Click here to switch to the map view.

The map label for this gene is ung [H]

Identifier: 126173209

GI number: 126173209

Start: 1109533

End: 1110198

Strand: Direct

Name: ung [H]

Synonym: Sbal_0965

Alternate gene names: 126173209

Gene position: 1109533-1110198 (Clockwise)

Preceding gene: 126173206

Following gene: 126173211

Centisome position: 21.64

GC content: 48.8

Gene sequence:

>666_bases
GTGACTCAGGCGACATGGCAAACATTTATCGATGGGCAAAGGGCATTGCCTTATTTTCAGCAACTAAGTGCGTTTGTAGA
CAATGAACGCAGGGCTGGGAAAGTGGTTTATCCACCCGAAGCCGATGTTTTTAATGCCTTTACTATGACTCCGCTTGAGA
AGGTCAAAGTGGTATTGATTGGCCAAGATCCCTATCACGGCCCAGATCAAGCCCATGGTTTATGCTTTTCGGTCAAACGC
GGTATTAAACCGCCGCCTTCCTTAGCCAATATGTACAAGGAATTAGCGACAGATATTGATGGCTTTACCATTCCATCCCA
CGGGGATTTATCCGCATGGGCGGAGCAGGGGATATTAATGCTCAATACGGTGCTGACCGTTGAGCAAGGCAAGGCGCACT
CCCATGCCAAAGCGGGTTGGGAAGTGTTTACGACTGCCGTGCTGGAATTATTAAATCGCCAGACTCAGCCGATTATCTTC
GTGCTTTGGGGCAGTCATGCCATCAAAAAAGGTCAAGTGATTAACGCACCGCAACATCAAGTGCTTACTGGGCCGCATCC
TTCACCTTTATCGGCCTATCGGGGTTTTTTTGGCTGTGGGCATTTTTCTCAAGTGAATCAATTATTACTTGAGCGGGGCG
AAGCGCCGATCCGCTGGCAGGTTTAA

Upstream 100 bases:

>100_bases
ACATAGCCTTATCACTCATCGACAAGCATAACCTTCAAACTTGCCATTCTACAGCAGGACTTTTAAGCTAGCCCGATAAT
AGGATTGAGGAAGTAAAATC

Downstream 100 bases:

>100_bases
TCTTAGGATTGCGAGTTTGAGGCAATAAAAAAGGTCTTACTGAGTAAGACCTTTTCTTTGGGCTAAAAATGAATTAGCGA
GTGATCAATGATTACGGTCG

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MTQATWQTFIDGQRALPYFQQLSAFVDNERRAGKVVYPPEADVFNAFTMTPLEKVKVVLIGQDPYHGPDQAHGLCFSVKR
GIKPPPSLANMYKELATDIDGFTIPSHGDLSAWAEQGILMLNTVLTVEQGKAHSHAKAGWEVFTTAVLELLNRQTQPIIF
VLWGSHAIKKGQVINAPQHQVLTGPHPSPLSAYRGFFGCGHFSQVNQLLLERGEAPIRWQV

Sequences:

>Translated_221_residues
MTQATWQTFIDGQRALPYFQQLSAFVDNERRAGKVVYPPEADVFNAFTMTPLEKVKVVLIGQDPYHGPDQAHGLCFSVKR
GIKPPPSLANMYKELATDIDGFTIPSHGDLSAWAEQGILMLNTVLTVEQGKAHSHAKAGWEVFTTAVLELLNRQTQPIIF
VLWGSHAIKKGQVINAPQHQVLTGPHPSPLSAYRGFFGCGHFSQVNQLLLERGEAPIRWQV
>Mature_220_residues
TQATWQTFIDGQRALPYFQQLSAFVDNERRAGKVVYPPEADVFNAFTMTPLEKVKVVLIGQDPYHGPDQAHGLCFSVKRG
IKPPPSLANMYKELATDIDGFTIPSHGDLSAWAEQGILMLNTVLTVEQGKAHSHAKAGWEVFTTAVLELLNRQTQPIIFV
LWGSHAIKKGQVINAPQHQVLTGPHPSPLSAYRGFFGCGHFSQVNQLLLERGEAPIRWQV

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=54.6296296296296, Blast_Score=253, Evalue=1e-67,
Organism=Homo sapiens, GI6224979, Length=216, Percent_Identity=54.6296296296296, Blast_Score=252, Evalue=2e-67,
Organism=Escherichia coli, GI1788934, Length=218, Percent_Identity=57.3394495412844, Blast_Score=268, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17556304, Length=220, Percent_Identity=45.9090909090909, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6323620, Length=221, Percent_Identity=47.0588235294118, Blast_Score=187, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24526; Mature: 24395

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQATWQTFIDGQRALPYFQQLSAFVDNERRAGKVVYPPEADVFNAFTMTPLEKVKVVLI
CCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHCCCHHHEEEEEE
GQDPYHGPDQAHGLCFSVKRGIKPPPSLANMYKELATDIDGFTIPSHGDLSAWAEQGILM
ECCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCEEE
LNTVLTVEQGKAHSHAKAGWEVFTTAVLELLNRQTQPIIFVLWGSHAIKKGQVINAPQHQ
EHHEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEECCCCCC
VLTGPHPSPLSAYRGFFGCGHFSQVNQLLLERGEAPIRWQV
EECCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure 
TQATWQTFIDGQRALPYFQQLSAFVDNERRAGKVVYPPEADVFNAFTMTPLEKVKVVLI
CCCHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHCCCHHHEEEEEE
GQDPYHGPDQAHGLCFSVKRGIKPPPSLANMYKELATDIDGFTIPSHGDLSAWAEQGILM
ECCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCEEE
LNTVLTVEQGKAHSHAKAGWEVFTTAVLELLNRQTQPIIFVLWGSHAIKKGQVINAPQHQ
EHHEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEECCCCCC
VLTGPHPSPLSAYRGFFGCGHFSQVNQLLLERGEAPIRWQV
EECCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]