVELTKSLSKVGVAAMLGVTPYYNKPTPKGLIAHYK
HHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
AVAASTDIPQILYNVPGRTAVDMLPETVAELVSVSNIIGVKEATGDLSRVKRLRELCGDD
HHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHCCCC
FLLYSGDDATAREFLLLGGNGVISVANNIVPQAFKAMCDAALAGNAELALSIDTPLRGLY
EEEECCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHH
STLFCEANPIPVKWAAHRMGLIECGHIRLPLTELSEQCHGLLIEAMTRAQIEVK
HHHHCCCCCCCEEHHHHHCCEEEECCEECCHHHHHHHHHHHHHHHHHHCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA