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The map label for this gene is ilvC [H]

Identifier: 125624101

GI number: 125624101

Start: 1246815

End: 1247837

Strand: Reverse

Name: ilvC [H]

Synonym: llmg_1277

Alternate gene names: 125624101

Gene position: 1247837-1246815 (Counterclockwise)

Preceding gene: 125624102

Following gene: 125624100

Centisome position: 49.33

GC content: 41.64

Gene sequence:

>1023_bases
ATGGCAGTTACAATGTATTATGAAGAAGATGTAGAAGTAGCCGCACTCGCGGGTAAGAAAATCGCAGTGATTGGATATGG
CTCACAAGGACACGCTCATGCACAAAACTTGCGTGATTCTGGTCATGATGTGATTATTGGTGTCCGTCAGGGGAAATCTT
TTGATAAAGCAAAAGAAGATGGTTTTGAAACATTTGAAGTAGGAGAAGCAGTAGCTAAAGCTGACGTCATTATGGTTCTG
GCACCTGATGAACTTCAACAATCTATTTATGAAGAGGACATAAAACCAAATTTGAAAGCAGGTTCAGCACTTGGTTTTGC
CCATGGTTTCAATATTCATTTTGGCTATATTGAAGTTCCAGAAGATGTTGATGTCTTCATGGTTGCGCCAAAAGCGCCGG
GACATCTCGTTCGGCGGACTTTTACCGAAGGTTTCGGAACGCCAGCTTTGTTCGTTTCGCATCAAAATGCCACTGGTCAT
GCGCGTGAAATTGCCATGGACTGGGCCAAAGGAATTGGCTGTGCCCGTGTCGGTATCATTGAAACAACTTTCAAAGAAGA
AACAGAAGAAGATTTGTTTGGCGAACAGGCCGTGCTTTGTGGCGGTTTGACAGCACTTGTTGAAGCTGGTTTTGAAACAC
TGACAGAAGCTGGATATGCTGGCGAATTGGCTTACTTTGAAGTGCTGCATGAAATGAAATTGATTGTTGACCTTATGTAC
GAAGGTGGTTTCACTAAAATGCGTCAGTCAATCTCAAACACTGCCGAATTTGGTGATTATGTGACTGGACCACGCATTAT
TACTGACGAAGTTAAAAAGAATATGAAACTCGTGTTGGCTGACATTCAATCAGGAAAATTTGCGCAAGATTTCGTTGATG
ATTTCAAAGCTGGACGTCCAAAATTAACTGCTTATCGTGAAGCAGCTAAAAATCTGGAAATTGAAAAAATCGGTGCAGAA
CTACGTAAAGCAATGCCATTTACACAATCTGGTGATGACGACGCCTTTAAAATTTATCAATAA

Upstream 100 bases:

>100_bases
CTTATGGCATTCTTAATATGGCTCGGACAGGCAGTGCAGGTTTTGAGCGGGGATAAATTTAAAAAAGTTAACAAATAAAT
AGAAAATAGAGGAAACAAAA

Downstream 100 bases:

>100_bases
TTTATCTTTTTAACATAATAAAGAAAACATAAAACTACTTTATGGAGGAATAAGATAAATGATAAATGCCAAAGAGGTCG
AAGAAGCCTATGATTTGTTA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MAVTMYYEEDVEVAALAGKKIAVIGYGSQGHAHAQNLRDSGHDVIIGVRQGKSFDKAKEDGFETFEVGEAVAKADVIMVL
APDELQQSIYEEDIKPNLKAGSALGFAHGFNIHFGYIEVPEDVDVFMVAPKAPGHLVRRTFTEGFGTPALFVSHQNATGH
AREIAMDWAKGIGCARVGIIETTFKEETEEDLFGEQAVLCGGLTALVEAGFETLTEAGYAGELAYFEVLHEMKLIVDLMY
EGGFTKMRQSISNTAEFGDYVTGPRIITDEVKKNMKLVLADIQSGKFAQDFVDDFKAGRPKLTAYREAAKNLEIEKIGAE
LRKAMPFTQSGDDDAFKIYQ

Sequences:

>Translated_340_residues
MAVTMYYEEDVEVAALAGKKIAVIGYGSQGHAHAQNLRDSGHDVIIGVRQGKSFDKAKEDGFETFEVGEAVAKADVIMVL
APDELQQSIYEEDIKPNLKAGSALGFAHGFNIHFGYIEVPEDVDVFMVAPKAPGHLVRRTFTEGFGTPALFVSHQNATGH
AREIAMDWAKGIGCARVGIIETTFKEETEEDLFGEQAVLCGGLTALVEAGFETLTEAGYAGELAYFEVLHEMKLIVDLMY
EGGFTKMRQSISNTAEFGDYVTGPRIITDEVKKNMKLVLADIQSGKFAQDFVDDFKAGRPKLTAYREAAKNLEIEKIGAE
LRKAMPFTQSGDDDAFKIYQ
>Mature_339_residues
AVTMYYEEDVEVAALAGKKIAVIGYGSQGHAHAQNLRDSGHDVIIGVRQGKSFDKAKEDGFETFEVGEAVAKADVIMVLA
PDELQQSIYEEDIKPNLKAGSALGFAHGFNIHFGYIEVPEDVDVFMVAPKAPGHLVRRTFTEGFGTPALFVSHQNATGHA
REIAMDWAKGIGCARVGIIETTFKEETEEDLFGEQAVLCGGLTALVEAGFETLTEAGYAGELAYFEVLHEMKLIVDLMYE
GGFTKMRQSISNTAEFGDYVTGPRIITDEVKKNMKLVLADIQSGKFAQDFVDDFKAGRPKLTAYREAAKNLEIEKIGAEL
RKAMPFTQSGDDDAFKIYQ

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=306, Percent_Identity=34.9673202614379, Blast_Score=159, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323387, Length=306, Percent_Identity=33.6601307189542, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 37259; Mature: 37127

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTMYYEEDVEVAALAGKKIAVIGYGSQGHAHAQNLRDSGHDVIIGVRQGKSFDKAKED
CEEEEEECCCCEEEEECCCEEEEEEECCCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHC
GFETFEVGEAVAKADVIMVLAPDELQQSIYEEDIKPNLKAGSALGFAHGFNIHFGYIEVP
CCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEEEEEECC
EDVDVFMVAPKAPGHLVRRTFTEGFGTPALFVSHQNATGHAREIAMDWAKGIGCARVGII
CCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEE
ETTFKEETEEDLFGEQAVLCGGLTALVEAGFETLTEAGYAGELAYFEVLHEMKLIVDLMY
EHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGFTKMRQSISNTAEFGDYVTGPRIITDEVKKNMKLVLADIQSGKFAQDFVDDFKAGRP
CCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCC
KLTAYREAAKNLEIEKIGAELRKAMPFTQSGDDDAFKIYQ
CHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEECC
>Mature Secondary Structure 
AVTMYYEEDVEVAALAGKKIAVIGYGSQGHAHAQNLRDSGHDVIIGVRQGKSFDKAKED
EEEEEECCCCEEEEECCCEEEEEEECCCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHC
GFETFEVGEAVAKADVIMVLAPDELQQSIYEEDIKPNLKAGSALGFAHGFNIHFGYIEVP
CCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEEEEEECC
EDVDVFMVAPKAPGHLVRRTFTEGFGTPALFVSHQNATGHAREIAMDWAKGIGCARVGII
CCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEE
ETTFKEETEEDLFGEQAVLCGGLTALVEAGFETLTEAGYAGELAYFEVLHEMKLIVDLMY
EHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGFTKMRQSISNTAEFGDYVTGPRIITDEVKKNMKLVLADIQSGKFAQDFVDDFKAGRP
CCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCC
KLTAYREAAKNLEIEKIGAELRKAMPFTQSGDDDAFKIYQ
CHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400210; 11337471 [H]