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The map label for this gene is fmt

Identifier: 125624918

GI number: 125624918

Start: 2109555

End: 2110526

Strand: Reverse

Name: fmt

Synonym: llmg_2147

Alternate gene names: 125624918

Gene position: 2110526-2109555 (Counterclockwise)

Preceding gene: 125624919

Following gene: 125624917

Centisome position: 83.44

GC content: 39.2

Gene sequence:

>972_bases
ATGACAAAAACAAAAATTATCTTTATGGGGACGCCACAATTTGCTGCGACCGTTTTGAAAGGTTTGATTGACTCTAATAA
ATATGAAATCCTAGCAGTTGTGACCCAACCAGACCGTAAAGTTGGTCGAAAACAGGAATTAAGAATGACACCAGTTAAAG
AACTTGCCTTAACGGTTAACTTGCCTGTTCTTCAACCAGAAAAACTTTCTGGGTCAGTAGAAATGACTCAAATCATGACG
CTCCTTGAATCAGGAGAAGTTGGAATTGTGACTGCCGCATTTGGACAATTTTTGCCAGGGAAATTATTAGTTGTTGCTCG
TTTTGCGGTAAATACACACGCTTCCTTACTACCGAAATATCGCGGTGGAGCGCCGATTCATTATGCCATTATGAATGGCG
AAAAAGAAGCTGGTGTGACAATTATGGAAATGATTCGTAAAATGGATGCCGGTGACATGATTGCTCAAAATTCTACTCCA
ATTCTTGAAGAAGACAATGTCGGCACTATGTTTGAAAAATTGGCTTTTGTGGGACGTGATTTACTCCTTGAAACATTACC
CAAGTATCTGGAGGGTCAACTCAAAGCTCAAGCTCAAAATGAAGATGAAGTGACTTTTAGTCCAAATATTTCACCAGAAG
AAGAAAAAATCGATTGGAACAAATCCGCACGTGAAATTTTCAATAAAGTTCGTGGCATGAATCCTTTTCCAGTCGCCCAT
ACCCTGTGGAATGGGGAACGCTTTAAGATTTATGAAAGCAAAGTAGCTGACGAAATTGTTAACAATTCTGATAATCCCTT
ACAGGCTGGTCAAATTGTGGAAAAAACAAAAAAATCATTAAAAGTTGCTACGGGCAATGGAATTCTCGAGCTTTTAACCG
TCCAACCGGCAGGCAAACCTAAAATGGACATTGTTAGTTTTCTTAATGGTTTAGGTCAAAAAATGCAAGTTGGGGATAAA
CTTGGGGATTAG

Upstream 100 bases:

>100_bases
TCATTCCAGAAAATCTGGGTCAATTAATGGCAAAAGGTGACAAGGCCGTTCAAGTATTAATGAAACAAAAGAAAATTATT
ATCGAGGAGTTTGAAAACTT

Downstream 100 bases:

>100_bases
ATAAAAAATAAGATATTTCAAATAGAAATATTTTCCACAGAAACTAAAAGTATGAGACCTGAGGTACAATTTATCTCTAA
AAAAGTTCTATCATTGTTAA

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTKTKIIFMGTPQFAATVLKGLIDSNKYEILAVVTQPDRKVGRKQELRMTPVKELALTVNLPVLQPEKLSGSVEMTQIMT
LLESGEVGIVTAAFGQFLPGKLLVVARFAVNTHASLLPKYRGGAPIHYAIMNGEKEAGVTIMEMIRKMDAGDMIAQNSTP
ILEEDNVGTMFEKLAFVGRDLLLETLPKYLEGQLKAQAQNEDEVTFSPNISPEEEKIDWNKSAREIFNKVRGMNPFPVAH
TLWNGERFKIYESKVADEIVNNSDNPLQAGQIVEKTKKSLKVATGNGILELLTVQPAGKPKMDIVSFLNGLGQKMQVGDK
LGD

Sequences:

