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The map label for this gene is dnaX [H]

Identifier: 125625234

GI number: 125625234

Start: 2435218

End: 2436879

Strand: Reverse

Name: dnaX [H]

Synonym: llmg_2478

Alternate gene names: 125625234

Gene position: 2436879-2435218 (Counterclockwise)

Preceding gene: 125625235

Following gene: 125625232

Centisome position: 96.34

GC content: 39.35

Gene sequence:

>1662_bases
ATGGCATATCAAGCATTATATAGAAAATATCGAAGTCAGAGATTTGATGAAATGGTGGGACAAGAAGTTGTAGCGACGAC
GCTTAAAAATGCGATTGTCAATCATCAAATTTCACATGCTTATCTTTTTTCTGGTCCAAGAGGAACAGGGAAAACCTCTG
CAGCTAAAATTTTTGCCAAGGCAATTAACTGCCCTAATCAAGTGGATGGAGAACCTTGTAATAATTGTTTTATTTGTGAT
TCAATCACAAAAGGAAGCTTAGATGATGTTATTGAACTTGATGCTGCTTCAAATAATGGGGTGGATGAAATTCGTGAAAT
TCGCGACAAGTCAACTTATGCGGCAAGTCAAGCAACTTATAAAGTTTATATCATTGATGAAGTGCATATGCTTTCGACAG
GCGCCTTTAATGCACTTTTGAAAACCCTCGAAGAACCTACAGAAAACGTGGTCTTCGTTTTGGCTACGACTGAATTGCAA
AAAATTCCAGCAACCATCATCTCAAGAGTTCAACGCTTTGCTTTTAAATCAATCACGACGGCTGATATTCGGACTTATTT
AGGAAAAATTCTTGGGGACGAAGGGGTTGAATTTGAAGATAAAGCCCTTGATGTGATTGCTAAAGCAGCTGAGGGCGGGA
TGCGAGATGCTTTGTCCTTACTAGACCAAGCCTTATCTTTTTCAGCAGGAAAATTGGAAGAAGAAGACGCCTTGCTTGTC
ACAGGCTCAATTGCGGCGGACGCTTTAGTGAGTTATGTCTTGGCACTTTTTGAAAATGACGAATCAAAAGCGCTGACAGA
ACTGGATAAGATTTTTGCTGAGGGTAAAAATATGCTTCGTTTTACAGAAGACTTACTTGCCTATCTTCGCGATTTGCTTT
TGGACAAGAACGCTCAATACGAACGCAATCAAATTTTTTCTTGGATAGATATTGCGATTGAGAGCTTGAAAACGATAAAG
GAAACAACACAAACGAAGATTGCGGCAGATGTCATGACTATGCGTTTGGCCGAAGTGGGTCAAACACATTTGCTGACAGC
TTCGCAAACAGAAGTTCCTAATGAAATAGGTGCTGAAATTGCTGCCCTAAAAGCAGAAATCAATCAGTTGAAAGCTCAGA
TTTCAACAGGTCAAGTTCAAGGAAGTTCAGATTCACAAAATAATCCTTTAACACGAGAAGTTAGAGAACGTCCAAAAGCG
GTAGCGCCTAAAAAACGACAGATTAATAAAGATTTAATTTATAAAGCTCTGGCCGAAGCAACAAATGAGGCTAGAAAGGC
TGCATTAAGCGCTTGGCCTGAACTTGTTGCCTCGGTAACTAAACCGGCAGACCGAGCTTTACTTAATAATACCTCTCCAG
TCGCTGCCTCAGAGAACTTTGTTGTTGTGACCTTTCCTCATGAAAATCTTGCAAAAAGAGTCAGTGAAAACGAAGAGCTG
CAAAACTTTTGTGGTAATCTCTTAAGTTCGATTATTGGTTTTGCTCCAGAAATAATTTCGCTTGCTGAACAAGATTGGCA
AGAAGTTCGAGCAGAATATGTGTCTAATCTAAAATCAGAGAGCCCCCAAGAAGATGAAGAGCAAGAAGACGAAAAAATAG
ATGAAACAGTTACATTAGCTAAAGAGCTTTTTGGTGAGAAAGTTGTTGAAATTAATGATTAA

Upstream 100 bases:

>100_bases
CTCGACAGAAATTTTGAAAGATTTAAATTATAGCCTCGGACAAGATTTGTACTAAACGGCGATTTAAAAAGAATAGTAAG
TAAAAAATTGGAAGAGAAAA

Downstream 100 bases:

>100_bases
TAAATAAAAAAGCCGCTCATTGAGCGACTTTTTTTAATCTTTATGACGACTTAAATCTACATCTTTTAGCGGAATAAGTT
TTGTCTTGTTTTTAAATTTA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MAYQALYRKYRSQRFDEMVGQEVVATTLKNAIVNHQISHAYLFSGPRGTGKTSAAKIFAKAINCPNQVDGEPCNNCFICD
SITKGSLDDVIELDAASNNGVDEIREIRDKSTYAASQATYKVYIIDEVHMLSTGAFNALLKTLEEPTENVVFVLATTELQ
KIPATIISRVQRFAFKSITTADIRTYLGKILGDEGVEFEDKALDVIAKAAEGGMRDALSLLDQALSFSAGKLEEEDALLV
TGSIAADALVSYVLALFENDESKALTELDKIFAEGKNMLRFTEDLLAYLRDLLLDKNAQYERNQIFSWIDIAIESLKTIK
ETTQTKIAADVMTMRLAEVGQTHLLTASQTEVPNEIGAEIAALKAEINQLKAQISTGQVQGSSDSQNNPLTREVRERPKA
VAPKKRQINKDLIYKALAEATNEARKAALSAWPELVASVTKPADRALLNNTSPVAASENFVVVTFPHENLAKRVSENEEL
QNFCGNLLSSIIGFAPEIISLAEQDWQEVRAEYVSNLKSESPQEDEEQEDEKIDETVTLAKELFGEKVVEIND

Sequences:

>Translated_553_residues
MAYQALYRKYRSQRFDEMVGQEVVATTLKNAIVNHQISHAYLFSGPRGTGKTSAAKIFAKAINCPNQVDGEPCNNCFICD
SITKGSLDDVIELDAASNNGVDEIREIRDKSTYAASQATYKVYIIDEVHMLSTGAFNALLKTLEEPTENVVFVLATTELQ
KIPATIISRVQRFAFKSITTADIRTYLGKILGDEGVEFEDKALDVIAKAAEGGMRDALSLLDQALSFSAGKLEEEDALLV
TGSIAADALVSYVLALFENDESKALTELDKIFAEGKNMLRFTEDLLAYLRDLLLDKNAQYERNQIFSWIDIAIESLKTIK
ETTQTKIAADVMTMRLAEVGQTHLLTASQTEVPNEIGAEIAALKAEINQLKAQISTGQVQGSSDSQNNPLTREVRERPKA
VAPKKRQINKDLIYKALAEATNEARKAALSAWPELVASVTKPADRALLNNTSPVAASENFVVVTFPHENLAKRVSENEEL
QNFCGNLLSSIIGFAPEIISLAEQDWQEVRAEYVSNLKSESPQEDEEQEDEKIDETVTLAKELFGEKVVEIND
>Mature_552_residues
AYQALYRKYRSQRFDEMVGQEVVATTLKNAIVNHQISHAYLFSGPRGTGKTSAAKIFAKAINCPNQVDGEPCNNCFICDS
ITKGSLDDVIELDAASNNGVDEIREIRDKSTYAASQATYKVYIIDEVHMLSTGAFNALLKTLEEPTENVVFVLATTELQK
IPATIISRVQRFAFKSITTADIRTYLGKILGDEGVEFEDKALDVIAKAAEGGMRDALSLLDQALSFSAGKLEEEDALLVT
GSIAADALVSYVLALFENDESKALTELDKIFAEGKNMLRFTEDLLAYLRDLLLDKNAQYERNQIFSWIDIAIESLKTIKE
TTQTKIAADVMTMRLAEVGQTHLLTASQTEVPNEIGAEIAALKAEINQLKAQISTGQVQGSSDSQNNPLTREVRERPKAV
APKKRQINKDLIYKALAEATNEARKAALSAWPELVASVTKPADRALLNNTSPVAASENFVVVTFPHENLAKRVSENEELQ
NFCGNLLSSIIGFAPEIISLAEQDWQEVRAEYVSNLKSESPQEDEEQEDEKIDETVTLAKELFGEKVVEIND

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=236, Percent_Identity=29.2372881355932, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI194306571, Length=236, Percent_Identity=29.2372881355932, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI194306567, Length=236, Percent_Identity=29.2372881355932, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI4506491, Length=309, Percent_Identity=23.9482200647249, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI31881687, Length=309, Percent_Identity=23.9482200647249, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI31563534, Length=221, Percent_Identity=27.6018099547511, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI194306569, Length=155, Percent_Identity=31.6129032258064, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786676, Length=275, Percent_Identity=45.0909090909091, Blast_Score=251, Evalue=1e-67,
Organism=Escherichia coli, GI1787119, Length=232, Percent_Identity=24.5689655172414, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71986063, Length=298, Percent_Identity=25.503355704698, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17554730, Length=220, Percent_Identity=28.1818181818182, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17541988, Length=287, Percent_Identity=25.7839721254355, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324039, Length=290, Percent_Identity=26.551724137931, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322528, Length=236, Percent_Identity=25.8474576271186, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324478, Length=367, Percent_Identity=23.7057220708447, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921076, Length=236, Percent_Identity=27.9661016949153, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI18859927, Length=222, Percent_Identity=28.8288288288288, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17647857, Length=282, Percent_Identity=24.822695035461, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 61003; Mature: 60872

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYQALYRKYRSQRFDEMVGQEVVATTLKNAIVNHQISHAYLFSGPRGTGKTSAAKIFAK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHH
AINCPNQVDGEPCNNCFICDSITKGSLDDVIELDAASNNGVDEIREIRDKSTYAASQATY
HHCCCCCCCCCCCCCEEEECCCCCCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCEE
KVYIIDEVHMLSTGAFNALLKTLEEPTENVVFVLATTELQKIPATIISRVQRFAFKSITT
EEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
ADIRTYLGKILGDEGVEFEDKALDVIAKAAEGGMRDALSLLDQALSFSAGKLEEEDALLV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEE
TGSIAADALVSYVLALFENDESKALTELDKIFAEGKNMLRFTEDLLAYLRDLLLDKNAQY
ECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCH
ERNQIFSWIDIAIESLKTIKETTQTKIAADVMTMRLAEVGQTHLLTASQTEVPNEIGAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCHHHHHHH
AALKAEINQLKAQISTGQVQGSSDSQNNPLTREVRERPKAVAPKKRQINKDLIYKALAEA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHCCHHHHHHHHHHH
TNEARKAALSAWPELVASVTKPADRALLNNTSPVAASENFVVVTFPHENLAKRVSENEEL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHCCHHHH
QNFCGNLLSSIIGFAPEIISLAEQDWQEVRAEYVSNLKSESPQEDEEQEDEKIDETVTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
KELFGEKVVEIND
HHHHCCCCEECCC
>Mature Secondary Structure 
AYQALYRKYRSQRFDEMVGQEVVATTLKNAIVNHQISHAYLFSGPRGTGKTSAAKIFAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHH
AINCPNQVDGEPCNNCFICDSITKGSLDDVIELDAASNNGVDEIREIRDKSTYAASQATY
HHCCCCCCCCCCCCCEEEECCCCCCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCEE
KVYIIDEVHMLSTGAFNALLKTLEEPTENVVFVLATTELQKIPATIISRVQRFAFKSITT
EEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
ADIRTYLGKILGDEGVEFEDKALDVIAKAAEGGMRDALSLLDQALSFSAGKLEEEDALLV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEE
TGSIAADALVSYVLALFENDESKALTELDKIFAEGKNMLRFTEDLLAYLRDLLLDKNAQY
ECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCH
ERNQIFSWIDIAIESLKTIKETTQTKIAADVMTMRLAEVGQTHLLTASQTEVPNEIGAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCHHHHHHH
AALKAEINQLKAQISTGQVQGSSDSQNNPLTREVRERPKAVAPKKRQINKDLIYKALAEA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHCCHHHHHHHHHHH
TNEARKAALSAWPELVASVTKPADRALLNNTSPVAASENFVVVTFPHENLAKRVSENEEL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHCCHHHH
QNFCGNLLSSIIGFAPEIISLAEQDWQEVRAEYVSNLKSESPQEDEEQEDEKIDETVTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
KELFGEKVVEIND
HHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]