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The map label for this gene is zwf [H]

Identifier: 125625255

GI number: 125625255

Start: 2454098

End: 2455609

Strand: Direct

Name: zwf [H]

Synonym: llmg_2499

Alternate gene names: 125625255

Gene position: 2454098-2455609 (Clockwise)

Preceding gene: 125625254

Following gene: 125625264

Centisome position: 97.02

GC content: 39.35

Gene sequence:

>1512_bases
ATGACCGAACAAAAACAAGCACTTTTCACCATTTTTGGAGCAACTGGTGACCTCGCTAAGAGAAAGCTCTACCCTTCACT
CTTTCGTCTTTTCAAAAAAGGCGAATTGGCTGAAAATTTTGCCGTAATTGGAACAGCCCGTCGTCCTTGGACAAATGATT
ATTATCGTGAAGTTGTTTTAGAATCAATCAAAGGTTTGATGAATTCAAAAACAGAAGCCGAAAACTTCGCAAGCCATTTT
TACTATCAAAGTCATGACGTTAGTGATAGTTCACATTATGTTAATTTGAAAGACTTGGGCGAAAGTCTACGTAAACAATA
TAAAACAGCTGGAAATCAAGTTTTCTTTCTCGCCATGGCTCCCCAATTCTTTGGCACTATTGCCGAACACCTCAAATCAG
AAAATATTTTGACAGGTGAAGGTTTTGAACGAATCGTTATCGAAAAACCATTCGGTACAAGTTACAATACTGCAAAATCA
CTCAATGACAGCCTCTCTAAAGTTTTTACTGAAGAACAAATCTTCCGAATTGACCACTATCTCGGTAAAGAAATGATTCA
AGCTGTTTCAGCTGTACGATTTGCCAACCCTATTTTTGAGTCTATTTGGAATAATCAGCACATTGACAATGTCCAAATAA
CTTTTGCTGAATTTATCGGCGTTGAAGACCGCGGAGGTTATTACGAAACTTCTGGTGCTTTGAAAGATATGATTCAAAAT
CACGTTTTACAGGTCCTCAGTCTGATTGCTATGGAAAAACCTCAAAAATTTGACGAAGCCCATATTGTCAAAGAAAAAGT
TAAGGCACTCAATGCCATGCGTCAATATTCTCCAGAGGAAGCTTTAAATAACTTTGTACGTGGTCAATATGTAGCTGGTC
GCTTTGATGGCGAAGATTACTCAGGCTATCGTGAAGAAGATTCCGTTGCTCCAGATAGCCGAACTGAAACTTTCGCCGCA
GGGAAGTTTGTTATTGATAACGAACGTTGGTCAGGTGTTCCTTTCTATGTTCGCTCAGGAAAACGAATGACTGAAAAAGG
AACTCGCATTAATATTGTATTCAAAAAAGACCCTGATAATCTTTTTGCTGACAATTGCGATGACCAGTCTGTACAAAATA
TTTTAACTATTTATATTCAACCAACAGAAGGTTTTTCACTTTCTGTTAACGGAAAAGCAGCCGGTCAAGGTTTCCACTTA
GAACCTTTGCGCTTGAATTTCCGTCACGACAGTGAATTCCTTGGAAATTCTCCTGAAGCGTATGAAAAACTCTTTTTAGA
TGTTCTTAATGGAGATGGTACGAACTTCTCTCACTGGGAAGAAGCCGCTCGTGCCTGGGAACTTATTGATGTTATTCGCG
AAGCTTGGGATAAAGAAACCTCTGAACTCCCAACTTATGCCGCTCGTACTATGGGACCTAAAGCTGCCTTTGATTTACTC
GAAAAAGAAGGGCATGAATGGGCTTGGCAGCCTGATGTCTGGTATCAAGAATGTGGTTACTACGATAAATAA

Upstream 100 bases:

>100_bases
TAATAAGTCTGTTAGTGAATTAGGATTTCTAATTTTAATGATATCTAGCTTTTTATTTCTGTCAGTAAATAAATTATTGT
TTTTTAAAAAAGGAAAAAAT

Downstream 100 bases:

