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The map label for this gene is pepC [H]

Identifier: 125624841

GI number: 125624841

Start: 2051813

End: 2053177

Strand: Reverse

Name: pepC [H]

Synonym: llmg_2069

Alternate gene names: 125624841

Gene position: 2053177-2051813 (Counterclockwise)

Preceding gene: 125624842

Following gene: 125624840

Centisome position: 81.17

GC content: 36.92

Gene sequence:

>1365_bases
ATGATTATTTTTATCGAAACTTTTGTCAGAAGTTTCGATTTATTGGGAGGTATTATGACAGTAACATCAGATTTCACACA
AAAACTCTACGAAAATTTTGCTGAAAACACAAAATTGCGTGCGGTGGAAAATGCCGTGACTAAAAATGGTTTGCTTTCAT
CACTCGAAGTGCGTGGTTCACATGCAGCGAATTTGCCTGAGTTTTCACTTGACTTGACAAAAGACCCTGTAACGAATCAA
AAACAATCTGGACGTTGCTGGATGTTTGCTGCTTTGAACACTTTCCGTCATAAATTTATTAATGAATTTAAAACAGAAGA
TTTTGAGTTTTCACAAGCTTATACTTTCTTCTGGGATAAATATGAAAAATCAAACTGGTTTATGGAACAAATTATAGGAG
ATGTTGCGATGGACGACCGTCGTTTGAAATTCCTCTTGCAAACTCCACAACAAGATGGTGGTCAATGGGATATGATGGTA
GCCATTTTTGACAAATATGGAATTGTTCCAAAAGCTGTTTATCCTGAATCACAAGCTTCAAGTAGCTCACGTGAATTGAA
TCAATACTTGAACAAATTGCTCCGACAAGATGCTGAAATCTTACGTTATACAATTGAGCAAGACGGTGATGTTCAAGCGG
TCAAAGAAGAACTTTTACAAGAAGTTTTTAATTTCCTTGCTGTAACTCTAGGTTTGCCACCACAAAATTTTGAATTTGCT
TTCCGAAACAAAGATAATGAATACAAAAAATTTGTTGGAACACCAAAAGAATTCTACAATGAATATGTTGGAATTGATTT
GAACAATTATGTTTCGGTCATTAATGCTCCAACTGCTGATAAACCTTATAACAAAAGCTATACCGTTGAATTTCTTGGCA
ATGTAGTCGGTGGTAAAGAAGTCAAACACTTGAACGTTGAAATGGACCGTTTCAAAAAATTGGCTATTGCCCAAATGCAA
GCGGGTGAAACTGTCTGGTTTGGTTGTGATGTTGGTCAGGAATCAAACCGTTCAGCAGGACTTTTGACAATGGATTCTTA
TGATTTTAAATCTTCATTGGATATTGAATTCACACAAAGTAAGGCTGGGCGTCTTGACTATGGCGAATCACTGATGACTC
ATGCCATGGTTTTAGCGGGTGTTGATTTAGATGCTGACGGAAATTCAACTAAATGGAAAGTTGAAAATTCTTGGGGTAAA
GATGCCGGTCAAAAAGGATATTTCGTTGCTTCTGATGAATGGATGGATGAATATACTTATCAAATTGTTGTCCGCAAAGA
CCTTTTAAGCGAAGAAGAATTAGCTGCTTATGAAGCAAAACCTCAAGTTCTGCTTCCATGGGATCCAATGGGAGCCTTGG
CTTAA

Upstream 100 bases:

>100_bases
AAGATTTAGAAAATCAGCTTTCCTAGCTGATTTTTTTGATAATTTAGATTATAATAGAAGAATGTAAAAAATAATAGAAT
ATCATTAATCAAAATCGATA

Downstream 100 bases:

>100_bases
TTTGTAAATTGAAACATTTAACTTTTGTTAAATGTTTTTTTATTGACTTAAAGTTCACTTCAAGTGTTAAAATAAAAGAA
TGAATATAAAAAAGGCCGCC

Product: PepC protein

Products: NA

Alternate protein names: Bleomycin hydrolase [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MIIFIETFVRSFDLLGGIMTVTSDFTQKLYENFAENTKLRAVENAVTKNGLLSSLEVRGSHAANLPEFSLDLTKDPVTNQ
KQSGRCWMFAALNTFRHKFINEFKTEDFEFSQAYTFFWDKYEKSNWFMEQIIGDVAMDDRRLKFLLQTPQQDGGQWDMMV
AIFDKYGIVPKAVYPESQASSSSRELNQYLNKLLRQDAEILRYTIEQDGDVQAVKEELLQEVFNFLAVTLGLPPQNFEFA
FRNKDNEYKKFVGTPKEFYNEYVGIDLNNYVSVINAPTADKPYNKSYTVEFLGNVVGGKEVKHLNVEMDRFKKLAIAQMQ
AGETVWFGCDVGQESNRSAGLLTMDSYDFKSSLDIEFTQSKAGRLDYGESLMTHAMVLAGVDLDADGNSTKWKVENSWGK
DAGQKGYFVASDEWMDEYTYQIVVRKDLLSEEELAAYEAKPQVLLPWDPMGALA

Sequences:

>Translated_454_residues
MIIFIETFVRSFDLLGGIMTVTSDFTQKLYENFAENTKLRAVENAVTKNGLLSSLEVRGSHAANLPEFSLDLTKDPVTNQ
KQSGRCWMFAALNTFRHKFINEFKTEDFEFSQAYTFFWDKYEKSNWFMEQIIGDVAMDDRRLKFLLQTPQQDGGQWDMMV
AIFDKYGIVPKAVYPESQASSSSRELNQYLNKLLRQDAEILRYTIEQDGDVQAVKEELLQEVFNFLAVTLGLPPQNFEFA
FRNKDNEYKKFVGTPKEFYNEYVGIDLNNYVSVINAPTADKPYNKSYTVEFLGNVVGGKEVKHLNVEMDRFKKLAIAQMQ
AGETVWFGCDVGQESNRSAGLLTMDSYDFKSSLDIEFTQSKAGRLDYGESLMTHAMVLAGVDLDADGNSTKWKVENSWGK
DAGQKGYFVASDEWMDEYTYQIVVRKDLLSEEELAAYEAKPQVLLPWDPMGALA
>Mature_454_residues
MIIFIETFVRSFDLLGGIMTVTSDFTQKLYENFAENTKLRAVENAVTKNGLLSSLEVRGSHAANLPEFSLDLTKDPVTNQ
KQSGRCWMFAALNTFRHKFINEFKTEDFEFSQAYTFFWDKYEKSNWFMEQIIGDVAMDDRRLKFLLQTPQQDGGQWDMMV
AIFDKYGIVPKAVYPESQASSSSRELNQYLNKLLRQDAEILRYTIEQDGDVQAVKEELLQEVFNFLAVTLGLPPQNFEFA
FRNKDNEYKKFVGTPKEFYNEYVGIDLNNYVSVINAPTADKPYNKSYTVEFLGNVVGGKEVKHLNVEMDRFKKLAIAQMQ
AGETVWFGCDVGQESNRSAGLLTMDSYDFKSSLDIEFTQSKAGRLDYGESLMTHAMVLAGVDLDADGNSTKWKVENSWGK
DAGQKGYFVASDEWMDEYTYQIVVRKDLLSEEELAAYEAKPQVLLPWDPMGALA

Specific function: Hydrolyzes naphthylamide-substituted amino acids as well as di- and tripeptides in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin and vasopressin. Has also a bleomycin hydrolase activity [H]

COG id: COG3579

COG function: function code E; Aminopeptidase C

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C1 family [H]

Homologues:

Organism=Homo sapiens, GI4557367, Length=451, Percent_Identity=39.9113082039911, Blast_Score=352, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6324090, Length=394, Percent_Identity=36.8020304568528, Blast_Score=283, Evalue=6e-77,
Organism=Drosophila melanogaster, GI24640588, Length=453, Percent_Identity=36.644591611479, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI161077632, Length=453, Percent_Identity=36.644591611479, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI161077630, Length=368, Percent_Identity=38.0434782608696, Blast_Score=271, Evalue=6e-73,
Organism=Drosophila melanogaster, GI20130175, Length=385, Percent_Identity=28.3116883116883, Blast_Score=157, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000169
- InterPro:   IPR004134 [H]

Pfam domain/function: PF03051 Peptidase_C1_2 [H]

EC number: =3.4.22.40 [H]

Molecular weight: Translated: 51881; Mature: 51881

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00139 THIOL_PROTEASE_CYS ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIFIETFVRSFDLLGGIMTVTSDFTQKLYENFAENTKLRAVENAVTKNGLLSSLEVRGS
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHEECCC
HAANLPEFSLDLTKDPVTNQKQSGRCWMFAALNTFRHKFINEFKTEDFEFSQAYTFFWDK
CCCCCCCCEEECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
YEKSNWFMEQIIGDVAMDDRRLKFLLQTPQQDGGQWDMMVAIFDKYGIVPKAVYPESQAS
HCCCHHHHHHHHHHHCCCCHHHHHEEECCCCCCCCEEEEEEEEHHCCCCCCCCCCCCCCC
SSSRELNQYLNKLLRQDAEILRYTIEQDGDVQAVKEELLQEVFNFLAVTLGLPPQNFEFA
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
FRNKDNEYKKFVGTPKEFYNEYVGIDLNNYVSVINAPTADKPYNKSYTVEFLGNVVGGKE
ECCCCCHHHHHCCCHHHHHHHHCCCCHHHHEEEEECCCCCCCCCCCCHHHHHHHHCCCCC
VKHLNVEMDRFKKLAIAQMQAGETVWFGCDVGQESNRSAGLLTMDSYDFKSSLDIEFTQS
EEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEECC
KAGRLDYGESLMTHAMVLAGVDLDADGNSTKWKVENSWGKDAGQKGYFVASDEWMDEYTY
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCEEEECHHHHHHHHE
QIVVRKDLLSEEELAAYEAKPQVLLPWDPMGALA
EEEEEHHHCCHHHHHHHCCCCCEEECCCCCCCCC
>Mature Secondary Structure
MIIFIETFVRSFDLLGGIMTVTSDFTQKLYENFAENTKLRAVENAVTKNGLLSSLEVRGS
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHEECCC
HAANLPEFSLDLTKDPVTNQKQSGRCWMFAALNTFRHKFINEFKTEDFEFSQAYTFFWDK
CCCCCCCCEEECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
YEKSNWFMEQIIGDVAMDDRRLKFLLQTPQQDGGQWDMMVAIFDKYGIVPKAVYPESQAS
HCCCHHHHHHHHHHHCCCCHHHHHEEECCCCCCCCEEEEEEEEHHCCCCCCCCCCCCCCC
SSSRELNQYLNKLLRQDAEILRYTIEQDGDVQAVKEELLQEVFNFLAVTLGLPPQNFEFA
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
FRNKDNEYKKFVGTPKEFYNEYVGIDLNNYVSVINAPTADKPYNKSYTVEFLGNVVGGKE
ECCCCCHHHHHCCCHHHHHHHHCCCCHHHHEEEEECCCCCCCCCCCCHHHHHHHHCCCCC
VKHLNVEMDRFKKLAIAQMQAGETVWFGCDVGQESNRSAGLLTMDSYDFKSSLDIEFTQS
EEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEECC
KAGRLDYGESLMTHAMVLAGVDLDADGNSTKWKVENSWGKDAGQKGYFVASDEWMDEYTY
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCEEEECHHHHHHHHE
QIVVRKDLLSEEELAAYEAKPQVLLPWDPMGALA
EEEEEHHHCCHHHHHHHCCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]