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The map label for this gene is mleR [H]

Identifier: 125624472

GI number: 125624472

Start: 1648077

End: 1648964

Strand: Reverse

Name: mleR [H]

Synonym: llmg_1674

Alternate gene names: 125624472

Gene position: 1648964-1648077 (Counterclockwise)

Preceding gene: 125624473

Following gene: 125624471

Centisome position: 65.19

GC content: 30.74

Gene sequence:

>888_bases
ATGAATTTAAATTTAAGAGATCTTGAGTATTTTTACCAATTGTCCAAATTACGATCTTTCACTAATGTCGCCAAATATTT
TAGAGTAAGTCAACCCACCATTTCTTATGCCATTAAAAGGCTGGAAAGTTATTACGATTGTGACTTGTTTTATAAAGATT
CCTCACATCAGGTGGTTGACTTGACGCCAGAAGGTGACCTTTTGGCGATGAGGACAAATGAAATTCTCTCAGAACTAAAT
CATACTAAAAAAGCAATCCATCGTTCTAGTATGAAGGACTTTAAAGTTGGTTTTCCTCCAATAATAAGTTCCTATCTATT
ATCAAAGATATTAAAAGAAGAAGAAAGTTTAAACTTTTTAAATGCCTTACATATGATTTATGGCGGTTCAAACGAATTAC
TGAGTCAGCTTTTAAATGGTGAAATAGATTCAAGCTTACTAGGAAGTTTAGAGAAAATTAAACATCCAGAACTAGAAATT
GAAGAACTTTTTCAAAAAGAATTTTTCATTATCATGTCTGACCACCATCCATTAGCGAGCAAGAAAGAACTTGCCTTTAA
AGATTTACTTAATGAAGATTTTATCTTGTTGGGCGAACATAATATTCATTTTACTGCTTTTAATTTATTAAACGAGAAAT
ATAACCATTCGGCGAATGCTGTCTTGAAACTTGATGATGCTCATACGATAAAAGAACTGGTGAGAAAAAATTTAGGAATT
AGTCTTATGGCAGATATTGGACTATCAGAAGATTTCAAACATCTGGTCAAAATTCCACTTATTGAAGCGGACAAACAATA
CTTCCATATCAATTATGCTTATCAAAAAATAGCTATTCTTTCTGAAAGTGAAAAAAACTTTTTAGAAATATTGAAAACTT
TAAAATAA

Upstream 100 bases:

>100_bases
GGCTTTTCTTATATTCAAATCCAAAAGAGTTGATAAATATTACTTATGAAGCCAAGAATAATGATAAATTTATGTTAAAA
TATTTTTTAGGAGCATAACT

Downstream 100 bases:

>100_bases
ATTGTAGAAAAAAACATCATTAATATGATGCTTTTTTGAATTAATAAAAATAGGCAAGCGATACCAAAAAATATCAGGAA
ATGTTATAATTAGAGTATTA

Product: malolactic fermentation system transcription activator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MNLNLRDLEYFYQLSKLRSFTNVAKYFRVSQPTISYAIKRLESYYDCDLFYKDSSHQVVDLTPEGDLLAMRTNEILSELN
HTKKAIHRSSMKDFKVGFPPIISSYLLSKILKEEESLNFLNALHMIYGGSNELLSQLLNGEIDSSLLGSLEKIKHPELEI
EELFQKEFFIIMSDHHPLASKKELAFKDLLNEDFILLGEHNIHFTAFNLLNEKYNHSANAVLKLDDAHTIKELVRKNLGI
SLMADIGLSEDFKHLVKIPLIEADKQYFHINYAYQKIAILSESEKNFLEILKTLK

Sequences:

>Translated_295_residues
MNLNLRDLEYFYQLSKLRSFTNVAKYFRVSQPTISYAIKRLESYYDCDLFYKDSSHQVVDLTPEGDLLAMRTNEILSELN
HTKKAIHRSSMKDFKVGFPPIISSYLLSKILKEEESLNFLNALHMIYGGSNELLSQLLNGEIDSSLLGSLEKIKHPELEI
EELFQKEFFIIMSDHHPLASKKELAFKDLLNEDFILLGEHNIHFTAFNLLNEKYNHSANAVLKLDDAHTIKELVRKNLGI
SLMADIGLSEDFKHLVKIPLIEADKQYFHINYAYQKIAILSESEKNFLEILKTLK
>Mature_295_residues
MNLNLRDLEYFYQLSKLRSFTNVAKYFRVSQPTISYAIKRLESYYDCDLFYKDSSHQVVDLTPEGDLLAMRTNEILSELN
HTKKAIHRSSMKDFKVGFPPIISSYLLSKILKEEESLNFLNALHMIYGGSNELLSQLLNGEIDSSLLGSLEKIKHPELEI
EELFQKEFFIIMSDHHPLASKKELAFKDLLNEDFILLGEHNIHFTAFNLLNEKYNHSANAVLKLDDAHTIKELVRKNLGI
SLMADIGLSEDFKHLVKIPLIEADKQYFHINYAYQKIAILSESEKNFLEILKTLK

Specific function: Required for malolactic fermentation. It is most probably a transcriptional activator [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=279, Percent_Identity=24.0143369175627, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790399, Length=298, Percent_Identity=23.8255033557047, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788887, Length=198, Percent_Identity=25.7575757575758, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34178; Mature: 34178

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLNLRDLEYFYQLSKLRSFTNVAKYFRVSQPTISYAIKRLESYYDCDLFYKDSSHQVVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCEEEE
LTPEGDLLAMRTNEILSELNHTKKAIHRSSMKDFKVGFPPIISSYLLSKILKEEESLNFL
ECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
NALHMIYGGSNELLSQLLNGEIDSSLLGSLEKIKHPELEIEELFQKEFFIIMSDHHPLAS
HHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHCEEEEEECCCCCCC
KKELAFKDLLNEDFILLGEHNIHFTAFNLLNEKYNHSANAVLKLDDAHTIKELVRKNLGI
HHHHHHHHHCCCCEEEEECCCEEEHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCE
SLMADIGLSEDFKHLVKIPLIEADKQYFHINYAYQKIAILSESEKNFLEILKTLK
EEEECCCCCHHHHHHHHCCCEECCCCEEEEEEHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNLNLRDLEYFYQLSKLRSFTNVAKYFRVSQPTISYAIKRLESYYDCDLFYKDSSHQVVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCEEEE
LTPEGDLLAMRTNEILSELNHTKKAIHRSSMKDFKVGFPPIISSYLLSKILKEEESLNFL
ECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
NALHMIYGGSNELLSQLLNGEIDSSLLGSLEKIKHPELEIEELFQKEFFIIMSDHHPLAS
HHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHCEEEEEECCCCCCC
KKELAFKDLLNEDFILLGEHNIHFTAFNLLNEKYNHSANAVLKLDDAHTIKELVRKNLGI
HHHHHHHHHCCCCEEEEECCCEEEHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCE
SLMADIGLSEDFKHLVKIPLIEADKQYFHINYAYQKIAILSESEKNFLEILKTLK
EEEECCCCCHHHHHHHHCCCEECCCCEEEEEEHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2498286; 11337471 [H]