>Translated_323_residues
MTKTKIIFMGTPQFAATVLKGLIDSNKYEILAVVTQPDRKVGRKQELRMTPVKELALTVNLPVLQPEKLSGSVEMTQIMT
LLESGEVGIVTAAFGQFLPGKLLVVARFAVNTHASLLPKYRGGAPIHYAIMNGEKEAGVTIMEMIRKMDAGDMIAQNSTP
ILEEDNVGTMFEKLAFVGRDLLLETLPKYLEGQLKAQAQNEDEVTFSPNISPEEEKIDWNKSAREIFNKVRGMNPFPVAH
TLWNGERFKIYESKVADEIVNNSDNPLQAGQIVEKTKKSLKVATGNGILELLTVQPAGKPKMDIVSFLNGLGQKMQVGDK
LGD
>Mature_322_residues
TKTKIIFMGTPQFAATVLKGLIDSNKYEILAVVTQPDRKVGRKQELRMTPVKELALTVNLPVLQPEKLSGSVEMTQIMTL
LESGEVGIVTAAFGQFLPGKLLVVARFAVNTHASLLPKYRGGAPIHYAIMNGEKEAGVTIMEMIRKMDAGDMIAQNSTPI
LEEDNVGTMFEKLAFVGRDLLLETLPKYLEGQLKAQAQNEDEVTFSPNISPEEEKIDWNKSAREIFNKVRGMNPFPVAHT
LWNGERFKIYESKVADEIVNNSDNPLQAGQIVEKTKKSLKVATGNGILELLTVQPAGKPKMDIVSFLNGLGQKMQVGDKL
GD

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI164663775, Length=258, Percent_Identity=27.906976744186, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI21614513, Length=160, Percent_Identity=27.5, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI238814322, Length=289, Percent_Identity=23.8754325259516, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1789683, Length=318, Percent_Identity=39.3081761006289, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1788589, Length=270, Percent_Identity=31.4814814814815, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI133930964, Length=263, Percent_Identity=27.7566539923954, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6319458, Length=274, Percent_Identity=25.1824817518248, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45550868, Length=317, Percent_Identity=28.7066246056782, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28571984, Length=229, Percent_Identity=31.0043668122271, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585660, Length=250, Percent_Identity=25.2, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_LACLM (A2RN27)

Other databases:

- EMBL:   AM406671
- RefSeq:   YP_001033401.1
- ProteinModelPortal:   A2RN27
- SMR:   A2RN27
- STRING:   A2RN27
- GeneID:   4799113
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_2147
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   VVAYGAI
- ProtClustDB:   PRK00005
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 35585; Mature: 35454

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTKIIFMGTPQFAATVLKGLIDSNKYEILAVVTQPDRKVGRKQELRMTPVKELALTVN
CCCEEEEEEECCHHHHHHHHHHHCCCCEEEEEEEECCHHHCCCHHHCCCCCHHHEEEEEC
LPVLQPEKLSGSVEMTQIMTLLESGEVGIVTAAFGQFLPGKLLVVARFAVNTHASLLPKY
CCCCCCHHCCCCHHHHHHHHHHHCCCEEEEEHHHHCCCCCCEEEEEHHHHHHHHHHCCCC
RGGAPIHYAIMNGEKEAGVTIMEMIRKMDAGDMIAQNSTPILEEDNVGTMFEKLAFVGRD
CCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHH
LLLETLPKYLEGQLKAQAQNEDEVTFSPNISPEEEKIDWNKSAREIFNKVRGMNPFPVAH
HHHHHHHHHHCCHHHHCCCCCCCEEECCCCCCCHHHCCCCHHHHHHHHHHCCCCCCCCHH
TLWNGERFKIYESKVADEIVNNSDNPLQAGQIVEKTKKSLKVATGNGILELLTVQPAGKP
EEECCCEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEECCCCEEEEEEECCCCCC
KMDIVSFLNGLGQKMQVGDKLGD
HHHHHHHHHHCCCHHHCCCCCCC
>Mature Secondary Structure 
TKTKIIFMGTPQFAATVLKGLIDSNKYEILAVVTQPDRKVGRKQELRMTPVKELALTVN
CCEEEEEEECCHHHHHHHHHHHCCCCEEEEEEEECCHHHCCCHHHCCCCCHHHEEEEEC
LPVLQPEKLSGSVEMTQIMTLLESGEVGIVTAAFGQFLPGKLLVVARFAVNTHASLLPKY
CCCCCCHHCCCCHHHHHHHHHHHCCCEEEEEHHHHCCCCCCEEEEEHHHHHHHHHHCCCC
RGGAPIHYAIMNGEKEAGVTIMEMIRKMDAGDMIAQNSTPILEEDNVGTMFEKLAFVGRD
CCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHH
LLLETLPKYLEGQLKAQAQNEDEVTFSPNISPEEEKIDWNKSAREIFNKVRGMNPFPVAH
HHHHHHHHHHCCHHHHCCCCCCCEEECCCCCCCHHHCCCCHHHHHHHHHHCCCCCCCCHH
TLWNGERFKIYESKVADEIVNNSDNPLQAGQIVEKTKKSLKVATGNGILELLTVQPAGKP
EEECCCEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEECCCCEEEEEEECCCCCC
KMDIVSFLNGLGQKMQVGDKLGD
HHHHHHHHHHCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA