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The map label for this gene is hisC

Identifier: 125624120

GI number: 125624120

Start: 1267458

End: 1268528

Strand: Reverse

Name: hisC

Synonym: llmg_1298

Alternate gene names: 125624120

Gene position: 1268528-1267458 (Counterclockwise)

Preceding gene: 125624121

Following gene: 125624119

Centisome position: 50.15

GC content: 33.71

Gene sequence:

>1071_bases
ATGAGTTGGCAAAATAATCTGCGTTCTGTAAGCCCCTATATTGCAGGAGAACAAGCAGAACTTACTGACATGATTAAATT
AAACACTAATGAAAATCCATATCCACCCTCTTTGCAGGTCCAAAAAGTAATTGAAGATTTCAAATCTGACAACTTGCGAC
TTTATCCAAGTACTGACGCAAAAGTTTTGAGAAAAGCATTGGCCACGTATCATCATTTAAATACTGACCAAGTCTTTATT
GGAAATGGTTCTGACGAAGTTTTATCGCTTAGTTTTCTGACTTTTTTCAATAGTGAAAAACCACTTTTGATGCCTGATAT
TAGTTATTCTTTTTATCCAATTTATTGTGGACTTTATCATATTCCTTATCAAAAAATTCCTTTGGCTGATGATTTTAGTC
TGTCAGTAAACTCTTACTTTCAAGAGAATGGTGGAATTGTCATTGCCAATCCCAATGCGCCAACTGGTATGGCTATTAGC
CTGCAAGAAATAGAAGAAATTTTACAAAATAATCAGGATTCTATTGTTTTAATTGATGAAGCTTATATTGACTTTGGCGG
GGAATCTTGTCTTCCTTTGCTTGAAAAATTTGATAATTTAGTAGTTGTACAAACTTTTTTTAAATCTCGGAGTTTGGCTG
GAATTCGTTTGGGAGTCGCCTTTGGCTCAGCCGAAGCAATTGCTCATTTGTATGATATGAAAAATTCTTTTAATTCTTAT
CCAATTGATAGCTTGGCGCAAAAAATTGGCGAAGCGAGTTTAAATGACGAAACTTATTTTCAAAAGTCTGTCAGTAAAAT
TATTACTACTCGTGAGAATTTCAAAAAGGAATTGATAAAGCTTGGTTTTCAAGTGACTGATTCTAAAACAAATTTTGTTT
TCGTTCATCATCCCAAAGTAGATGCTACAACACTTTTCAAGGCACTCTATGAAGCAAAAATTATTGTCAGACATTGGAAT
CAAGCACGAATTTCTGATTGGTTACGGATTACGATTGGCACTGATAGAGAAATGAACACAGTGATTCAATTCTTAAAGGA
ATATTTAAAAAACAAGGAGAAAAGTTACTGA

Upstream 100 bases:

>100_bases
ATTAAGGTGGAACCACGACATTACCGTCCTTTAAGCCAAGTGCTTAAAGGCGCTTTTTTTGTATTATATTTATCATTTTT
ATTCTCGAAAGGAGAAACAT

Downstream 100 bases:

>100_bases
TGAAAAAAATGAACTATTTGCTCCCCGAAGAATCGGGTGAAATGACATTGTCAGGAATTACGACACTTCGCAAGATAGAA
CAGAAGTTGCGGAACTTGTT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSWQNNLRSVSPYIAGEQAELTDMIKLNTNENPYPPSLQVQKVIEDFKSDNLRLYPSTDAKVLRKALATYHHLNTDQVFI
GNGSDEVLSLSFLTFFNSEKPLLMPDISYSFYPIYCGLYHIPYQKIPLADDFSLSVNSYFQENGGIVIANPNAPTGMAIS
LQEIEEILQNNQDSIVLIDEAYIDFGGESCLPLLEKFDNLVVVQTFFKSRSLAGIRLGVAFGSAEAIAHLYDMKNSFNSY
PIDSLAQKIGEASLNDETYFQKSVSKIITTRENFKKELIKLGFQVTDSKTNFVFVHHPKVDATTLFKALYEAKIIVRHWN
QARISDWLRITIGTDREMNTVIQFLKEYLKNKEKSY

Sequences:

>Translated_356_residues
MSWQNNLRSVSPYIAGEQAELTDMIKLNTNENPYPPSLQVQKVIEDFKSDNLRLYPSTDAKVLRKALATYHHLNTDQVFI
GNGSDEVLSLSFLTFFNSEKPLLMPDISYSFYPIYCGLYHIPYQKIPLADDFSLSVNSYFQENGGIVIANPNAPTGMAIS
LQEIEEILQNNQDSIVLIDEAYIDFGGESCLPLLEKFDNLVVVQTFFKSRSLAGIRLGVAFGSAEAIAHLYDMKNSFNSY
PIDSLAQKIGEASLNDETYFQKSVSKIITTRENFKKELIKLGFQVTDSKTNFVFVHHPKVDATTLFKALYEAKIIVRHWN
QARISDWLRITIGTDREMNTVIQFLKEYLKNKEKSY
>Mature_355_residues
SWQNNLRSVSPYIAGEQAELTDMIKLNTNENPYPPSLQVQKVIEDFKSDNLRLYPSTDAKVLRKALATYHHLNTDQVFIG
NGSDEVLSLSFLTFFNSEKPLLMPDISYSFYPIYCGLYHIPYQKIPLADDFSLSVNSYFQENGGIVIANPNAPTGMAISL
QEIEEILQNNQDSIVLIDEAYIDFGGESCLPLLEKFDNLVVVQTFFKSRSLAGIRLGVAFGSAEAIAHLYDMKNSFNSYP
IDSLAQKIGEASLNDETYFQKSVSKIITTRENFKKELIKLGFQVTDSKTNFVFVHHPKVDATTLFKALYEAKIIVRHWNQ
ARISDWLRITIGTDREMNTVIQFLKEYLKNKEKSY

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=354, Percent_Identity=27.4011299435028, Blast_Score=125, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6322075, Length=378, Percent_Identity=29.6296296296296, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_LACLM (A2RKS5)

Other databases:

- EMBL:   AM406671
- RefSeq:   YP_001032603.1
- ProteinModelPortal:   A2RKS5
- SMR:   A2RKS5
- STRING:   A2RKS5
- GeneID:   4798509
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_1298
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   MQAELND
- ProtClustDB:   PRK05387
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40540; Mature: 40408

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWQNNLRSVSPYIAGEQAELTDMIKLNTNENPYPPSLQVQKVIEDFKSDNLRLYPSTDA
CCCCCCCHHCCCCCCCCCHHHEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCH
KVLRKALATYHHLNTDQVFIGNGSDEVLSLSFLTFFNSEKPLLMPDISYSFYPIYCGLYH
HHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEHHHHCCCCCEEECCCCCCEEEEEEEEEE
IPYQKIPLADDFSLSVNSYFQENGGIVIANPNAPTGMAISLQEIEEILQNNQDSIVLIDE
CCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCEEEEHHHHHHHHHCCCCCEEEEEE
AYIDFGGESCLPLLEKFDNLVVVQTFFKSRSLAGIRLGVAFGSAEAIAHLYDMKNSFNSY
EEECCCCCCHHHHHHHCCCEEEEEEHHHCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCC
PIDSLAQKIGEASLNDETYFQKSVSKIITTRENFKKELIKLGFQVTDSKTNFVFVHHPKV
CHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCCC
DATTLFKALYEAKIIVRHWNQARISDWLRITIGTDREMNTVIQFLKEYLKNKEKSY
CHHHHHHHHHHHHHEEHHCCCHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SWQNNLRSVSPYIAGEQAELTDMIKLNTNENPYPPSLQVQKVIEDFKSDNLRLYPSTDA
CCCCCCHHCCCCCCCCCHHHEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCH
KVLRKALATYHHLNTDQVFIGNGSDEVLSLSFLTFFNSEKPLLMPDISYSFYPIYCGLYH
HHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEHHHHCCCCCEEECCCCCCEEEEEEEEEE
IPYQKIPLADDFSLSVNSYFQENGGIVIANPNAPTGMAISLQEIEEILQNNQDSIVLIDE
CCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCEEEEHHHHHHHHHCCCCCEEEEEE
AYIDFGGESCLPLLEKFDNLVVVQTFFKSRSLAGIRLGVAFGSAEAIAHLYDMKNSFNSY
EEECCCCCCHHHHHHHCCCEEEEEEHHHCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCC
PIDSLAQKIGEASLNDETYFQKSVSKIITTRENFKKELIKLGFQVTDSKTNFVFVHHPKV
CHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCCC
DATTLFKALYEAKIIVRHWNQARISDWLRITIGTDREMNTVIQFLKEYLKNKEKSY
CHHHHHHHHHHHHHEEHHCCCHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA