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The map label for this gene is pmsR [H]

Identifier: 125625046

GI number: 125625046

Start: 2236972

End: 2237493

Strand: Reverse

Name: pmsR [H]

Synonym: llmg_2281

Alternate gene names: 125625046

Gene position: 2237493-2236972 (Counterclockwise)

Preceding gene: 125625047

Following gene: 125625045

Centisome position: 88.46

GC content: 36.59

Gene sequence:

>522_bases
ATGGCAACAGAAAGAGCAATATTTGCAGGTGGATGTTTTTGGTGTATGGTACAACCATTTGAAGAACGTGAAGGAATTTT
ATCGGTCACGAGTGGTTATACAGGTGGAAATGTTGAAAATCCAACTTACGAACAAGTAAAAATGCACCTGACCGGCCACA
CAGAAGCAGTAGAAATTATTTTTGATAATAGTAAAATTAATTATCAGACACTTGTTGAACTTTACTGGACACTGACAGAC
CCCACAGATGCTTTTGGTCAATTTGAAGATCGAGGGGATAACTATCGTCCAGTTATTTTCGTTGAAAATAATGAACAAGA
AAAGATTGCCAAAGAAAGTAAAGCACAATTGCAAGCCAGTGGAAACTTCGACTCTCCAATTGTGACAAGTATTGAGAAGA
CTCAAAAATTTTGGCCAGCAGAAGACTATCATCAAGGATTTTACAGAAAAAATCCAGAAGATTATGCTGAATCAAGCAAA
ATCCGCCATGATTTTTTGGAAAAACAATGGGAAGACAAATAA

Upstream 100 bases:

>100_bases
TTAAAAAATTTCTGTCAGTAAAAAAAGGTAGCTCTAAAAGCTACTTTTTTTTGAGCTATGCTATAATATTTCACAAGACA
ACTAAAGCAAAGGAGAAATA

Downstream 100 bases:

>100_bases
AAAATCCTATGAATCACTAGATAGAAAGAGAAAATGACATTTTATAATTACCTAATGCGCCATCGCGCACCAGTAGAGAA
AGACGATGCGACTCGTCTTG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MATERAIFAGGCFWCMVQPFEEREGILSVTSGYTGGNVENPTYEQVKMHLTGHTEAVEIIFDNSKINYQTLVELYWTLTD
PTDAFGQFEDRGDNYRPVIFVENNEQEKIAKESKAQLQASGNFDSPIVTSIEKTQKFWPAEDYHQGFYRKNPEDYAESSK
IRHDFLEKQWEDK

Sequences:

>Translated_173_residues
MATERAIFAGGCFWCMVQPFEEREGILSVTSGYTGGNVENPTYEQVKMHLTGHTEAVEIIFDNSKINYQTLVELYWTLTD
PTDAFGQFEDRGDNYRPVIFVENNEQEKIAKESKAQLQASGNFDSPIVTSIEKTQKFWPAEDYHQGFYRKNPEDYAESSK
IRHDFLEKQWEDK
>Mature_172_residues
ATERAIFAGGCFWCMVQPFEEREGILSVTSGYTGGNVENPTYEQVKMHLTGHTEAVEIIFDNSKINYQTLVELYWTLTDP
TDAFGQFEDRGDNYRPVIFVENNEQEKIAKESKAQLQASGNFDSPIVTSIEKTQKFWPAEDYHQGFYRKNPEDYAESSKI
RHDFLEKQWEDK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=35.6687898089172, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=35.6687898089172, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=35.1851851851852, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=40.7894736842105, Blast_Score=115, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=35.1724137931034, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=26.7515923566879, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24664627, Length=165, Percent_Identity=29.6969696969697, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45553131, Length=160, Percent_Identity=29.375, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664631, Length=165, Percent_Identity=29.0909090909091, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20055; Mature: 19924

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATERAIFAGGCFWCMVQPFEEREGILSVTSGYTGGNVENPTYEQVKMHLTGHTEAVEII
CCCCCEEEECCEEEEEECCHHCCCCEEEEECCCCCCCCCCCCHHHEEEEECCCCEEEEEE
FDNSKINYQTLVELYWTLTDPTDAFGQFEDRGDNYRPVIFVENNEQEKIAKESKAQLQAS
ECCCCCCHHEEEEEHEEECCCHHHHCCHHHCCCCCCCEEEEECCCHHHHHHHHHHHEEEC
GNFDSPIVTSIEKTQKFWPAEDYHQGFYRKNPEDYAESSKIRHDFLEKQWEDK
CCCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ATERAIFAGGCFWCMVQPFEEREGILSVTSGYTGGNVENPTYEQVKMHLTGHTEAVEII
CCCCEEEECCEEEEEECCHHCCCCEEEEECCCCCCCCCCCCHHHEEEEECCCCEEEEEE
FDNSKINYQTLVELYWTLTDPTDAFGQFEDRGDNYRPVIFVENNEQEKIAKESKAQLQAS
ECCCCCCHHEEEEEHEEECCCHHHHCCHHHCCCCCCCEEEEECCCHHHHHHHHHHHEEEC
GNFDSPIVTSIEKTQKFWPAEDYHQGFYRKNPEDYAESSKIRHDFLEKQWEDK
CCCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]