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The map label for this gene is folP [H]

Identifier: 125624156

GI number: 125624156

Start: 1312265

End: 1313338

Strand: Reverse

Name: folP [H]

Synonym: llmg_1336

Alternate gene names: 125624156

Gene position: 1313338-1312265 (Counterclockwise)

Preceding gene: 125624157

Following gene: 125624155

Centisome position: 51.92

GC content: 34.64

Gene sequence:

>1074_bases
ATGAAAATCTTAGAACTTAATCAAGAATCTTTTTCTTTAAAAAATATTGTGATAAAATTTGAAGAATTAAGTAATGATGA
ATTGACAGGCTTACAAAAAAAGCTTTATAGAATTGGAAGTCTTGCAAAACTGAGCGAAAATAGTCTTCTAGCTGTTTTAA
CTATTGATGAGTTGGCAAAACTACTTAATCATTTGGAAAATATTGAAGTAAAAAATGAGCTTGAACTGATTTATAAACGG
CATCAAATTATTTGGTCAGGAAAAAATTTCAATTTTGATTTGACTAGAAAATCAATCGTTTACTCAATTGTTAATGTTAC
TCCCGATTCCTTTTATGATGGCAATCCAGATAATTTAAACATTTCTCATATTCTTAAAAGAGTAGAGTCCGATTTAGAAA
ATGGAGCATCTGTACTTGAGTTAGGTGGAAAATCATCTCGTCCTGGTTATGCGGACATTAGTCCAGAGGAAGAATGGAGC
AGATTAAAAGAACCCATTGCTCAAATTAGAAAGTATTTTCCAAAAGCTGTCTTAGCCGTGGATACGGATGAAGCTTATGT
TATGGGAAGGGTGTTAGAGGCTGGTGTCGATATTATTAATGATATTGATGGTTTTGACACAGCGGATAAGCTAAAAGTGA
TTGAAAAGTACCAGCCAGCAGTGGTTGCCATGAATAATGGTCGGGCAGGTTTTAAGTATGCTGACAATGTTTATGAAGAA
CTTCCTTTATTTTTTAAAGATAAAAAAATCGAACTGACTCAGCTTGGAATGAATCCTGAAAAAATTTCTATTGACCCCGG
AGTTGGTTTTTTCAATGGAGATTCAGGCTCTGATAGTCTTCAACGTGTTAAAACAACGGAACTTTTGAGCAGACTTGGTC
TGCCGGTTATGATTGCGATTTCTCGCAAGTCATTTATGGGAAGACTCTTCAATGCTCAAGGAGAAGAGCGACTTTTTTCA
AGTTTGATGTTAGAGGGACAAATGGTTGCTGATGGTGGACGTATCCTTAGAGTTCATGATGTGAAAGAAACGAAACGTTT
GCTTGACGCAATTGAAATTTATAAGGAATTTTAA

Upstream 100 bases:

>100_bases
GCGGTGTGAAAAAAGTAAATTCGTTGACCAAAACTTCTTATTTCTTAGGTGAATTTAAAGAAAACGGCGAAAAAAGAATG
GAATTTTTAGAAAGTCTTTT

Downstream 100 bases:

>100_bases
TCATGAATGAGGATTTGATTTCTCAAATAAAAGAAGTGGTAACTGCTGAAAATCAGGAAAAATTGATAAAAATTATTCAA
TTACTGGAAAGTTCAAATTA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKILELNQESFSLKNIVIKFEELSNDELTGLQKKLYRIGSLAKLSENSLLAVLTIDELAKLLNHLENIEVKNELELIYKR
HQIIWSGKNFNFDLTRKSIVYSIVNVTPDSFYDGNPDNLNISHILKRVESDLENGASVLELGGKSSRPGYADISPEEEWS
RLKEPIAQIRKYFPKAVLAVDTDEAYVMGRVLEAGVDIINDIDGFDTADKLKVIEKYQPAVVAMNNGRAGFKYADNVYEE
LPLFFKDKKIELTQLGMNPEKISIDPGVGFFNGDSGSDSLQRVKTTELLSRLGLPVMIAISRKSFMGRLFNAQGEERLFS
SLMLEGQMVADGGRILRVHDVKETKRLLDAIEIYKEF

Sequences:

>Translated_357_residues
MKILELNQESFSLKNIVIKFEELSNDELTGLQKKLYRIGSLAKLSENSLLAVLTIDELAKLLNHLENIEVKNELELIYKR
HQIIWSGKNFNFDLTRKSIVYSIVNVTPDSFYDGNPDNLNISHILKRVESDLENGASVLELGGKSSRPGYADISPEEEWS
RLKEPIAQIRKYFPKAVLAVDTDEAYVMGRVLEAGVDIINDIDGFDTADKLKVIEKYQPAVVAMNNGRAGFKYADNVYEE
LPLFFKDKKIELTQLGMNPEKISIDPGVGFFNGDSGSDSLQRVKTTELLSRLGLPVMIAISRKSFMGRLFNAQGEERLFS
SLMLEGQMVADGGRILRVHDVKETKRLLDAIEIYKEF
>Mature_357_residues
MKILELNQESFSLKNIVIKFEELSNDELTGLQKKLYRIGSLAKLSENSLLAVLTIDELAKLLNHLENIEVKNELELIYKR
HQIIWSGKNFNFDLTRKSIVYSIVNVTPDSFYDGNPDNLNISHILKRVESDLENGASVLELGGKSSRPGYADISPEEEWS
RLKEPIAQIRKYFPKAVLAVDTDEAYVMGRVLEAGVDIINDIDGFDTADKLKVIEKYQPAVVAMNNGRAGFKYADNVYEE
LPLFFKDKKIELTQLGMNPEKISIDPGVGFFNGDSGSDSLQRVKTTELLSRLGLPVMIAISRKSFMGRLFNAQGEERLFS
SLMLEGQMVADGGRILRVHDVKETKRLLDAIEIYKEF

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=272, Percent_Identity=31.9852941176471, Blast_Score=126, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 40330; Mature: 40330

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILELNQESFSLKNIVIKFEELSNDELTGLQKKLYRIGSLAKLSENSLLAVLTIDELAK
CCEEECCCHHHHHHHHEEEEECCCCCHHHHHHHHHHHHCCHHEECCCCEEEEEEHHHHHH
LLNHLENIEVKNELELIYKRHQIIWSGKNFNFDLTRKSIVYSIVNVTPDSFYDGNPDNLN
HHHHHHCCCHHHHHHHHHHHHHEEECCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCC
ISHILKRVESDLENGASVLELGGKSSRPGYADISPEEEWSRLKEPIAQIRKYFPKAVLAV
HHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE
DTDEAYVMGRVLEAGVDIINDIDGFDTADKLKVIEKYQPAVVAMNNGRAGFKYADNVYEE
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHH
LPLFFKDKKIELTQLGMNPEKISIDPGVGFFNGDSGSDSLQRVKTTELLSRLGLPVMIAI
CCCEECCCEEEEEECCCCCCEEEECCCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEE
SRKSFMGRLFNAQGEERLFSSLMLEGQMVADGGRILRVHDVKETKRLLDAIEIYKEF
CHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCEEEEECHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKILELNQESFSLKNIVIKFEELSNDELTGLQKKLYRIGSLAKLSENSLLAVLTIDELAK
CCEEECCCHHHHHHHHEEEEECCCCCHHHHHHHHHHHHCCHHEECCCCEEEEEEHHHHHH
LLNHLENIEVKNELELIYKRHQIIWSGKNFNFDLTRKSIVYSIVNVTPDSFYDGNPDNLN
HHHHHHCCCHHHHHHHHHHHHHEEECCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCC
ISHILKRVESDLENGASVLELGGKSSRPGYADISPEEEWSRLKEPIAQIRKYFPKAVLAV
HHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE
DTDEAYVMGRVLEAGVDIINDIDGFDTADKLKVIEKYQPAVVAMNNGRAGFKYADNVYEE
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHH
LPLFFKDKKIELTQLGMNPEKISIDPGVGFFNGDSGSDSLQRVKTTELLSRLGLPVMIAI
CCCEECCCEEEEEECCCCCCEEEECCCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEE
SRKSFMGRLFNAQGEERLFSSLMLEGQMVADGGRILRVHDVKETKRLLDAIEIYKEF
CHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCEEEEECHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1400191; 10761919 [H]