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The map label for this gene is lysP [H]

Identifier: 125625233

GI number: 125625233

Start: 2433658

End: 2435184

Strand: Direct

Name: lysP [H]

Synonym: llmg_2477

Alternate gene names: 125625233

Gene position: 2433658-2435184 (Clockwise)

Preceding gene: 125625227

Following gene: 125625237

Centisome position: 96.21

GC content: 40.01

Gene sequence:

>1527_bases
GTGAGGGTAAGTCTGAGTCTAACAAGTCGGTGTAGAATAAATTTTATTAGGGAGAGAATTTTGGAAAATTCTTCAAACTC
AACTACTGAGACGCAAGTAAAACGCGCCTTAAAATCACGTCATGTATCCATGATTGCCCTTGGCGGAACAATCGGAACTG
GTTTATTTCTGACTTCAGGGGATGTCATTCACACGGCAGGACCATTTGGGGCACTGACTGCCTATGTTCTTATCGGAGCA
ATGGTTTACTTCCTCATGACTTCACTTGGCGAAATGGCCACTTATCTACCAACGTCTGGTTCTTTTTCAGACTATGGAAC
ACGTTATGTTGATCCAGCTTTTGGTTTTGCTCTAGGTTGGAATTATTGGTTAAACTGGGCAATTACAGTAGCAGTTGATT
TAACCGCCGTTGCTCTTTGTATCAAATTCTGGTTACCTGATGTTCCAAGTTGGATTTTTTCACTGATTGCTTTGATTATC
GTCTTTTCAATCAATGCCTTATCAGTGAAAACTTTTGGTGAAACAGAGTATTGGCTGTCAGCCATTAAAATTACCGTCGT
TGTTTTATTCTTGATTATTGGCTTCTTATCTATTTTTGGAATTATGGGCGGACATATTGATGTCGCTAAAAACCTTTCAG
TTGGTAATCATGGCTTTGTCGGAGGACTTGGTAGCTTCACGACTGGTGGAGGAATCCTTGGTGTTCTCTTAGTTGCTGGT
TTCTCTTTCCAAGGAACAGAGCTACTCGGAATTACTGCTGGTGAAGCCGAAAATCCAGAAAAATCAATTCCCAAAGCCAT
GAACTCTATTTTCTGGCGTATCCTTGTCTTTTATATTTTATCTATATTTGTAATGGCAGCAATCATTCCATTCACGGACC
CACATTTGGTTGGTGGTAATTCAGCAGCTCAAAGTCCGTTCACAATTGTATTTGAACGTGTTGGATTTTCTATCGCAGCC
TCTATCATGAATGCCGTTGTTTTAACATCTGTTGTCTCTGCAGCCAATTCTGGAATGTACGCCTCTACTCGAATGCTTTA
TTCTTTGGCTAAAGATGGTGGTGCACCAAAAATCTTCTCAAAAACTTCTAAAAACGGGATTCCTTTCATCGCCTTGTTGG
CAACAACCGCTGTTGCATTGCTCACATTCTTAACTTCAATTTATGGGGTCAGCTTCTTTACTCTCCTAGTCTCTGCTTCT
GGTTTAACTGGTTTCATTGCTTGGATTGGAATTGCGATTAGCCATTTCCGCTTCCGTCGGGCTTATGTTGCTCAAGGAAA
AGACGTGAAAAAACTTCCTTATCATGCTAAACTCTTCCCATTTGGTCCGATTTTAGCTCTCATTATGACCGTTTTAGTAA
CGTTAGGTCAAGACCCAATGTTATTGTTTGGAAAAACTTGGGTGCAAGGGGTGGTCATGTATGCCGCAATCCCACTCTTC
TTTATTCTTTACTTAGGTTATAAATTTAAAAACAAGACAAAACTTATTCCGCTAAAAGATGTAGATTTAAGTCGTCATAA
AGATTAA

Upstream 100 bases:

>100_bases
TCAAGAAAATTTTTAAAATTTTGTCGGACCTTTAGCAATCTATTCTATCTAGTAGGATTGCTTTTTTTGTTTTTCTCAGA
CTTTTCTAAACTAAACAGGA

Downstream 100 bases:

>100_bases
AAAAAGTCGCTCAATGAGCGGCTTTTTTATTTATTAATCATTAATTTCAACAACTTTCTCACCAAAAAGCTCTTTAGCTA
ATGTAACTGTTTCATCTATT

Product: lysine specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MRVSLSLTSRCRINFIRERILENSSNSTTETQVKRALKSRHVSMIALGGTIGTGLFLTSGDVIHTAGPFGALTAYVLIGA
MVYFLMTSLGEMATYLPTSGSFSDYGTRYVDPAFGFALGWNYWLNWAITVAVDLTAVALCIKFWLPDVPSWIFSLIALII
VFSINALSVKTFGETEYWLSAIKITVVVLFLIIGFLSIFGIMGGHIDVAKNLSVGNHGFVGGLGSFTTGGGILGVLLVAG
FSFQGTELLGITAGEAENPEKSIPKAMNSIFWRILVFYILSIFVMAAIIPFTDPHLVGGNSAAQSPFTIVFERVGFSIAA
SIMNAVVLTSVVSAANSGMYASTRMLYSLAKDGGAPKIFSKTSKNGIPFIALLATTAVALLTFLTSIYGVSFFTLLVSAS
GLTGFIAWIGIAISHFRFRRAYVAQGKDVKKLPYHAKLFPFGPILALIMTVLVTLGQDPMLLFGKTWVQGVVMYAAIPLF
FILYLGYKFKNKTKLIPLKDVDLSRHKD

Sequences:

>Translated_508_residues
MRVSLSLTSRCRINFIRERILENSSNSTTETQVKRALKSRHVSMIALGGTIGTGLFLTSGDVIHTAGPFGALTAYVLIGA
MVYFLMTSLGEMATYLPTSGSFSDYGTRYVDPAFGFALGWNYWLNWAITVAVDLTAVALCIKFWLPDVPSWIFSLIALII
VFSINALSVKTFGETEYWLSAIKITVVVLFLIIGFLSIFGIMGGHIDVAKNLSVGNHGFVGGLGSFTTGGGILGVLLVAG
FSFQGTELLGITAGEAENPEKSIPKAMNSIFWRILVFYILSIFVMAAIIPFTDPHLVGGNSAAQSPFTIVFERVGFSIAA
SIMNAVVLTSVVSAANSGMYASTRMLYSLAKDGGAPKIFSKTSKNGIPFIALLATTAVALLTFLTSIYGVSFFTLLVSAS
GLTGFIAWIGIAISHFRFRRAYVAQGKDVKKLPYHAKLFPFGPILALIMTVLVTLGQDPMLLFGKTWVQGVVMYAAIPLF
FILYLGYKFKNKTKLIPLKDVDLSRHKD
>Mature_508_residues
MRVSLSLTSRCRINFIRERILENSSNSTTETQVKRALKSRHVSMIALGGTIGTGLFLTSGDVIHTAGPFGALTAYVLIGA
MVYFLMTSLGEMATYLPTSGSFSDYGTRYVDPAFGFALGWNYWLNWAITVAVDLTAVALCIKFWLPDVPSWIFSLIALII
VFSINALSVKTFGETEYWLSAIKITVVVLFLIIGFLSIFGIMGGHIDVAKNLSVGNHGFVGGLGSFTTGGGILGVLLVAG
FSFQGTELLGITAGEAENPEKSIPKAMNSIFWRILVFYILSIFVMAAIIPFTDPHLVGGNSAAQSPFTIVFERVGFSIAA
SIMNAVVLTSVVSAANSGMYASTRMLYSLAKDGGAPKIFSKTSKNGIPFIALLATTAVALLTFLTSIYGVSFFTLLVSAS
GLTGFIAWIGIAISHFRFRRAYVAQGKDVKKLPYHAKLFPFGPILALIMTVLVTLGQDPMLLFGKTWVQGVVMYAAIPLF
FILYLGYKFKNKTKLIPLKDVDLSRHKD

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=403, Percent_Identity=24.8138957816377, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1788480, Length=492, Percent_Identity=51.219512195122, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI87081708, Length=469, Percent_Identity=36.6737739872068, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI1786302, Length=470, Percent_Identity=38.5106382978723, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1786789, Length=447, Percent_Identity=37.3601789709172, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI48994972, Length=435, Percent_Identity=37.2413793103448, Blast_Score=279, Evalue=4e-76,
Organism=Escherichia coli, GI1789017, Length=407, Percent_Identity=34.8894348894349, Blast_Score=254, Evalue=7e-69,
Organism=Escherichia coli, GI1790653, Length=490, Percent_Identity=33.265306122449, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1786602, Length=408, Percent_Identity=38.9705882352941, Blast_Score=251, Evalue=9e-68,
Organism=Escherichia coli, GI87081915, Length=412, Percent_Identity=36.6504854368932, Blast_Score=251, Evalue=1e-67,
Organism=Escherichia coli, GI87082023, Length=485, Percent_Identity=24.3298969072165, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87081869, Length=506, Percent_Identity=22.9249011857708, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=500, Percent_Identity=24, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320772, Length=502, Percent_Identity=38.0478087649402, Blast_Score=321, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6324061, Length=516, Percent_Identity=36.4341085271318, Blast_Score=319, Evalue=5e-88,
Organism=Saccharomyces cerevisiae, GI6324990, Length=511, Percent_Identity=36.399217221135, Blast_Score=302, Evalue=7e-83,
Organism=Saccharomyces cerevisiae, GI6324059, Length=508, Percent_Identity=37.5984251968504, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6324924, Length=518, Percent_Identity=32.6254826254826, Blast_Score=280, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6322892, Length=497, Percent_Identity=34.6076458752515, Blast_Score=270, Evalue=5e-73,
Organism=Saccharomyces cerevisiae, GI6321629, Length=504, Percent_Identity=32.7380952380952, Blast_Score=261, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6320717, Length=508, Percent_Identity=31.2992125984252, Blast_Score=256, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6319824, Length=529, Percent_Identity=31.3799621928166, Blast_Score=256, Evalue=8e-69,
Organism=Saccharomyces cerevisiae, GI6321053, Length=492, Percent_Identity=32.3170731707317, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6319542, Length=529, Percent_Identity=31.3799621928166, Blast_Score=251, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6324553, Length=438, Percent_Identity=34.2465753424658, Blast_Score=250, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6320251, Length=515, Percent_Identity=31.6504854368932, Blast_Score=246, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6319543, Length=526, Percent_Identity=31.3688212927757, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6322967, Length=437, Percent_Identity=32.7231121281465, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6319608, Length=500, Percent_Identity=27.2, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6324981, Length=534, Percent_Identity=29.7752808988764, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320364, Length=557, Percent_Identity=26.032315978456, Blast_Score=179, Evalue=6e-46,
Organism=Drosophila melanogaster, GI281366235, Length=430, Percent_Identity=22.5581395348837, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007820, Length=430, Percent_Identity=22.5581395348837, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54974; Mature: 54974

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVSLSLTSRCRINFIRERILENSSNSTTETQVKRALKSRHVSMIALGGTIGTGLFLTSG
CEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEEECCCHHCCEEEECC
DVIHTAGPFGALTAYVLIGAMVYFLMTSLGEMATYLPTSGSFSDYGTRYVDPAFGFALGW
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
NYWLNWAITVAVDLTAVALCIKFWLPDVPSWIFSLIALIIVFSINALSVKTFGETEYWLS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHH
AIKITVVVLFLIIGFLSIFGIMGGHIDVAKNLSVGNHGFVGGLGSFTTGGGILGVLLVAG
HHHHHHHHHHHHHHHHHHHHHHCCCEEHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
FSFQGTELLGITAGEAENPEKSIPKAMNSIFWRILVFYILSIFVMAAIIPFTDPHLVGGN
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
SAAQSPFTIVFERVGFSIAASIMNAVVLTSVVSAANSGMYASTRMLYSLAKDGGAPKIFS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHC
KTSKNGIPFIALLATTAVALLTFLTSIYGVSFFTLLVSASGLTGFIAWIGIAISHFRFRR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AYVAQGKDVKKLPYHAKLFPFGPILALIMTVLVTLGQDPMLLFGKTWVQGVVMYAAIPLF
HHHHCCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHH
FILYLGYKFKNKTKLIPLKDVDLSRHKD
HHHHHHHCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MRVSLSLTSRCRINFIRERILENSSNSTTETQVKRALKSRHVSMIALGGTIGTGLFLTSG
CEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEEECCCHHCCEEEECC
DVIHTAGPFGALTAYVLIGAMVYFLMTSLGEMATYLPTSGSFSDYGTRYVDPAFGFALGW
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
NYWLNWAITVAVDLTAVALCIKFWLPDVPSWIFSLIALIIVFSINALSVKTFGETEYWLS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHH
AIKITVVVLFLIIGFLSIFGIMGGHIDVAKNLSVGNHGFVGGLGSFTTGGGILGVLLVAG
HHHHHHHHHHHHHHHHHHHHHHCCCEEHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
FSFQGTELLGITAGEAENPEKSIPKAMNSIFWRILVFYILSIFVMAAIIPFTDPHLVGGN
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
SAAQSPFTIVFERVGFSIAASIMNAVVLTSVVSAANSGMYASTRMLYSLAKDGGAPKIFS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHC
KTSKNGIPFIALLATTAVALLTFLTSIYGVSFFTLLVSASGLTGFIAWIGIAISHFRFRR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AYVAQGKDVKKLPYHAKLFPFGPILALIMTVLVTLGQDPMLLFGKTWVQGVVMYAAIPLF
HHHHCCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHH
FILYLGYKFKNKTKLIPLKDVDLSRHKD
HHHHHHHCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]