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The map label for this gene is yvbW [H]

Identifier: 125624537

GI number: 125624537

Start: 1728858

End: 1730168

Strand: Direct

Name: yvbW [H]

Synonym: llmg_1747

Alternate gene names: 125624537

Gene position: 1728858-1730168 (Clockwise)

Preceding gene: 125624519

Following gene: 125624551

Centisome position: 68.35

GC content: 36.31

Gene sequence:

>1311_bases
ATGGCCGCACGCCATATTACTATGATTGCTCTTGGTGGAGCAATTGGTGCTGGTCTTTTCAAAGGAAGCTCATCAGCCAT
TGCTGCCGCTGGTCCCTCTGTCTTAATCGCTTATTTTATCGGAGGAATCGTTCTTTATTTTGTAATGAAGAGTTTAGAAA
AGCTTGTTCTAAGTTCAAAAGATCCACACGGCTTGTCCGGACTTGTTCAGCCTTATCTGGGTAATCATACGGCTGATTTT
ACGGACTGGGTTTATTGGTCAATGTGGATGATTAATATCATTGCTGAGGCTGTTCCTGCTGCAAGTTTTTTGCAGCTCTG
GTTTGCTAATGTTCCCACTTGGGTTTTTGTCTTGATTATTGCCCTTTTAACTTCCCTTATTAACTTATTCTCAGTTGCTC
TCTTTGCTGAGACAGAATACTGGTTGGCATTTATTAAAATTAGTGTTGTTATTTTGTTGATTATTTTTGGTGTTTTTCTT
GTGGCAAAACAAATTTTTGATACTAATCTAGTGACTACTTTCTCTGGAATGACCGCTCATGGTGGCTTTGCTCCTCATGG
CTTTAAAGGGGTCATTAATTCTTTATTAATTGTTATCTATTCGTATGGTGGTTCTGAATTAATTGCTATTACAGTTAGTG
AAACAGAAGATCCTAAAAGAGCCATTCCTAAAGCCATCCGCGGTGTAATCGGTCGAATTATTTCATTTTATATTATTCCG
ATGTTCTTACTTCTTGTGATTTATAATTGGCAAACGTTGGCTACTTCTTCAATGAGCCCTTTTGTGATGGTCTTTAATAA
AATGCATATTCCTTTTGCTGGCGATATTGTCAACTTGATTATCATTCTTGCCCTCTTCTCATCAATTAATTCTGGAATCT
ATGCTTCATCTCGACTTTTGTATTTCCGTTTAAAAAATCGTCAAGGTAAAATGGCTCAAAGAATGGCTCATTTAAATAAA
CATCACGTTCCTCAAAGAGCTGTTATTTTCTGTTCAGGTACACTTTATCTCGGTGTTGTTCTTTCTTATTTTGTCGGTGA
TCGTTTGTTTAATTACTTGGCTGGTTCCCTTTCTTACACTGTTTTAGCTGTTTGGATTTTAATTAGTCTCGCTGGTTTTG
GTCTCTCTCTTAAAACAAAATCATTATCCGGTAAAACAATGAGTCTCTTAGCACTGATTGCTCTCTTTCTCATTCTGATT
GGTATTTTATTTACTAATCCAATTGGTGTGACTGTCTTCACAGCAATTCTTTATTTCATCATCTTTATCAGTTATCGAAA
AAAGAATGATTCTGTCAGTAATTTAAACTAA

Upstream 100 bases:

>100_bases
TATTATCAATTTATTAGTCAATAAAAGAGAGACGTCTCTGCTTATTGATTTAGAAAGCTAGGAATTATCGTTGGAAACTA
ATCAATCCTTAAAGAAAAAA

Downstream 100 bases:

>100_bases
TAAAAAAGACTTGATAATTAATCAAGTCTTTTTATTTTTACTGACAGAATTATCTGTCAGTATTTTTTTGCTCAAAATAT
TTTTGAACAAAATAACCAGA

Product: amino acid permease

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MAARHITMIALGGAIGAGLFKGSSSAIAAAGPSVLIAYFIGGIVLYFVMKSLEKLVLSSKDPHGLSGLVQPYLGNHTADF
TDWVYWSMWMINIIAEAVPAASFLQLWFANVPTWVFVLIIALLTSLINLFSVALFAETEYWLAFIKISVVILLIIFGVFL
VAKQIFDTNLVTTFSGMTAHGGFAPHGFKGVINSLLIVIYSYGGSELIAITVSETEDPKRAIPKAIRGVIGRIISFYIIP
MFLLLVIYNWQTLATSSMSPFVMVFNKMHIPFAGDIVNLIIILALFSSINSGIYASSRLLYFRLKNRQGKMAQRMAHLNK
HHVPQRAVIFCSGTLYLGVVLSYFVGDRLFNYLAGSLSYTVLAVWILISLAGFGLSLKTKSLSGKTMSLLALIALFLILI
GILFTNPIGVTVFTAILYFIIFISYRKKNDSVSNLN

Sequences:

>Translated_436_residues
MAARHITMIALGGAIGAGLFKGSSSAIAAAGPSVLIAYFIGGIVLYFVMKSLEKLVLSSKDPHGLSGLVQPYLGNHTADF
TDWVYWSMWMINIIAEAVPAASFLQLWFANVPTWVFVLIIALLTSLINLFSVALFAETEYWLAFIKISVVILLIIFGVFL
VAKQIFDTNLVTTFSGMTAHGGFAPHGFKGVINSLLIVIYSYGGSELIAITVSETEDPKRAIPKAIRGVIGRIISFYIIP
MFLLLVIYNWQTLATSSMSPFVMVFNKMHIPFAGDIVNLIIILALFSSINSGIYASSRLLYFRLKNRQGKMAQRMAHLNK
HHVPQRAVIFCSGTLYLGVVLSYFVGDRLFNYLAGSLSYTVLAVWILISLAGFGLSLKTKSLSGKTMSLLALIALFLILI
GILFTNPIGVTVFTAILYFIIFISYRKKNDSVSNLN
>Mature_435_residues
AARHITMIALGGAIGAGLFKGSSSAIAAAGPSVLIAYFIGGIVLYFVMKSLEKLVLSSKDPHGLSGLVQPYLGNHTADFT
DWVYWSMWMINIIAEAVPAASFLQLWFANVPTWVFVLIIALLTSLINLFSVALFAETEYWLAFIKISVVILLIIFGVFLV
AKQIFDTNLVTTFSGMTAHGGFAPHGFKGVINSLLIVIYSYGGSELIAITVSETEDPKRAIPKAIRGVIGRIISFYIIPM
FLLLVIYNWQTLATSSMSPFVMVFNKMHIPFAGDIVNLIIILALFSSINSGIYASSRLLYFRLKNRQGKMAQRMAHLNKH
HVPQRAVIFCSGTLYLGVVLSYFVGDRLFNYLAGSLSYTVLAVWILISLAGFGLSLKTKSLSGKTMSLLALIALFLILIG
ILFTNPIGVTVFTAILYFIIFISYRKKNDSVSNLN

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of The Aromatic Amino Acids (Phenylalanine, Tyrosine, And Tryptophan). [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786302, Length=370, Percent_Identity=34.8648648648649, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI48994972, Length=431, Percent_Identity=33.6426914153132, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1786789, Length=368, Percent_Identity=34.5108695652174, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1790653, Length=341, Percent_Identity=34.3108504398827, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1789017, Length=371, Percent_Identity=31.8059299191375, Blast_Score=214, Evalue=9e-57,
Organism=Escherichia coli, GI87081915, Length=371, Percent_Identity=33.1536388140162, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1786602, Length=444, Percent_Identity=32.8828828828829, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI87081708, Length=415, Percent_Identity=33.4939759036145, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1788480, Length=381, Percent_Identity=33.0708661417323, Blast_Score=183, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324061, Length=413, Percent_Identity=29.2978208232446, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6320772, Length=410, Percent_Identity=29.0243902439024, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319824, Length=458, Percent_Identity=28.3842794759825, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324059, Length=450, Percent_Identity=29.1111111111111, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322892, Length=317, Percent_Identity=30.9148264984227, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6324924, Length=372, Percent_Identity=30.1075268817204, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324553, Length=400, Percent_Identity=29, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324990, Length=396, Percent_Identity=29.5454545454545, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6321053, Length=331, Percent_Identity=27.7945619335347, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320717, Length=447, Percent_Identity=27.5167785234899, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320251, Length=427, Percent_Identity=23.6533957845433, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6321629, Length=455, Percent_Identity=24.6153846153846, Blast_Score=112, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6322967, Length=403, Percent_Identity=27.2952853598015, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319542, Length=424, Percent_Identity=23.5849056603774, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319543, Length=388, Percent_Identity=28.3505154639175, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324981, Length=423, Percent_Identity=26.9503546099291, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319608, Length=346, Percent_Identity=23.121387283237, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 47863; Mature: 47732

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARHITMIALGGAIGAGLFKGSSSAIAAAGPSVLIAYFIGGIVLYFVMKSLEKLVLSSK
CCCCEEEEEEECHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DPHGLSGLVQPYLGNHTADFTDWVYWSMWMINIIAEAVPAASFLQLWFANVPTWVFVLII
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHH
ALLTSLINLFSVALFAETEYWLAFIKISVVILLIIFGVFLVAKQIFDTNLVTTFSGMTAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
GGFAPHGFKGVINSLLIVIYSYGGSELIAITVSETEDPKRAIPKAIRGVIGRIISFYIIP
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
MFLLLVIYNWQTLATSSMSPFVMVFNKMHIPFAGDIVNLIIILALFSSINSGIYASSRLL
HHHHHHHHCCHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEE
YFRLKNRQGKMAQRMAHLNKHHVPQRAVIFCSGTLYLGVVLSYFVGDRLFNYLAGSLSYT
EEEECCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLAVWILISLAGFGLSLKTKSLSGKTMSLLALIALFLILIGILFTNPIGVTVFTAILYFI
HHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
IFISYRKKNDSVSNLN
HHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AARHITMIALGGAIGAGLFKGSSSAIAAAGPSVLIAYFIGGIVLYFVMKSLEKLVLSSK
CCCEEEEEEECHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DPHGLSGLVQPYLGNHTADFTDWVYWSMWMINIIAEAVPAASFLQLWFANVPTWVFVLII
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHH
ALLTSLINLFSVALFAETEYWLAFIKISVVILLIIFGVFLVAKQIFDTNLVTTFSGMTAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
GGFAPHGFKGVINSLLIVIYSYGGSELIAITVSETEDPKRAIPKAIRGVIGRIISFYIIP
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
MFLLLVIYNWQTLATSSMSPFVMVFNKMHIPFAGDIVNLIIILALFSSINSGIYASSRLL
HHHHHHHHCCHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEE
YFRLKNRQGKMAQRMAHLNKHHVPQRAVIFCSGTLYLGVVLSYFVGDRLFNYLAGSLSYT
EEEECCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLAVWILISLAGFGLSLKTKSLSGKTMSLLALIALFLILIGILFTNPIGVTVFTAILYFI
HHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
IFISYRKKNDSVSNLN
HHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]