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The map label for this gene is adhA [H]

Identifier: 125624768

GI number: 125624768

Start: 1978043

End: 1979065

Strand: Reverse

Name: adhA [H]

Synonym: llmg_1991

Alternate gene names: 125624768

Gene position: 1979065-1978043 (Counterclockwise)

Preceding gene: 125624770

Following gene: 125624767

Centisome position: 78.24

GC content: 40.66

Gene sequence:

>1023_bases
ATGAAAGCAGCAGTAGTACGGCAAAATCCGGATGGCTATGCGGATGTTGTTGAAAAGGAACTTCGGATGATTAAGCCCAA
TGAAGCTTTACTCGACATGGAATATTGTGGAGTCTGTCATACAGACTTGCATGTAGCAGCAGGCGATTATGGCAACAAAG
CTGGAACGGTCCTTGGTCATGAAGGAATCGGTATTGTCAAAGAAATTGGTAGTGAAGTCACTTCCTTAAAAGTTGGAGAT
CGCGTGTCAGTCGCTTGGTTTTTCGAAGGATGTGGGCATTGCGAATACTGTGTTTCTGGTAATGAAACTTTTTGTCGAGA
GGTCAAAAATGCTGGTTATTCAGTTGACGGTGGAATGGCCGAACAAGCGATTGTAACAGCTGATTATGCGGTAAAAGTTC
CAGAGGGACTTGATCCTATTGAAGCAAGTTCAATCACTTGTGCTGGAGTTACGACTTACAAAGCAATCAAGGTTTCTGGA
GTTAAGCCAGGAGATTGGCAAGTCATCTTTGGTGCCGGTGGACTAGGTAATCTAGCTATTCAATACGCTAAAAATTTTTT
TGGGGCAAAAGTAATTGCAGTTGATATTAATCAAGATAAATTAGACTTAGCTAAAAAAATTGGTGCAGATGTGATTATCA
ATTCTGGTGAAGTCAATCCAATTGATGAAATAAAAAAAATCACTGGTGGTTTAGGAGCACAAAGTGCTGTTGTTTGCGCC
GTTGCAAGAATAGCATTTGAACAAGCAGTCGCTTCTTTGAAACCAATGGGTAAAATGGTTGCGGTGGCACTGCCTAATAC
CGAAATGACTTTGTCTGTTCCGACAGTTGTTTTTGATGGTGTGGAAGTTGCTGGCTCACTTGTTGGAACAAGACTTGATT
TAGCAGAAGCATTTCAATTTGGTGCTGAAGGTAAAGTCAAACCAATTGTTGCGACACGCAAGCTTGAAGAAATCAATGAG
ATTATTGATGAAATGAAAGCAGGAAAAATTGAAGGCCGGATGGTCATTGATTTTACTAAATAA

Upstream 100 bases:

>100_bases
TTTTTTTGCTACTTTAATGATACAAAACGAGGTGAAAAGTGTTATAATAAATTAAAAAGAATGCGTTTACAAAAATATAA
TATATAGAGGAGACTTTCTT

Downstream 100 bases:

>100_bases
AATAAAAAGAGGCGATACAGATGAATTCAAAGGATTTAGTCAACTATTCAAGTGATGAATTTAACAATCTTTCGCAATTT
CAACAAGAAGAAATTACAAA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKAAVVRQNPDGYADVVEKELRMIKPNEALLDMEYCGVCHTDLHVAAGDYGNKAGTVLGHEGIGIVKEIGSEVTSLKVGD
RVSVAWFFEGCGHCEYCVSGNETFCREVKNAGYSVDGGMAEQAIVTADYAVKVPEGLDPIEASSITCAGVTTYKAIKVSG
VKPGDWQVIFGAGGLGNLAIQYAKNFFGAKVIAVDINQDKLDLAKKIGADVIINSGEVNPIDEIKKITGGLGAQSAVVCA
VARIAFEQAVASLKPMGKMVAVALPNTEMTLSVPTVVFDGVEVAGSLVGTRLDLAEAFQFGAEGKVKPIVATRKLEEINE
IIDEMKAGKIEGRMVIDFTK

