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The map label for this gene is lrgB [H]

Identifier: 125624588

GI number: 125624588

Start: 1776656

End: 1777354

Strand: Direct

Name: lrgB [H]

Synonym: llmg_1799

Alternate gene names: 125624588

Gene position: 1776656-1777354 (Clockwise)

Preceding gene: 125624587

Following gene: 125624607

Centisome position: 70.24

GC content: 40.77

Gene sequence:

>699_bases
ATGAATATTATCACTACTGACCCACTCTTTGGCTTTGTCCTTACCGTTCTTGTCTTTATGATTGGTGTACGAATTAATGA
AAACTTTCGTAAGCCTTGGACAAATCCTCTCCTCTTTGCTACTGTCGTCATTATTCTCATTCTCTCACTAGCTCATATTC
CCTATAAAAATTATTATATTGGGGGTTCAATCATCAATGACCTCATCGGTCCTAGTACCGTTGCTCTTGGAATTCCTCTT
TATAAAACTTTCCATTTAATGAAACACCACGCGCGTTCAATCGTTAGCTCAATTGCTATTGCGGCATTAGTCAATTGTGT
CTTTACTGCTCTCTGTGCTAAATTTTTCAGCCTCAGTAAACTCGCCTCTCTTTCAATCTTCCCAAAATCAGTAACTACTG
CAATGGCTATGGGAATTTCTGATAAAATGCATGGCGTGGAACAAATTACCGTTGTTGTCGTGGTTGCTACAGGAATTCTC
ACCAGTGTGCTTGGCGGCCCATTATTAAAACTCTTTAGAATTACAGACCCTGTTGCTCAAGGAATTGCCCTTGGAGGAAC
TGGACATGCTGTCGGAACTGGAACAGCGATCGAACTTGGTAAAACGCAAGGAGCAATGGCAGCACTCAGTATTGGTGTCA
CTGGTATCATGTATGTTATCTTCGCACCAATCATCGCTAAAATTATTCTCGGTTATTAA

Upstream 100 bases:

>100_bases
ATGGATTAAAGTTAAATTTGAAGGCGATTATGTCGCTTTAAAACCAGATACTACCGTCACTTCTTCCACTGAAGACCAAT
AATTTGGAGTATTTAAAATC

Downstream 100 bases:

>100_bases
CTATCTAAAAAAACGTTGAACTTTATTTGTCCAGCGTTTTTTTATATGCCTAGGAGTAATTATTTTACTTAACTTCTTCT
TCGTTTTTACTGTGCTTCTT

Product: LrgB family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNIITTDPLFGFVLTVLVFMIGVRINENFRKPWTNPLLFATVVIILILSLAHIPYKNYYIGGSIINDLIGPSTVALGIPL
YKTFHLMKHHARSIVSSIAIAALVNCVFTALCAKFFSLSKLASLSIFPKSVTTAMAMGISDKMHGVEQITVVVVVATGIL
TSVLGGPLLKLFRITDPVAQGIALGGTGHAVGTGTAIELGKTQGAMAALSIGVTGIMYVIFAPIIAKIILGY

Sequences:

>Translated_232_residues
MNIITTDPLFGFVLTVLVFMIGVRINENFRKPWTNPLLFATVVIILILSLAHIPYKNYYIGGSIINDLIGPSTVALGIPL
YKTFHLMKHHARSIVSSIAIAALVNCVFTALCAKFFSLSKLASLSIFPKSVTTAMAMGISDKMHGVEQITVVVVVATGIL
TSVLGGPLLKLFRITDPVAQGIALGGTGHAVGTGTAIELGKTQGAMAALSIGVTGIMYVIFAPIIAKIILGY
>Mature_232_residues
MNIITTDPLFGFVLTVLVFMIGVRINENFRKPWTNPLLFATVVIILILSLAHIPYKNYYIGGSIINDLIGPSTVALGIPL
YKTFHLMKHHARSIVSSIAIAALVNCVFTALCAKFFSLSKLASLSIFPKSVTTAMAMGISDKMHGVEQITVVVVVATGIL
TSVLGGPLLKLFRITDPVAQGIALGGTGHAVGTGTAIELGKTQGAMAALSIGVTGIMYVIFAPIIAKIILGY

Specific function: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in p

COG id: COG1346

COG function: function code M; Putative effector of murein hydrolase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidB/LrgB family. LrgB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788464, Length=218, Percent_Identity=37.1559633027523, Blast_Score=136, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007300 [H]

Pfam domain/function: PF04172 LrgB [H]

EC number: NA

Molecular weight: Translated: 24542; Mature: 24542

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIITTDPLFGFVLTVLVFMIGVRINENFRKPWTNPLLFATVVIILILSLAHIPYKNYYI
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
GGSIINDLIGPSTVALGIPLYKTFHLMKHHARSIVSSIAIAALVNCVFTALCAKFFSLSK
CHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LASLSIFPKSVTTAMAMGISDKMHGVEQITVVVVVATGILTSVLGGPLLKLFRITDPVAQ
HHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GIALGGTGHAVGTGTAIELGKTQGAMAALSIGVTGIMYVIFAPIIAKIILGY
CEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIITTDPLFGFVLTVLVFMIGVRINENFRKPWTNPLLFATVVIILILSLAHIPYKNYYI
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
GGSIINDLIGPSTVALGIPLYKTFHLMKHHARSIVSSIAIAALVNCVFTALCAKFFSLSK
CHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LASLSIFPKSVTTAMAMGISDKMHGVEQITVVVVVATGILTSVLGGPLLKLFRITDPVAQ
HHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GIALGGTGHAVGTGTAIELGKTQGAMAALSIGVTGIMYVIFAPIIAKIILGY
CEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA