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The map label for this gene is ubiH [H]

Identifier: 126172864

GI number: 126172864

Start: 699398

End: 700663

Strand: Direct

Name: ubiH [H]

Synonym: Sbal_0615

Alternate gene names: 126172864

Gene position: 699398-700663 (Clockwise)

Preceding gene: 126172863

Following gene: 126172865

Centisome position: 13.64

GC content: 53.08

Gene sequence:

>1266_bases
ATGGCATTAGTGAAATGCCAAAGTTTGAATGAGATCCCCATGACGGCCACAAATCACATGGATACTTCAGTTCAACACGT
CGACATCGCGATTGTAGGCGGTGCGATGGCGGGGGCGACTCTCGCGTTGGCTCTCGCGCGTCTGTCTTTATCTGCCGCTA
GGCCGCTTTCCATCGCCTTAATCGAGGCGCACCTTCCCGATAAACAACACCCCGGATTCGATGCTCGCTCCATCGCTATC
GCCCACGGTTCAATTTTCGAATTGTCCCGTTTAGGTCTATGGCCAAAGCTCGCCCATTTGGGCACGGCGATTGAAAATAT
CCATGTATCGGATCGCGGCCACTTTGGCATGACAGAGCTCAATGCCGCGCAGTTCCATTTAGATGCCCTAGGCCAAGTGG
TCGAGCTTGAGCGTGTCGGCCAAGTGTTGTTTAACGAGTTGAATAAGAGCGAGGTAAAACTCTATTGCCCCGCCAAGCTT
GCCCAAGTGGAACCCGCCGTCGAAGGCCACACCTTAGTGCTCGATACGGGCAAGCGCCTTAAAGCCAAACTCGTGGTTGC
CGCCGATGGTCTGCAATCCAAAGTGCGCAGCAGTTTTGATTTGCCCGTGACCCAAGTGGCCTTCGAGCAAACCGCGATTA
TTGCCAATATTCAAACCGACAAGCCGCATCAACATTTGGCCTATGAGCGTTTTACCCAAACGGGTCCCTTAGCGTTGTTG
CCTATGGCTGATAGCCAAGGTAAACCTCGCTTATCACTGGTGTGGGCGCTCGATGATGCACGGGCTAAACAGATGCAAAC
CGCGCCTAAAGCGGAATTTTTAGCGGCGCTGCAGCAGGCCTTTGGTTATCGAGCAGGCACGTTTATCGATGTCAGCGCGC
GCCATGCGTATCCGCTTAATTTGTCGTATATGCCAAGGCCAATCCATCACAGATGTGTCTTCATCGGCAATGCGGCGCAG
ACGCTGCATCCAATTGCGGGGCAAGGATTTAACCTAGGCCTGCGGGATGTAGTGAGCTTACTTGAGGTGCTCAAGACGGC
GCTAGATCAGGGTGATGATATCGGCTCCGCCGCCGTGACCCATGCTTATCTCAATGCCCGCGAGCACGACAGAAACAGCA
CTATCCGCAATATCGAATTTTTAGTCCGTGGCTTTTCAAACCAATACTGGCCGATGGCGCTGGGTCGTAACTTAGGCTTG
CGCTTATTATCTTGGTTTCCGCCACTTAAAACCCCCGTTGCTCAAAAGGCGATGGGCTGGAAATAA

Upstream 100 bases:

>100_bases
TAAGTTAACGTAGTAGTGGCTTCATTTGATATCAAAGGCGGACAAACCTGCCTTTGAATCCATAGCACTGGTGTTTTTGA
GTGCATAGCACTGATGTTTA

Downstream 100 bases:

>100_bases
CTCGCTTTTCATTACTGGTATCGCAACGCGAAAAGGATGTACCCATGTTAAGTTCACAAGCCTATGACATCGCCATTGTG
GGTGGCGGCATGGTGGGACT

Product: 2-polyprenyl-6-methoxyphenol 4-hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MALVKCQSLNEIPMTATNHMDTSVQHVDIAIVGGAMAGATLALALARLSLSAARPLSIALIEAHLPDKQHPGFDARSIAI
AHGSIFELSRLGLWPKLAHLGTAIENIHVSDRGHFGMTELNAAQFHLDALGQVVELERVGQVLFNELNKSEVKLYCPAKL
AQVEPAVEGHTLVLDTGKRLKAKLVVAADGLQSKVRSSFDLPVTQVAFEQTAIIANIQTDKPHQHLAYERFTQTGPLALL
PMADSQGKPRLSLVWALDDARAKQMQTAPKAEFLAALQQAFGYRAGTFIDVSARHAYPLNLSYMPRPIHHRCVFIGNAAQ
TLHPIAGQGFNLGLRDVVSLLEVLKTALDQGDDIGSAAVTHAYLNAREHDRNSTIRNIEFLVRGFSNQYWPMALGRNLGL
RLLSWFPPLKTPVAQKAMGWK

Sequences:

>Translated_421_residues
MALVKCQSLNEIPMTATNHMDTSVQHVDIAIVGGAMAGATLALALARLSLSAARPLSIALIEAHLPDKQHPGFDARSIAI
AHGSIFELSRLGLWPKLAHLGTAIENIHVSDRGHFGMTELNAAQFHLDALGQVVELERVGQVLFNELNKSEVKLYCPAKL
AQVEPAVEGHTLVLDTGKRLKAKLVVAADGLQSKVRSSFDLPVTQVAFEQTAIIANIQTDKPHQHLAYERFTQTGPLALL
PMADSQGKPRLSLVWALDDARAKQMQTAPKAEFLAALQQAFGYRAGTFIDVSARHAYPLNLSYMPRPIHHRCVFIGNAAQ
TLHPIAGQGFNLGLRDVVSLLEVLKTALDQGDDIGSAAVTHAYLNAREHDRNSTIRNIEFLVRGFSNQYWPMALGRNLGL
RLLSWFPPLKTPVAQKAMGWK
>Mature_420_residues
ALVKCQSLNEIPMTATNHMDTSVQHVDIAIVGGAMAGATLALALARLSLSAARPLSIALIEAHLPDKQHPGFDARSIAIA
HGSIFELSRLGLWPKLAHLGTAIENIHVSDRGHFGMTELNAAQFHLDALGQVVELERVGQVLFNELNKSEVKLYCPAKLA
QVEPAVEGHTLVLDTGKRLKAKLVVAADGLQSKVRSSFDLPVTQVAFEQTAIIANIQTDKPHQHLAYERFTQTGPLALLP
MADSQGKPRLSLVWALDDARAKQMQTAPKAEFLAALQQAFGYRAGTFIDVSARHAYPLNLSYMPRPIHHRCVFIGNAAQT
LHPIAGQGFNLGLRDVVSLLEVLKTALDQGDDIGSAAVTHAYLNAREHDRNSTIRNIEFLVRGFSNQYWPMALGRNLGLR
LLSWFPPLKTPVAQKAMGWK

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=407, Percent_Identity=26.7813267813268, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI32967307, Length=335, Percent_Identity=27.7611940298507, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI1789274, Length=396, Percent_Identity=46.2121212121212, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1789273, Length=401, Percent_Identity=33.6658354114713, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1786883, Length=382, Percent_Identity=31.151832460733, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25146631, Length=437, Percent_Identity=26.0869565217391, Blast_Score=139, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6321694, Length=451, Percent_Identity=22.6164079822616, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI19920760, Length=454, Percent_Identity=26.6519823788546, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 45968; Mature: 45836

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVKCQSLNEIPMTATNHMDTSVQHVDIAIVGGAMAGATLALALARLSLSAARPLSIAL
CCEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEE
IEAHLPDKQHPGFDARSIAIAHGSIFELSRLGLWPKLAHLGTAIENIHVSDRGHFGMTEL
EEECCCCCCCCCCCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHEEEECCCCCCCCCCC
NAAQFHLDALGQVVELERVGQVLFNELNKSEVKLYCPAKLAQVEPAVEGHTLVLDTGKRL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHCCCCCCCCEEEEECCCCE
KAKLVVAADGLQSKVRSSFDLPVTQVAFEQTAIIANIQTDKPHQHLAYERFTQTGPLALL
EEEEEEEECCHHHHHHCCCCCCHHHHHHHHEEEEEEECCCCCHHHHHHHHHCCCCCEEEE
PMADSQGKPRLSLVWALDDARAKQMQTAPKAEFLAALQQAFGYRAGTFIDVSARHAYPLN
EECCCCCCCCEEEEEEECCHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEECCCCEEECC
LSYMPRPIHHRCVFIGNAAQTLHPIAGQGFNLGLRDVVSLLEVLKTALDQGDDIGSAAVT
CCCCCCCCCCEEEEECCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
HAYLNAREHDRNSTIRNIEFLVRGFSNQYWPMALGRNLGLRLLSWFPPLKTPVAQKAMGW
HHHHCCHHCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHCCCCCCCHHHHHCCC
K
C
>Mature Secondary Structure 
ALVKCQSLNEIPMTATNHMDTSVQHVDIAIVGGAMAGATLALALARLSLSAARPLSIAL
CEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEE
IEAHLPDKQHPGFDARSIAIAHGSIFELSRLGLWPKLAHLGTAIENIHVSDRGHFGMTEL
EEECCCCCCCCCCCCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHEEEECCCCCCCCCCC
NAAQFHLDALGQVVELERVGQVLFNELNKSEVKLYCPAKLAQVEPAVEGHTLVLDTGKRL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHCCCCCCCCEEEEECCCCE
KAKLVVAADGLQSKVRSSFDLPVTQVAFEQTAIIANIQTDKPHQHLAYERFTQTGPLALL
EEEEEEEECCHHHHHHCCCCCCHHHHHHHHEEEEEEECCCCCHHHHHHHHHCCCCCEEEE
PMADSQGKPRLSLVWALDDARAKQMQTAPKAEFLAALQQAFGYRAGTFIDVSARHAYPLN
EECCCCCCCCEEEEEEECCHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEECCCCEEECC
LSYMPRPIHHRCVFIGNAAQTLHPIAGQGFNLGLRDVVSLLEVLKTALDQGDDIGSAAVT
CCCCCCCCCCEEEEECCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
HAYLNAREHDRNSTIRNIEFLVRGFSNQYWPMALGRNLGLRLLSWFPPLKTPVAQKAMGW
HHHHCCHHCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHCCCCCCCHHHHHCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]