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The map label for this gene is pepA [H]

Identifier: 126173185

GI number: 126173185

Start: 1080992

End: 1082530

Strand: Direct

Name: pepA [H]

Synonym: Sbal_0941

Alternate gene names: 126173185

Gene position: 1080992-1082530 (Clockwise)

Preceding gene: 126173181

Following gene: 126173186

Centisome position: 21.08

GC content: 51.46

Gene sequence:

>1539_bases
ATGTTTCAAGTTAACTTCGTTGATGTAAAAGCAGAAAATGCCATTTTTGATGGTGAAGGTTGGGATGCAGTTGTGGTGGT
GACGCCCGATCTGGATACCATAGGTTTTGATGAGATCAGTTTATTGGCTCAGCACGGTGCCCACGTGGATAAGCGCGTAG
GTAAGAGCCCGACATTACTGTTTGCCCCGGGTCTGGCGGGCGGTCGCTTGATCATTGCGCCTGTCACCCAAGTGAACGAC
GAGTATGTAGATGTGCGTGTATATGCTGATGCCGCAAGGGCGGCGATTGCCATTGCAAAAGAGGCGGGCGCCAAACGTCC
GTTATTATATGTGGTGCCATCGAAGGATTTGCGTTTTAGTTTTGCCTCTGAAGTCGCGGCGTTAGCCTGCGCTCAAGAAC
TGTGGCAAACCTTAGAGCTGCGTGAAGCGACGGGCTTAACGCCTGCATTTGAGGCCATAGGATTACTATCGTCATCAACT
CATAACAGCAATTTGCTCAATGCGTTAGAAGCGGGTCGCGTATTAGCGCGGGATTTATGTGGTACAGAACCTGAGCGCAT
GTCGGCTAAAGCCTTTGCTGACTATTGTCTACAATCCTTAGCGGGCAGCGTGATCAAAACCGCAGTGGTAGAAGACAGAG
ATATTTTAGAGCGTGACTATCCGCTGCTCAGTGCAGTAGCGCGTTCCTCTTTTGCCGTCGGTCGTCATCAACCTCGGGTG
GTGAAATTAGAATATCTGCCAGAGAGTGAAGTGACTCGCACTTTCCTGTTCGCGGGTAAGGGCGTGATTTACGATACCGG
CGGCGCCGATCTGAAAGTCGGCGGTTCTATGGCGGGCATGAGCCGTGATAAAGGCGGCGCTTCTGCTGTGGCGGGGCTAT
TCAAAACCCTGTCAATGCTCAAGCCTAAGGGCATTCGAGTGATTGCCGAGTTAGGTTTAGTGCGTAATAGCATAGGCAGC
GAAGCCTTCGTGACCGATGAAATCATCACCAGTCATGCGGGTGTACGAGTGCGGATTGGTAATACGGATGCCGAAGGGCG
CTTAGTGCTGGCGGATTTATTGAGTCATTTACGCATCAAAGCCGTGTCGGCGGTGAAGCCTGAAATGTTTTCGGTAGCAA
CACTCACGGGTCACGTAGTGCGTTGTTATGGCAGTTATCCTGCGGCGGTGGAAAACTCAGTGGCGAGTTCGCAGCAATGC
GCTGTCACTTTACAACAGCAGGCGACTCAATGGGGCGAACCCTTTGAAGTGTCTACATTGCGACCTGAAGACTTCGCGAA
GATCCGCGATGTGTCAGGCGCTGCTGAAATGTTATCTTCAAATAATGCCCCATCATCGATTACCGCGCGCGGACATCAAT
ATCCTGCGGCATTTTTACTGAAAGCGTCGGGGCTATTTGACCATGGTGTAACAGCCCCGATTCCCTTAGCTTATATGCAC
TTAGATATCGCAGGCAGTGCGACAGAAGGCGATCCGCTCTACGGCAAACCTACGGCCAGTCCGCTAGTGGGCTTGTATCA
ATATCTGATCAATCGCTAA

Upstream 100 bases:

>100_bases
CCAGTTGGGATTTTTCAGAGGGTCTCGATACCACTTTTAGATTGGTAATTAGGCGATAGAGCGGGAATAATGCAGACACA
ATAATGAAAAAGGATGGGTC

Downstream 100 bases:

