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The map label for this gene is phhA [H]

Identifier: 126173722

GI number: 126173722

Start: 1725758

End: 1726558

Strand: Direct

Name: phhA [H]

Synonym: Sbal_1484

Alternate gene names: 126173722

Gene position: 1725758-1726558 (Clockwise)

Preceding gene: 126173715

Following gene: 126173723

Centisome position: 33.66

GC content: 47.57

Gene sequence:

>801_bases
ATGACGAAAGGAACAGAGTACATCGCTCACAGAGCCGATGACACTGGGTTTATCCATTACCCGCAAGAAGAGCACGATAT
TTGGCGTCAGCTTTACGCCCGTCAAGCCGTTAATCTCCCCGGTCGTGCCTGCAAGGAATATCTGCAAGGGCTCGATGCCT
TGGGTATGCCAAAGGATCGCATTCCGCAACTTGCCGAAATTGATGCGGTATTACAAGCGACCACTGGATGGAAAACGGCG
GCGGTACCTGCGTTGATTTCCTTCGGCCGTTTCTTTGAATTACTGGCCAACAAAGAGTTTCCTGTGGCCACCTTTATTCG
CCGCAAGGAAGAGTTTGATTACCTGCAAGAGCCAGATATCTTCCACGAGATTTTTGGCCACTGCCCTTTGCTCACCAATC
CTTCATTTGCCAATTTCTCTCATATGTATGGCCAGTTAGGTTTACATGCCAGCAAAGAGGAAAGGGTATTTTTAGCGCGT
TTGTACTGGTTTACGGTTGAGTTTGGCATACTGCAACCTAAAAATGGTCCCTTATGTATCTATGGCGGCGGCATTTTAAG
CTCTCCCGGGGAAACCTTGTATGCGATGGAAAGTGATGTGCCAGAGCGTCAACCCTTTGATTTGTTGGATGTGCTGCGAA
CCCCATATCGGATCGACATTATGCAGCCGATTTATTATGTGATTGAGCATATTGATATGCTGGATGAAATTGCCAAGATG
GACATCATGGGTTATGTCACTAAGGCGCGTCAGTTAGGTTTATTTGCCCCTAAATTTCCGCCAAAAGCCAAGGCGAGTTA
G

Upstream 100 bases:

>100_bases
ACGTCACAGTAGCGGCACAAGAATAAAGTGTGAGGGAGTTAACAAATTTAAAGCCTTAGACCACTATGGAGTCATGAGTG
TTAGCCACCAAGTGAAGATT

Downstream 100 bases:

>100_bases
CCTCGATTAGATTGATGAGTTGACTCGTTATTTGGCTGGCATCTAATTTAGCCATCTGATTGAGTGATGTGATTTAAGTT
ATTAATAGAAAATGAGTACA

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MTKGTEYIAHRADDTGFIHYPQEEHDIWRQLYARQAVNLPGRACKEYLQGLDALGMPKDRIPQLAEIDAVLQATTGWKTA
AVPALISFGRFFELLANKEFPVATFIRRKEEFDYLQEPDIFHEIFGHCPLLTNPSFANFSHMYGQLGLHASKEERVFLAR
LYWFTVEFGILQPKNGPLCIYGGGILSSPGETLYAMESDVPERQPFDLLDVLRTPYRIDIMQPIYYVIEHIDMLDEIAKM
DIMGYVTKARQLGLFAPKFPPKAKAS

Sequences:

>Translated_266_residues
MTKGTEYIAHRADDTGFIHYPQEEHDIWRQLYARQAVNLPGRACKEYLQGLDALGMPKDRIPQLAEIDAVLQATTGWKTA
AVPALISFGRFFELLANKEFPVATFIRRKEEFDYLQEPDIFHEIFGHCPLLTNPSFANFSHMYGQLGLHASKEERVFLAR
LYWFTVEFGILQPKNGPLCIYGGGILSSPGETLYAMESDVPERQPFDLLDVLRTPYRIDIMQPIYYVIEHIDMLDEIAKM
DIMGYVTKARQLGLFAPKFPPKAKAS
>Mature_265_residues
TKGTEYIAHRADDTGFIHYPQEEHDIWRQLYARQAVNLPGRACKEYLQGLDALGMPKDRIPQLAEIDAVLQATTGWKTAA
VPALISFGRFFELLANKEFPVATFIRRKEEFDYLQEPDIFHEIFGHCPLLTNPSFANFSHMYGQLGLHASKEERVFLARL
YWFTVEFGILQPKNGPLCIYGGGILSSPGETLYAMESDVPERQPFDLLDVLRTPYRIDIMQPIYYVIEHIDMLDEIAKMD
IMGYVTKARQLGLFAPKFPPKAKAS

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=248, Percent_Identity=34.6774193548387, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI88900505, Length=248, Percent_Identity=34.6774193548387, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI88900501, Length=248, Percent_Identity=34.6774193548387, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI4557819, Length=219, Percent_Identity=35.6164383561644, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI4759248, Length=216, Percent_Identity=35.1851851851852, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI31795563, Length=223, Percent_Identity=34.0807174887892, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71980736, Length=232, Percent_Identity=34.4827586206897, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17531391, Length=218, Percent_Identity=39.9082568807339, Blast_Score=130, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI115533973, Length=194, Percent_Identity=33.5051546391753, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI115532103, Length=237, Percent_Identity=30.379746835443, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71980731, Length=156, Percent_Identity=32.0512820512821, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17136774, Length=220, Percent_Identity=36.8181818181818, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17136776, Length=217, Percent_Identity=37.3271889400922, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI62472054, Length=223, Percent_Identity=33.6322869955157, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24660393, Length=223, Percent_Identity=33.6322869955157, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24654994, Length=186, Percent_Identity=33.8709677419355, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 30410; Mature: 30279

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKGTEYIAHRADDTGFIHYPQEEHDIWRQLYARQAVNLPGRACKEYLQGLDALGMPKDR
CCCCHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHH
IPQLAEIDAVLQATTGWKTAAVPALISFGRFFELLANKEFPVATFIRRKEEFDYLQEPDI
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHH
FHEIFGHCPLLTNPSFANFSHMYGQLGLHASKEERVFLARLYWFTVEFGILQPKNGPLCI
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCEECCCCCCEEE
YGGGILSSPGETLYAMESDVPERQPFDLLDVLRTPYRIDIMQPIYYVIEHIDMLDEIAKM
ECCCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHH
DIMGYVTKARQLGLFAPKFPPKAKAS
HHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TKGTEYIAHRADDTGFIHYPQEEHDIWRQLYARQAVNLPGRACKEYLQGLDALGMPKDR
CCCHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHH
IPQLAEIDAVLQATTGWKTAAVPALISFGRFFELLANKEFPVATFIRRKEEFDYLQEPDI
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHH
FHEIFGHCPLLTNPSFANFSHMYGQLGLHASKEERVFLARLYWFTVEFGILQPKNGPLCI
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCEECCCCCCEEE
YGGGILSSPGETLYAMESDVPERQPFDLLDVLRTPYRIDIMQPIYYVIEHIDMLDEIAKM
ECCCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHH
DIMGYVTKARQLGLFAPKFPPKAKAS
HHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8108417; 10984043 [H]