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The map label for this gene is murC [H]

Identifier: 125625078

GI number: 125625078

Start: 2267316

End: 2268647

Strand: Reverse

Name: murC [H]

Synonym: llmg_2316

Alternate gene names: 125625078

Gene position: 2268647-2267316 (Counterclockwise)

Preceding gene: 125625079

Following gene: 125625076

Centisome position: 89.69

GC content: 37.91

Gene sequence:

>1332_bases
ATGGAAAAAACATATCATTTTACCGGTATTAAAGGTTCAGGCATGAGTGCACTTGCATTGATGTTACATCAAATGGGCAA
AAACGTTCAAGGTTCAGATTCAACAGACTACTTTTTTACACAACGTGGTCTTGAACAAGCGGGTGTTCCACTTTTGCCGT
TTGACGAAAAAAATATTAAACCTGAGTTTGAATTGATTGTTGGGAATGCTTTTCGTGATGATAATAATGTCGAAATTGCT
TTCGCGCATAAAAATGGCTTCCCATTCAAACGTTATCATGAATTTTTGGGCCATTTCATGGAAGATTTCACAAGTATTGG
GGTTGCAGGCGCACACGGTAAGACTTCAACAACTGGAATGTTAGCTCATGTGATGTCGAATATCGTGGACACTTCTTACC
TAATTGGTGATGGAACTGGGCGTGGGAATGCTGGAAGTGAATATTTTGTCTTTGAATCTGATGAGTATGAACGTCATTTC
ATGCCATATCATCCTGAATATACCATTATGACAAATATTGACTTTGACCACCCTGACTATTTTGAAGGAATTGAAGATGT
CACTTCAGCTTTTCAAGACTATGCAAATAATATTAAAAAAGGAATCTTTGCTTATGGTGAAGATGTGAATTTGCGTAAAT
TGTCTGCTAAAGCGCCTATTTATTATTATGGTTTTGAAGCTAATGATGATTACCGTGCAGAAAACTTGATTAGAAGTACA
CGCGGTTCATCTTTTGATGCCTATTTCCGTGGTGAAAAAATTGGTCATTTTGTTGTTCCTGCCTATGGAAAACATAATGT
CTTGAATGCTTTATCTGTTGTGGCCGTTTGCCATAATCTTGGTTTGGATATGACAGATGTTGCTGACCACCTCTTGACTT
TCCGAGGAGTAAAACGCCGTTTTACTGAGAAAAAAGTAGGAGAAACAGTAATTATTGATGACTTCGCTCATCATCCAACT
GAGATTGAAGCAACATTGGATGCGGCTCGTCAAAAATATCCTGACCGTGAAATCGTTGCGGTATTCCAACCTCATACATT
TACCAGAACCATTGCTTTTGCTGATGAGTTTGCAGAAGTTCTTGACCATGCGGATACTGTTTATCTGGCACAAATTTATG
GCTCAGCTCGTGAAGTAGACCATCATGAAATTACGGCACAAGATTTAGCTGATAAAGTTCGTAAACCAGCCAAAGTAATT
GAGCTTGACAATGTTTCACCATTGTTAGACCACGACCGAGGAGTTTATGTCTTTATGGGAGCAGGGAATATTCAAAAATA
TGAAATTGCTTTTGAAAAATTACTTAGCCAAACTTCAACAAACTTACAATAA

Upstream 100 bases:

>100_bases
GGCGTGACTTTTAAATAAATAAAAAATTTTAACTGTAAGAAAAGAAGGGAAATTTCTGTCAGTTGCTGATGAATAAAAGT
AACTGACAGAAAATTTTATC

Downstream 100 bases:

>100_bases
AATTAAAAAAAAGCACTGACAGTATTGTTAGTGCTTTTTTATTAATAAAAAATTCAAGTCACGGGAGTGTGACTTGAATC
AAAGGGGTTTATGAAGAAAT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MEKTYHFTGIKGSGMSALALMLHQMGKNVQGSDSTDYFFTQRGLEQAGVPLLPFDEKNIKPEFELIVGNAFRDDNNVEIA
FAHKNGFPFKRYHEFLGHFMEDFTSIGVAGAHGKTSTTGMLAHVMSNIVDTSYLIGDGTGRGNAGSEYFVFESDEYERHF
MPYHPEYTIMTNIDFDHPDYFEGIEDVTSAFQDYANNIKKGIFAYGEDVNLRKLSAKAPIYYYGFEANDDYRAENLIRST
RGSSFDAYFRGEKIGHFVVPAYGKHNVLNALSVVAVCHNLGLDMTDVADHLLTFRGVKRRFTEKKVGETVIIDDFAHHPT
EIEATLDAARQKYPDREIVAVFQPHTFTRTIAFADEFAEVLDHADTVYLAQIYGSAREVDHHEITAQDLADKVRKPAKVI
ELDNVSPLLDHDRGVYVFMGAGNIQKYEIAFEKLLSQTSTNLQ

Sequences:

>Translated_443_residues
MEKTYHFTGIKGSGMSALALMLHQMGKNVQGSDSTDYFFTQRGLEQAGVPLLPFDEKNIKPEFELIVGNAFRDDNNVEIA
FAHKNGFPFKRYHEFLGHFMEDFTSIGVAGAHGKTSTTGMLAHVMSNIVDTSYLIGDGTGRGNAGSEYFVFESDEYERHF
MPYHPEYTIMTNIDFDHPDYFEGIEDVTSAFQDYANNIKKGIFAYGEDVNLRKLSAKAPIYYYGFEANDDYRAENLIRST
RGSSFDAYFRGEKIGHFVVPAYGKHNVLNALSVVAVCHNLGLDMTDVADHLLTFRGVKRRFTEKKVGETVIIDDFAHHPT
EIEATLDAARQKYPDREIVAVFQPHTFTRTIAFADEFAEVLDHADTVYLAQIYGSAREVDHHEITAQDLADKVRKPAKVI
ELDNVSPLLDHDRGVYVFMGAGNIQKYEIAFEKLLSQTSTNLQ
>Mature_443_residues
MEKTYHFTGIKGSGMSALALMLHQMGKNVQGSDSTDYFFTQRGLEQAGVPLLPFDEKNIKPEFELIVGNAFRDDNNVEIA
FAHKNGFPFKRYHEFLGHFMEDFTSIGVAGAHGKTSTTGMLAHVMSNIVDTSYLIGDGTGRGNAGSEYFVFESDEYERHF
MPYHPEYTIMTNIDFDHPDYFEGIEDVTSAFQDYANNIKKGIFAYGEDVNLRKLSAKAPIYYYGFEANDDYRAENLIRST
RGSSFDAYFRGEKIGHFVVPAYGKHNVLNALSVVAVCHNLGLDMTDVADHLLTFRGVKRRFTEKKVGETVIIDDFAHHPT
EIEATLDAARQKYPDREIVAVFQPHTFTRTIAFADEFAEVLDHADTVYLAQIYGSAREVDHHEITAQDLADKVRKPAKVI
ELDNVSPLLDHDRGVYVFMGAGNIQKYEIAFEKLLSQTSTNLQ

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1790680, Length=388, Percent_Identity=30.9278350515464, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1786279, Length=404, Percent_Identity=30.6930693069307, Blast_Score=152, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 49951; Mature: 49951

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTYHFTGIKGSGMSALALMLHQMGKNVQGSDSTDYFFTQRGLEQAGVPLLPFDEKNIK
CCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCHHHCCCCCCCCCCCCCC
PEFELIVGNAFRDDNNVEIAFAHKNGFPFKRYHEFLGHFMEDFTSIGVAGAHGKTSTTGM
CCEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LAHVMSNIVDTSYLIGDGTGRGNAGSEYFVFESDEYERHFMPYHPEYTIMTNIDFDHPDY
HHHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCHH
FEGIEDVTSAFQDYANNIKKGIFAYGEDVNLRKLSAKAPIYYYGFEANDDYRAENLIRST
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHH
RGSSFDAYFRGEKIGHFVVPAYGKHNVLNALSVVAVCHNLGLDMTDVADHLLTFRGVKRR
CCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FTEKKVGETVIIDDFAHHPTEIEATLDAARQKYPDREIVAVFQPHTFTRTIAFADEFAEV
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHH
LDHADTVYLAQIYGSAREVDHHEITAQDLADKVRKPAKVIELDNVSPLLDHDRGVYVFMG
HCCCCCEEEHHHHCCHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCCCEEEEEE
AGNIQKYEIAFEKLLSQTSTNLQ
CCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEKTYHFTGIKGSGMSALALMLHQMGKNVQGSDSTDYFFTQRGLEQAGVPLLPFDEKNIK
CCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCHHHCCCCCCCCCCCCCC
PEFELIVGNAFRDDNNVEIAFAHKNGFPFKRYHEFLGHFMEDFTSIGVAGAHGKTSTTGM
CCEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LAHVMSNIVDTSYLIGDGTGRGNAGSEYFVFESDEYERHFMPYHPEYTIMTNIDFDHPDY
HHHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCHH
FEGIEDVTSAFQDYANNIKKGIFAYGEDVNLRKLSAKAPIYYYGFEANDDYRAENLIRST
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHH
RGSSFDAYFRGEKIGHFVVPAYGKHNVLNALSVVAVCHNLGLDMTDVADHLLTFRGVKRR
CCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FTEKKVGETVIIDDFAHHPTEIEATLDAARQKYPDREIVAVFQPHTFTRTIAFADEFAEV
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHH
LDHADTVYLAQIYGSAREVDHHEITAQDLADKVRKPAKVIELDNVSPLLDHDRGVYVFMG
HCCCCCEEEHHHHCCHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCCCEEEEEE
AGNIQKYEIAFEKLLSQTSTNLQ
CCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]