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The map label for this gene is metC [H]

Identifier: 126174064

GI number: 126174064

Start: 2133434

End: 2134633

Strand: Reverse

Name: metC [H]

Synonym: Sbal_1838

Alternate gene names: 126174064

Gene position: 2134633-2133434 (Counterclockwise)

Preceding gene: 126174065

Following gene: 126174063

Centisome position: 41.63

GC content: 50.17

Gene sequence:

>1200_bases
ATGACAGATAAACATCATCAAGCCACCCAAATCGTCAGCTTAGGTCGAGACAAAAAATGGACCAAAGGCGTGATCAATCC
GCCCGTTTTTCGTGCTTCGACTATCGTCTTCGAAACGATGGATGAAATGCGCCACGCCGCGAAAAATAAAACCAACGGCG
AGATGTTTTATGGCCGCCGTGGTACCCCGACCCATTTTTCGTTTCAAGCGGCGATTACTGAATTAGAAGGCGGCGTCGGT
ACAGCGCTGTATCCCTCTGGCGCGGCGGCGATCAGTGCGGCGTTATTGTCATTTTTAAAAGCGGGCGATCACCTATTGAT
GGTCGATAGCGTGTATGAGCCAACGCGGGATCTGTGTACCCATATTCTCGGCAGTTTTGGTATCGAAACCACTTATTACA
ATCCGCTGATTGGCGCGGGCATTCGCGACCTTATTCGCCCCAATACTAAAGTGTTGTTTTTAGAGTCACCAGGCTCCATC
ACCATGGAAGTGCAAGATGTACCGACCTTGTGCCGCATCGCCCACGAACATGGGCTGATTACTATGCTGGACAACACTTG
GGCATCCCCAATCAACAGCAAGCCCTTTGAAATGGGTGTAGATATCTCAATTCAAGCGGCGACCAAATACATTGTCGGTC
ACTCGGATGTGATGATAGGCACAGCTACCGCCAACGAAAAATACTGGCCACAATTGCGCGAACACAGCTATTTGATGGGA
CAAACCACCTCCCCTGATGATGTGTACCTTGCCGCCCGTGGCCTGCGTACCTTAGGCGTGCGTATGGCGCAGCATGAAAA
AAATGCCCTGCAAGTTGCCAACTGGTTGAAAACCCGACCAGAAGTCGATCATCTGCGTCATCCGGCGTTTGATACCTGCC
CTGGCCATGAGTTCTTTAAACGCGACTTCAGCGCCTCCAACGGTTTATTCTCCTTTGTATTGAAACAAGGAGATGCCGAT
GCGGTCACCGCACTGGTTGAGAATATGAGTCACTTTAAGATGGGCTTTTCTTGGGGCGGCTACGAGAGTTTGATCCTCGG
CATTTTCGGCATTGAAAAAATTCGCTCGGCGACCAAGTGGGATGCGAGCAAACCGTTAATTCGTTTGCATATTGGTTTAG
AAGATCCCGCGGATTTAATTGCCGATCTCAGTGCAGGGTTTGAACGCTTTAACGCAGTACTGGCGGCCAAAGCTAAGTAG

Upstream 100 bases:

>100_bases
CTAAGATGACCGCCATAACAATAGATTAGATATCTCCAATGGTTCTTCTCCAACATTGTTCAACCTCTTCGTTCAACCTA
AATGCCAAGGTAATGATCCA

Downstream 100 bases:

>100_bases
CGATAATGATCGTGATAGAAATTAAGCGAGGTCGTTAGAGGGCTAATATTTATTGCGTTATGTCATTAGCGACTAAATGC
GCGCAGCCTATAAAAACAAA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTDKHHQATQIVSLGRDKKWTKGVINPPVFRASTIVFETMDEMRHAAKNKTNGEMFYGRRGTPTHFSFQAAITELEGGVG
TALYPSGAAAISAALLSFLKAGDHLLMVDSVYEPTRDLCTHILGSFGIETTYYNPLIGAGIRDLIRPNTKVLFLESPGSI
TMEVQDVPTLCRIAHEHGLITMLDNTWASPINSKPFEMGVDISIQAATKYIVGHSDVMIGTATANEKYWPQLREHSYLMG
QTTSPDDVYLAARGLRTLGVRMAQHEKNALQVANWLKTRPEVDHLRHPAFDTCPGHEFFKRDFSASNGLFSFVLKQGDAD
AVTALVENMSHFKMGFSWGGYESLILGIFGIEKIRSATKWDASKPLIRLHIGLEDPADLIADLSAGFERFNAVLAAKAK

Sequences:

>Translated_399_residues
MTDKHHQATQIVSLGRDKKWTKGVINPPVFRASTIVFETMDEMRHAAKNKTNGEMFYGRRGTPTHFSFQAAITELEGGVG
TALYPSGAAAISAALLSFLKAGDHLLMVDSVYEPTRDLCTHILGSFGIETTYYNPLIGAGIRDLIRPNTKVLFLESPGSI
TMEVQDVPTLCRIAHEHGLITMLDNTWASPINSKPFEMGVDISIQAATKYIVGHSDVMIGTATANEKYWPQLREHSYLMG
QTTSPDDVYLAARGLRTLGVRMAQHEKNALQVANWLKTRPEVDHLRHPAFDTCPGHEFFKRDFSASNGLFSFVLKQGDAD
AVTALVENMSHFKMGFSWGGYESLILGIFGIEKIRSATKWDASKPLIRLHIGLEDPADLIADLSAGFERFNAVLAAKAK
>Mature_398_residues
TDKHHQATQIVSLGRDKKWTKGVINPPVFRASTIVFETMDEMRHAAKNKTNGEMFYGRRGTPTHFSFQAAITELEGGVGT
ALYPSGAAAISAALLSFLKAGDHLLMVDSVYEPTRDLCTHILGSFGIETTYYNPLIGAGIRDLIRPNTKVLFLESPGSIT
MEVQDVPTLCRIAHEHGLITMLDNTWASPINSKPFEMGVDISIQAATKYIVGHSDVMIGTATANEKYWPQLREHSYLMGQ
TTSPDDVYLAARGLRTLGVRMAQHEKNALQVANWLKTRPEVDHLRHPAFDTCPGHEFFKRDFSASNGLFSFVLKQGDADA
VTALVENMSHFKMGFSWGGYESLILGIFGIEKIRSATKWDASKPLIRLHIGLEDPADLIADLSAGFERFNAVLAAKAK

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=376, Percent_Identity=32.9787234042553, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI299473759, Length=376, Percent_Identity=30.3191489361702, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI25453487, Length=375, Percent_Identity=29.6, Blast_Score=147, Evalue=1e-35,
Organism=Escherichia coli, GI1789383, Length=395, Percent_Identity=52.6582278481013, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1790375, Length=396, Percent_Identity=32.5757575757576, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71980708, Length=372, Percent_Identity=31.989247311828, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17538055, Length=381, Percent_Identity=29.9212598425197, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17560056, Length=378, Percent_Identity=29.8941798941799, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI193202265, Length=85, Percent_Identity=37.6470588235294, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321170, Length=333, Percent_Identity=48.3483483483483, Blast_Score=331, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6319307, Length=351, Percent_Identity=30.7692307692308, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6321904, Length=386, Percent_Identity=24.3523316062176, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323333, Length=414, Percent_Identity=25.1207729468599, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6321254, Length=398, Percent_Identity=25.6281407035176, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI19922554, Length=377, Percent_Identity=31.2997347480106, Blast_Score=191, Evalue=7e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44027; Mature: 43896

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKHHQATQIVSLGRDKKWTKGVINPPVFRASTIVFETMDEMRHAAKNKTNGEMFYGRR
CCCCHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
GTPTHFSFQAAITELEGGVGTALYPSGAAAISAALLSFLKAGDHLLMVDSVYEPTRDLCT
CCCCCEEHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
HILGSFGIETTYYNPLIGAGIRDLIRPNTKVLFLESPGSITMEVQDVPTLCRIAHEHGLI
HHHHHCCCCCEECCCHHHHCHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCCEE
TMLDNTWASPINSKPFEMGVDISIQAATKYIVGHSDVMIGTATANEKYWPQLREHSYLMG
EEECCCCCCCCCCCCCEECCCEEEEEHHEEEECCCCEEEEEECCCCCCCHHHHHCCEEEC
QTTSPDDVYLAARGLRTLGVRMAQHEKNALQVANWLKTRPEVDHLRHPAFDTCPGHEFFK
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHH
RDFSASNGLFSFVLKQGDADAVTALVENMSHFKMGFSWGGYESLILGIFGIEKIRSATKW
HHCCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
DASKPLIRLHIGLEDPADLIADLSAGFERFNAVLAAKAK
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDKHHQATQIVSLGRDKKWTKGVINPPVFRASTIVFETMDEMRHAAKNKTNGEMFYGRR
CCCHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
GTPTHFSFQAAITELEGGVGTALYPSGAAAISAALLSFLKAGDHLLMVDSVYEPTRDLCT
CCCCCEEHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
HILGSFGIETTYYNPLIGAGIRDLIRPNTKVLFLESPGSITMEVQDVPTLCRIAHEHGLI
HHHHHCCCCCEECCCHHHHCHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCCEE
TMLDNTWASPINSKPFEMGVDISIQAATKYIVGHSDVMIGTATANEKYWPQLREHSYLMG
EEECCCCCCCCCCCCCEECCCEEEEEHHEEEECCCCEEEEEECCCCCCCHHHHHCCEEEC
QTTSPDDVYLAARGLRTLGVRMAQHEKNALQVANWLKTRPEVDHLRHPAFDTCPGHEFFK
CCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHH
RDFSASNGLFSFVLKQGDADAVTALVENMSHFKMGFSWGGYESLILGIFGIEKIRSATKW
HHCCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
DASKPLIRLHIGLEDPADLIADLSAGFERFNAVLAAKAK
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659970; 11677609 [H]