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The map label for this gene is lpxD [H]

Identifier: 126173698

GI number: 126173698

Start: 1693476

End: 1694501

Strand: Direct

Name: lpxD [H]

Synonym: Sbal_1460

Alternate gene names: 126173698

Gene position: 1693476-1694501 (Clockwise)

Preceding gene: 126173697

Following gene: 126173699

Centisome position: 33.03

GC content: 45.22

Gene sequence:

>1026_bases
ATGAATAGTGTGACTTTAAAAGAGCTAGGCCTGTTATTAGACGGTGATATCCAAGGCGACGAAACGCTAATTATTGATAG
TGTGGCGACCTTAGAACATGCCAAAGCAGGTCAAATCTCTTTTTTAGCCAACAGTAAATATCGCTCTCAGCTTGAGGAAA
CTCAAGCGAGTGCGGTGTTATTGTCAGCTAAAGATGCGCAGGATTATCAAGGTACTGCGTTAATTGTAAAAGATCCTTAT
GTCGGTTTTGCCCGTGTTGCCCAGTATTTGGACACTACGCCTAAAGCGGCGGTGGGTATCCATCCTTCGGCTCAAATTGA
CGCTTCTGCTCATATAGGTGAAGGTGTTGCGATTGGGGCGAATGCGGTTATTGGTGCGAACGTCATTTTAGGTGAAAATG
TCCAGATAGGTGCCGGTGTCGTGCTCGGACAAGATGTGGTTATTGGCTCAAAAACGCGTTTGTGGGCTAATGTCACTGTC
TATCACGATGTGCATTTAGGACAAGATTGTATTATCCATTCGGGCGCTGTATTAGGCTCCGATGGTTTTGGTTATGCGAA
TGATCGCGGTCAGTGGATTAAAATCCCACAAACGGGCGGCGTTCGTATCGGCGATCGAGTTGAAATAGGCGCGAATTCAA
CGGTAGATCGGGGGGCATTAGGCCATACCGAGATCCACGATGGTGTAATTATCGATAACCAAGTACAAATTGCCCATAAC
GATATTATCGGTGAGAATACCGCTATCGCAGGCAGTACGACTGTCGCAGGCAGTGTCACCATAGGTAAATATTGTATTAT
TGGTGGTAGTTGTGCCATCGCAGGTCATTTGAGCATTGCCGATGGTGTGCATGTGTCTGGTGGGACTAACATTACCAGTA
CTATGCGTGAGCCTGGTTTATACTCTTCTGCCACTGTGGCAATGGACAATAAACTTTGGCGTAAAAACACAGTTCGTTTC
CGTCAGTTAGATGAACTGTTCCATCGTGTTAAAACGTTGGAAAAAAATTTAAAAACACCAGATTAA

Upstream 100 bases:

>100_bases
ATATGATTTGGTATTACAACGTGGTGCTGTCATTTATGTTAAGCCTAACGCTGACATCAGTGGCAAAGTGGTTGAAGCCT
TAAGCAAAGGCAAGTAATAG

Downstream 100 bases:

>100_bases
TTGCTCCAAGGCAATTTGAGGAACTCGGTTCGTGTCTAATCAAATGAACACTATGGATATTAAAGAAATACTTAAATATC
TGCCCCATAGATATCCATTC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MNSVTLKELGLLLDGDIQGDETLIIDSVATLEHAKAGQISFLANSKYRSQLEETQASAVLLSAKDAQDYQGTALIVKDPY
VGFARVAQYLDTTPKAAVGIHPSAQIDASAHIGEGVAIGANAVIGANVILGENVQIGAGVVLGQDVVIGSKTRLWANVTV
YHDVHLGQDCIIHSGAVLGSDGFGYANDRGQWIKIPQTGGVRIGDRVEIGANSTVDRGALGHTEIHDGVIIDNQVQIAHN
DIIGENTAIAGSTTVAGSVTIGKYCIIGGSCAIAGHLSIADGVHVSGGTNITSTMREPGLYSSATVAMDNKLWRKNTVRF
RQLDELFHRVKTLEKNLKTPD

Sequences:

>Translated_341_residues
MNSVTLKELGLLLDGDIQGDETLIIDSVATLEHAKAGQISFLANSKYRSQLEETQASAVLLSAKDAQDYQGTALIVKDPY
VGFARVAQYLDTTPKAAVGIHPSAQIDASAHIGEGVAIGANAVIGANVILGENVQIGAGVVLGQDVVIGSKTRLWANVTV
YHDVHLGQDCIIHSGAVLGSDGFGYANDRGQWIKIPQTGGVRIGDRVEIGANSTVDRGALGHTEIHDGVIIDNQVQIAHN
DIIGENTAIAGSTTVAGSVTIGKYCIIGGSCAIAGHLSIADGVHVSGGTNITSTMREPGLYSSATVAMDNKLWRKNTVRF
RQLDELFHRVKTLEKNLKTPD
>Mature_341_residues
MNSVTLKELGLLLDGDIQGDETLIIDSVATLEHAKAGQISFLANSKYRSQLEETQASAVLLSAKDAQDYQGTALIVKDPY
VGFARVAQYLDTTPKAAVGIHPSAQIDASAHIGEGVAIGANAVIGANVILGENVQIGAGVVLGQDVVIGSKTRLWANVTV
YHDVHLGQDCIIHSGAVLGSDGFGYANDRGQWIKIPQTGGVRIGDRVEIGANSTVDRGALGHTEIHDGVIIDNQVQIAHN
DIIGENTAIAGSTTVAGSVTIGKYCIIGGSCAIAGHLSIADGVHVSGGTNITSTMREPGLYSSATVAMDNKLWRKNTVRF
RQLDELFHRVKTLEKNLKTPD

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=341, Percent_Identity=51.6129032258064, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1786378, Length=195, Percent_Identity=29.2307692307692, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 35866; Mature: 35866

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSVTLKELGLLLDGDIQGDETLIIDSVATLEHAKAGQISFLANSKYRSQLEETQASAVL
CCCCCHHHHCEEEECCCCCCCEEEEECHHHHHHCCCCEEEEEECCHHHHHHHHHHHEEEE
LSAKDAQDYQGTALIVKDPYVGFARVAQYLDTTPKAAVGIHPSAQIDASAHIGEGVAIGA
EEECCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEECC
NAVIGANVILGENVQIGAGVVLGQDVVIGSKTRLWANVTVYHDVHLGQDCIIHSGAVLGS
CEEEECEEEECCCEEECCEEEECCEEEECCCCEEEEEEEEEEEEECCCCEEEECCEEECC
DGFGYANDRGQWIKIPQTGGVRIGDRVEIGANSTVDRGALGHTEIHDGVIIDNQVQIAHN
CCCCCCCCCCCEEEECCCCCEEECCEEEECCCCCCCCCCCCCCCCCCCEEECCEEEEEEC
DIIGENTAIAGSTTVAGSVTIGKYCIIGGSCAIAGHLSIADGVHVSGGTNITSTMREPGL
CCCCCCCEECCCCEEEEEEEECEEEEECCCEEEEEEEEECCCEEECCCCCHHHHHCCCCC
YSSATVAMDNKLWRKNTVRFRQLDELFHRVKTLEKNLKTPD
CCCEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNSVTLKELGLLLDGDIQGDETLIIDSVATLEHAKAGQISFLANSKYRSQLEETQASAVL
CCCCCHHHHCEEEECCCCCCCEEEEECHHHHHHCCCCEEEEEECCHHHHHHHHHHHEEEE
LSAKDAQDYQGTALIVKDPYVGFARVAQYLDTTPKAAVGIHPSAQIDASAHIGEGVAIGA
EEECCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEECC
NAVIGANVILGENVQIGAGVVLGQDVVIGSKTRLWANVTVYHDVHLGQDCIIHSGAVLGS
CEEEECEEEECCCEEECCEEEECCEEEECCCCEEEEEEEEEEEEECCCCEEEECCEEECC
DGFGYANDRGQWIKIPQTGGVRIGDRVEIGANSTVDRGALGHTEIHDGVIIDNQVQIAHN
CCCCCCCCCCCEEEECCCCCEEECCEEEECCCCCCCCCCCCCCCCCCCEEECCEEEEEEC
DIIGENTAIAGSTTVAGSVTIGKYCIIGGSCAIAGHLSIADGVHVSGGTNITSTMREPGL
CCCCCCCEECCCCEEEEEEEECEEEEECCCEEEEEEEEECCCEEECCCCCHHHHHCCCCC
YSSATVAMDNKLWRKNTVRFRQLDELFHRVKTLEKNLKTPD
CCCEEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]