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The map label for this gene is ycnB [H]

Identifier: 125624038

GI number: 125624038

Start: 1177542

End: 1179101

Strand: Direct

Name: ycnB [H]

Synonym: llmg_1210

Alternate gene names: 125624038

Gene position: 1177542-1179101 (Clockwise)

Preceding gene: 125624037

Following gene: 125624039

Centisome position: 46.55

GC content: 40.26

Gene sequence:

>1560_bases
ATGCCTGAACTAATGGGAAAAGACTATTCAAAAGATATTCATGGCAATCATTATTTTAGAAATGTCATGTTTGCAATGAT
TTTGATTGGGACCTTTGCTGGAATGTTAGGACAAACGTTTTTATCTACAGCTTACCCAACCTTGATGGACAAATTTAACA
TCAGCCTCTCCACAGCACAAGGGGCAACGACATGGTACCTGCTTGCTAATGGAATTATGGTTCCAGTATCAGCTTATCTG
ACGACCAAAATTCCGACTCGTTGGTTATTCATGATTGCCTATGGATTTACAGCTGCTGGCACATTGATTGCCATGGTTGC
ACCCACTTCCAACTACAATATTTTCCTTTTAGGTCGTGTAGTGATGGCGATGGGCGTTGGAATTTCATTACCACTGATGA
TGACTGTTATCACAAACATCTTTCCACCTGAAAAAATCGGAGTTCCAATGGGAATGGGCGGACTTGTGATTGGACTTGCT
CCTGCGATTGGTCCTACTTATGGGGGCTGGATTTTATCTGGAAATACAAAGTTTTTAGGAATTTTACAATTGGGTGATTG
GCGCACACTTTTTCTTGCTCCCTTTGTTTTACTGATTATTGTGACCGTTTTGACCCCATTTTTAATGGCGGATGTCCTGC
CTAACCGAAATATGAAACTTGATTTTATTTCATTACTAGAATCGCTACTTGGATTTGGTTTATTTTTATACGGTTTCACT
AATGTCGGAAATGAAGGCTGGGGAGACGCTCAGAGCGTTATTGCTCCAATTATTATTGGATTGGTCATTATTGCTTTCTT
TATTCGTCGTCAACTTCACATGGCGGATCCTTTCCTTGATTTGTACGTCTTTAAAATCAAACAATTTACGGTTACTACAA
TCGCAGCAGCGATTAATACAATGGCAATGATGGGCGTTGAGATGATGCTGCCAACTTACATCCAAAATGTTCACGGATTA
ACAGCTTTACAATCTGGATTATTACTTTTACCTGGTTCGGTCATGATGGCGTTAATGTCGCCTATCGCGGGGGGAATTTA
TGATAAATTTGGTGCAAAGAAATTAAGTTTTATTGGTTTTATTCTCTTAGCCATCGGAACTTTGCCTTATCTCTTCTTGA
CGGCAACAACACCAGAGGCTTTTATTACCATTACTTATTGGGTGCGTTTTGTTGCGATTGGTTTAATCATGATGCCTTTA
ATCACTTCGGGTATGAATGCTTTGCCAGTTGAAAAATCAGCACAGGGTTCTGCTTCAAACAATACGGTACGGATGATCGC
GTCCTCTGTTGTTGTTGCGATATTGGCCTCAGTTACAACCAATGTCATCAATAGTACGAAACCCGCACATCATCTGTCAA
CGACTAATCCGCTTCAATATGCGGATAAGATGATTCAAGCATCACTCAATGGATTTCATGTTTCATTTGGAATCGCATTT
GGCTTTGCTGTATTAGGAATCTTCGTAGCACTCTTTTTGCATAAAGGAAAGGTCGCACCAGCGCCTGTACGAGAAGCTAA
TAAACAAGAAGTCACAGAAGAAGGAGGTCAAAAATCATGA

Upstream 100 bases:

>100_bases
AGCAATGGGAGAAGAGAGAACTCAACAATTTATCGAAGCTTGGGCGCTCTTTATACAAACGAGCATGTCAATCTTAGAAC
AAGAAAAGGAGGAACAATAA

Downstream 100 bases:

>100_bases
TACTTTTCATTATTATATTAGTTGTTATTTTGATGATTGTGGGTTTCTTCTACATCAAAGGTTCCACAGGAAATATCCTT
GGCGGAATTGCTACCCTTCT

Product: multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MPELMGKDYSKDIHGNHYFRNVMFAMILIGTFAGMLGQTFLSTAYPTLMDKFNISLSTAQGATTWYLLANGIMVPVSAYL
TTKIPTRWLFMIAYGFTAAGTLIAMVAPTSNYNIFLLGRVVMAMGVGISLPLMMTVITNIFPPEKIGVPMGMGGLVIGLA
PAIGPTYGGWILSGNTKFLGILQLGDWRTLFLAPFVLLIIVTVLTPFLMADVLPNRNMKLDFISLLESLLGFGLFLYGFT
NVGNEGWGDAQSVIAPIIIGLVIIAFFIRRQLHMADPFLDLYVFKIKQFTVTTIAAAINTMAMMGVEMMLPTYIQNVHGL
TALQSGLLLLPGSVMMALMSPIAGGIYDKFGAKKLSFIGFILLAIGTLPYLFLTATTPEAFITITYWVRFVAIGLIMMPL
ITSGMNALPVEKSAQGSASNNTVRMIASSVVVAILASVTTNVINSTKPAHHLSTTNPLQYADKMIQASLNGFHVSFGIAF
GFAVLGIFVALFLHKGKVAPAPVREANKQEVTEEGGQKS

Sequences:

>Translated_519_residues
MPELMGKDYSKDIHGNHYFRNVMFAMILIGTFAGMLGQTFLSTAYPTLMDKFNISLSTAQGATTWYLLANGIMVPVSAYL
TTKIPTRWLFMIAYGFTAAGTLIAMVAPTSNYNIFLLGRVVMAMGVGISLPLMMTVITNIFPPEKIGVPMGMGGLVIGLA
PAIGPTYGGWILSGNTKFLGILQLGDWRTLFLAPFVLLIIVTVLTPFLMADVLPNRNMKLDFISLLESLLGFGLFLYGFT
NVGNEGWGDAQSVIAPIIIGLVIIAFFIRRQLHMADPFLDLYVFKIKQFTVTTIAAAINTMAMMGVEMMLPTYIQNVHGL
TALQSGLLLLPGSVMMALMSPIAGGIYDKFGAKKLSFIGFILLAIGTLPYLFLTATTPEAFITITYWVRFVAIGLIMMPL
ITSGMNALPVEKSAQGSASNNTVRMIASSVVVAILASVTTNVINSTKPAHHLSTTNPLQYADKMIQASLNGFHVSFGIAF
GFAVLGIFVALFLHKGKVAPAPVREANKQEVTEEGGQKS
>Mature_518_residues
PELMGKDYSKDIHGNHYFRNVMFAMILIGTFAGMLGQTFLSTAYPTLMDKFNISLSTAQGATTWYLLANGIMVPVSAYLT
TKIPTRWLFMIAYGFTAAGTLIAMVAPTSNYNIFLLGRVVMAMGVGISLPLMMTVITNIFPPEKIGVPMGMGGLVIGLAP
AIGPTYGGWILSGNTKFLGILQLGDWRTLFLAPFVLLIIVTVLTPFLMADVLPNRNMKLDFISLLESLLGFGLFLYGFTN
VGNEGWGDAQSVIAPIIIGLVIIAFFIRRQLHMADPFLDLYVFKIKQFTVTTIAAAINTMAMMGVEMMLPTYIQNVHGLT
ALQSGLLLLPGSVMMALMSPIAGGIYDKFGAKKLSFIGFILLAIGTLPYLFLTATTPEAFITITYWVRFVAIGLIMMPLI
TSGMNALPVEKSAQGSASNNTVRMIASSVVVAILASVTTNVINSTKPAHHLSTTNPLQYADKMIQASLNGFHVSFGIAFG
FAVLGIFVALFLHKGKVAPAPVREANKQEVTEEGGQKS

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=464, Percent_Identity=25.2155172413793, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788710, Length=445, Percent_Identity=22.247191011236, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI87081983, Length=335, Percent_Identity=25.9701492537313, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 56053; Mature: 55922

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELMGKDYSKDIHGNHYFRNVMFAMILIGTFAGMLGQTFLSTAYPTLMDKFNISLSTAQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCC
GATTWYLLANGIMVPVSAYLTTKIPTRWLFMIAYGFTAAGTLIAMVAPTSNYNIFLLGRV
CCEEEEEECCCHHEEHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEHHHH
VMAMGVGISLPLMMTVITNIFPPEKIGVPMGMGGLVIGLAPAIGPTYGGWILSGNTKFLG
HHHHCCCCHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCEEEE
ILQLGDWRTLFLAPFVLLIIVTVLTPFLMADVLPNRNMKLDFISLLESLLGFGLFLYGFT
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
NVGNEGWGDAQSVIAPIIIGLVIIAFFIRRQLHMADPFLDLYVFKIKQFTVTTIAAAINT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
MAMMGVEMMLPTYIQNVHGLTALQSGLLLLPGSVMMALMSPIAGGIYDKFGAKKLSFIGF
HHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHCHHHHHHCCHHHHHHHH
ILLAIGTLPYLFLTATTPEAFITITYWVRFVAIGLIMMPLITSGMNALPVEKSAQGSASN
HHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NTVRMIASSVVVAILASVTTNVINSTKPAHHLSTTNPLQYADKMIQASLNGFHVSFGIAF
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHH
GFAVLGIFVALFLHKGKVAPAPVREANKQEVTEEGGQKS
HHHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHCCCCCC
>Mature Secondary Structure 
PELMGKDYSKDIHGNHYFRNVMFAMILIGTFAGMLGQTFLSTAYPTLMDKFNISLSTAQ
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCC
GATTWYLLANGIMVPVSAYLTTKIPTRWLFMIAYGFTAAGTLIAMVAPTSNYNIFLLGRV
CCEEEEEECCCHHEEHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEHHHH
VMAMGVGISLPLMMTVITNIFPPEKIGVPMGMGGLVIGLAPAIGPTYGGWILSGNTKFLG
HHHHCCCCHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCEEEE
ILQLGDWRTLFLAPFVLLIIVTVLTPFLMADVLPNRNMKLDFISLLESLLGFGLFLYGFT
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
NVGNEGWGDAQSVIAPIIIGLVIIAFFIRRQLHMADPFLDLYVFKIKQFTVTTIAAAINT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
MAMMGVEMMLPTYIQNVHGLTALQSGLLLLPGSVMMALMSPIAGGIYDKFGAKKLSFIGF
HHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHCHHHHHHCCHHHHHHHH
ILLAIGTLPYLFLTATTPEAFITITYWVRFVAIGLIMMPLITSGMNALPVEKSAQGSASN
HHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NTVRMIASSVVVAILASVTTNVINSTKPAHHLSTTNPLQYADKMIQASLNGFHVSFGIAF
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHH
GFAVLGIFVALFLHKGKVAPAPVREANKQEVTEEGGQKS
HHHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]