Sequences:

>Translated_340_residues
MKAAVVRQNPDGYADVVEKELRMIKPNEALLDMEYCGVCHTDLHVAAGDYGNKAGTVLGHEGIGIVKEIGSEVTSLKVGD
RVSVAWFFEGCGHCEYCVSGNETFCREVKNAGYSVDGGMAEQAIVTADYAVKVPEGLDPIEASSITCAGVTTYKAIKVSG
VKPGDWQVIFGAGGLGNLAIQYAKNFFGAKVIAVDINQDKLDLAKKIGADVIINSGEVNPIDEIKKITGGLGAQSAVVCA
VARIAFEQAVASLKPMGKMVAVALPNTEMTLSVPTVVFDGVEVAGSLVGTRLDLAEAFQFGAEGKVKPIVATRKLEEINE
IIDEMKAGKIEGRMVIDFTK
>Mature_340_residues
MKAAVVRQNPDGYADVVEKELRMIKPNEALLDMEYCGVCHTDLHVAAGDYGNKAGTVLGHEGIGIVKEIGSEVTSLKVGD
RVSVAWFFEGCGHCEYCVSGNETFCREVKNAGYSVDGGMAEQAIVTADYAVKVPEGLDPIEASSITCAGVTTYKAIKVSG
VKPGDWQVIFGAGGLGNLAIQYAKNFFGAKVIAVDINQDKLDLAKKIGADVIINSGEVNPIDEIKKITGGLGAQSAVVCA
VARIAFEQAVASLKPMGKMVAVALPNTEMTLSVPTVVFDGVEVAGSLVGTRLDLAEAFQFGAEGKVKPIVATRKLEEINE
IIDEMKAGKIEGRMVIDFTK

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=375, Percent_Identity=29.3333333333333, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4501933, Length=368, Percent_Identity=28.804347826087, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI4501929, Length=364, Percent_Identity=28.8461538461538, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI156627571, Length=316, Percent_Identity=28.4810126582279, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI71743840, Length=355, Percent_Identity=25.9154929577465, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI262073058, Length=355, Percent_Identity=25.9154929577465, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI71565154, Length=231, Percent_Identity=30.3030303030303, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI156523966, Length=359, Percent_Identity=25.9052924791086, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=25.9052924791086, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71565152, Length=252, Percent_Identity=26.984126984127, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI194239674, Length=324, Percent_Identity=24.6913580246914, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI13236495, Length=324, Percent_Identity=24.6913580246914, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87081918, Length=338, Percent_Identity=63.3136094674556, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI87082401, Length=334, Percent_Identity=26.0479041916168, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1786518, Length=325, Percent_Identity=28.9230769230769, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790045, Length=324, Percent_Identity=26.5432098765432, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788073, Length=260, Percent_Identity=28.4615384615385, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1788075, Length=321, Percent_Identity=24.9221183800623, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787863, Length=351, Percent_Identity=26.7806267806268, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786552, Length=362, Percent_Identity=29.2817679558011, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87082125, Length=358, Percent_Identity=26.536312849162, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI226510992, Length=292, Percent_Identity=26.7123287671233, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790718, Length=197, Percent_Identity=30.9644670050761, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1788407, Length=220, Percent_Identity=30.4545454545455, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790485, Length=239, Percent_Identity=29.2887029288703, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=327, Percent_Identity=36.085626911315, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17562584, Length=343, Percent_Identity=34.1107871720117, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17562582, Length=318, Percent_Identity=37.7358490566038, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17562876, Length=248, Percent_Identity=33.0645161290323, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17562878, Length=239, Percent_Identity=30.9623430962343, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17565904, Length=218, Percent_Identity=29.8165137614679, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=219, Percent_Identity=30.1369863013699, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=209, Percent_Identity=30.622009569378, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507255, Length=332, Percent_Identity=25.3012048192771, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323729, Length=321, Percent_Identity=39.2523364485981, Blast_Score=212, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6323961, Length=321, Percent_Identity=38.3177570093458, Blast_Score=203, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6319621, Length=344, Percent_Identity=36.046511627907, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324486, Length=329, Percent_Identity=37.3860182370821, Blast_Score=196, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6319949, Length=323, Percent_Identity=26.625386996904, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6323980, Length=319, Percent_Identity=29.7805642633229, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6322619, Length=321, Percent_Identity=29.2834890965732, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=321, Percent_Identity=29.2834890965732, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=217, Percent_Identity=33.1797235023041, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=307, Percent_Identity=28.0130293159609, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319258, Length=267, Percent_Identity=27.3408239700375, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=324, Percent_Identity=26.8518518518519, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6319520, Length=257, Percent_Identity=27.6264591439689, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737897, Length=197, Percent_Identity=30.4568527918782, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17137530, Length=197, Percent_Identity=30.4568527918782, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17737895, Length=219, Percent_Identity=31.5068493150685, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35922; Mature: 35922

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVVRQNPDGYADVVEKELRMIKPNEALLDMEYCGVCHTDLHVAAGDYGNKAGTVLGH
CCCEEEECCCCCHHHHHHHHHHHCCCCHHEEEHHHHCCCCCCEEEEECCCCCCCCEEECC
EGIGIVKEIGSEVTSLKVGDRVSVAWFFEGCGHCEYCVSGNETFCREVKNAGYSVDGGMA
CCCHHHHHHCCHHHEEECCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHCCCCCCCCCC
EQAIVTADYAVKVPEGLDPIEASSITCAGVTTYKAIKVSGVKPGDWQVIFGAGGLGNLAI
CCEEEEECEEEECCCCCCCCCCCCEEEECEEEEEEEEECCCCCCCCEEEEECCCHHHHHH
QYAKNFFGAKVIAVDINQDKLDLAKKIGADVIINSGEVNPIDEIKKITGGLGAQSAVVCA
HHHHHHCCCEEEEEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHH
VARIAFEQAVASLKPMGKMVAVALPNTEMTLSVPTVVFDGVEVAGSLVGTRLDLAEAFQF
HHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECHHEECCHHHHHHHHHHHHHHHHHHHC
GAEGKVKPIVATRKLEEINEIIDEMKAGKIEGRMVIDFTK
CCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKAAVVRQNPDGYADVVEKELRMIKPNEALLDMEYCGVCHTDLHVAAGDYGNKAGTVLGH
CCCEEEECCCCCHHHHHHHHHHHCCCCHHEEEHHHHCCCCCCEEEEECCCCCCCCEEECC
EGIGIVKEIGSEVTSLKVGDRVSVAWFFEGCGHCEYCVSGNETFCREVKNAGYSVDGGMA
CCCHHHHHHCCHHHEEECCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHCCCCCCCCCC
EQAIVTADYAVKVPEGLDPIEASSITCAGVTTYKAIKVSGVKPGDWQVIFGAGGLGNLAI
CCEEEEECEEEECCCCCCCCCCCCEEEECEEEEEEEEECCCCCCCCEEEEECCCHHHHHH
QYAKNFFGAKVIAVDINQDKLDLAKKIGADVIINSGEVNPIDEIKKITGGLGAQSAVVCA
HHHHHHCCCEEEEEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHH
VARIAFEQAVASLKPMGKMVAVALPNTEMTLSVPTVVFDGVEVAGSLVGTRLDLAEAFQF
HHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECHHEECCHHHHHHHHHHHHHHHHHHHC
GAEGKVKPIVATRKLEEINEIIDEMKAGKIEGRMVIDFTK
CCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA