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The map label for this gene is dctA [H]

Identifier: 126172847

GI number: 126172847

Start: 682120

End: 683298

Strand: Direct

Name: dctA [H]

Synonym: Sbal_0598

Alternate gene names: 126172847

Gene position: 682120-683298 (Clockwise)

Preceding gene: 126172846

Following gene: 126172850

Centisome position: 13.3

GC content: 49.11

Gene sequence:

>1179_bases
ATGATGAAATCACTTTCGACGCGGATCTTTATAGGTCTGTTTGCGGGTCTTATTTTCGGCACAATAGTGCAGTACTTCTT
AAACGATATCGGCTTCTTCTCGGACAATTTGGTCGAGCTTGCCGGCGGCGTTGGCACTATGTTCGTCAATATGATCATGA
TGCTAGTCGTGCCATTAGTGTTTGTGAGTATTGTTTGTGGTGTCTGTGAGCTGCAAGATCTCAAAAGTTTTGGCCGTTTA
GGCGGTAAGACCTTCGGTTTTTATATCATCAATACCTTTGTCGCGATCGCGACGGCATTATTAGTCGTGCTGTTACTCGA
CCCAGGTAAAGGTGTCGATATGAGCAGCACAGACGGCCTGGCCATTACTGCAACTGAGCTGCCAAGTTTGATGGCACTGG
TGATCGACATAGTCCCGCGTAACCCTGTAGCGGCGTTTATGTCGGGCAATATGCTGCAAGTGATCTTTATGGCTTTAATG
CTTGGCGGCGTGATTAAGTCACTCGGTGAGCATGTAGCTGGCGCAGTGCAAGGTTTTCAAACCGCGAATAAAATCATGAT
GAAGCTGATTTCTGTGGTGATGAGCCTAGCGCCCTACGGTGTGTTTGCCTTGATGTTCAAGCTCGGCGCGACCTTAGATG
CTGGCGTGTTTATGAGCGTAGTTGAGTACATGGTGCTGATCCTCGCGCTGCTACTGCTGTGGATTTTTGTGGTTTACCCA
ATGGCGGTGGGCATATTTACCCCAATTTCGGCCAAAACCTTCCGCGAGAAGACCCAAGAGCAAGTGCTGTTTTCACTGTC
GACCGCAAGCTCGAATGCGACTATCCCTGTGACTATGCGTACCTTAACCGAAAAGTTAGGCGTGAATCGCGCGGTAGCTG
GCTTTGGGGTGCCGCTCGGCGCGACCATGAACATGGGCGGCGTGGCGATTTACATCACTATCGCGATTTTCTTTGTCGCT
AACGCCTTTGGCATGCCTATCACCTCTGATCAATTGCCTTCTATAGCGCGTCAATTAGCTTGGCCGATCCAGCGACAATT
AACTTGGCCGGTTGAGACTCGGTTTAATTTAGTTTGTTTTGGGCTTCTTTTCGCCTGTAGCTTTCTCCTTTGCATTGCAA
AATTTTCGCGTGGTGGATCAGCCTATCGATTGCAGCTACGGTCATCACTGTGTCACTGA

Upstream 100 bases:

>100_bases
TGTTTCACTATCCCCTGCCTAAGCCAAAAATGGATTGGCAATTGTGCTCATCATGGAAGATGAATAACAAAAAAACTACA
TTTCTGGGGAAACCACAAGC

Downstream 100 bases:

>100_bases
ATAACTTATCCCAATCTTCGAATGATTGGTTTGAGGTTATTATTAGGCTATATCTTTCATAACGATGCGCGATAAGCTCG
AACAAGACGCTAGTTTCTTC

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MMKSLSTRIFIGLFAGLIFGTIVQYFLNDIGFFSDNLVELAGGVGTMFVNMIMMLVVPLVFVSIVCGVCELQDLKSFGRL
GGKTFGFYIINTFVAIATALLVVLLLDPGKGVDMSSTDGLAITATELPSLMALVIDIVPRNPVAAFMSGNMLQVIFMALM
LGGVIKSLGEHVAGAVQGFQTANKIMMKLISVVMSLAPYGVFALMFKLGATLDAGVFMSVVEYMVLILALLLLWIFVVYP
MAVGIFTPISAKTFREKTQEQVLFSLSTASSNATIPVTMRTLTEKLGVNRAVAGFGVPLGATMNMGGVAIYITIAIFFVA
NAFGMPITSDQLPSIARQLAWPIQRQLTWPVETRFNLVCFGLLFACSFLLCIAKFSRGGSAYRLQLRSSLCH

Sequences:

>Translated_392_residues
MMKSLSTRIFIGLFAGLIFGTIVQYFLNDIGFFSDNLVELAGGVGTMFVNMIMMLVVPLVFVSIVCGVCELQDLKSFGRL
GGKTFGFYIINTFVAIATALLVVLLLDPGKGVDMSSTDGLAITATELPSLMALVIDIVPRNPVAAFMSGNMLQVIFMALM
LGGVIKSLGEHVAGAVQGFQTANKIMMKLISVVMSLAPYGVFALMFKLGATLDAGVFMSVVEYMVLILALLLLWIFVVYP
MAVGIFTPISAKTFREKTQEQVLFSLSTASSNATIPVTMRTLTEKLGVNRAVAGFGVPLGATMNMGGVAIYITIAIFFVA
NAFGMPITSDQLPSIARQLAWPIQRQLTWPVETRFNLVCFGLLFACSFLLCIAKFSRGGSAYRLQLRSSLCH
>Mature_392_residues
MMKSLSTRIFIGLFAGLIFGTIVQYFLNDIGFFSDNLVELAGGVGTMFVNMIMMLVVPLVFVSIVCGVCELQDLKSFGRL
GGKTFGFYIINTFVAIATALLVVLLLDPGKGVDMSSTDGLAITATELPSLMALVIDIVPRNPVAAFMSGNMLQVIFMALM
LGGVIKSLGEHVAGAVQGFQTANKIMMKLISVVMSLAPYGVFALMFKLGATLDAGVFMSVVEYMVLILALLLLWIFVVYP
MAVGIFTPISAKTFREKTQEQVLFSLSTASSNATIPVTMRTLTEKLGVNRAVAGFGVPLGATMNMGGVAIYITIAIFFVA
NAFGMPITSDQLPSIARQLAWPIQRQLTWPVETRFNLVCFGLLFACSFLLCIAKFSRGGSAYRLQLRSSLCH

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI262359914, Length=350, Percent_Identity=25.1428571428571, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI169790839, Length=347, Percent_Identity=25.0720461095101, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI21314632, Length=335, Percent_Identity=25.9701492537313, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI40254478, Length=383, Percent_Identity=25.5874673629243, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI194239697, Length=344, Percent_Identity=24.4186046511628, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI66773030, Length=173, Percent_Identity=30.635838150289, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI5032093, Length=299, Percent_Identity=26.7558528428094, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI4827012, Length=160, Percent_Identity=29.375, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI223468566, Length=183, Percent_Identity=28.4153005464481, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI223468564, Length=174, Percent_Identity=28.1609195402299, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790514, Length=341, Percent_Identity=27.8592375366569, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1789947, Length=329, Percent_Identity=26.4437689969605, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788024, Length=319, Percent_Identity=29.153605015674, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789473, Length=338, Percent_Identity=28.4023668639053, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71983106, Length=342, Percent_Identity=27.4853801169591, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71983099, Length=342, Percent_Identity=27.4853801169591, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17537407, Length=358, Percent_Identity=26.2569832402235, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI193206654, Length=331, Percent_Identity=27.4924471299094, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI193206505, Length=333, Percent_Identity=24.6246246246246, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71996953, Length=330, Percent_Identity=25.7575757575758, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17541374, Length=337, Percent_Identity=24.0356083086053, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281360481, Length=370, Percent_Identity=24.0540540540541, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI281360483, Length=370, Percent_Identity=24.0540540540541, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17137666, Length=370, Percent_Identity=24.0540540540541, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24583025, Length=349, Percent_Identity=25.5014326647564, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17137668, Length=349, Percent_Identity=25.5014326647564, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583023, Length=349, Percent_Identity=25.5014326647564, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 42289; Mature: 42289

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA