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The map label for this gene is qor [C]

Identifier: 125624639

GI number: 125624639

Start: 1829375

End: 1830361

Strand: Direct

Name: qor [C]

Synonym: llmg_1850

Alternate gene names: 125624639

Gene position: 1829375-1830361 (Clockwise)

Preceding gene: 125624631

Following gene: 125624641

Centisome position: 72.32

GC content: 37.79

Gene sequence:

>987_bases
ATGAAAGCAATCGGAACAGTTGACTCTGGTCGAAATTTTATTGACTTTGAAATAGAAAAGCCAATCTTAAGACCGCATGA
TTTACTAATTAAAGTTGAAGCCATTTCAATCAATCCTGTCGATACAAAAGTTCGAAAATCAATCAAAGGGACACTAACTC
AGCCAAAAATTCTTGGTTGGGATGGATTGGGAACTGTGGTCGAAGTTGGCAGTCAAAGCAAATTTTTTAAAGTTGGAGAT
TCTGTTTTTTGGGCTGGAGATGTCACACGAGCGGGTTCAAACGCTGAATTTCAGGCAGTTGATGAACGAATTGTTGGCTT
TGCTCCTAAAAACCTGTCCAAAGAAAAAGCCGTCGCCATGCCTCTAACAAGTTTAACAGCTTATGAACTTCTTTTTGAAA
AACTTCAAGTTACCAGTGAGTCAAAAGGGAAGTCAATTCTTATCATTAATGGCGCAGGTGGCGTCGGTTCAGTAGCAACT
CAAATGGCCAAAAATTCAGGATTGACAGTAATTGCTACAGCATCAAATCCCCAAGCCATTGAATGGGTCAAGAATTTTGG
CGCCGATTATACCGTCAATCATCATGAAAATCTGGTGCCTCAAGTTCATGAGCTTGGCTTTAAGTTTGTTGATTATATTT
TAATTTTAAATGCTGTTGTTGAACATATGCCTGCAGTAAATGAGTTAATTGCTCCTCAAGGTTCGATTGCAAATATTGTT
GAACCAGGGCAAGCTATTAATTTAGATAAACTGGCTCATAAATCTGCTCGTTTTAACTTTGAGTGGATGTTTACTAAAGT
GGTTTCAGACACTGATGATTTACAAAGTCAGCATGACATATTAAATCAAGTTTCTGAATGGCTAGATAATGGCACTCTTA
CAAGCACAATGACTCAAAATTTAGGTGCTCTTACTGCTGACAATGTTAGAAAAGCTCATGAGCTTATTGAAGAAAATCAT
ACCATCGGAAAAATTGTCCTCACTTGA

Upstream 100 bases:

>100_bases
AAATTTTTAATGTTGTGATGAAAATATATAATATTAAATTCAAGTGATTGACTTAGGAGTCACACTGGTATACACTTTTA
CTTATAAGTGAGGTAGAAAA

Downstream 100 bases:

>100_bases
ACAAAAAAATCCTCATTTTTGAGGATTTTTAAATTTCATCAAAACGAACAATTAAATAAACTGCCCCTATCATGAAAGTG
GAGCCCATCATTGTCCAACT

Product: quinone oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MKAIGTVDSGRNFIDFEIEKPILRPHDLLIKVEAISINPVDTKVRKSIKGTLTQPKILGWDGLGTVVEVGSQSKFFKVGD
SVFWAGDVTRAGSNAEFQAVDERIVGFAPKNLSKEKAVAMPLTSLTAYELLFEKLQVTSESKGKSILIINGAGGVGSVAT
QMAKNSGLTVIATASNPQAIEWVKNFGADYTVNHHENLVPQVHELGFKFVDYILILNAVVEHMPAVNELIAPQGSIANIV
EPGQAINLDKLAHKSARFNFEWMFTKVVSDTDDLQSQHDILNQVSEWLDNGTLTSTMTQNLGALTADNVRKAHELIEENH
TIGKIVLT

Sequences:

>Translated_328_residues
MKAIGTVDSGRNFIDFEIEKPILRPHDLLIKVEAISINPVDTKVRKSIKGTLTQPKILGWDGLGTVVEVGSQSKFFKVGD
SVFWAGDVTRAGSNAEFQAVDERIVGFAPKNLSKEKAVAMPLTSLTAYELLFEKLQVTSESKGKSILIINGAGGVGSVAT
QMAKNSGLTVIATASNPQAIEWVKNFGADYTVNHHENLVPQVHELGFKFVDYILILNAVVEHMPAVNELIAPQGSIANIV
EPGQAINLDKLAHKSARFNFEWMFTKVVSDTDDLQSQHDILNQVSEWLDNGTLTSTMTQNLGALTADNVRKAHELIEENH
TIGKIVLT
>Mature_328_residues
MKAIGTVDSGRNFIDFEIEKPILRPHDLLIKVEAISINPVDTKVRKSIKGTLTQPKILGWDGLGTVVEVGSQSKFFKVGD
SVFWAGDVTRAGSNAEFQAVDERIVGFAPKNLSKEKAVAMPLTSLTAYELLFEKLQVTSESKGKSILIINGAGGVGSVAT
QMAKNSGLTVIATASNPQAIEWVKNFGADYTVNHHENLVPQVHELGFKFVDYILILNAVVEHMPAVNELIAPQGSIANIV
EPGQAINLDKLAHKSARFNFEWMFTKVVSDTDDLQSQHDILNQVSEWLDNGTLTSTMTQNLGALTADNVRKAHELIEENH
TIGKIVLT

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=204, Percent_Identity=31.8627450980392, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI13236495, Length=204, Percent_Identity=31.8627450980392, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI194239676, Length=197, Percent_Identity=31.4720812182741, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI47519420, Length=349, Percent_Identity=25.214899713467, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1790485, Length=184, Percent_Identity=32.6086956521739, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17507255, Length=230, Percent_Identity=32.6086956521739, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71987554, Length=355, Percent_Identity=24.2253521126761, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319520, Length=199, Percent_Identity=31.1557788944724, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35771; Mature: 35771

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIGTVDSGRNFIDFEIEKPILRPHDLLIKVEAISINPVDTKVRKSIKGTLTQPKILGW
CCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEEEECCCHHHHHHHHHCCCCCCEEECC
DGLGTVVEVGSQSKFFKVGDSVFWAGDVTRAGSNAEFQAVDERIVGFAPKNLSKEKAVAM
CCCCHHHHCCCCCCEEEECCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHC
PLTSLTAYELLFEKLQVTSESKGKSILIINGAGGVGSVATQMAKNSGLTVIATASNPQAI
CHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCHHH
EWVKNFGADYTVNHHENLVPQVHELGFKFVDYILILNAVVEHMPAVNELIAPQGSIANIV
HHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHC
EPGQAINLDKLAHKSARFNFEWMFTKVVSDTDDLQSQHDILNQVSEWLDNGTLTSTMTQN
CCCCCCCHHHHHHHHHCCCEEEEEEEHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LGALTADNVRKAHELIEENHTIGKIVLT
CCCCCHHHHHHHHHHHHCCCCEEEEEEC
>Mature Secondary Structure
MKAIGTVDSGRNFIDFEIEKPILRPHDLLIKVEAISINPVDTKVRKSIKGTLTQPKILGW
CCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEEEECCCHHHHHHHHHCCCCCCEEECC
DGLGTVVEVGSQSKFFKVGDSVFWAGDVTRAGSNAEFQAVDERIVGFAPKNLSKEKAVAM
CCCCHHHHCCCCCCEEEECCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHC
PLTSLTAYELLFEKLQVTSESKGKSILIINGAGGVGSVATQMAKNSGLTVIATASNPQAI
CHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCHHH
EWVKNFGADYTVNHHENLVPQVHELGFKFVDYILILNAVVEHMPAVNELIAPQGSIANIV
HHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHC
EPGQAINLDKLAHKSARFNFEWMFTKVVSDTDDLQSQHDILNQVSEWLDNGTLTSTMTQN
CCCCCCCHHHHHHHHHCCCEEEEEEEHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LGALTADNVRKAHELIEENHTIGKIVLT
CCCCCHHHHHHHHHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]