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The map label for this gene is menB [H]

Identifier: 125624620

GI number: 125624620

Start: 1811711

End: 1812553

Strand: Direct

Name: menB [H]

Synonym: llmg_1831

Alternate gene names: 125624620

Gene position: 1811711-1812553 (Clockwise)

Preceding gene: 125624619

Following gene: 125624621

Centisome position: 71.62

GC content: 42.47

Gene sequence:

>843_bases
ATGTCAAAATTTAACTGGGTTGCCCTTAATCGTAACTACGAAGATATTATTTATGAAACTTATAATGGAATTGCTAAGAT
TACCATTAATCGTCCTGAAGTTCGCAATGCTTTTCGTCCAAAAACAGTCGTTGAAATGATTGACGCTTTTAGTATTGCAC
GTGATGACACAAATGTCGGTGTCATTATTTTAACCGGTGCTAATCATGGCAAAGGTGAAGATAAAGAAGCCTTTTGTTCT
GGTGGCGACCAAAAAGTTCGTGGAAATGGTGGTTATGTTGGTGAAGACCAAATTCCTCGTTTGAATGTTTTAGATTTACA
ACATTTGATTCGGATTACGCCAAAACCTGTTATTGCCATGGTCAATGGTTTTGCCATCGGCGGAGGTCATGTTTTACATA
TCGTTTGTGACTTGACCATCGCTTCTGAAAATGCTAAATTCGGACAAACTGGTCCACGTGTTGGTTCATTTGATGCTGGT
TATGGTGCTGGTTTGCTGGCGGCCATGGTTGGTCAAAAGAAAGCGCGTGAAATCTGGTTCCTCTGCCGTCAATATACTGC
CAAAGAAGCAATGGACATGGGCATGGTCAATACAGTTGTACCTTTTGACCGTCTTGAAGAAGAAACTGTTCAATGGGCCG
AAGAAATGCTCGCCCTCTCACCAATGGCCCTCCGTATGCTCAAAGGTTCAATGAATGCAGCGACTGACGGACTTGCTGGA
CTGCAACAATTTGCGGGAGACGCAACACTCATGTTCTATACCACTGATGAAGCCAAAGAAGGGCGCGACGCTTTCAAAGA
AAAACGCAAACCTGATTTTGACCAATTTCCAAAATTCCCATAA

Upstream 100 bases:

>100_bases
ATGAAAATAGATAAAATGGAACCTGGGCGGTGCCCAGAACCTCATTTTTCTAATTTTCATAACTTCTAAACGCTCGCCCT
CACATCTTAAAGGAGAAATC

Downstream 100 bases:

>100_bases
ACTTTTTAAAAATTGCTGATAAAGCGTCATTTTGGCGCTTTTTGTGATTTAAAGTTACTGACAGCTTTTTAAAATTATGA
AAAATTACTGACAAGATTTC

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MSKFNWVALNRNYEDIIYETYNGIAKITINRPEVRNAFRPKTVVEMIDAFSIARDDTNVGVIILTGANHGKGEDKEAFCS
GGDQKVRGNGGYVGEDQIPRLNVLDLQHLIRITPKPVIAMVNGFAIGGGHVLHIVCDLTIASENAKFGQTGPRVGSFDAG
YGAGLLAAMVGQKKAREIWFLCRQYTAKEAMDMGMVNTVVPFDRLEEETVQWAEEMLALSPMALRMLKGSMNAATDGLAG
LQQFAGDATLMFYTTDEAKEGRDAFKEKRKPDFDQFPKFP

Sequences:

>Translated_280_residues
MSKFNWVALNRNYEDIIYETYNGIAKITINRPEVRNAFRPKTVVEMIDAFSIARDDTNVGVIILTGANHGKGEDKEAFCS
GGDQKVRGNGGYVGEDQIPRLNVLDLQHLIRITPKPVIAMVNGFAIGGGHVLHIVCDLTIASENAKFGQTGPRVGSFDAG
YGAGLLAAMVGQKKAREIWFLCRQYTAKEAMDMGMVNTVVPFDRLEEETVQWAEEMLALSPMALRMLKGSMNAATDGLAG
LQQFAGDATLMFYTTDEAKEGRDAFKEKRKPDFDQFPKFP
>Mature_279_residues
SKFNWVALNRNYEDIIYETYNGIAKITINRPEVRNAFRPKTVVEMIDAFSIARDDTNVGVIILTGANHGKGEDKEAFCSG
GDQKVRGNGGYVGEDQIPRLNVLDLQHLIRITPKPVIAMVNGFAIGGGHVLHIVCDLTIASENAKFGQTGPRVGSFDAGY
GAGLLAAMVGQKKAREIWFLCRQYTAKEAMDMGMVNTVVPFDRLEEETVQWAEEMLALSPMALRMLKGSMNAATDGLAGL
QQFAGDATLMFYTTDEAKEGRDAFKEKRKPDFDQFPKFP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=268, Percent_Identity=33.5820895522388, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI31542718, Length=267, Percent_Identity=28.8389513108614, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI45643119, Length=221, Percent_Identity=27.1493212669683, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI260275230, Length=221, Percent_Identity=27.1493212669683, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI260274832, Length=221, Percent_Identity=27.1493212669683, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4502327, Length=269, Percent_Identity=28.2527881040892, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4757966, Length=224, Percent_Identity=25.4464285714286, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI51538581, Length=224, Percent_Identity=25.4464285714286, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI25453481, Length=224, Percent_Identity=25.4464285714286, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI51538573, Length=224, Percent_Identity=25.4464285714286, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788597, Length=277, Percent_Identity=63.5379061371841, Blast_Score=360, Evalue=1e-101,
Organism=Escherichia coli, GI1787659, Length=263, Percent_Identity=30.7984790874525, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI221142681, Length=265, Percent_Identity=30.188679245283, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI87082183, Length=270, Percent_Identity=27.4074074074074, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787660, Length=267, Percent_Identity=29.2134831460674, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=254, Percent_Identity=32.2834645669291, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25145438, Length=253, Percent_Identity=32.4110671936759, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17540714, Length=232, Percent_Identity=27.5862068965517, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17549921, Length=224, Percent_Identity=25.8928571428571, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17560910, Length=197, Percent_Identity=28.9340101522843, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535521, Length=209, Percent_Identity=25.3588516746411, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20129971, Length=277, Percent_Identity=31.7689530685921, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653477, Length=277, Percent_Identity=31.7689530685921, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653139, Length=258, Percent_Identity=29.4573643410853, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21357171, Length=195, Percent_Identity=30.2564102564103, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI19922422, Length=266, Percent_Identity=24.4360902255639, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24650670, Length=193, Percent_Identity=31.0880829015544, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 30895; Mature: 30764

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFNWVALNRNYEDIIYETYNGIAKITINRPEVRNAFRPKTVVEMIDAFSIARDDTNVG
CCCCEEEEECCCHHHHHHHHCCCEEEEEECCHHHHHCCCHHHHHHHHHHHHHHCCCCCEE
VIILTGANHGKGEDKEAFCSGGDQKVRGNGGYVGEDQIPRLNVLDLQHLIRITPKPVIAM
EEEEECCCCCCCCCCHHHHCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCHHEEE
VNGFAIGGGHVLHIVCDLTIASENAKFGQTGPRVGSFDAGYGAGLLAAMVGQKKAREIWF
ECCEEECCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHH
LCRQYTAKEAMDMGMVNTVVPFDRLEEETVQWAEEMLALSPMALRMLKGSMNAATDGLAG
HHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LQQFAGDATLMFYTTDEAKEGRDAFKEKRKPDFDQFPKFP
HHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHCCCCC
>Mature Secondary Structure 
SKFNWVALNRNYEDIIYETYNGIAKITINRPEVRNAFRPKTVVEMIDAFSIARDDTNVG
CCCEEEEECCCHHHHHHHHCCCEEEEEECCHHHHHCCCHHHHHHHHHHHHHHCCCCCEE
VIILTGANHGKGEDKEAFCSGGDQKVRGNGGYVGEDQIPRLNVLDLQHLIRITPKPVIAM
EEEEECCCCCCCCCCHHHHCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCHHEEE
VNGFAIGGGHVLHIVCDLTIASENAKFGQTGPRVGSFDAGYGAGLLAAMVGQKKAREIWF
ECCEEECCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHH
LCRQYTAKEAMDMGMVNTVVPFDRLEEETVQWAEEMLALSPMALRMLKGSMNAATDGLAG
HHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LQQFAGDATLMFYTTDEAKEGRDAFKEKRKPDFDQFPKFP
HHHHCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]