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The map label for this gene is thiD1 [H]

Identifier: 125624043

GI number: 125624043

Start: 1185043

End: 1185843

Strand: Direct

Name: thiD1 [H]

Synonym: llmg_1217

Alternate gene names: 125624043

Gene position: 1185043-1185843 (Clockwise)

Preceding gene: 125624042

Following gene: 125624044

Centisome position: 46.85

GC content: 36.95

Gene sequence:

>801_bases
ATGATTACTATTCCACAGGTTGTGACAATTGCTGGAATTGATTCTTCTGGTGGTGCCGGAATTAATGCGGACATGAAAAC
TTTTCATAATCAAAAAGTTTGTTCAGCAACGATCGTAACAGGCTTAACGGCACAAAATAATTATGGCGTACAAAAAATTT
TACCGACAAATAAAGATTTTATTTTAGCTCAATTTGACTCGGTATTTTCTGATTTGGAAATTTCGGCAGCCAAAACAGGA
GCACTTTTTGATACTGCTCAAGTTGAAGGGGTGATTCAAGGATTAAAAAAATACAAACCAAAACATTTGGTGGTTGACCC
AGTAATGGTGGCTAAAGGTGGGGCTATTCTTTTAACGAAGGAAGCGATTGACTTGATAAAAGATGAGTTACTTCCCTTAG
CAGAGTTAGTTACTCCTAATTTGGAGGAAGCAGAGGTCATGACCGGCTATCAAATTACTGACGAAAATTCGCTTTTAAAT
TCGCTTCATGATATTCAAAAATTAGGAGCAAAAAATGTTCTTATTAAGGGAGGACATGGTCAAGGAGAACTTGTCAGAGA
TTATTTATTACTGACGGATGGTTCTGTCAGTACTTATGACTCTAAAAGATTACTGACAGAAAGAACACATGGAACTGGAG
ATACACTTTCTTCCTATATTACTGCTCATTTAGCTATGGGAGAAAGTCTGAGAGAAATCATGCCTAATGCGAAAGCTTTT
ATTAGTGAGGCAATTTCTAAAACGATTATGGTGGGGCATGGTCATGGGCCATTGAATCATTGGGTGAATATTAATGACTA
A

Upstream 100 bases:

>100_bases
AGCGACCAAACAAGTGCAAAATTTACCAGGTAATTTTGTCAATAGTCTTCTGGACACACTTTATCAAACGACACACGAAA
TAAAATAAAGGAGTATTACA

Downstream 100 bases:

>100_bases
GAAAACTTTAGATTTAAGTGTTTATTTTATTGCCGGATCACAAAATTTTTCAGAATGTTCACTAGATGAAGCAACGCAAA
AGATTGCTTTAATTATAAAA

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MITIPQVVTIAGIDSSGGAGINADMKTFHNQKVCSATIVTGLTAQNNYGVQKILPTNKDFILAQFDSVFSDLEISAAKTG
ALFDTAQVEGVIQGLKKYKPKHLVVDPVMVAKGGAILLTKEAIDLIKDELLPLAELVTPNLEEAEVMTGYQITDENSLLN
SLHDIQKLGAKNVLIKGGHGQGELVRDYLLLTDGSVSTYDSKRLLTERTHGTGDTLSSYITAHLAMGESLREIMPNAKAF
ISEAISKTIMVGHGHGPLNHWVNIND

Sequences:

>Translated_266_residues
MITIPQVVTIAGIDSSGGAGINADMKTFHNQKVCSATIVTGLTAQNNYGVQKILPTNKDFILAQFDSVFSDLEISAAKTG
ALFDTAQVEGVIQGLKKYKPKHLVVDPVMVAKGGAILLTKEAIDLIKDELLPLAELVTPNLEEAEVMTGYQITDENSLLN
SLHDIQKLGAKNVLIKGGHGQGELVRDYLLLTDGSVSTYDSKRLLTERTHGTGDTLSSYITAHLAMGESLREIMPNAKAF
ISEAISKTIMVGHGHGPLNHWVNIND
>Mature_266_residues
MITIPQVVTIAGIDSSGGAGINADMKTFHNQKVCSATIVTGLTAQNNYGVQKILPTNKDFILAQFDSVFSDLEISAAKTG
ALFDTAQVEGVIQGLKKYKPKHLVVDPVMVAKGGAILLTKEAIDLIKDELLPLAELVTPNLEEAEVMTGYQITDENSLLN
SLHDIQKLGAKNVLIKGGHGQGELVRDYLLLTDGSVSTYDSKRLLTERTHGTGDTLSSYITAHLAMGESLREIMPNAKAF
ISEAISKTIMVGHGHGPLNHWVNIND

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=256, Percent_Identity=39.0625, Blast_Score=179, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6325378, Length=284, Percent_Identity=33.4507042253521, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324517, Length=281, Percent_Identity=34.1637010676157, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324997, Length=276, Percent_Identity=34.0579710144928, Blast_Score=108, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28591; Mature: 28591

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIPQVVTIAGIDSSGGAGINADMKTFHNQKVCSATIVTGLTAQNNYGVQKILPTNKDF
CCCCCCEEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHHCEECCCCCCCEEECCCCCCE
ILAQFDSVFSDLEISAAKTGALFDTAQVEGVIQGLKKYKPKHLVVDPVMVAKGGAILLTK
EEEEHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCEEEECCCEEEEEH
EAIDLIKDELLPLAELVTPNLEEAEVMTGYQITDENSLLNSLHDIQKLGAKNVLIKGGHG
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEECCHHHHHHHHHHHHHCCCCCEEEECCCC
QGELVRDYLLLTDGSVSTYDSKRLLTERTHGTGDTLSSYITAHLAMGESLREIMPNAKAF
CHHHHHHEEEEECCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ISEAISKTIMVGHGHGPLNHWVNIND
HHHHHHHEEEEECCCCCCCCCEECCC
>Mature Secondary Structure
MITIPQVVTIAGIDSSGGAGINADMKTFHNQKVCSATIVTGLTAQNNYGVQKILPTNKDF
CCCCCCEEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHHCEECCCCCCCEEECCCCCCE
ILAQFDSVFSDLEISAAKTGALFDTAQVEGVIQGLKKYKPKHLVVDPVMVAKGGAILLTK
EEEEHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCEEEECCCEEEEEH
EAIDLIKDELLPLAELVTPNLEEAEVMTGYQITDENSLLNSLHDIQKLGAKNVLIKGGHG
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEECCHHHHHHHHHHHHHCCCCCEEEECCCC
QGELVRDYLLLTDGSVSTYDSKRLLTERTHGTGDTLSSYITAHLAMGESLREIMPNAKAF
CHHHHHHEEEEECCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ISEAISKTIMVGHGHGPLNHWVNIND
HHHHHHHEEEEECCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]