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The map label for this gene is kdsB

Identifier: 126174588

GI number: 126174588

Start: 2764272

End: 2765009

Strand: Direct

Name: kdsB

Synonym: Sbal_2375

Alternate gene names: 126174588

Gene position: 2764272-2765009 (Clockwise)

Preceding gene: 126174587

Following gene: 126174589

Centisome position: 53.91

GC content: 47.56

Gene sequence:

>738_bases
ATGAATGTGACTCTGTTAATCCCGGCTCGTTACGGTTCAAGCCGCTTCCCGGGCAAACCCTTAGCCCCGATTAACGGCAA
GCCAATGATCCAACACGTGTATGAACGCGCGTCGTTAGCCAAAGGCCTCACCAATATTTATGTCGCTACCGATGATGACC
GCATTAAAGCGGCCGTTGAAGGTTTTGGCGGCAAAGTGGTCATGACCAGCCCAGAAGCGGCATCGGGTACAGATCGTATC
AATGATGCGATAAACCAACTGGGACTGAAAGATGACGACTTAGTGATCAACCTACAGGGCGATCAACCCCTTATTGACCC
CACCTCTATCGAGCAAGTCATCAGCCTCTTCGAGCGTCACCCAGGTGAGTTTGAAATGGCCACCTTAGGCTTTGAAATCG
TCAATAAAGCCGAGCTTGACGATCCTATGCATGTGAAGATGGTGTTCGATAACAACAACTATGCCTTGTATTTCTCTCGT
TCGCGTATTCCTTTTGGCCGCGACACCCAAGATTACCCCGTTTATAAGCACTTAGGTGTGTATGCTTATACCCGAAAATT
CGTCCAAGCCTTCGCCGCTCTGCCATTAGGACGTCTAGAAGATCTGGAAAAACTCGAGCAATTGCGTGCATTAGAATACG
GTCATAAAATCAAAATCGCCATTAGCGCCTTTGATTCTATTGAAGTTGATACGCCAGAAGACATTCGTAAATGTGAGCAA
CGTTTAGCGGTTGATTAA

Upstream 100 bases:

>100_bases
TAAGCTCTAACACATATTAAAAGGGCTCAATTGTGAGCCCTTTTGTCTATATACATTGTATTTCTACACTGTATATCTTT
GATAAAAGTAGGATAATTTG

Downstream 100 bases:

>100_bases
TCGCCCGTGAGTCTTGTGCGCGAGTCTATTCGAAACAGGAGCTGAGTATGTCGACCTTAGAAGTCTGGATCATTATTATT
TTGATCGTCGGTGTCATCGC

Product: 3-deoxy-manno-octulosonate cytidylyltransferase

Products: NA

Alternate protein names: CMP-2-keto-3-deoxyoctulosonic acid synthase; CKS; CMP-KDO synthase

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MNVTLLIPARYGSSRFPGKPLAPINGKPMIQHVYERASLAKGLTNIYVATDDDRIKAAVEGFGGKVVMTSPEAASGTDRI
NDAINQLGLKDDDLVINLQGDQPLIDPTSIEQVISLFERHPGEFEMATLGFEIVNKAELDDPMHVKMVFDNNNYALYFSR
SRIPFGRDTQDYPVYKHLGVYAYTRKFVQAFAALPLGRLEDLEKLEQLRALEYGHKIKIAISAFDSIEVDTPEDIRKCEQ
RLAVD

Sequences:

>Translated_245_residues
MNVTLLIPARYGSSRFPGKPLAPINGKPMIQHVYERASLAKGLTNIYVATDDDRIKAAVEGFGGKVVMTSPEAASGTDRI
NDAINQLGLKDDDLVINLQGDQPLIDPTSIEQVISLFERHPGEFEMATLGFEIVNKAELDDPMHVKMVFDNNNYALYFSR
SRIPFGRDTQDYPVYKHLGVYAYTRKFVQAFAALPLGRLEDLEKLEQLRALEYGHKIKIAISAFDSIEVDTPEDIRKCEQ
RLAVD
>Mature_245_residues
MNVTLLIPARYGSSRFPGKPLAPINGKPMIQHVYERASLAKGLTNIYVATDDDRIKAAVEGFGGKVVMTSPEAASGTDRI
NDAINQLGLKDDDLVINLQGDQPLIDPTSIEQVISLFERHPGEFEMATLGFEIVNKAELDDPMHVKMVFDNNNYALYFSR
SRIPFGRDTQDYPVYKHLGVYAYTRKFVQAFAALPLGRLEDLEKLEQLRALEYGHKIKIAISAFDSIEVDTPEDIRKCEQ
RLAVD

Specific function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria

COG id: COG1212

COG function: function code M; CMP-2-keto-3-deoxyoctulosonic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsB family

Homologues:

Organism=Escherichia coli, GI1787147, Length=251, Percent_Identity=43.0278884462151, Blast_Score=191, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSB_SHEB2 (B8E9F5)

Other databases:

- EMBL:   CP001252
- RefSeq:   YP_002357911.1
- ProteinModelPortal:   B8E9F5
- SMR:   B8E9F5
- GeneID:   7086818
- GenomeReviews:   CP001252_GR
- KEGG:   sbp:Sbal223_1984
- HOGENOM:   HBG637773
- OMA:   IIPARLK
- ProtClustDB:   PRK05450
- GO:   GO:0005737
- HAMAP:   MF_00057
- InterPro:   IPR003329
- InterPro:   IPR004528
- TIGRFAMs:   TIGR00466

Pfam domain/function: PF02348 CTP_transf_3

EC number: =2.7.7.38

Molecular weight: Translated: 27448; Mature: 27448

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVTLLIPARYGSSRFPGKPLAPINGKPMIQHVYERASLAKGLTNIYVATDDDRIKAAVE
CCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHH
GFGGKVVMTSPEAASGTDRINDAINQLGLKDDDLVINLQGDQPLIDPTSIEQVISLFERH
CCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHC
PGEFEMATLGFEIVNKAELDDPMHVKMVFDNNNYALYFSRSRIPFGRDTQDYPVYKHLGV
CCCEEEEEHHHHHHHHHCCCCCEEEEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHH
YAYTRKFVQAFAALPLGRLEDLEKLEQLRALEYGHKIKIAISAFDSIEVDTPEDIRKCEQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHH
RLAVD
HHCCC
>Mature Secondary Structure
MNVTLLIPARYGSSRFPGKPLAPINGKPMIQHVYERASLAKGLTNIYVATDDDRIKAAVE
CCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHH
GFGGKVVMTSPEAASGTDRINDAINQLGLKDDDLVINLQGDQPLIDPTSIEQVISLFERH
CCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHC
PGEFEMATLGFEIVNKAELDDPMHVKMVFDNNNYALYFSRSRIPFGRDTQDYPVYKHLGV
CCCEEEEEHHHHHHHHHCCCCCEEEEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHH
YAYTRKFVQAFAALPLGRLEDLEKLEQLRALEYGHKIKIAISAFDSIEVDTPEDIRKCEQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHH
RLAVD
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA