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The map label for this gene is dltA [H]

Identifier: 125624045

GI number: 125624045

Start: 1186831

End: 1188330

Strand: Direct

Name: dltA [H]

Synonym: llmg_1219

Alternate gene names: 125624045

Gene position: 1186831-1188330 (Clockwise)

Preceding gene: 125624044

Following gene: 125624046

Centisome position: 46.92

GC content: 36.2

Gene sequence:

>1500_bases
ATGAAATTATTAGAACAAATTTTTGAAATTGCAAACAAAAACCCTGACCTTATCGTGCTTGCCGAGCGTGAGCAGAAATT
TACTTACCGCCAATTATTCGTCGCTGTATCGGAGATTTCAAAACAAATCAAGGAGCGGACATTAGTGAATCGTCCAATCC
TAATTTTTGGTAAAAACGACTTTATTAGTTTAGCAGCAATGCTAGCAGCAAATTTGACTGGACATGCTTATATTCCAGTC
GATGCGCACACTCCATTTGAGCGGACAGAAATGATTAATTCAGCAGCAAAACCAGCAGTTGTGATAACGACTGTTAAACT
TTCAGAAGATTTTTCTGCTCTTTTTACTGACAGAATCTCAGTTAATCTAAACACTCTATCTCTCGATGAAAAACTTCCAG
AACTTGATTTTAGTCAAGCCGTTTCTGGTACTGACAGCAATTATATTATCTATACTTCGGGAACAACTGGAGTACCAAAA
GGTGTTGAAGTCAGCCATGATAATCTTGTGACCTTCACAAACTGGATGAACAACGACTTTAACAAAATTGAAAATAATCA
AATTTTATCACAAGCCCTTTATAGCTTTGACTTATCAATTTTTAGTTTGTATCCAAGCCTGACAACTGGTGGAACATTAG
TCTCACTTTCACGTGACGAAACAACAAACTTTAAATTGCTTTTTGAACGATTGAATTCAACAGTCATCAATACTTGGATT
TCGACACCATCATTTGTTGATATTTGCTTATTGGATCCCTCATTCACAGAGAAAGAACATCCTAATTTAGTACAATTCAT
CTTTTGTGGAGAAGAATTGACGAAAAAAACAGCTGAAAAATTACTGACAGCATTTCCGTCAGCAACTATTTATAATACTT
ATGGTCCAACAGAAGCAACAGGAGCCATTTCATCAATAAAAGTGACTGAAAAATTACTGACAGAAAATGACCGTCTTCCT
ATTGGTTTTGCCAAATCTGGTGTAGAACTAAAAATCATGGATGGTGAAATCATTATTATCGGTGATTCCGTTGCTAAAGG
TTACTTTGAAAACCCAGAGAAAACTGCTCAAGCCTTTTTCACAGTAGATGGAAAACCTGCCTATCATACAGGCGATGCCG
GTTCACTAACTGATGAGGGCATGCTTCGTTATCAAGGACGAATTGATTTTCAAGTCAAATTTAATGGATTTAGGATTGAA
CTTCAAGATATTGAAGCTAATATTCAAAACCTAAAAGATATCGAAAAATCAGTGGTTTTACCTAAAACGAATGACCAACA
TAAAGTTACAGCTTTAATCGCTTATCTTGAAAGTGACAAAACATTTGCGGATCGTGCTGAAGAACGAGCCTTTACAAAGC
AACTCAAAGCAGAGCTTTCAAAAACAATTATGGATTATATGATGCCAACCAAATTTATTTATCTCAAAAAGTTCCCTCTG
AATCAAAATGGAAAAGTTGACCGTAAGGCACTCGCCCAAAAAGAGCGAGGTGACAACTAG

Upstream 100 bases:

>100_bases
AATTATATTAATTCTACTCTATCTTTATTCCTACAGTCATACTGGGGGAGCACACTTTATTTACAACGAATTTTAGAGAG
ATTTATTGGAGAAGTTAATT

Downstream 100 bases:

>100_bases
TGCAACCCTATTCAACTCCCTTTTACTTCCTGATTCTAGGCCTGGCTTTAATTCCGATTGTTATTGCTCAGCTCCTTGGC
AAAAAGCTTATGTGGTATCA

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MKLLEQIFEIANKNPDLIVLAEREQKFTYRQLFVAVSEISKQIKERTLVNRPILIFGKNDFISLAAMLAANLTGHAYIPV
DAHTPFERTEMINSAAKPAVVITTVKLSEDFSALFTDRISVNLNTLSLDEKLPELDFSQAVSGTDSNYIIYTSGTTGVPK
GVEVSHDNLVTFTNWMNNDFNKIENNQILSQALYSFDLSIFSLYPSLTTGGTLVSLSRDETTNFKLLFERLNSTVINTWI
STPSFVDICLLDPSFTEKEHPNLVQFIFCGEELTKKTAEKLLTAFPSATIYNTYGPTEATGAISSIKVTEKLLTENDRLP
IGFAKSGVELKIMDGEIIIIGDSVAKGYFENPEKTAQAFFTVDGKPAYHTGDAGSLTDEGMLRYQGRIDFQVKFNGFRIE
LQDIEANIQNLKDIEKSVVLPKTNDQHKVTALIAYLESDKTFADRAEERAFTKQLKAELSKTIMDYMMPTKFIYLKKFPL
NQNGKVDRKALAQKERGDN

Sequences:

>Translated_499_residues
MKLLEQIFEIANKNPDLIVLAEREQKFTYRQLFVAVSEISKQIKERTLVNRPILIFGKNDFISLAAMLAANLTGHAYIPV
DAHTPFERTEMINSAAKPAVVITTVKLSEDFSALFTDRISVNLNTLSLDEKLPELDFSQAVSGTDSNYIIYTSGTTGVPK
GVEVSHDNLVTFTNWMNNDFNKIENNQILSQALYSFDLSIFSLYPSLTTGGTLVSLSRDETTNFKLLFERLNSTVINTWI
STPSFVDICLLDPSFTEKEHPNLVQFIFCGEELTKKTAEKLLTAFPSATIYNTYGPTEATGAISSIKVTEKLLTENDRLP
IGFAKSGVELKIMDGEIIIIGDSVAKGYFENPEKTAQAFFTVDGKPAYHTGDAGSLTDEGMLRYQGRIDFQVKFNGFRIE
LQDIEANIQNLKDIEKSVVLPKTNDQHKVTALIAYLESDKTFADRAEERAFTKQLKAELSKTIMDYMMPTKFIYLKKFPL
NQNGKVDRKALAQKERGDN
>Mature_499_residues
MKLLEQIFEIANKNPDLIVLAEREQKFTYRQLFVAVSEISKQIKERTLVNRPILIFGKNDFISLAAMLAANLTGHAYIPV
DAHTPFERTEMINSAAKPAVVITTVKLSEDFSALFTDRISVNLNTLSLDEKLPELDFSQAVSGTDSNYIIYTSGTTGVPK
GVEVSHDNLVTFTNWMNNDFNKIENNQILSQALYSFDLSIFSLYPSLTTGGTLVSLSRDETTNFKLLFERLNSTVINTWI
STPSFVDICLLDPSFTEKEHPNLVQFIFCGEELTKKTAEKLLTAFPSATIYNTYGPTEATGAISSIKVTEKLLTENDRLP
IGFAKSGVELKIMDGEIIIIGDSVAKGYFENPEKTAQAFFTVDGKPAYHTGDAGSLTDEGMLRYQGRIDFQVKFNGFRIE
LQDIEANIQNLKDIEKSVVLPKTNDQHKVTALIAYLESDKTFADRAEERAFTKQLKAELSKTIMDYMMPTKFIYLKKFPL
NQNGKVDRKALAQKERGDN

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=395, Percent_Identity=24.8101265822785, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI45580730, Length=367, Percent_Identity=22.6158038147139, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI115511026, Length=375, Percent_Identity=24.2666666666667, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI38505220, Length=440, Percent_Identity=22.2727272727273, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1786801, Length=522, Percent_Identity=28.9272030651341, Blast_Score=168, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI32563687, Length=488, Percent_Identity=26.0245901639344, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17558820, Length=515, Percent_Identity=26.9902912621359, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=485, Percent_Identity=25.5670103092783, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17556356, Length=353, Percent_Identity=24.6458923512748, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=378, Percent_Identity=24.0740740740741, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319591, Length=567, Percent_Identity=24.1622574955908, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319699, Length=373, Percent_Identity=24.3967828418231, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24648676, Length=459, Percent_Identity=29.8474945533769, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI18859661, Length=418, Percent_Identity=21.2918660287081, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356947, Length=361, Percent_Identity=25.7617728531856, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21355181, Length=398, Percent_Identity=23.6180904522613, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356441, Length=293, Percent_Identity=23.8907849829352, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24648260, Length=484, Percent_Identity=22.1074380165289, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.1.1.13 [H]

Molecular weight: Translated: 55962; Mature: 55962

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLEQIFEIANKNPDLIVLAEREQKFTYRQLFVAVSEISKQIKERTLVNRPILIFGKND
CHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCH
FISLAAMLAANLTGHAYIPVDAHTPFERTEMINSAAKPAVVITTVKLSEDFSALFTDRIS
HHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHEEE
VNLNTLSLDEKLPELDFSQAVSGTDSNYIIYTSGTTGVPKGVEVSHDNLVTFTNWMNNDF
EEEEEEECHHHCCCCCHHHHCCCCCCCEEEEECCCCCCCCCCEECCCCEEEEECCCCCCH
NKIENNQILSQALYSFDLSIFSLYPSLTTGGTLVSLSRDETTNFKLLFERLNSTVINTWI
HHHCCHHHHHHHHHHHCCHHHEECCCCCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHC
STPSFVDICLLDPSFTEKEHPNLVQFIFCGEELTKKTAEKLLTAFPSATIYNTYGPTEAT
CCCCEEEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
GAISSIKVTEKLLTENDRLPIGFAKSGVELKIMDGEIIIIGDSVAKGYFENPEKTAQAFF
CCHHHHHHHHHHHCCCCCCCEEEECCCCEEEEECCEEEEEECHHHCCCCCCCHHHEEEEE
TVDGKPAYHTGDAGSLTDEGMLRYQGRIDFQVKFNGFRIELQDIEANIQNLKDIEKSVVL
EECCCCCCCCCCCCCCCCCCEEEECCEEEEEEEECCEEEEEEHHHHHHHHHHHHHHHEEC
PKTNDQHKVTALIAYLESDKTFADRAEERAFTKQLKAELSKTIMDYMMPTKFIYLKKFPL
CCCCCCHHHEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
NQNGKVDRKALAQKERGDN
CCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKLLEQIFEIANKNPDLIVLAEREQKFTYRQLFVAVSEISKQIKERTLVNRPILIFGKND
CHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCH
FISLAAMLAANLTGHAYIPVDAHTPFERTEMINSAAKPAVVITTVKLSEDFSALFTDRIS
HHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHEEE
VNLNTLSLDEKLPELDFSQAVSGTDSNYIIYTSGTTGVPKGVEVSHDNLVTFTNWMNNDF
EEEEEEECHHHCCCCCHHHHCCCCCCCEEEEECCCCCCCCCCEECCCCEEEEECCCCCCH
NKIENNQILSQALYSFDLSIFSLYPSLTTGGTLVSLSRDETTNFKLLFERLNSTVINTWI
HHHCCHHHHHHHHHHHCCHHHEECCCCCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHC
STPSFVDICLLDPSFTEKEHPNLVQFIFCGEELTKKTAEKLLTAFPSATIYNTYGPTEAT
CCCCEEEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
GAISSIKVTEKLLTENDRLPIGFAKSGVELKIMDGEIIIIGDSVAKGYFENPEKTAQAFF
CCHHHHHHHHHHHCCCCCCCEEEECCCCEEEEECCEEEEEECHHHCCCCCCCHHHEEEEE
TVDGKPAYHTGDAGSLTDEGMLRYQGRIDFQVKFNGFRIELQDIEANIQNLKDIEKSVVL
EECCCCCCCCCCCCCCCCCCEEEECCEEEEEEEECCEEEEEEHHHHHHHHHHHHHHHEEC
PKTNDQHKVTALIAYLESDKTFADRAEERAFTKQLKAELSKTIMDYMMPTKFIYLKKFPL
CCCCCCHHHEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
NQNGKVDRKALAQKERGDN
CCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]