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The map label for this gene is zwf [H]

Identifier: 126174457

GI number: 126174457

Start: 2591064

End: 2592536

Strand: Reverse

Name: zwf [H]

Synonym: Sbal_2241

Alternate gene names: 126174457

Gene position: 2592536-2591064 (Counterclockwise)

Preceding gene: 126174460

Following gene: 126174456

Centisome position: 50.56

GC content: 47.25

Gene sequence:

>1473_bases
ATGGGCAAAACAACATCAGGCGCCAAAGCTTGTGACTTCGTACTCTTTGGTACTAAAGGCGATTTGGCACGACGCAAGTT
GTTACCTTCTTTATACCAGCTAGATAAAGCTGAACTTCTCGATAAAGATACGAAAGTGATCGGTGTCGCGAAAGACGAGT
TTACTCAAGATGAGTTTATCGAATTAGTCACGCTTGCATTAAACACCTTCGTGAAAGAGCCTTTGTGCGAAGAGACTCTC
CAACGTTTCCTGTCCCGCTGCCACTATATAGGCACTAACTTTACCGATTCAGCGGGCTACAGTGCCTTCCATGAACTGCT
CAAACCAGAAGAGCGCGTCATGGTCAGTTATTTTGCTACGCCACCTGCGATATTCGGCGACATTTGCCGTTGTTTGCATG
AACAAGATCTTATCCACCCCGATTCACGCGTGGTGCTCGAAAAGCCAATCGGTTCAGATTTAGACTCTTCTCGCGTTATC
AATGATCAAGTTTCCGCTTACTTCAAAGAACGTCAGGTTTACCGTATCGACCATTACTTAGGTAAAGAAACCGTACAGAA
CTTGATTGCGCTGCGTTTTGCTAACTCTTTATTTGCCTCTAAGTGGGACAACCGTACGATTGACCACGTCCAGATCACAG
TAGCAGAAGAAGTGGGTATCGAAGGCCGTTGGGGTTACTTCGACAAAGCGGGTCAGATGCGCGACATGATCCAAAACCAT
TTGCTACAAGTGTTAACGCTCGTTGCTATGGATCCACCAGTCAACTTAGACGCTGACAGCATCCGTGATGAAAAAGTCAA
AGTGCTCAAATCACTACGTCCGATTAATTCTGACAATGTGTATGAAAATACCGTACGCGGTCAGTACAGCGCAGGCTTCT
TAAAAGGCAGCCCAGTACCGGGTTATTTAGAAGAGGAAGGCGCTAACCTTCAGTCACACACAGAAACCTTCGTGGCGATT
CGTGTGGATATCGACAACTGGCGTTGGGCGGGCGTGCCTTTCTATTTGCGTAGCGGTAAACGTATGCCGTTTAAGAGCTC
TGAAATTGTGGTGTATTTCAAAAACCCACCGCATAACTTGTATCGCTCAAGCTACCGTAATCTGCCACCGAACAAGCTGA
CTATTCGTCTGCAACCCCATGAAGGGGTTGAAATCCAGATGATGAACAAAGTGCCAGGTTTGGAGCAAAAACAACGTCTA
CAAACCACTAAACTCGATTTGAGCTTCTCCGATACCTTCAAAAATGAACGTATCGCCGATGCCTACGAGCGTCTATTACT
CGAAGCTATGCTCGGTAATCAAGCGCTGTTCGTGCGCCGCGACGAAGTCGAGCAGGCATGGACTTGGGTGGATGGCATTA
TCCAATCGTGGGAACAAAGCAACGAAAAACCAAAACCTTATCCTGCGGGTACTTGGGGTCCAGTTGCGTCAGTTGCTTTG
ATCACCAAAGATGGCCGTTCGTGGGACGAGTAG

Upstream 100 bases:

>100_bases
AATAGATGCATTTAACAAATTCTGTTGTTATATTACAACAAAAGTGTGGATTTCTTCATCGACATGAAGGGACACGACAT
ACAAAGGAGATCGTAACGCA

Downstream 100 bases:

>100_bases
GAGACTTTGATGATTAAAGAAACCGTATTCAAATCTTTCGATACGCCAAGTGCGTTAGAACAGCAACTGGCCAGCAAGAT
TGCAAGCCAGTTACAGGAAG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MGKTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKAELLDKDTKVIGVAKDEFTQDEFIELVTLALNTFVKEPLCEETL
QRFLSRCHYIGTNFTDSAGYSAFHELLKPEERVMVSYFATPPAIFGDICRCLHEQDLIHPDSRVVLEKPIGSDLDSSRVI
NDQVSAYFKERQVYRIDHYLGKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNH
LLQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINSDNVYENTVRGQYSAGFLKGSPVPGYLEEEGANLQSHTETFVAI
RVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNLYRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKQRL
QTTKLDLSFSDTFKNERIADAYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQSWEQSNEKPKPYPAGTWGPVASVAL
ITKDGRSWDE

Sequences:

>Translated_490_residues
MGKTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKAELLDKDTKVIGVAKDEFTQDEFIELVTLALNTFVKEPLCEETL
QRFLSRCHYIGTNFTDSAGYSAFHELLKPEERVMVSYFATPPAIFGDICRCLHEQDLIHPDSRVVLEKPIGSDLDSSRVI
NDQVSAYFKERQVYRIDHYLGKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNH
LLQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINSDNVYENTVRGQYSAGFLKGSPVPGYLEEEGANLQSHTETFVAI
RVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNLYRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKQRL
QTTKLDLSFSDTFKNERIADAYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQSWEQSNEKPKPYPAGTWGPVASVAL
ITKDGRSWDE
>Mature_489_residues
GKTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKAELLDKDTKVIGVAKDEFTQDEFIELVTLALNTFVKEPLCEETLQ
RFLSRCHYIGTNFTDSAGYSAFHELLKPEERVMVSYFATPPAIFGDICRCLHEQDLIHPDSRVVLEKPIGSDLDSSRVIN
DQVSAYFKERQVYRIDHYLGKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNHL
LQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINSDNVYENTVRGQYSAGFLKGSPVPGYLEEEGANLQSHTETFVAIR
VDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNLYRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKQRLQ
TTKLDLSFSDTFKNERIADAYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQSWEQSNEKPKPYPAGTWGPVASVALI
TKDGRSWDE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=483, Percent_Identity=36.231884057971, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI108773793, Length=483, Percent_Identity=36.231884057971, Blast_Score=316, Evalue=4e-86,
Organism=Homo sapiens, GI52145310, Length=507, Percent_Identity=28.5996055226824, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1788158, Length=486, Percent_Identity=65.2263374485597, Blast_Score=669, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=38.7628865979381, Blast_Score=322, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6324088, Length=472, Percent_Identity=35.1694915254237, Blast_Score=295, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24643350, Length=474, Percent_Identity=36.9198312236287, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24643352, Length=474, Percent_Identity=36.9198312236287, Blast_Score=305, Evalue=3e-83,
Organism=Drosophila melanogaster, GI221513548, Length=484, Percent_Identity=26.8595041322314, Blast_Score=179, Evalue=4e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55980; Mature: 55849

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKAELLDKDTKVIGVAKDEFTQDEFI
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEHHHCCHHHHH
ELVTLALNTFVKEPLCEETLQRFLSRCHYIGTNFTDSAGYSAFHELLKPEERVMVSYFAT
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHEEEEEECC
PPAIFGDICRCLHEQDLIHPDSRVVLEKPIGSDLDSSRVINDQVSAYFKERQVYRIDHYL
CHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNH
CHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHHH
LLQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINSDNVYENTVRGQYSAGFLKGSPVP
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCC
GYLEEEGANLQSHTETFVAIRVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNL
CCHHHCCCCCCCCCCEEEEEEEEECCCEECCCCCEECCCCCCCCCCCCEEEEECCCCHHH
YRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKQRLQTTKLDLSFSDTFKNERIAD
HHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHEEEEEHHHHCCCHHHH
AYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQSWEQSNEKPKPYPAGTWGPVASVAL
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEE
ITKDGRSWDE
EEECCCCCCC
>Mature Secondary Structure 
GKTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKAELLDKDTKVIGVAKDEFTQDEFI
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHCCCCEEEEEEHHHCCHHHHH
ELVTLALNTFVKEPLCEETLQRFLSRCHYIGTNFTDSAGYSAFHELLKPEERVMVSYFAT
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHEEEEEECC
PPAIFGDICRCLHEQDLIHPDSRVVLEKPIGSDLDSSRVINDQVSAYFKERQVYRIDHYL
CHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNH
CHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHHH
LLQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINSDNVYENTVRGQYSAGFLKGSPVP
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCC
GYLEEEGANLQSHTETFVAIRVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNL
CCHHHCCCCCCCCCCEEEEEEEEECCCEECCCCCEECCCCCCCCCCCCEEEEECCCCHHH
YRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKQRLQTTKLDLSFSDTFKNERIAD
HHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHEEEEEHHHHCCCHHHH
AYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQSWEQSNEKPKPYPAGTWGPVASVAL
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEE
ITKDGRSWDE
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8145647 [H]