>100_bases
CGGGTAGGGCGTGTTGACGTTTCAGGGTTATTTTTGCAGCGAGTTGGCTGGCTTTTATGCAAGGTAAAGCCCGTGCGGTG
TAGTTATTCTACATAAACGG

Product: peptidase M17, leucyl aminopeptidase domain-containing protein

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MFQVNFVDVKAENAIFDGEGWDAVVVVTPDLDTIGFDEISLLAQHGAHVDKRVGKSPTLLFAPGLAGGRLIIAPVTQVND
EYVDVRVYADAARAAIAIAKEAGAKRPLLYVVPSKDLRFSFASEVAALACAQELWQTLELREATGLTPAFEAIGLLSSST
HNSNLLNALEAGRVLARDLCGTEPERMSAKAFADYCLQSLAGSVIKTAVVEDRDILERDYPLLSAVARSSFAVGRHQPRV
VKLEYLPESEVTRTFLFAGKGVIYDTGGADLKVGGSMAGMSRDKGGASAVAGLFKTLSMLKPKGIRVIAELGLVRNSIGS
EAFVTDEIITSHAGVRVRIGNTDAEGRLVLADLLSHLRIKAVSAVKPEMFSVATLTGHVVRCYGSYPAAVENSVASSQQC
AVTLQQQATQWGEPFEVSTLRPEDFAKIRDVSGAAEMLSSNNAPSSITARGHQYPAAFLLKASGLFDHGVTAPIPLAYMH
LDIAGSATEGDPLYGKPTASPLVGLYQYLINR

Sequences:

>Translated_512_residues
MFQVNFVDVKAENAIFDGEGWDAVVVVTPDLDTIGFDEISLLAQHGAHVDKRVGKSPTLLFAPGLAGGRLIIAPVTQVND
EYVDVRVYADAARAAIAIAKEAGAKRPLLYVVPSKDLRFSFASEVAALACAQELWQTLELREATGLTPAFEAIGLLSSST
HNSNLLNALEAGRVLARDLCGTEPERMSAKAFADYCLQSLAGSVIKTAVVEDRDILERDYPLLSAVARSSFAVGRHQPRV
VKLEYLPESEVTRTFLFAGKGVIYDTGGADLKVGGSMAGMSRDKGGASAVAGLFKTLSMLKPKGIRVIAELGLVRNSIGS
EAFVTDEIITSHAGVRVRIGNTDAEGRLVLADLLSHLRIKAVSAVKPEMFSVATLTGHVVRCYGSYPAAVENSVASSQQC
AVTLQQQATQWGEPFEVSTLRPEDFAKIRDVSGAAEMLSSNNAPSSITARGHQYPAAFLLKASGLFDHGVTAPIPLAYMH
LDIAGSATEGDPLYGKPTASPLVGLYQYLINR
>Mature_512_residues
MFQVNFVDVKAENAIFDGEGWDAVVVVTPDLDTIGFDEISLLAQHGAHVDKRVGKSPTLLFAPGLAGGRLIIAPVTQVND
EYVDVRVYADAARAAIAIAKEAGAKRPLLYVVPSKDLRFSFASEVAALACAQELWQTLELREATGLTPAFEAIGLLSSST
HNSNLLNALEAGRVLARDLCGTEPERMSAKAFADYCLQSLAGSVIKTAVVEDRDILERDYPLLSAVARSSFAVGRHQPRV
VKLEYLPESEVTRTFLFAGKGVIYDTGGADLKVGGSMAGMSRDKGGASAVAGLFKTLSMLKPKGIRVIAELGLVRNSIGS
EAFVTDEIITSHAGVRVRIGNTDAEGRLVLADLLSHLRIKAVSAVKPEMFSVATLTGHVVRCYGSYPAAVENSVASSQQC
AVTLQQQATQWGEPFEVSTLRPEDFAKIRDVSGAAEMLSSNNAPSSITARGHQYPAAFLLKASGLFDHGVTAPIPLAYMH
LDIAGSATEGDPLYGKPTASPLVGLYQYLINR

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI47155554, Length=363, Percent_Identity=29.2011019283747, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI41393561, Length=355, Percent_Identity=25.6338028169014, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI87082123, Length=271, Percent_Identity=31.3653136531365, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790710, Length=269, Percent_Identity=29.7397769516729, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17565172, Length=448, Percent_Identity=41.9642857142857, Blast_Score=329, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17556903, Length=350, Percent_Identity=29.7142857142857, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646701, Length=450, Percent_Identity=42.4444444444444, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI24646703, Length=450, Percent_Identity=42.4444444444444, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI21358201, Length=450, Percent_Identity=42.4444444444444, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI221379063, Length=288, Percent_Identity=30.2083333333333, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221379062, Length=288, Percent_Identity=30.2083333333333, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357381, Length=288, Percent_Identity=30.2083333333333, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54535; Mature: 54535

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQVNFVDVKAENAIFDGEGWDAVVVVTPDLDTIGFDEISLLAQHGAHVDKRVGKSPTLL
CEEEEEEEEECCCEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHCCHHHHHCCCCCCEE
FAPGLAGGRLIIAPVTQVNDEYVDVRVYADAARAAIAIAKEAGAKRPLLYVVPSKDLRFS
EECCCCCCEEEEEEHHHCCCCEEEEEEEECHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
FASEVAALACAQELWQTLELREATGLTPAFEAIGLLSSSTHNSNLLNALEAGRVLARDLC
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
GTEPERMSAKAFADYCLQSLAGSVIKTAVVEDRDILERDYPLLSAVARSSFAVGRHQPRV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHCCCCCCEE
VKLEYLPESEVTRTFLFAGKGVIYDTGGADLKVGGSMAGMSRDKGGASAVAGLFKTLSML
EEEEECCCHHHHHHHEEECCCEEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
KPKGIRVIAELGLVRNSIGSEAFVTDEIITSHAGVRVRIGNTDAEGRLVLADLLSHLRIK
CCCCHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCEEEEECCCCCCCCEEHHHHHHHHHHH
AVSAVKPEMFSVATLTGHVVRCYGSYPAAVENSVASSQQCAVTLQQQATQWGEPFEVSTL
HHHHCCCCHHHHHHHHCEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECC
RPEDFAKIRDVSGAAEMLSSNNAPSSITARGHQYPAAFLLKASGLFDHGVTAPIPLAYMH
CCHHHHHHHHCCHHHHHHHCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCCCCCEEEEE
LDIAGSATEGDPLYGKPTASPLVGLYQYLINR
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MFQVNFVDVKAENAIFDGEGWDAVVVVTPDLDTIGFDEISLLAQHGAHVDKRVGKSPTLL
CEEEEEEEEECCCEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHCCHHHHHCCCCCCEE
FAPGLAGGRLIIAPVTQVNDEYVDVRVYADAARAAIAIAKEAGAKRPLLYVVPSKDLRFS
EECCCCCCEEEEEEHHHCCCCEEEEEEEECHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
FASEVAALACAQELWQTLELREATGLTPAFEAIGLLSSSTHNSNLLNALEAGRVLARDLC
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
GTEPERMSAKAFADYCLQSLAGSVIKTAVVEDRDILERDYPLLSAVARSSFAVGRHQPRV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHCCCCCCEE
VKLEYLPESEVTRTFLFAGKGVIYDTGGADLKVGGSMAGMSRDKGGASAVAGLFKTLSML
EEEEECCCHHHHHHHEEECCCEEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
KPKGIRVIAELGLVRNSIGSEAFVTDEIITSHAGVRVRIGNTDAEGRLVLADLLSHLRIK
CCCCHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCEEEEECCCCCCCCEEHHHHHHHHHHH
AVSAVKPEMFSVATLTGHVVRCYGSYPAAVENSVASSQQCAVTLQQQATQWGEPFEVSTL
HHHHCCCCHHHHHHHHCEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECC
RPEDFAKIRDVSGAAEMLSSNNAPSSITARGHQYPAAFLLKASGLFDHGVTAPIPLAYMH
CCHHHHHHHHCCHHHHHHHCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCCCCCEEEEE
LDIAGSATEGDPLYGKPTASPLVGLYQYLINR
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]