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The map label for this gene is guaC [H]

Identifier: 125624224

GI number: 125624224

Start: 1380599

End: 1381588

Strand: Reverse

Name: guaC [H]

Synonym: llmg_1412

Alternate gene names: 125624224

Gene position: 1381588-1380599 (Counterclockwise)

Preceding gene: 125624225

Following gene: 125624223

Centisome position: 54.62

GC content: 39.6

Gene sequence:

>990_bases
ATGAATAACCTAAACTCAGTATTTGACTACGAAGACATTCAACTTATCCCAAATAAATGTGTCATTAACAGTCGCTCAGA
AGCAGACACAAGCGTTAAACTAGGCAACTATACTTTTAAATTGCCTGTCGTACCAGCTAATATGCAAACGATTATTGATG
ATAAAATTGCTGAAATGCTTGCAAAAGAAGGGTATTTCTACATCATGCACCGTTTTGAAGCAGAAAATAGAGCCGCTTTT
ATCAAGAAGATGCACAAAGATGGTCTGATTGCCTCAATTTCTGTCGGAGTTAAAGCAGACGAACATGCCTTTATTCGTGA
AATTTCAGCAGAAGCTCTCATTCCGGAATTTATCACGATTGATATTGCTCATGGTCACGCAGACTCTGTTATCAAAACCA
TTCAATTAATTAAACGTCTCATGCCCCAAACATTTGTCATTGCAGGAAATGTTGGAACACCAGAAGCTGTTCGTGAGCTT
GAAAATGCCGGAGCAGATGCAACTAAAGTTGGGATTGGCCCAGGTAAAGTTTGTATCACGAAAGTTAAAACTGGATTTGG
TACAGGTGGTTGGCAGCTTGCTGCGGTTAAATGGTGTGCTAAAGCAGCTAGTAAACCAGTTATTGCAGATGGTGGAATCC
GTACACACGGTGACGTTGCTAAATCAATCCGCATGGGTGCGACGATGGTCATGGTTGGTTCTCTTTTTGCTGCCCATGAA
GAATCTCCAGGACAAACAGTTGAACGTGATGGTCAGCTTTTTAAAGAATACTTTGGTTCAGCTTCAGAATATCAAAAAGG
TGAACATAAAAATGTTGAAGGTAAGAAAATTCTTCTTCCGCACAAAGGCTCTCTCAAAGATACTTTGAAAGAAATGGAAG
AAGACCTTCAAAGCTCGATTTCTTATGCTGGTGGTCGTGATTTGTCTGCACTTACTAAAGTTGACTATGTTGTTGTTAAA
AACTCAATTTGGAATGGTGATGCTATTTAG

Upstream 100 bases:

>100_bases
TAGGGTTTGGTCGGTCTTTTCTGTAAATCAAATCATTAATGAGTTCATAGGCTAAAAAGTACTCAGAAATAGCCTAGTCA
CACTCCAAGGAGAAATTACA

Downstream 100 bases:

>100_bases
TAAGCATTTTCTTTCCCATTGTTCGGGAATACCAAAACTTATGCTTGAAAAACTTTAGTATTTAGTCTATAATAGAACAA
TCTTATTTATACCTAGAATA

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MNNLNSVFDYEDIQLIPNKCVINSRSEADTSVKLGNYTFKLPVVPANMQTIIDDKIAEMLAKEGYFYIMHRFEAENRAAF
IKKMHKDGLIASISVGVKADEHAFIREISAEALIPEFITIDIAHGHADSVIKTIQLIKRLMPQTFVIAGNVGTPEAVREL
ENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAAVKWCAKAASKPVIADGGIRTHGDVAKSIRMGATMVMVGSLFAAHE
ESPGQTVERDGQLFKEYFGSASEYQKGEHKNVEGKKILLPHKGSLKDTLKEMEEDLQSSISYAGGRDLSALTKVDYVVVK
NSIWNGDAI

Sequences:

>Translated_329_residues
MNNLNSVFDYEDIQLIPNKCVINSRSEADTSVKLGNYTFKLPVVPANMQTIIDDKIAEMLAKEGYFYIMHRFEAENRAAF
IKKMHKDGLIASISVGVKADEHAFIREISAEALIPEFITIDIAHGHADSVIKTIQLIKRLMPQTFVIAGNVGTPEAVREL
ENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAAVKWCAKAASKPVIADGGIRTHGDVAKSIRMGATMVMVGSLFAAHE
ESPGQTVERDGQLFKEYFGSASEYQKGEHKNVEGKKILLPHKGSLKDTLKEMEEDLQSSISYAGGRDLSALTKVDYVVVK
NSIWNGDAI
>Mature_329_residues
MNNLNSVFDYEDIQLIPNKCVINSRSEADTSVKLGNYTFKLPVVPANMQTIIDDKIAEMLAKEGYFYIMHRFEAENRAAF
IKKMHKDGLIASISVGVKADEHAFIREISAEALIPEFITIDIAHGHADSVIKTIQLIKRLMPQTFVIAGNVGTPEAVREL
ENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAAVKWCAKAASKPVIADGGIRTHGDVAKSIRMGATMVMVGSLFAAHE
ESPGQTVERDGQLFKEYFGSASEYQKGEHKNVEGKKILLPHKGSLKDTLKEMEEDLQSSISYAGGRDLSALTKVDYVVVK
NSIWNGDAI

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541954, Length=325, Percent_Identity=32.9230769230769, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI50541952, Length=325, Percent_Identity=32.9230769230769, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI50541948, Length=325, Percent_Identity=32.9230769230769, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI50541956, Length=325, Percent_Identity=32.9230769230769, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI156104880, Length=326, Percent_Identity=30.6748466257669, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI217035146, Length=243, Percent_Identity=31.2757201646091, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI217035148, Length=243, Percent_Identity=31.2757201646091, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI217035150, Length=245, Percent_Identity=31.8367346938775, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI156616279, Length=243, Percent_Identity=31.2757201646091, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI34328930, Length=245, Percent_Identity=31.8367346938775, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI34328928, Length=243, Percent_Identity=31.2757201646091, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI217035152, Length=245, Percent_Identity=31.8367346938775, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI66933016, Length=255, Percent_Identity=30.9803921568627, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1786293, Length=341, Percent_Identity=33.1378299120235, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788855, Length=225, Percent_Identity=36, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17560440, Length=326, Percent_Identity=31.9018404907975, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71994389, Length=151, Percent_Identity=37.0860927152318, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994385, Length=151, Percent_Identity=37.0860927152318, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323585, Length=231, Percent_Identity=29.4372294372294, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6322012, Length=242, Percent_Identity=29.3388429752066, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323464, Length=217, Percent_Identity=30.8755760368664, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24641071, Length=259, Percent_Identity=29.7297297297297, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24641073, Length=259, Percent_Identity=29.7297297297297, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI28571163, Length=259, Percent_Identity=29.7297297297297, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005994
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 35815; Mature: 35815

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00487 IMP_DH_GMP_RED ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLNSVFDYEDIQLIPNKCVINSRSEADTSVKLGNYTFKLPVVPANMQTIIDDKIAEML
CCCCCCCCCCCCEEECCCCEEECCCCCCCCEEEECCEEEEEEEECCCHHHHHHHHHHHHH
AKEGYFYIMHRFEAENRAAFIKKMHKDGLIASISVGVKADEHAFIREISAEALIPEFITI
HHCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEE
DIAHGHADSVIKTIQLIKRLMPQTFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCIT
EEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEE
KVKTGFGTGGWQLAAVKWCAKAASKPVIADGGIRTHGDVAKSIRMGATMVMVGSLFAAHE
EECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHCC
ESPGQTVERDGQLFKEYFGSASEYQKGEHKNVEGKKILLPHKGSLKDTLKEMEEDLQSSI
CCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
SYAGGRDLSALTKVDYVVVKNSIWNGDAI
HHCCCCCHHHHHHHEEEEEECCCCCCCCC
>Mature Secondary Structure
MNNLNSVFDYEDIQLIPNKCVINSRSEADTSVKLGNYTFKLPVVPANMQTIIDDKIAEML
CCCCCCCCCCCCEEECCCCEEECCCCCCCCEEEECCEEEEEEEECCCHHHHHHHHHHHHH
AKEGYFYIMHRFEAENRAAFIKKMHKDGLIASISVGVKADEHAFIREISAEALIPEFITI
HHCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEE
DIAHGHADSVIKTIQLIKRLMPQTFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCIT
EEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEE
KVKTGFGTGGWQLAAVKWCAKAASKPVIADGGIRTHGDVAKSIRMGATMVMVGSLFAAHE
EECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHCC
ESPGQTVERDGQLFKEYFGSASEYQKGEHKNVEGKKILLPHKGSLKDTLKEMEEDLQSSI
CCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
SYAGGRDLSALTKVDYVVVKNSIWNGDAI
HHCCCCCHHHHHHHEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]