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The map label for this gene is copA [H]

Identifier: 125624520

GI number: 125624520

Start: 1706892

End: 1709054

Strand: Reverse

Name: copA [H]

Synonym: llmg_1729

Alternate gene names: 125624520

Gene position: 1709054-1706892 (Counterclockwise)

Preceding gene: 125624521

Following gene: 125624516

Centisome position: 67.57

GC content: 36.99

Gene sequence:

>2163_bases
ATGAGAAGTCAATCATTTGTAATTACAGGAATGACCTGTGCAAATTGTGTAAATACAGTATCAAAAACTTTGAATCAGTC
AGATAAAATTGTTGAAGCGACAGTTAATTTAGCCACGGAAAAAGCTAAAATTGTAGCTGATGATAGCTTAACTGATCAGG
AAATTATCAATTTAGTGGAAAAAGCGGGTTATGGTGCCATTGTTAATGACAAGGCTCACCAAGAGAAAATCGCAAGACAG
GCGGCAAGAAAAGCGAGAAACTTGTCTTTATCTTTTTGGATTTCTTTAATTTTGACTTTGCCCTTAGTAGTTGCAATGTT
TGCTGATATTTTTGGAGTACATGCAAATTGGGTGATGTTTTTACATGAACCGCTCTTACAGTTGATTTTAGCAAGTCCGG
TACAATTTATTGTTGGTTGGCGCTTTTATGTCGGAGCTTATCATGCTTTACGTAATAAATCGGCAAATATGGATGTTCTT
GTTGCTTTAGGAACATCTGTAGCTTATTTTTCAAGTTTGATTTTGGCTGTTTTTATGGGTCAAAAAAATGCTTTAAATTT
TGAATCATCAATGGTGATTATTACTTTAGTGGTCATGGGTAAACTTTTAGAAAATAATGCAAAAGAGAAAACAACACAGG
CAATTACTGGGTTAATGTCTAGTCGAGCAAGCGTTGTTCATACAGAATCTGCTGATTTAGCAATTGAAGAAGTGGAAATG
GGACAAGTCATTCGGATTTTACCAGGGGAAAAAGTTCCTTTGGACGCCATAATTCTTTCTGGGAAAGCTTCGTTCGATGA
ATCCATTTTGACTGGTGAGTCCCTCCCAGTGGTCAAAATGGATGATGAGATTGTTTTTGAAGGAACGATAAATCTAGATG
GCGAAGTCAAAGCCGTTGTTGTCCATGATTTAAATGATTCAACCATCTCTCGCATGGTGGAAATGATGAGCGAAGCTCAG
GGTTCTAAGCCAAATATTCAAAAATTAGCTGACAAGATTTCGGGAATTTTTGTTCCAATTGTCCTCGCAATTGCTTTGGT
TACTTTTGTTGCAACTTGGGCTGTCAGTGGAATTTTACTGACAGCAATCATGCACGCCGTGGCTGTATTGGTCATTGCCT
GCCCTTGTGCCCTTGGTTTAGCAACACCAACAGCAATTATCTCGGGAACTGGCTTGGCGGCAAAGAATGGTCTATTGATT
AAAAATGCTAATGCTTTGGAACTTGCTGGTTTAGTTGACACAATCTTTTTTGACAAAACAGGGACGATTACAACAGGTGA
ATTTGAACTGACAGACTTTAAATTGCTGACAGAAAATGAAAAAATTACTGACAGAACTGAGTCTATCAAATCAAAAATGT
TAACTGATGAATTTAAAATTTTGGCGAGTCTTGAGGCACATTCTAATCATCCTTTGGCTAAGTCGCTCAAATTTTCTGGT
GATTTTTATGACTTAACAGATTTATCTGAACTTGCTGGTCGTGGTTTGTCAGCAAAAATTAATGGTCAAGAATATTTTGC
AGGAAATGATAAATTGATGACGGATTTTAATTTATCAGTTCCTGAAACTGAAGATACGGTCATTTATCTAGCGGATAAAG
AAAAATTACTGGCAATGGCTATCTTTAGTTCAAGTCTAAAAGAAGATAGTGTTGATACAATTCGTGCCTTGCAAAAACGT
GGAATAAAAACGGTGATGTTGACAGGAGATAATGCCAATTCAGCCGAAAAAATACAAGAGCTGATTCATTTAGATGAAAT
CAAAAGTGGTTTGCGACCTGAAGAAAAAGCTGAAATTGTCCAATCAACACCAAATTCAATGATGGTGGGTGATGGAATTA
ATGATGCCATTGCCCTAGCTTCAGCAACCGTGGGTCTGGCAATGGCAACCGGTTCTGACATTGCTATGGAAGCTGGAGAT
GTAACGGTGATTGGTGGGCAACTCCATAAAATTTCAACTTTCTTTGAAGTCGCCAAAAAGACGATTTCAAAAATTAAACA
AAATTACTTTTGGGCATTTGTTTATAATATTATAGGAATTCCGCTTGCTGCCTTTGGATTACTTAATCCAATGCTTGCCG
CCGCGGCAATGAGTTTATCATCAGTTTCAGTTATCTTGAATTCATTACTTTTAACTAAAGCAAAAATAAAAAGCGTTGAT
TAA

Upstream 100 bases:

>100_bases
CAGGTCATCTTCATTCCCCAAATGGAGATGATTTTTTCTTGACTTTTTAAGTTTACAATTGTAAACTATACATATAGATA
AAATATGAGAAGAGGAACTA

Downstream 100 bases:

>100_bases
TCAACGCTTTTTATTTGTAGAATTACTGACAGAAGTGAAAATTTTACTAACAAACCTGTGAGATTCTATTTATTTTTATA
GAGGTCTGGGTCAAGTAGGC

Product: copper/potassium-transporting ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 720; Mature: 720

Protein sequence:

>720_residues
MRSQSFVITGMTCANCVNTVSKTLNQSDKIVEATVNLATEKAKIVADDSLTDQEIINLVEKAGYGAIVNDKAHQEKIARQ
AARKARNLSLSFWISLILTLPLVVAMFADIFGVHANWVMFLHEPLLQLILASPVQFIVGWRFYVGAYHALRNKSANMDVL
VALGTSVAYFSSLILAVFMGQKNALNFESSMVIITLVVMGKLLENNAKEKTTQAITGLMSSRASVVHTESADLAIEEVEM
GQVIRILPGEKVPLDAIILSGKASFDESILTGESLPVVKMDDEIVFEGTINLDGEVKAVVVHDLNDSTISRMVEMMSEAQ
GSKPNIQKLADKISGIFVPIVLAIALVTFVATWAVSGILLTAIMHAVAVLVIACPCALGLATPTAIISGTGLAAKNGLLI
KNANALELAGLVDTIFFDKTGTITTGEFELTDFKLLTENEKITDRTESIKSKMLTDEFKILASLEAHSNHPLAKSLKFSG
DFYDLTDLSELAGRGLSAKINGQEYFAGNDKLMTDFNLSVPETEDTVIYLADKEKLLAMAIFSSSLKEDSVDTIRALQKR
GIKTVMLTGDNANSAEKIQELIHLDEIKSGLRPEEKAEIVQSTPNSMMVGDGINDAIALASATVGLAMATGSDIAMEAGD
VTVIGGQLHKISTFFEVAKKTISKIKQNYFWAFVYNIIGIPLAAFGLLNPMLAAAAMSLSSVSVILNSLLLTKAKIKSVD

Sequences:

>Translated_720_residues
MRSQSFVITGMTCANCVNTVSKTLNQSDKIVEATVNLATEKAKIVADDSLTDQEIINLVEKAGYGAIVNDKAHQEKIARQ
AARKARNLSLSFWISLILTLPLVVAMFADIFGVHANWVMFLHEPLLQLILASPVQFIVGWRFYVGAYHALRNKSANMDVL
VALGTSVAYFSSLILAVFMGQKNALNFESSMVIITLVVMGKLLENNAKEKTTQAITGLMSSRASVVHTESADLAIEEVEM
GQVIRILPGEKVPLDAIILSGKASFDESILTGESLPVVKMDDEIVFEGTINLDGEVKAVVVHDLNDSTISRMVEMMSEAQ
GSKPNIQKLADKISGIFVPIVLAIALVTFVATWAVSGILLTAIMHAVAVLVIACPCALGLATPTAIISGTGLAAKNGLLI
KNANALELAGLVDTIFFDKTGTITTGEFELTDFKLLTENEKITDRTESIKSKMLTDEFKILASLEAHSNHPLAKSLKFSG
DFYDLTDLSELAGRGLSAKINGQEYFAGNDKLMTDFNLSVPETEDTVIYLADKEKLLAMAIFSSSLKEDSVDTIRALQKR
GIKTVMLTGDNANSAEKIQELIHLDEIKSGLRPEEKAEIVQSTPNSMMVGDGINDAIALASATVGLAMATGSDIAMEAGD
VTVIGGQLHKISTFFEVAKKTISKIKQNYFWAFVYNIIGIPLAAFGLLNPMLAAAAMSLSSVSVILNSLLLTKAKIKSVD
>Mature_720_residues
MRSQSFVITGMTCANCVNTVSKTLNQSDKIVEATVNLATEKAKIVADDSLTDQEIINLVEKAGYGAIVNDKAHQEKIARQ
AARKARNLSLSFWISLILTLPLVVAMFADIFGVHANWVMFLHEPLLQLILASPVQFIVGWRFYVGAYHALRNKSANMDVL
VALGTSVAYFSSLILAVFMGQKNALNFESSMVIITLVVMGKLLENNAKEKTTQAITGLMSSRASVVHTESADLAIEEVEM
GQVIRILPGEKVPLDAIILSGKASFDESILTGESLPVVKMDDEIVFEGTINLDGEVKAVVVHDLNDSTISRMVEMMSEAQ
GSKPNIQKLADKISGIFVPIVLAIALVTFVATWAVSGILLTAIMHAVAVLVIACPCALGLATPTAIISGTGLAAKNGLLI
KNANALELAGLVDTIFFDKTGTITTGEFELTDFKLLTENEKITDRTESIKSKMLTDEFKILASLEAHSNHPLAKSLKFSG
DFYDLTDLSELAGRGLSAKINGQEYFAGNDKLMTDFNLSVPETEDTVIYLADKEKLLAMAIFSSSLKEDSVDTIRALQKR
GIKTVMLTGDNANSAEKIQELIHLDEIKSGLRPEEKAEIVQSTPNSMMVGDGINDAIALASATVGLAMATGSDIAMEAGD
VTVIGGQLHKISTFFEVAKKTISKIKQNYFWAFVYNIIGIPLAAFGLLNPMLAAAAMSLSSVSVILNSLLLTKAKIKSVD

Specific function: Probably involved in copper import under copper limiting conditions [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=830, Percent_Identity=30.6024096385542, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI55743071, Length=797, Percent_Identity=32.4968632371393, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI55743073, Length=556, Percent_Identity=31.1151079136691, Blast_Score=232, Evalue=9e-61,
Organism=Homo sapiens, GI21361181, Length=250, Percent_Identity=26.4, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI237681111, Length=250, Percent_Identity=26.4, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI237681109, Length=250, Percent_Identity=26.4, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI153946397, Length=258, Percent_Identity=27.906976744186, Blast_Score=67, Evalue=7e-11,
Organism=Homo sapiens, GI51944966, Length=256, Percent_Identity=26.5625, Blast_Score=67, Evalue=8e-11,
Organism=Escherichia coli, GI1786691, Length=759, Percent_Identity=35.9683794466403, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1789879, Length=743, Percent_Identity=30.9555854643338, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI1786914, Length=471, Percent_Identity=26.1146496815287, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI2367363, Length=319, Percent_Identity=23.1974921630094, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17556548, Length=757, Percent_Identity=30.779392338177, Blast_Score=297, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17559224, Length=334, Percent_Identity=24.5508982035928, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320475, Length=652, Percent_Identity=32.6687116564417, Blast_Score=297, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6319772, Length=676, Percent_Identity=28.8461538461538, Blast_Score=272, Evalue=1e-73,
Organism=Drosophila melanogaster, GI221329854, Length=529, Percent_Identity=34.0264650283554, Blast_Score=254, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 77491; Mature: 77491

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSQSFVITGMTCANCVNTVSKTLNQSDKIVEATVNLATEKAKIVADDSLTDQEIINLVE
CCCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHH
KAGYGAIVNDKAHQEKIARQAARKARNLSLSFWISLILTLPLVVAMFADIFGVHANWVMF
HCCCCCEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHEPLLQLILASPVQFIVGWRFYVGAYHALRNKSANMDVLVALGTSVAYFSSLILAVFMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHC
QKNALNFESSMVIITLVVMGKLLENNAKEKTTQAITGLMSSRASVVHTESADLAIEEVEM
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHCC
GQVIRILPGEKVPLDAIILSGKASFDESILTGESLPVVKMDDEIVFEGTINLDGEVKAVV
CCEEEECCCCCCCCEEEEECCCCCCCCHHHCCCCCCEEEECCCEEEEEEECCCCCEEEEE
VHDLNDSTISRMVEMMSEAQGSKPNIQKLADKISGIFVPIVLAIALVTFVATWAVSGILL
EECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAIMHAVAVLVIACPCALGLATPTAIISGTGLAAKNGLLIKNANALELAGLVDTIFFDKT
HHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCCEEEECCCHHHHHHHHHHHHCCCC
GTITTGEFELTDFKLLTENEKITDRTESIKSKMLTDEFKILASLEAHSNHPLAKSLKFSG
CCEECCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCC
DFYDLTDLSELAGRGLSAKINGQEYFAGNDKLMTDFNLSVPETEDTVIYLADKEKLLAMA
CCCCCCCHHHHHCCCCEEEECCCEEECCCCCEEEEECCCCCCCCCCEEEEECCHHHHHHH
IFSSSLKEDSVDTIRALQKRGIKTVMLTGDNANSAEKIQELIHLDEIKSGLRPEEKAEIV
HHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
QSTPNSMMVGDGINDAIALASATVGLAMATGSDIAMEAGDVTVIGGQLHKISTFFEVAKK
HCCCCCEEECCCCCHHHHHHHHHHHEEEECCCCCEEECCCEEEECCCHHHHHHHHHHHHH
TISKIKQNYFWAFVYNIIGIPLAAFGLLNPMLAAAAMSLSSVSVILNSLLLTKAKIKSVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRSQSFVITGMTCANCVNTVSKTLNQSDKIVEATVNLATEKAKIVADDSLTDQEIINLVE
CCCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHH
KAGYGAIVNDKAHQEKIARQAARKARNLSLSFWISLILTLPLVVAMFADIFGVHANWVMF
HCCCCCEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHEPLLQLILASPVQFIVGWRFYVGAYHALRNKSANMDVLVALGTSVAYFSSLILAVFMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHC
QKNALNFESSMVIITLVVMGKLLENNAKEKTTQAITGLMSSRASVVHTESADLAIEEVEM
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHCC
GQVIRILPGEKVPLDAIILSGKASFDESILTGESLPVVKMDDEIVFEGTINLDGEVKAVV
CCEEEECCCCCCCCEEEEECCCCCCCCHHHCCCCCCEEEECCCEEEEEEECCCCCEEEEE
VHDLNDSTISRMVEMMSEAQGSKPNIQKLADKISGIFVPIVLAIALVTFVATWAVSGILL
EECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAIMHAVAVLVIACPCALGLATPTAIISGTGLAAKNGLLIKNANALELAGLVDTIFFDKT
HHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCCEEEECCCHHHHHHHHHHHHCCCC
GTITTGEFELTDFKLLTENEKITDRTESIKSKMLTDEFKILASLEAHSNHPLAKSLKFSG
CCEECCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCC
DFYDLTDLSELAGRGLSAKINGQEYFAGNDKLMTDFNLSVPETEDTVIYLADKEKLLAMA
CCCCCCCHHHHHCCCCEEEECCCEEECCCCCEEEEECCCCCCCCCCEEEEECCHHHHHHH
IFSSSLKEDSVDTIRALQKRGIKTVMLTGDNANSAEKIQELIHLDEIKSGLRPEEKAEIV
HHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
QSTPNSMMVGDGINDAIALASATVGLAMATGSDIAMEAGDVTVIGGQLHKISTFFEVAKK
HCCCCCEEECCCCCHHHHHHHHHHHEEEECCCCCEEECCCEEEECCCHHHHHHHHHHHHH
TISKIKQNYFWAFVYNIIGIPLAAFGLLNPMLAAAAMSLSSVSVILNSLLLTKAKIKSVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8048974; 7876197 [H]