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The map label for this gene is kefB [H]

Identifier: 126173706

GI number: 126173706

Start: 1704176

End: 1706122

Strand: Direct

Name: kefB [H]

Synonym: Sbal_1468

Alternate gene names: 126173706

Gene position: 1704176-1706122 (Clockwise)

Preceding gene: 126173704

Following gene: 126173708

Centisome position: 33.24

GC content: 48.54

Gene sequence:

>1947_bases
ATGGAACATAGCTTCTTAATCCAAGTACTACTTATGTTAGTGATTGCCATTGTGGCTATTGCTGTGCTGCGCCGTTTGGG
CTTACCCGCAATTCTGGCTTATTTACTCACTGGTGTAGTGAGTGGACCGAGCGGTTTTCATTGGTTTACCCAGCATCAAA
TGCAATCTGTCGCTGAACTTGGGGTGGTGCTACTGATGTTTACCTTAGGCTTAGAGTTCTCTGTGCCGCGGCTGTGGGCC
ATGCGCCGTACCGTATTTGGCTTAGGCAGTGCACAGATGGTAATAACGACCCTGTTGACTATGGGCGTGGCCCTGTTGTG
TGGTCTTAATTGGGTCGAAGCCTTAGTTATCGGAGCTGCCATTGCCTTATCATCCACTGCCATCGTCCTTAAATTACTCA
ATGAGCAAGGATGGTTGCGTCGTCGTCATGGTGAGCTATCCGTCAGTGTCTTATTATTCCAAGATTTAGCGGTTGTGCCG
CTGTTGATCCTATTGCCATTACTGGCCAATGGCGGCGAACCTTTGATGGTCGCGGATATCGCCTTTGCCTTGCTCAAAGG
TATTTTGGCTTTTTTCCTCTTGATGGCTTTTGGCAAATGGGCATTGCCGCGGATTTTTGACGAAGTTGCCCGCTCCCGCT
CTAACGAACTCTTCGTGTTATCAACACTAGTGGTGGCTTTAGTGACAGGCGCATTTACCCAATGGCTGGGATTATCAATG
GCGCTGGGGGCATTTATGGCGGGCATGCTGCTGGGGGAAAGCCAGTACCGTCGCCAACTTGAGGCGGATATCCGGCCGTT
TCGCGATCTATTGATGGGGCTGTTTTTCATTTCCATCGGCATGATGCTGGACTTTACCTTAGTGATGCGTTTCTGGTGGC
AGATATTGTTGATCTTAGTGGCCGTTGTACTCGGTAAGGCGCTGATCATTCATGGGATCTTAAGATTGGTTGGCGAACCC
TTTCGGATTGCGATGAGCACCGCCATGAGCCTAGCCCAAGTGGGCGAATTCAGTTTTGTGGTGTTGGCTTTAGCGGTTAA
CTATCAACTTCTAGATAATGAAATCAGTACCATGTTAGTCATGGTCGCCGTGCTTTCCATGACGATAGCCCCGTGGTTAG
TTCGCCATAGCGTGGATATTGCTAAGTGGGTGTTAGGAATAAGGCAGGCAAAACATGTGGATGAAGCTGTGCCACTCTTG
ATGGATGAGCATGATCTGGTGATGATTTTTGGTTACGGCCGAGTAGGGCAGACCATCGCCCGTTTTTTGAAAACCGAAGC
TGTACCTTATCTGGTCATGGATCTCGATCCGACTCGTGTCTCTGAGGCGCGCCGTGCTGGCGAACCTATTTATTTTGGTG
ATGTGTGTAAACGGGCGATGTTAAAACAAATAGGCGTTAAGCAGGCCAAGATGATCGTCATCACTTTTTGTGAGTCGCGT
AGTTTAGAAGAAGTCTTACCTTTATGTAAGTTATTGGCGCCAGGCGCTAAAATTTTAGTCAGAACTAAAGACGACAGTGA
TTTAGACTTACTGAAAAAAGCCGGTGCCAATCAAGTGATCCCAGAATCTTTGGAAGGCAGCCTGATGTTAGTGTCACAGG
TGTTACATCAATGTGGTGTGCCTTTGGCGCGCATTTTAAAACGCTTAGAGTCAGAGCGGCGCAGTCATTATCAATTTTTA
CATGGCTTCTTTTCCGGTACAGAAACCGACTTCACCTTAGAGTCATTGCATGCGGTGGCGTTACCGCGTGGTGCAGATGC
GATTGGTAAAACCGTTGCTGAGATCATGTGGGAAACATTGAGGGTGGAGTTAAGGGCGATTCGTCGCAGTGGCGCCGAAG
TGGAACATCCTGAGCAGGACTGGGTTTTTCGTGCAGGGGATATCTTACTGATAGTGGGTAAACCACGAAGACTTGAGAAA
GCGGAAGCTAAACTGCTGCACGGCTAA

Upstream 100 bases:

>100_bases
ATTTGTTAATAAAATTTGTCTTTGTTAGTCATTCAGTTAAGCTTAAAACTCAGCGTTATTTTTTTGACACGTCAGCATTT
TGACAGGAGTCATAGCCCCA

Downstream 100 bases:

>100_bases
AGGTTGATGGTCAGCGTGAGTGATGGATGAAAACGCAGATATAAAAATGCCGACATAATGTCGGCATTTTTGTCTGGAAT
TTGTTAACTTAAATTAGACA

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter; NEM-activatable K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 648; Mature: 648

Protein sequence:

>648_residues
MEHSFLIQVLLMLVIAIVAIAVLRRLGLPAILAYLLTGVVSGPSGFHWFTQHQMQSVAELGVVLLMFTLGLEFSVPRLWA
MRRTVFGLGSAQMVITTLLTMGVALLCGLNWVEALVIGAAIALSSTAIVLKLLNEQGWLRRRHGELSVSVLLFQDLAVVP
LLILLPLLANGGEPLMVADIAFALLKGILAFFLLMAFGKWALPRIFDEVARSRSNELFVLSTLVVALVTGAFTQWLGLSM
ALGAFMAGMLLGESQYRRQLEADIRPFRDLLMGLFFISIGMMLDFTLVMRFWWQILLILVAVVLGKALIIHGILRLVGEP
FRIAMSTAMSLAQVGEFSFVVLALAVNYQLLDNEISTMLVMVAVLSMTIAPWLVRHSVDIAKWVLGIRQAKHVDEAVPLL
MDEHDLVMIFGYGRVGQTIARFLKTEAVPYLVMDLDPTRVSEARRAGEPIYFGDVCKRAMLKQIGVKQAKMIVITFCESR
SLEEVLPLCKLLAPGAKILVRTKDDSDLDLLKKAGANQVIPESLEGSLMLVSQVLHQCGVPLARILKRLESERRSHYQFL
HGFFSGTETDFTLESLHAVALPRGADAIGKTVAEIMWETLRVELRAIRRSGAEVEHPEQDWVFRAGDILLIVGKPRRLEK
AEAKLLHG

Sequences:

>Translated_648_residues
MEHSFLIQVLLMLVIAIVAIAVLRRLGLPAILAYLLTGVVSGPSGFHWFTQHQMQSVAELGVVLLMFTLGLEFSVPRLWA
MRRTVFGLGSAQMVITTLLTMGVALLCGLNWVEALVIGAAIALSSTAIVLKLLNEQGWLRRRHGELSVSVLLFQDLAVVP
LLILLPLLANGGEPLMVADIAFALLKGILAFFLLMAFGKWALPRIFDEVARSRSNELFVLSTLVVALVTGAFTQWLGLSM
ALGAFMAGMLLGESQYRRQLEADIRPFRDLLMGLFFISIGMMLDFTLVMRFWWQILLILVAVVLGKALIIHGILRLVGEP
FRIAMSTAMSLAQVGEFSFVVLALAVNYQLLDNEISTMLVMVAVLSMTIAPWLVRHSVDIAKWVLGIRQAKHVDEAVPLL
MDEHDLVMIFGYGRVGQTIARFLKTEAVPYLVMDLDPTRVSEARRAGEPIYFGDVCKRAMLKQIGVKQAKMIVITFCESR
SLEEVLPLCKLLAPGAKILVRTKDDSDLDLLKKAGANQVIPESLEGSLMLVSQVLHQCGVPLARILKRLESERRSHYQFL
HGFFSGTETDFTLESLHAVALPRGADAIGKTVAEIMWETLRVELRAIRRSGAEVEHPEQDWVFRAGDILLIVGKPRRLEK
AEAKLLHG
>Mature_648_residues
MEHSFLIQVLLMLVIAIVAIAVLRRLGLPAILAYLLTGVVSGPSGFHWFTQHQMQSVAELGVVLLMFTLGLEFSVPRLWA
MRRTVFGLGSAQMVITTLLTMGVALLCGLNWVEALVIGAAIALSSTAIVLKLLNEQGWLRRRHGELSVSVLLFQDLAVVP
LLILLPLLANGGEPLMVADIAFALLKGILAFFLLMAFGKWALPRIFDEVARSRSNELFVLSTLVVALVTGAFTQWLGLSM
ALGAFMAGMLLGESQYRRQLEADIRPFRDLLMGLFFISIGMMLDFTLVMRFWWQILLILVAVVLGKALIIHGILRLVGEP
FRIAMSTAMSLAQVGEFSFVVLALAVNYQLLDNEISTMLVMVAVLSMTIAPWLVRHSVDIAKWVLGIRQAKHVDEAVPLL
MDEHDLVMIFGYGRVGQTIARFLKTEAVPYLVMDLDPTRVSEARRAGEPIYFGDVCKRAMLKQIGVKQAKMIVITFCESR
SLEEVLPLCKLLAPGAKILVRTKDDSDLDLLKKAGANQVIPESLEGSLMLVSQVLHQCGVPLARILKRLESERRSHYQFL
HGFFSGTETDFTLESLHAVALPRGADAIGKTVAEIMWETLRVELRAIRRSGAEVEHPEQDWVFRAGDILLIVGKPRRLEK
AEAKLLHG

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=407, Percent_Identity=25.7985257985258, Blast_Score=94, Evalue=6e-19,
Organism=Escherichia coli, GI1789749, Length=545, Percent_Identity=35.7798165137615, Blast_Score=288, Evalue=9e-79,
Organism=Escherichia coli, GI1786232, Length=569, Percent_Identity=32.8646748681898, Blast_Score=275, Evalue=7e-75,
Organism=Escherichia coli, GI1786685, Length=523, Percent_Identity=29.8279158699809, Blast_Score=202, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6322367, Length=409, Percent_Identity=22.7383863080685, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR020884
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 71787; Mature: 71787

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHSFLIQVLLMLVIAIVAIAVLRRLGLPAILAYLLTGVVSGPSGFHWFTQHQMQSVAEL
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GVVLLMFTLGLEFSVPRLWAMRRTVFGLGSAQMVITTLLTMGVALLCGLNWVEALVIGAA
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IALSSTAIVLKLLNEQGWLRRRHGELSVSVLLFQDLAVVPLLILLPLLANGGEPLMVADI
HHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
AFALLKGILAFFLLMAFGKWALPRIFDEVARSRSNELFVLSTLVVALVTGAFTQWLGLSM
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
ALGAFMAGMLLGESQYRRQLEADIRPFRDLLMGLFFISIGMMLDFTLVMRFWWQILLILV
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVLGKALIIHGILRLVGEPFRIAMSTAMSLAQVGEFSFVVLALAVNYQLLDNEISTMLV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
MVAVLSMTIAPWLVRHSVDIAKWVLGIRQAKHVDEAVPLLMDEHDLVMIFGYGRVGQTIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHH
RFLKTEAVPYLVMDLDPTRVSEARRAGEPIYFGDVCKRAMLKQIGVKQAKMIVITFCESR
HHHHHCCCCEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHEEEEEECCCC
SLEEVLPLCKLLAPGAKILVRTKDDSDLDLLKKAGANQVIPESLEGSLMLVSQVLHQCGV
CHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHCCC
PLARILKRLESERRSHYQFLHGFFSGTETDFTLESLHAVALPRGADAIGKTVAEIMWETL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
RVELRAIRRSGAEVEHPEQDWVFRAGDILLIVGKPRRLEKAEAKLLHG
HHHHHHHHHCCCCCCCCCCCCEEECCCEEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure
MEHSFLIQVLLMLVIAIVAIAVLRRLGLPAILAYLLTGVVSGPSGFHWFTQHQMQSVAEL
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GVVLLMFTLGLEFSVPRLWAMRRTVFGLGSAQMVITTLLTMGVALLCGLNWVEALVIGAA
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IALSSTAIVLKLLNEQGWLRRRHGELSVSVLLFQDLAVVPLLILLPLLANGGEPLMVADI
HHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
AFALLKGILAFFLLMAFGKWALPRIFDEVARSRSNELFVLSTLVVALVTGAFTQWLGLSM
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
ALGAFMAGMLLGESQYRRQLEADIRPFRDLLMGLFFISIGMMLDFTLVMRFWWQILLILV
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVLGKALIIHGILRLVGEPFRIAMSTAMSLAQVGEFSFVVLALAVNYQLLDNEISTMLV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
MVAVLSMTIAPWLVRHSVDIAKWVLGIRQAKHVDEAVPLLMDEHDLVMIFGYGRVGQTIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHH
RFLKTEAVPYLVMDLDPTRVSEARRAGEPIYFGDVCKRAMLKQIGVKQAKMIVITFCESR
HHHHHCCCCEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHEEEEEECCCC
SLEEVLPLCKLLAPGAKILVRTKDDSDLDLLKKAGANQVIPESLEGSLMLVSQVLHQCGV
CHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHCCC
PLARILKRLESERRSHYQFLHGFFSGTETDFTLESLHAVALPRGADAIGKTVAEIMWETL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
RVELRAIRRSGAEVEHPEQDWVFRAGDILLIVGKPRRLEKAEAKLLHG
HHHHHHHHHCCCCCCCCCCCCEEECCCEEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA