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The map label for this gene is hemL [H]

Identifier: 126173398

GI number: 126173398

Start: 1337917

End: 1339209

Strand: Reverse

Name: hemL [H]

Synonym: Sbal_1159

Alternate gene names: 126173398

Gene position: 1339209-1337917 (Counterclockwise)

Preceding gene: 126173399

Following gene: 126173397

Centisome position: 26.12

GC content: 49.5

Gene sequence:

>1293_bases
ATGACCCGTTCCGAAGCGCTATTTGAACAGGCTAAAAAAACCATCCCCGGCGGCGTTAACTCTCCGGTTCGTGCATTTAA
TGGTGTAGGCGGTTCGCCCCTGTTTATTGAAAAAGCAAACGGCGCTTATATTTACGATGCCGATGGCAAAGCTTATATCG
ACTATGTCGGTTCTTGGGGCCCGATGATCCTCGGCCACAATCACCCTAAAATCCGTGCAGCGGTATTAGCGGCAGTGGAA
AATGGCTTGTCTTTTGGCGCACCAACAGAACTTGAAGTGCAAATGGCCGAGAAAGTCATCTCTATGGTGCCTTCTATCGA
GCAAGTTCGTATGGTGAGCTCTGGTACAGAAGCCACTATGAGCGCCATTCGTTTAGCACGCGGTTTTACTAATCGTGACA
AGATCTTAAAATTCGAAGGTTGTTACCACGGCCATGCGGATTGCCTGTTAGTTAAGGCGGGTTCTGGCGCACTAACTTTA
GGCCAACCTAGCTCACCCGGTATTCCAGAAGATTTCGCCAAGCACACCTTAACGGCTGTGTATAACGACTTAGATTCTGT
CAGAACCCTGTTCGAGCAGTATCCAACTGACATTTCTTGCATCATCATCGAGCCCGTTGCTGGCAACATGAACTGTATTC
CACCTATCCCAGGTTTCCTTCAAGGTCTGCGTGATATTTGTGACGAGTTCGGTGCCTTAATGATCATCGACGAAGTGATG
ACAGGGTTCCGCGTATCACAAAGCGGCGCTCAAGGTTACTACGGCGTCACACCTGACTTGACCACGCTGGGTAAAGTGAT
TGGTGGCGGTATGCCAGTGGGTGCCTTCGGTGGCCGTAAAGATGTGATGCAGTTTATCGCGCCTACGGGTCCGGTTTACC
AAGCGGGAACGTTATCTGGTAACCCAATTGCGATGTCAGCAGGTTTGGCGCAAATGGAAGCCCTGTGTGAAGAAGGTCTA
TACGAAAAGTTAAGCGCGAAAACTAAACGTATCGCCGAAGGTTTTAAAGCGGCAGCTGACAAGCACGGTATTCCAATGGC
GATCAACTATGTTGGCGGCATGTTCGGTTTCTTCTTCACAGAACAACCGGAAATCACCCGTTTTGACCAAGTGACCCAAT
GTAATATTGAGCAGTTCCGTATTTTCTACCACGGCATGTTAGATGAAGGCGTGTACTTGGCACCTAGCGCTTATGAAGCC
GGTTTCCTGTCTATGGCCCATGGCGAAGAAGAAATGCGCTTGACCTTAGAAGCGGCTGACCGCGTATTAGCGAGCATGAA
AGCGGCAAGCTAA

Upstream 100 bases:

>100_bases
CACTCGGCGTTGATCATCAACTCGAAAAATATGAGTGTCCGGTTAATTGGTATTCACGTAAAGCCGATCGCTAGTTGGCT
ACAGACTTTAAGGACTAAAC

Downstream 100 bases:

>100_bases
ACCTAGATCTTAGGGTTGCTACACCTTAAAAATAACAAAGGGACGCTAATGCGTCCCTTTGTTTTTATTAAATTTAATTA
GCTTTACTTAAATTCAGTAA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MTRSEALFEQAKKTIPGGVNSPVRAFNGVGGSPLFIEKANGAYIYDADGKAYIDYVGSWGPMILGHNHPKIRAAVLAAVE
NGLSFGAPTELEVQMAEKVISMVPSIEQVRMVSSGTEATMSAIRLARGFTNRDKILKFEGCYHGHADCLLVKAGSGALTL
GQPSSPGIPEDFAKHTLTAVYNDLDSVRTLFEQYPTDISCIIIEPVAGNMNCIPPIPGFLQGLRDICDEFGALMIIDEVM
TGFRVSQSGAQGYYGVTPDLTTLGKVIGGGMPVGAFGGRKDVMQFIAPTGPVYQAGTLSGNPIAMSAGLAQMEALCEEGL
YEKLSAKTKRIAEGFKAAADKHGIPMAINYVGGMFGFFFTEQPEITRFDQVTQCNIEQFRIFYHGMLDEGVYLAPSAYEA
GFLSMAHGEEEMRLTLEAADRVLASMKAAS

Sequences:

>Translated_430_residues
MTRSEALFEQAKKTIPGGVNSPVRAFNGVGGSPLFIEKANGAYIYDADGKAYIDYVGSWGPMILGHNHPKIRAAVLAAVE
NGLSFGAPTELEVQMAEKVISMVPSIEQVRMVSSGTEATMSAIRLARGFTNRDKILKFEGCYHGHADCLLVKAGSGALTL
GQPSSPGIPEDFAKHTLTAVYNDLDSVRTLFEQYPTDISCIIIEPVAGNMNCIPPIPGFLQGLRDICDEFGALMIIDEVM
TGFRVSQSGAQGYYGVTPDLTTLGKVIGGGMPVGAFGGRKDVMQFIAPTGPVYQAGTLSGNPIAMSAGLAQMEALCEEGL
YEKLSAKTKRIAEGFKAAADKHGIPMAINYVGGMFGFFFTEQPEITRFDQVTQCNIEQFRIFYHGMLDEGVYLAPSAYEA
GFLSMAHGEEEMRLTLEAADRVLASMKAAS
>Mature_429_residues
TRSEALFEQAKKTIPGGVNSPVRAFNGVGGSPLFIEKANGAYIYDADGKAYIDYVGSWGPMILGHNHPKIRAAVLAAVEN
GLSFGAPTELEVQMAEKVISMVPSIEQVRMVSSGTEATMSAIRLARGFTNRDKILKFEGCYHGHADCLLVKAGSGALTLG
QPSSPGIPEDFAKHTLTAVYNDLDSVRTLFEQYPTDISCIIIEPVAGNMNCIPPIPGFLQGLRDICDEFGALMIIDEVMT
GFRVSQSGAQGYYGVTPDLTTLGKVIGGGMPVGAFGGRKDVMQFIAPTGPVYQAGTLSGNPIAMSAGLAQMEALCEEGLY
EKLSAKTKRIAEGFKAAADKHGIPMAINYVGGMFGFFFTEQPEITRFDQVTQCNIEQFRIFYHGMLDEGVYLAPSAYEAG
FLSMAHGEEEMRLTLEAADRVLASMKAAS

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=302, Percent_Identity=29.1390728476821, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI284507298, Length=145, Percent_Identity=33.7931034482759, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=69.9530516431925, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI1789016, Length=362, Percent_Identity=31.4917127071823, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1788044, Length=338, Percent_Identity=29.585798816568, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI145693181, Length=414, Percent_Identity=27.2946859903382, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1789759, Length=337, Percent_Identity=29.080118694362, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1787560, Length=369, Percent_Identity=28.7262872628726, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786991, Length=426, Percent_Identity=25.8215962441315, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=299, Percent_Identity=27.4247491638796, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI71992977, Length=462, Percent_Identity=26.8398268398268, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI32564660, Length=337, Percent_Identity=28.1899109792285, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25144274, Length=147, Percent_Identity=34.0136054421769, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=308, Percent_Identity=27.9220779220779, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324432, Length=353, Percent_Identity=25.4957507082153, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357415, Length=297, Percent_Identity=28.956228956229, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356575, Length=343, Percent_Identity=29.1545189504373, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46095; Mature: 45964

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSEALFEQAKKTIPGGVNSPVRAFNGVGGSPLFIEKANGAYIYDADGKAYIDYVGSWG
CCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEEEECCCEEEEECCCCEEEEEECCCC
PMILGHNHPKIRAAVLAAVENGLSFGAPTELEVQMAEKVISMVPSIEQVRMVSSGTEATM
CEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SAIRLARGFTNRDKILKFEGCYHGHADCLLVKAGSGALTLGQPSSPGIPEDFAKHTLTAV
HHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHH
YNDLDSVRTLFEQYPTDISCIIIEPVAGNMNCIPPIPGFLQGLRDICDEFGALMIIDEVM
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHH
TGFRVSQSGAQGYYGVTPDLTTLGKVIGGGMPVGAFGGRKDVMQFIAPTGPVYQAGTLSG
HCCEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPIAMSAGLAQMEALCEEGLYEKLSAKTKRIAEGFKAAADKHGIPMAINYVGGMFGFFFT
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCC
EQPEITRFDQVTQCNIEQFRIFYHGMLDEGVYLAPSAYEAGFLSMAHGEEEMRLTLEAAD
CCCCCCHHHHHHHCCHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHCCCHHHEEHHHHHH
RVLASMKAAS
HHHHHHHCCC
>Mature Secondary Structure 
TRSEALFEQAKKTIPGGVNSPVRAFNGVGGSPLFIEKANGAYIYDADGKAYIDYVGSWG
CCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEEEECCCEEEEECCCCEEEEEECCCC
PMILGHNHPKIRAAVLAAVENGLSFGAPTELEVQMAEKVISMVPSIEQVRMVSSGTEATM
CEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SAIRLARGFTNRDKILKFEGCYHGHADCLLVKAGSGALTLGQPSSPGIPEDFAKHTLTAV
HHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHH
YNDLDSVRTLFEQYPTDISCIIIEPVAGNMNCIPPIPGFLQGLRDICDEFGALMIIDEVM
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHH
TGFRVSQSGAQGYYGVTPDLTTLGKVIGGGMPVGAFGGRKDVMQFIAPTGPVYQAGTLSG
HCCEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPIAMSAGLAQMEALCEEGLYEKLSAKTKRIAEGFKAAADKHGIPMAINYVGGMFGFFFT
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCC
EQPEITRFDQVTQCNIEQFRIFYHGMLDEGVYLAPSAYEAGFLSMAHGEEEMRLTLEAAD
CCCCCCHHHHHHHCCHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHCCCHHHEEHHHHHH
RVLASMKAAS
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA