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The map label for this gene is arcB [H]

Identifier: 125625074

GI number: 125625074

Start: 2262171

End: 2263235

Strand: Reverse

Name: arcB [H]

Synonym: llmg_2312

Alternate gene names: 125625074

Gene position: 2263235-2262171 (Counterclockwise)

Preceding gene: 125625075

Following gene: 125625073

Centisome position: 89.47

GC content: 36.34

Gene sequence:

>1065_bases
ATGACATCACCACTTATTACAAAAGCAGAAGTAAACTCAGTATTCCAAGGTCGTAGCTTGCTTGCTGAAAAAGATTTTAC
ACCAGCTGAAATTAACTACCTTGTTGATTTTGGTCTTCATTTGAAAGCATTGAAACAACAAAATATTCCTCACCACTATC
TTGAAGGTAAAAATATTGCCTTGTTATTTGCAAAAACTTCAACTCGTACACGTGCCGCATTTACAACTGCTGCAATTGAC
CTTGGGGCTCATCCTGAATATCTTGGTGCAAATGATATCCAACTCGGAATCAAAGAATCAACAGAAGATACAGCACGTGT
TCTTGGTTCAATGTTTGATGCTATTGAACGTCGTGGATTTTCTCAAAAAGAAGTTGAAGATTTGGCAAAATACTCTGGTG
TTCCAGTTTGGAATGGTTTGACAGATGATTGGCATCCAACACAAATGATTGCTGACTTTATGACAGTAAAAGAAAACTTT
GGTTACCTTAAAGGGTTGACATTAGTTTACGTTGGTGATGGTCGTAACAACATGGCAAATTCACTCATTGTAACTGGTTC
TATGCTTGGCGTGAATGTTCATATTGTTGCTCCAGATTCACTTCATCCTTCTAAAGAAGTTATGGATATTGCAAATAAAT
TTGCTGAAAAATCAGGTGCTAAACCTCTTGCAACTTCAAATATTGAAGAAGGTGTTAAAGGCGCAAACATTATTTACTCA
GATGTTTGGGTATCAATGGGAGAATCTAACTGGGAAGAACGTGTTAAACTTTTGACACCATATCGCATCACAATGGATAT
GTTGAAAATGACAGGAAATGCTGACAACGGTAAACTTATCTTTATGCACTGCTTACCAGCTTTCCATGACACTGAAACTG
AATATGGTAAAGAAATCAAAGAAAAATATGGTTTGACAGAAATGGAAGTTACTGACGAAGTTTTCCGTTCTAAATATGCT
CGTCAATTTGAAGAAGCAGAAAATCGTATGCACTCAATCAAAGCAATTATGGCTGCAACTTTGGGTAATTTATTTATCCC
AGCAGTTCCTGAAGATTTTAAATAA

Upstream 100 bases:

>100_bases
ATTTAGTTTTATAGGTTCGTAAAATTAAAGATAAAAAATAGCTCATTAATGTAATTTAAAAAATTCATTAAATATTTAAA
AATAGAAAAAGGAAAAAATA

Downstream 100 bases:

>100_bases
TTAAAATAGATAATTTGTCAGTTTACTGACAGAGCTGTCAGTAAACTGATAGATTTTGATTTAAGTCGTTGAAAGCAGTC
TAAGATAGTTTTTAGACTGT

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTSPLITKAEVNSVFQGRSLLAEKDFTPAEINYLVDFGLHLKALKQQNIPHHYLEGKNIALLFAKTSTRTRAAFTTAAID
LGAHPEYLGANDIQLGIKESTEDTARVLGSMFDAIERRGFSQKEVEDLAKYSGVPVWNGLTDDWHPTQMIADFMTVKENF
GYLKGLTLVYVGDGRNNMANSLIVTGSMLGVNVHIVAPDSLHPSKEVMDIANKFAEKSGAKPLATSNIEEGVKGANIIYS
DVWVSMGESNWEERVKLLTPYRITMDMLKMTGNADNGKLIFMHCLPAFHDTETEYGKEIKEKYGLTEMEVTDEVFRSKYA
RQFEEAENRMHSIKAIMAATLGNLFIPAVPEDFK

Sequences:

>Translated_354_residues
MTSPLITKAEVNSVFQGRSLLAEKDFTPAEINYLVDFGLHLKALKQQNIPHHYLEGKNIALLFAKTSTRTRAAFTTAAID
LGAHPEYLGANDIQLGIKESTEDTARVLGSMFDAIERRGFSQKEVEDLAKYSGVPVWNGLTDDWHPTQMIADFMTVKENF
GYLKGLTLVYVGDGRNNMANSLIVTGSMLGVNVHIVAPDSLHPSKEVMDIANKFAEKSGAKPLATSNIEEGVKGANIIYS
DVWVSMGESNWEERVKLLTPYRITMDMLKMTGNADNGKLIFMHCLPAFHDTETEYGKEIKEKYGLTEMEVTDEVFRSKYA
RQFEEAENRMHSIKAIMAATLGNLFIPAVPEDFK
>Mature_353_residues
TSPLITKAEVNSVFQGRSLLAEKDFTPAEINYLVDFGLHLKALKQQNIPHHYLEGKNIALLFAKTSTRTRAAFTTAAIDL
GAHPEYLGANDIQLGIKESTEDTARVLGSMFDAIERRGFSQKEVEDLAKYSGVPVWNGLTDDWHPTQMIADFMTVKENFG
YLKGLTLVYVGDGRNNMANSLIVTGSMLGVNVHIVAPDSLHPSKEVMDIANKFAEKSGAKPLATSNIEEGVKGANIIYSD
VWVSMGESNWEERVKLLTPYRITMDMLKMTGNADNGKLIFMHCLPAFHDTETEYGKEIKEKYGLTEMEVTDEVFRSKYAR
QFEEAENRMHSIKAIMAATLGNLFIPAVPEDFK

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=340, Percent_Identity=36.4705882352941, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI18105007, Length=350, Percent_Identity=25.1428571428571, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1790703, Length=334, Percent_Identity=47.6047904191617, Blast_Score=317, Evalue=8e-88,
Organism=Escherichia coli, GI1786469, Length=323, Percent_Identity=48.9164086687306, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI48994908, Length=381, Percent_Identity=26.509186351706, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI2367364, Length=239, Percent_Identity=31.3807531380753, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193204318, Length=248, Percent_Identity=27.8225806451613, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322373, Length=332, Percent_Identity=33.7349397590361, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322331, Length=195, Percent_Identity=30.2564102564103, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24642586, Length=333, Percent_Identity=26.4264264264264, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 39469; Mature: 39337

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPLITKAEVNSVFQGRSLLAEKDFTPAEINYLVDFGLHLKALKQQNIPHHYLEGKNIA
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHCCCCCEE
LLFAKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGIKESTEDTARVLGSMFDAIERRGF
EEEEECCCCHHHHHHHHEEECCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCC
SQKEVEDLAKYSGVPVWNGLTDDWHPTQMIADFMTVKENFGYLKGLTLVYVGDGRNNMAN
CHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC
SLIVTGSMLGVNVHIVAPDSLHPSKEVMDIANKFAEKSGAKPLATSNIEEGVKGANIIYS
EEEEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEEE
DVWVSMGESNWEERVKLLTPYRITMDMLKMTGNADNGKLIFMHCLPAFHDTETEYGKEIK
HHHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHH
EKYGLTEMEVTDEVFRSKYARQFEEAENRMHSIKAIMAATLGNLFIPAVPEDFK
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TSPLITKAEVNSVFQGRSLLAEKDFTPAEINYLVDFGLHLKALKQQNIPHHYLEGKNIA
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHCCCCCEE
LLFAKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGIKESTEDTARVLGSMFDAIERRGF
EEEEECCCCHHHHHHHHEEECCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCC
SQKEVEDLAKYSGVPVWNGLTDDWHPTQMIADFMTVKENFGYLKGLTLVYVGDGRNNMAN
CHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC
SLIVTGSMLGVNVHIVAPDSLHPSKEVMDIANKFAEKSGAKPLATSNIEEGVKGANIIYS
EEEEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEEE
DVWVSMGESNWEERVKLLTPYRITMDMLKMTGNADNGKLIFMHCLPAFHDTETEYGKEIK
HHHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHH
EKYGLTEMEVTDEVFRSKYARQFEEAENRMHSIKAIMAATLGNLFIPAVPEDFK
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]