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The map label for this gene is adk [H]

Identifier: 125625120

GI number: 125625120

Start: 2313809

End: 2314456

Strand: Reverse

Name: adk [H]

Synonym: llmg_2359

Alternate gene names: 125625120

Gene position: 2314456-2313809 (Counterclockwise)

Preceding gene: 125625121

Following gene: 125625119

Centisome position: 91.5

GC content: 36.11

Gene sequence:

>648_bases
ATGAATTTATTAATCATGGGACTTCCAGGAGCTGGTAAAGGAACTCAAGCCGAATTTATCGTTAAAAATTATGGTGTAAA
CCATATTTCAACAGGAGATATGTTCCGTGCAGCGATGAAAAATGAAACAGAAATGGGTAAACTTGCTAAATCTTTTATTG
ATAAAGGTGAACTCGTTCCTGATGAAGTAACCAATGGTATTGTCAAAGAACGTTTAGCACAAGATGATATCAAAGCTTCA
GGTTTCTTGCTTGATGGATACCCACGTACGATTGACCAAGCGCATGCTCTTGATACAATGCTTGAAGAACTTGGCATTAA
ACTTGATGCTGTTGTAAATATTGTTGTTAATCCAAATATTTTGGTTGATCGTTTAAGTGGTCGTTACATCTGCCGTAATT
GTGGAGCAACTTATCACAAAATTTTCAACCCAACTAAAGTTGAAGGAACTTGTGACGTTTGTGGTAGCCATGACCTTTAC
CAACGTGCTGATGATGTACCAGAAACAGTTAAAAACCGTTTAGATGTCAACATCAAAGAATCTGCGCCAATTATTGAACA
TTACACTGAACTTGGACTTGTTAAAAATATCGAAGGCGAACAAGAAATTAGTCAAGTGACAGATGATATTAAAAAAGTTT
TAGGCTAA

Upstream 100 bases:

>100_bases
AAAAATACGCTAAAATAGTGTAGGTAAAAGACAGTGTACATCTGCATTTTACTGACAGAGCTGTCAGTAATTTATAAAAT
CAAAATCAGGAGAAAACAAA

Downstream 100 bases:

>100_bases
TAAATCATAAAACCTCTGTCAGAGGTTTTTTATTTTAAATATGAAAAATGAAAGATAAAATTTACTGACAGAAAAGTCAA
CAAGCTTAAAAATAAAAAGA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MNLLIMGLPGAGKGTQAEFIVKNYGVNHISTGDMFRAAMKNETEMGKLAKSFIDKGELVPDEVTNGIVKERLAQDDIKAS
GFLLDGYPRTIDQAHALDTMLEELGIKLDAVVNIVVNPNILVDRLSGRYICRNCGATYHKIFNPTKVEGTCDVCGSHDLY
QRADDVPETVKNRLDVNIKESAPIIEHYTELGLVKNIEGEQEISQVTDDIKKVLG

Sequences:

>Translated_215_residues
MNLLIMGLPGAGKGTQAEFIVKNYGVNHISTGDMFRAAMKNETEMGKLAKSFIDKGELVPDEVTNGIVKERLAQDDIKAS
GFLLDGYPRTIDQAHALDTMLEELGIKLDAVVNIVVNPNILVDRLSGRYICRNCGATYHKIFNPTKVEGTCDVCGSHDLY
QRADDVPETVKNRLDVNIKESAPIIEHYTELGLVKNIEGEQEISQVTDDIKKVLG
>Mature_215_residues
MNLLIMGLPGAGKGTQAEFIVKNYGVNHISTGDMFRAAMKNETEMGKLAKSFIDKGELVPDEVTNGIVKERLAQDDIKAS
GFLLDGYPRTIDQAHALDTMLEELGIKLDAVVNIVVNPNILVDRLSGRYICRNCGATYHKIFNPTKVEGTCDVCGSHDLY
QRADDVPETVKNRLDVNIKESAPIIEHYTELGLVKNIEGEQEISQVTDDIKKVLG

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=198, Percent_Identity=38.3838383838384, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI4502013, Length=198, Percent_Identity=38.3838383838384, Blast_Score=147, Evalue=7e-36,
Organism=Homo sapiens, GI19923437, Length=204, Percent_Identity=38.7254901960784, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI310110345, Length=201, Percent_Identity=37.8109452736318, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI53832003, Length=201, Percent_Identity=37.8109452736318, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI8051579, Length=201, Percent_Identity=37.8109452736318, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI53832001, Length=201, Percent_Identity=37.8109452736318, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI4502011, Length=208, Percent_Identity=27.8846153846154, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI7706497, Length=216, Percent_Identity=26.8518518518519, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI28144899, Length=208, Percent_Identity=30.7692307692308, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI28144897, Length=208, Percent_Identity=30.7692307692308, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI22749187, Length=209, Percent_Identity=28.7081339712919, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI1786680, Length=220, Percent_Identity=46.3636363636364, Blast_Score=184, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17552384, Length=215, Percent_Identity=34.8837209302326, Blast_Score=136, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17537943, Length=202, Percent_Identity=33.6633663366337, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17567503, Length=213, Percent_Identity=31.4553990610329, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17533833, Length=215, Percent_Identity=30.2325581395349, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17550688, Length=215, Percent_Identity=29.3023255813954, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=38.1395348837209, Blast_Score=159, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=36.0406091370558, Blast_Score=127, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322828, Length=215, Percent_Identity=27.906976744186, Blast_Score=90, Evalue=3e-19,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=36.9158878504673, Blast_Score=150, Evalue=5e-37,
Organism=Drosophila melanogaster, GI17737899, Length=198, Percent_Identity=38.8888888888889, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24645822, Length=198, Percent_Identity=38.8888888888889, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221459597, Length=216, Percent_Identity=27.3148148148148, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21356893, Length=216, Percent_Identity=27.3148148148148, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24663208, Length=91, Percent_Identity=34.0659340659341, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17647141, Length=91, Percent_Identity=34.0659340659341, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23675; Mature: 23675

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLIMGLPGAGKGTQAEFIVKNYGVNHISTGDMFRAAMKNETEMGKLAKSFIDKGELVP
CCEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
DEVTNGIVKERLAQDDIKASGFLLDGYPRTIDQAHALDTMLEELGIKLDAVVNIVVNPNI
HHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCEEEHEEEEEECCCE
LVDRLSGRYICRNCGATYHKIFNPTKVEGTCDVCGSHDLYQRADDVPETVKNRLDVNIKE
EEECCCCCHHHHHCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCC
SAPIIEHYTELGLVKNIEGEQEISQVTDDIKKVLG
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNLLIMGLPGAGKGTQAEFIVKNYGVNHISTGDMFRAAMKNETEMGKLAKSFIDKGELVP
CCEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
DEVTNGIVKERLAQDDIKASGFLLDGYPRTIDQAHALDTMLEELGIKLDAVVNIVVNPNI
HHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCEEEHEEEEEECCCE
LVDRLSGRYICRNCGATYHKIFNPTKVEGTCDVCGSHDLYQRADDVPETVKNRLDVNIKE
EEECCCCCHHHHHCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCC
SAPIIEHYTELGLVKNIEGEQEISQVTDDIKKVLG
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]