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The map label for this gene is proC [H]

Identifier: 125624849

GI number: 125624849

Start: 2057845

End: 2058636

Strand: Direct

Name: proC [H]

Synonym: llmg_2077

Alternate gene names: 125624849

Gene position: 2057845-2058636 (Clockwise)

Preceding gene: 125624826

Following gene: 125624882

Centisome position: 81.35

GC content: 36.74

Gene sequence:

>792_bases
ATGCAAACTATAGGATTTATCGGAGTCGGAAAAATGGCCACAGCTATCATTTCTGGACTTGATAAAAATAAATTTGAAAT
CATCATTTCTGGTCACAATTTACCCAAGACAAAAAAACAAGCTGAGGAACTTGATGTTAAAGCTGCTGAAAATCATGAAG
AACTTGTTCAACAATCAGACTTCATTGTTCTCTCTGTCAAACCACAGGTTCTTCCGTCTGTTTTAAGCCAGCTGATTAAT
CATTTATCAAAAGATAAAACATTGATATCAATTGCTGCTGGATTAACTTTATCTGACTTAAAACATCTAGCTGATTCAGA
AAATCAACCGATTATTCGGGTAATGCCTAATATCAATGCTCAAATCGGTCAATCTACCTCTGCGATTGTCAAAAATGAAT
TTGTTGATGACTCAGCTTACGAAATAGCCCAAAGAATTTTTAATGCAGTCGGCTCTGTCCACGAGATTGCTGAAAAAGAT
TTTTCAACTTTTGCAGCAATCGCTGGATCAAGTCCTGCATTTATTTATATGTTTATTGATGCTATGGCTCGCGCCGGTGT
ACTTCATGGACTTCCTAAAGATCAAGCTACTGCTATTGTTTCTGAAACAGTCAAAGCCTCAGCTGAAATGCTTCTACAGA
GTGGTGAAAATCCTTGGTCTTTAGTTGATAAGGTTTCAAGTCCTGGTGGAACTACTGTAGCAGGTGTAGTAAGCTTAGAA
CAAAACCATTTTGGCGGAACAGTTATTGATGCAATTTCTGCAACAATCGAAAGAGAAAAACATCTTAAATAA

Upstream 100 bases:

>100_bases
TTTTCAAAAAAATAGCTAGATTTAATTTGTGATACTAACATATCGATTTCTCGCTTTAAATTATGATAAAATGGACTGAA
AGATAGAAAGGATTTTATTT

Downstream 100 bases:

>100_bases
ATTTAAAAATCTAAAAAAGAAGAATTTCTTTTTTAGATTTTTAATTTCAAATAATAAAAAAAATGCCAAATGGCATTTTT
TTATTAACGACGAAGTCCCA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MQTIGFIGVGKMATAIISGLDKNKFEIIISGHNLPKTKKQAEELDVKAAENHEELVQQSDFIVLSVKPQVLPSVLSQLIN
HLSKDKTLISIAAGLTLSDLKHLADSENQPIIRVMPNINAQIGQSTSAIVKNEFVDDSAYEIAQRIFNAVGSVHEIAEKD
FSTFAAIAGSSPAFIYMFIDAMARAGVLHGLPKDQATAIVSETVKASAEMLLQSGENPWSLVDKVSSPGGTTVAGVVSLE
QNHFGGTVIDAISATIEREKHLK

Sequences:

>Translated_263_residues
MQTIGFIGVGKMATAIISGLDKNKFEIIISGHNLPKTKKQAEELDVKAAENHEELVQQSDFIVLSVKPQVLPSVLSQLIN
HLSKDKTLISIAAGLTLSDLKHLADSENQPIIRVMPNINAQIGQSTSAIVKNEFVDDSAYEIAQRIFNAVGSVHEIAEKD
FSTFAAIAGSSPAFIYMFIDAMARAGVLHGLPKDQATAIVSETVKASAEMLLQSGENPWSLVDKVSSPGGTTVAGVVSLE
QNHFGGTVIDAISATIEREKHLK
>Mature_263_residues
MQTIGFIGVGKMATAIISGLDKNKFEIIISGHNLPKTKKQAEELDVKAAENHEELVQQSDFIVLSVKPQVLPSVLSQLIN
HLSKDKTLISIAAGLTLSDLKHLADSENQPIIRVMPNINAQIGQSTSAIVKNEFVDDSAYEIAQRIFNAVGSVHEIAEKD
FSTFAAIAGSSPAFIYMFIDAMARAGVLHGLPKDQATAIVSETVKASAEMLLQSGENPWSLVDKVSSPGGTTVAGVVSLE
QNHFGGTVIDAISATIEREKHLK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=29.5454545454545, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI21361454, Length=274, Percent_Identity=30.6569343065693, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI24797095, Length=270, Percent_Identity=30, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI24797097, Length=270, Percent_Identity=30, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1786585, Length=272, Percent_Identity=37.1323529411765, Blast_Score=173, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17569021, Length=265, Percent_Identity=31.6981132075472, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17540664, Length=269, Percent_Identity=35.6877323420074, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320861, Length=273, Percent_Identity=23.4432234432234, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=35.4716981132075, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24648116, Length=273, Percent_Identity=30.7692307692308, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=31.9526627218935, Blast_Score=100, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28157; Mature: 28157

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIGFIGVGKMATAIISGLDKNKFEIIISGHNLPKTKKQAEELDVKAAENHEELVQQSD
CCCCCEEEHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHCCC
FIVLSVKPQVLPSVLSQLINHLSKDKTLISIAAGLTLSDLKHLADSENQPIIRVMPNINA
EEEEEECHHHHHHHHHHHHHHHCCCCCEEHHHHCCCHHHHHHHHCCCCCCEEEECCCCCC
QIGQSTSAIVKNEFVDDSAYEIAQRIFNAVGSVHEIAEKDFSTFAAIAGSSPAFIYMFID
HHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AMARAGVLHGLPKDQATAIVSETVKASAEMLLQSGENPWSLVDKVSSPGGTTVAGVVSLE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEEC
QNHFGGTVIDAISATIEREKHLK
CCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQTIGFIGVGKMATAIISGLDKNKFEIIISGHNLPKTKKQAEELDVKAAENHEELVQQSD
CCCCCEEEHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHCCC
FIVLSVKPQVLPSVLSQLINHLSKDKTLISIAAGLTLSDLKHLADSENQPIIRVMPNINA
EEEEEECHHHHHHHHHHHHHHHCCCCCEEHHHHCCCHHHHHHHHCCCCCCEEEECCCCCC
QIGQSTSAIVKNEFVDDSAYEIAQRIFNAVGSVHEIAEKDFSTFAAIAGSSPAFIYMFID
HHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AMARAGVLHGLPKDQATAIVSETVKASAEMLLQSGENPWSLVDKVSSPGGTTVAGVVSLE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEEC
QNHFGGTVIDAISATIEREKHLK
CCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]