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The map label for this gene is pgaC [H]

Identifier: 125624466

GI number: 125624466

Start: 1641869

End: 1643197

Strand: Reverse

Name: pgaC [H]

Synonym: llmg_1667

Alternate gene names: 125624466

Gene position: 1643197-1641869 (Counterclockwise)

Preceding gene: 125624467

Following gene: 125624465

Centisome position: 64.96

GC content: 34.16

Gene sequence:

>1329_bases
ATGATTAGCTTTTTTCAAACAGGTAATGGTATTGTTGATCTTATTTTGACAATAATGTTTTTAATATTGGTCACCTATCC
TATCTTGGGTGGTTTTGCTTGGTTCATTGGTGTTTTGTGTTATAGTTTTTTGTTTAAATATAAGCAAAAATCATGGGATG
AAATTCCAGTAGAAGTTGAGCCTTTTGTCACGATTATGGTCCCAGCCCATAATGAAGAAGTTGTCATTGAAGATACAATC
AATTATTTAATGACGAAAATTAATTATGAAAACTATGAAGTTTTGGTTACTGACGACGGGTCAACAGATCGTACGCCAGA
AATTTTAAAAAACTTACAGGAAAAATATGCAAAATTACGAGTGGTTCGTATTGAAAAAAATAAAGGAAAAGCACATGCTT
TTAATATTGGATTGGCCTTTGCAAAAGGAAAATTGATTCTGAGTAATGACGCTGATACGGTTCCAGAACCTGATTCTCTC
AATCGTTATATCAATTATTTTATTCGCCCAGACTCTACCAATATTTCAGCTGTAACGGCTAATATGGATGTTCAAAATCG
GGCCAAGTTAATAGCGAAATCACAGACAGTTGAGTTCTCCAGTATTGTAGGAATTATTAAGCGCACTCAACTTGGTGTCT
TGGGAAGTATTTATGCCTATAGTGGGGCAAATACGATGTATCGTAAAGATGCTCTGGTTGATGTTGGTTTATTTAGACAA
GACCGAGCAACCGAAGATATTAGTATTGCTTGGGATCATCAAATGGATGGTTGGTTATCACTTTTTGCTCCTCAAATTAT
GTTTTTCATGGAAGTTCCTGAATCCTTAAAAATGCTATCTCGCCAAAGAAAACGTTGGGCTAAGGGTGGTACAGAAGTAT
GGTTGACAAATTTTAGAAAAGTTTTCTTGCATCCTTTTGACAATATCGGAAGGACTATTATGTTTATTGACCAAACTTTA
AGTATTATTTGGTCCTTCTTTTTTTGGATTTCATCAGCACTATTTATCTACTCTATGGTTTATTTTGCTTTGGGTGGAAA
TCTAGAACGAATTTATCACATTCTGACAATGGCTTTTCTCTTTGTTTGTTTTGAAATGGTTTCTGGAACTTTTCAATTAA
TTGCTTCTTTAATCGTTGATGATCGTGGCCGAAAGGTTAAATATTTACTTTTTGCTCCGCTATACATGCTTTTCTATTGG
ATGATGAATGCTTTAACAATTGTGACAACTTTTATTCCAGCAGTAAAAACGATACTTGGTTTAGGCTCTGGAACTTGGAA
AAGTCCTGAACGCAAAGGAATAAAAGTGACTAATAAAAAAGATAAGTAA

Upstream 100 bases:

>100_bases
TCGGAAGAATTTCGGCATAAGGTTTGTTTTTATTCAGTCAAAGAGGAGCAGAATTTAGAAACAGATTTTGTCAAAAAACT
TTATCAGGAAGGAGAAAAGA

Downstream 100 bases:

>100_bases
TTTTAGTTGATAAATTAAAAGAAGCAGAGGAGTTTAACTACTCCTCTTTTTAAATTTCTAAATATTTGATTAGATATAAA
TCATATTTTATTTTATAAAA

Product: glycosyltransferase

Products: NA

Alternate protein names: PGA synthase; Poly-beta-1,6-GlcNAc synthase; Biofilm PGA synthesis protein PgaC; N-acetylglucosaminyltransferase PgaC [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MISFFQTGNGIVDLILTIMFLILVTYPILGGFAWFIGVLCYSFLFKYKQKSWDEIPVEVEPFVTIMVPAHNEEVVIEDTI
NYLMTKINYENYEVLVTDDGSTDRTPEILKNLQEKYAKLRVVRIEKNKGKAHAFNIGLAFAKGKLILSNDADTVPEPDSL
NRYINYFIRPDSTNISAVTANMDVQNRAKLIAKSQTVEFSSIVGIIKRTQLGVLGSIYAYSGANTMYRKDALVDVGLFRQ
DRATEDISIAWDHQMDGWLSLFAPQIMFFMEVPESLKMLSRQRKRWAKGGTEVWLTNFRKVFLHPFDNIGRTIMFIDQTL
SIIWSFFFWISSALFIYSMVYFALGGNLERIYHILTMAFLFVCFEMVSGTFQLIASLIVDDRGRKVKYLLFAPLYMLFYW
MMNALTIVTTFIPAVKTILGLGSGTWKSPERKGIKVTNKKDK

Sequences:

>Translated_442_residues
MISFFQTGNGIVDLILTIMFLILVTYPILGGFAWFIGVLCYSFLFKYKQKSWDEIPVEVEPFVTIMVPAHNEEVVIEDTI
NYLMTKINYENYEVLVTDDGSTDRTPEILKNLQEKYAKLRVVRIEKNKGKAHAFNIGLAFAKGKLILSNDADTVPEPDSL
NRYINYFIRPDSTNISAVTANMDVQNRAKLIAKSQTVEFSSIVGIIKRTQLGVLGSIYAYSGANTMYRKDALVDVGLFRQ
DRATEDISIAWDHQMDGWLSLFAPQIMFFMEVPESLKMLSRQRKRWAKGGTEVWLTNFRKVFLHPFDNIGRTIMFIDQTL
SIIWSFFFWISSALFIYSMVYFALGGNLERIYHILTMAFLFVCFEMVSGTFQLIASLIVDDRGRKVKYLLFAPLYMLFYW
MMNALTIVTTFIPAVKTILGLGSGTWKSPERKGIKVTNKKDK
>Mature_442_residues
MISFFQTGNGIVDLILTIMFLILVTYPILGGFAWFIGVLCYSFLFKYKQKSWDEIPVEVEPFVTIMVPAHNEEVVIEDTI
NYLMTKINYENYEVLVTDDGSTDRTPEILKNLQEKYAKLRVVRIEKNKGKAHAFNIGLAFAKGKLILSNDADTVPEPDSL
NRYINYFIRPDSTNISAVTANMDVQNRAKLIAKSQTVEFSSIVGIIKRTQLGVLGSIYAYSGANTMYRKDALVDVGLFRQ
DRATEDISIAWDHQMDGWLSLFAPQIMFFMEVPESLKMLSRQRKRWAKGGTEVWLTNFRKVFLHPFDNIGRTIMFIDQTL
SIIWSFFFWISSALFIYSMVYFALGGNLERIYHILTMAFLFVCFEMVSGTFQLIASLIVDDRGRKVKYLLFAPLYMLFYW
MMNALTIVTTFIPAVKTILGLGSGTWKSPERKGIKVTNKKDK

Specific function: Probable N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N- acetylglucosamine to produce the linear homopolymer poly-beta-1,6- N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide [H]

COG id: COG1215

COG function: function code M; Glycosyltransferases, probably involved in cell wall biogenesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 2 family [H]

Homologues:

Organism=Homo sapiens, GI7019323, Length=115, Percent_Identity=33.0434782608696, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1787259, Length=438, Percent_Identity=29.2237442922374, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1786560, Length=206, Percent_Identity=27.1844660194175, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25146207, Length=98, Percent_Identity=35.7142857142857, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: NA

Molecular weight: Translated: 50732; Mature: 50732

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISFFQTGNGIVDLILTIMFLILVTYPILGGFAWFIGVLCYSFLFKYKQKSWDEIPVEVE
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
PFVTIMVPAHNEEVVIEDTINYLMTKINYENYEVLVTDDGSTDRTPEILKNLQEKYAKLR
CEEEEEEECCCCCEEEHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHEE
VVRIEKNKGKAHAFNIGLAFAKGKLILSNDADTVPEPDSLNRYINYFIRPDSTNISAVTA
EEEEECCCCCEEEEEEEEEEECCEEEECCCCCCCCCCHHHHHHEEEEECCCCCCEEEEEE
NMDVQNRAKLIAKSQTVEFSSIVGIIKRTQLGVLGSIYAYSGANTMYRKDALVDVGLFRQ
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
DRATEDISIAWDHQMDGWLSLFAPQIMFFMEVPESLKMLSRQRKRWAKGGTEVWLTNFRK
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
VFLHPFDNIGRTIMFIDQTLSIIWSFFFWISSALFIYSMVYFALGGNLERIYHILTMAFL
HHCCCCHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
FVCFEMVSGTFQLIASLIVDDRGRKVKYLLFAPLYMLFYWMMNALTIVTTFIPAVKTILG
HHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGSGTWKSPERKGIKVTNKKDK
CCCCCCCCCCCCCCEECCCCCC
>Mature Secondary Structure
MISFFQTGNGIVDLILTIMFLILVTYPILGGFAWFIGVLCYSFLFKYKQKSWDEIPVEVE
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
PFVTIMVPAHNEEVVIEDTINYLMTKINYENYEVLVTDDGSTDRTPEILKNLQEKYAKLR
CEEEEEEECCCCCEEEHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHEE
VVRIEKNKGKAHAFNIGLAFAKGKLILSNDADTVPEPDSLNRYINYFIRPDSTNISAVTA
EEEEECCCCCEEEEEEEEEEECCEEEECCCCCCCCCCHHHHHHEEEEECCCCCCEEEEEE
NMDVQNRAKLIAKSQTVEFSSIVGIIKRTQLGVLGSIYAYSGANTMYRKDALVDVGLFRQ
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
DRATEDISIAWDHQMDGWLSLFAPQIMFFMEVPESLKMLSRQRKRWAKGGTEVWLTNFRK
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
VFLHPFDNIGRTIMFIDQTLSIIWSFFFWISSALFIYSMVYFALGGNLERIYHILTMAFL
HHCCCCHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
FVCFEMVSGTFQLIASLIVDDRGRKVKYLLFAPLYMLFYWMMNALTIVTTFIPAVKTILG
HHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGSGTWKSPERKGIKVTNKKDK
CCCCCCCCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]