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The map label for this gene is galM [H]

Identifier: 125625003

GI number: 125625003

Start: 2198351

End: 2199370

Strand: Reverse

Name: galM [H]

Synonym: llmg_2236

Alternate gene names: 125625003

Gene position: 2199370-2198351 (Counterclockwise)

Preceding gene: 125625004

Following gene: 125625002

Centisome position: 86.95

GC content: 36.08

Gene sequence:

>1020_bases
ATGGAAATTACAACAAAAGATTTTGGTTTAGGAAGTAGCCTAATTAGTCTAACGAACAAAAATGATGTTACAATTGCTTT
TACAAACTTAGGAGCTCGCATTGTTGATTGGCAAAAAGACGGGAAACATTTTATTTTAGGATTTGATTCCGCCCAAGAAT
ATTTAGAAAAAGATGCTTATCCAGGGGCCACAGTTGGACGTACAGCTGGCAGAATCAAAGATGGTTTGGTTGATATTTCT
GGAAAAACATATCATTTAAATCAAAATGAAGCTCCCCAAACCTTACATGGTGGAGAAGATAGCATTCATACCAAACTTTG
GACTTATGAAATTAATGATTTAGGAGATGAAGTTCAAGTCAAATTTAGCTTAGTTTCCAATGATGGAGAAAATGGATATC
CTGGTAAAATAGAGATGTCGGTGACTCATTCTTTTGATGAAGAGAACAATTGGAAAATTAAGTATGAAGCAATTTCTGAC
AAAGATACGGTATTTAATCCCACAGGACATGTCTATTTCAACTTAAATGGGGATGCTAGCAAGTCTATTGAAAATCATCA
ACTCAAGCTTGCTGCTTCAAGATTTGTACCTTTAAAAGATCAAACAGAAATTGTCCGTGGCGATATCGTTGATACAAAAA
ATACTGACTTAGACTTCCGTCAGGAAAAACAATTATCAAAAGCCTTAGAGTCTAGCATGGAACAAGTTCAACTGGTTGGT
GGAATTGACCACCCCTTCTTATTAGATGAACAGAGCCTTGAGAAAGAACAAGCGCGTTTATCTTTAGATGACTTGTCAGT
TTCCGTTTATACTGACCAACCAAGTATTGTAATTTTTACAGCAAACTTTGGAGATTTGGGGACCGTTTATCACGGGAAAA
ATCAAGTTCATCATGGTGGTATTACCTTTGAATGTCAAGTTTCACCCGGGTCACAACAGATTCCAGAACTTGGAGACATT
AGTTTAAAGGCAGGAGATGAATATCAAGCCACCACCATTTATAGTTTACATACAAATTAA

Upstream 100 bases:

>100_bases
GATTATTGGAATGGATAACTTTTTATAGATATACTAAATTTTCATTAGTAAAACTTTTAAGAAAAAGTTGACCTCAGGTT
AGCCCTAGTTAGGAAATCAC

Downstream 100 bases:

>100_bases
GGAAATGAATTTAGAGGAGAGAAGAAATGTCAATAGTTGTCGAAAATAGTACTGTATTATCAGCGTTAACAGAAAAATTT
GCAGAAGTTTTTGGAGATAC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MEITTKDFGLGSSLISLTNKNDVTIAFTNLGARIVDWQKDGKHFILGFDSAQEYLEKDAYPGATVGRTAGRIKDGLVDIS
GKTYHLNQNEAPQTLHGGEDSIHTKLWTYEINDLGDEVQVKFSLVSNDGENGYPGKIEMSVTHSFDEENNWKIKYEAISD
KDTVFNPTGHVYFNLNGDASKSIENHQLKLAASRFVPLKDQTEIVRGDIVDTKNTDLDFRQEKQLSKALESSMEQVQLVG
GIDHPFLLDEQSLEKEQARLSLDDLSVSVYTDQPSIVIFTANFGDLGTVYHGKNQVHHGGITFECQVSPGSQQIPELGDI
SLKAGDEYQATTIYSLHTN

Sequences:

>Translated_339_residues
MEITTKDFGLGSSLISLTNKNDVTIAFTNLGARIVDWQKDGKHFILGFDSAQEYLEKDAYPGATVGRTAGRIKDGLVDIS
GKTYHLNQNEAPQTLHGGEDSIHTKLWTYEINDLGDEVQVKFSLVSNDGENGYPGKIEMSVTHSFDEENNWKIKYEAISD
KDTVFNPTGHVYFNLNGDASKSIENHQLKLAASRFVPLKDQTEIVRGDIVDTKNTDLDFRQEKQLSKALESSMEQVQLVG
GIDHPFLLDEQSLEKEQARLSLDDLSVSVYTDQPSIVIFTANFGDLGTVYHGKNQVHHGGITFECQVSPGSQQIPELGDI
SLKAGDEYQATTIYSLHTN
>Mature_339_residues
MEITTKDFGLGSSLISLTNKNDVTIAFTNLGARIVDWQKDGKHFILGFDSAQEYLEKDAYPGATVGRTAGRIKDGLVDIS
GKTYHLNQNEAPQTLHGGEDSIHTKLWTYEINDLGDEVQVKFSLVSNDGENGYPGKIEMSVTHSFDEENNWKIKYEAISD
KDTVFNPTGHVYFNLNGDASKSIENHQLKLAASRFVPLKDQTEIVRGDIVDTKNTDLDFRQEKQLSKALESSMEQVQLVG
GIDHPFLLDEQSLEKEQARLSLDDLSVSVYTDQPSIVIFTANFGDLGTVYHGKNQVHHGGITFECQVSPGSQQIPELGDI
SLKAGDEYQATTIYSLHTN

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=338, Percent_Identity=33.1360946745562, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1786971, Length=334, Percent_Identity=30.8383233532934, Blast_Score=138, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17557428, Length=344, Percent_Identity=27.906976744186, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI115533334, Length=344, Percent_Identity=27.906976744186, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6319493, Length=216, Percent_Identity=27.7777777777778, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322004, Length=291, Percent_Identity=25.4295532646048, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324399, Length=207, Percent_Identity=26.5700483091787, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24668278, Length=336, Percent_Identity=30.6547619047619, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24583720, Length=360, Percent_Identity=27.2222222222222, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24659048, Length=345, Percent_Identity=27.536231884058, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24668282, Length=342, Percent_Identity=23.9766081871345, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24641876, Length=366, Percent_Identity=24.0437158469945, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37606; Mature: 37606

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEITTKDFGLGSSLISLTNKNDVTIAFTNLGARIVDWQKDGKHFILGFDSAQEYLEKDAY
CCCCCCCCCCCCCEEEECCCCCEEEEEECCCCEEEEEECCCCEEEEEECHHHHHHHHCCC
PGATVGRTAGRIKDGLVDISGKTYHLNQNEAPQTLHGGEDSIHTKLWTYEINDLGDEVQV
CCCCCCCCCCHHCCCEEEECCCEEEECCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEE
KFSLVSNDGENGYPGKIEMSVTHSFDEENNWKIKYEAISDKDTVFNPTGHVYFNLNGDAS
EEEEEECCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCCEECCCCEEEEEECCCCC
KSIENHQLKLAASRFVPLKDQTEIVRGDIVDTKNTDLDFRQEKQLSKALESSMEQVQLVG
CCCCCCEEEEEHHHCCCCCCCCCEEECCEECCCCCCCCHHHHHHHHHHHHHHHHHEEEEC
GIDHPFLLDEQSLEKEQARLSLDDLSVSVYTDQPSIVIFTANFGDLGTVYHGKNQVHHGG
CCCCCEEECHHHHHHHHHHEEEEHEEEEEEECCCCEEEEEECCCCCCEEEECCCEEEECC
ITFECQVSPGSQQIPELGDISLKAGDEYQATTIYSLHTN
EEEEEEECCCCCCCCCCCCEEEECCCCEEEEEEEEEECC
>Mature Secondary Structure
MEITTKDFGLGSSLISLTNKNDVTIAFTNLGARIVDWQKDGKHFILGFDSAQEYLEKDAY
CCCCCCCCCCCCCEEEECCCCCEEEEEECCCCEEEEEECCCCEEEEEECHHHHHHHHCCC
PGATVGRTAGRIKDGLVDISGKTYHLNQNEAPQTLHGGEDSIHTKLWTYEINDLGDEVQV
CCCCCCCCCCHHCCCEEEECCCEEEECCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEE
KFSLVSNDGENGYPGKIEMSVTHSFDEENNWKIKYEAISDKDTVFNPTGHVYFNLNGDAS
EEEEEECCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCCEECCCCEEEEEECCCCC
KSIENHQLKLAASRFVPLKDQTEIVRGDIVDTKNTDLDFRQEKQLSKALESSMEQVQLVG
CCCCCCEEEEEHHHCCCCCCCCCEEECCEECCCCCCCCHHHHHHHHHHHHHHHHHEEEEC
GIDHPFLLDEQSLEKEQARLSLDDLSVSVYTDQPSIVIFTANFGDLGTVYHGKNQVHHGG
CCCCCEEECHHHHHHHHHHEEEEHEEEEEEECCCCEEEEEECCCCCCEEEECCCEEEECC
ITFECQVSPGSQQIPELGDISLKAGDEYQATTIYSLHTN
EEEEEEECCCCCCCCCCCCEEEECCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]