>100_bases
TAAATAAAAAAACCTATCAGTAAGCAAGATAGGTTTTTTTACGTTTTCCACAAACTTTTACACAGTTTTCCACATATTTG
TGGAAAGACTTCACAATTCT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MTEQKQALFTIFGATGDLAKRKLYPSLFRLFKKGELAENFAVIGTARRPWTNDYYREVVLESIKGLMNSKTEAENFASHF
YYQSHDVSDSSHYVNLKDLGESLRKQYKTAGNQVFFLAMAPQFFGTIAEHLKSENILTGEGFERIVIEKPFGTSYNTAKS
LNDSLSKVFTEEQIFRIDHYLGKEMIQAVSAVRFANPIFESIWNNQHIDNVQITFAEFIGVEDRGGYYETSGALKDMIQN
HVLQVLSLIAMEKPQKFDEAHIVKEKVKALNAMRQYSPEEALNNFVRGQYVAGRFDGEDYSGYREEDSVAPDSRTETFAA
GKFVIDNERWSGVPFYVRSGKRMTEKGTRINIVFKKDPDNLFADNCDDQSVQNILTIYIQPTEGFSLSVNGKAAGQGFHL
EPLRLNFRHDSEFLGNSPEAYEKLFLDVLNGDGTNFSHWEEAARAWELIDVIREAWDKETSELPTYAARTMGPKAAFDLL
EKEGHEWAWQPDVWYQECGYYDK

Sequences:

>Translated_503_residues
MTEQKQALFTIFGATGDLAKRKLYPSLFRLFKKGELAENFAVIGTARRPWTNDYYREVVLESIKGLMNSKTEAENFASHF
YYQSHDVSDSSHYVNLKDLGESLRKQYKTAGNQVFFLAMAPQFFGTIAEHLKSENILTGEGFERIVIEKPFGTSYNTAKS
LNDSLSKVFTEEQIFRIDHYLGKEMIQAVSAVRFANPIFESIWNNQHIDNVQITFAEFIGVEDRGGYYETSGALKDMIQN
HVLQVLSLIAMEKPQKFDEAHIVKEKVKALNAMRQYSPEEALNNFVRGQYVAGRFDGEDYSGYREEDSVAPDSRTETFAA
GKFVIDNERWSGVPFYVRSGKRMTEKGTRINIVFKKDPDNLFADNCDDQSVQNILTIYIQPTEGFSLSVNGKAAGQGFHL
EPLRLNFRHDSEFLGNSPEAYEKLFLDVLNGDGTNFSHWEEAARAWELIDVIREAWDKETSELPTYAARTMGPKAAFDLL
EKEGHEWAWQPDVWYQECGYYDK
>Mature_502_residues
TEQKQALFTIFGATGDLAKRKLYPSLFRLFKKGELAENFAVIGTARRPWTNDYYREVVLESIKGLMNSKTEAENFASHFY
YQSHDVSDSSHYVNLKDLGESLRKQYKTAGNQVFFLAMAPQFFGTIAEHLKSENILTGEGFERIVIEKPFGTSYNTAKSL
NDSLSKVFTEEQIFRIDHYLGKEMIQAVSAVRFANPIFESIWNNQHIDNVQITFAEFIGVEDRGGYYETSGALKDMIQNH
VLQVLSLIAMEKPQKFDEAHIVKEKVKALNAMRQYSPEEALNNFVRGQYVAGRFDGEDYSGYREEDSVAPDSRTETFAAG
KFVIDNERWSGVPFYVRSGKRMTEKGTRINIVFKKDPDNLFADNCDDQSVQNILTIYIQPTEGFSLSVNGKAAGQGFHLE
PLRLNFRHDSEFLGNSPEAYEKLFLDVLNGDGTNFSHWEEAARAWELIDVIREAWDKETSELPTYAARTMGPKAAFDLLE
KEGHEWAWQPDVWYQECGYYDK

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=483, Percent_Identity=34.9896480331263, Blast_Score=291, Evalue=1e-78,
Organism=Homo sapiens, GI108773793, Length=483, Percent_Identity=34.9896480331263, Blast_Score=291, Evalue=1e-78,
Organism=Homo sapiens, GI52145310, Length=368, Percent_Identity=30.7065217391304, Blast_Score=166, Evalue=6e-41,
Organism=Escherichia coli, GI1788158, Length=494, Percent_Identity=37.4493927125506, Blast_Score=331, Evalue=8e-92,
Organism=Caenorhabditis elegans, GI17538218, Length=481, Percent_Identity=35.7588357588358, Blast_Score=305, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6324088, Length=500, Percent_Identity=33.6, Blast_Score=273, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24643352, Length=471, Percent_Identity=35.6687898089172, Blast_Score=291, Evalue=6e-79,
Organism=Drosophila melanogaster, GI24643350, Length=471, Percent_Identity=35.6687898089172, Blast_Score=291, Evalue=6e-79,
Organism=Drosophila melanogaster, GI221513548, Length=499, Percent_Identity=27.0541082164329, Blast_Score=195, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57587; Mature: 57456

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQKQALFTIFGATGDLAKRKLYPSLFRLFKKGELAENFAVIGTARRPWTNDYYREVVL
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHCCEEEEECCCCCCCHHHHHHHHH
ESIKGLMNSKTEAENFASHFYYQSHDVSDSSHYVNLKDLGESLRKQYKTAGNQVFFLAMA
HHHHHHHCCCHHHHHHHHHHEECCCCCCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEEEC
PQFFGTIAEHLKSENILTGEGFERIVIEKPFGTSYNTAKSLNDSLSKVFTEEQIFRIDHY
HHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGKEMIQAVSAVRFANPIFESIWNNQHIDNVQITFAEFIGVEDRGGYYETSGALKDMIQN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHCCCCCCCEEECHHHHHHHHHH
HVLQVLSLIAMEKPQKFDEAHIVKEKVKALNAMRQYSPEEALNNFVRGQYVAGRFDGEDY
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCC
SGYREEDSVAPDSRTETFAAGKFVIDNERWSGVPFYVRSGKRMTEKGTRINIVFKKDPDN
CCCCCCCCCCCCCCCCCEECCEEEEECCCCCCCCEEEECCCEECCCCCEEEEEEEECCCC
LFADNCDDQSVQNILTIYIQPTEGFSLSVNGKAAGQGFHLEPLRLNFRHDSEFLGNSPEA
CCCCCCCHHHHCCEEEEEEECCCCCEEEECCCCCCCCCCCCCEEEECCCCHHHHCCCHHH
YEKLFLDVLNGDGTNFSHWEEAARAWELIDVIREAWDKETSELPTYAARTMGPKAAFDLL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHCCHHHHHHHH
EKEGHEWAWQPDVWYQECGYYDK
HHCCCCCCCCCCCHHHHCCCCCC
>Mature Secondary Structure 
TEQKQALFTIFGATGDLAKRKLYPSLFRLFKKGELAENFAVIGTARRPWTNDYYREVVL
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHCCEEEEECCCCCCCHHHHHHHHH
ESIKGLMNSKTEAENFASHFYYQSHDVSDSSHYVNLKDLGESLRKQYKTAGNQVFFLAMA
HHHHHHHCCCHHHHHHHHHHEECCCCCCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEEEC
PQFFGTIAEHLKSENILTGEGFERIVIEKPFGTSYNTAKSLNDSLSKVFTEEQIFRIDHY
HHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGKEMIQAVSAVRFANPIFESIWNNQHIDNVQITFAEFIGVEDRGGYYETSGALKDMIQN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHCCCCCCCEEECHHHHHHHHHH
HVLQVLSLIAMEKPQKFDEAHIVKEKVKALNAMRQYSPEEALNNFVRGQYVAGRFDGEDY
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCC
SGYREEDSVAPDSRTETFAAGKFVIDNERWSGVPFYVRSGKRMTEKGTRINIVFKKDPDN
CCCCCCCCCCCCCCCCCEECCEEEEECCCCCCCCEEEECCCEECCCCCEEEEEEEECCCC
LFADNCDDQSVQNILTIYIQPTEGFSLSVNGKAAGQGFHLEPLRLNFRHDSEFLGNSPEA
CCCCCCCHHHHCCEEEEEEECCCCCEEEECCCCCCCCCCCCCEEEECCCCHHHHCCCHHH
YEKLFLDVLNGDGTNFSHWEEAARAWELIDVIREAWDKETSELPTYAARTMGPKAAFDLL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHCCHHHHHHHH
EKEGHEWAWQPDVWYQECGYYDK
HHCCCCCCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916; 9466257; 9533725 [H]